Modern Nmr Approaches To The Structure Elucidation Of Natural Products Data Acquisition And Applications To Compound Classes

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Modern NMR Approaches to the Structure Elucidation of Natural Products

Antony Williams,Gary Martin,David Rovnyak
Modern NMR Approaches to the Structure Elucidation of Natural Products Book PDF

Author : Antony Williams,Gary Martin,David Rovnyak
Publisher : Royal Society of Chemistry
Page : 516 pages
File Size : 51,5 Mb
Release : 2016-12-12
Category : Science
ISBN : 9781849734684

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony Williams,Gary Martin,David Rovnyak Pdf

The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 μg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.

Modern NMR Approaches to the Structure Elucidation of Natural Products

Antony J. Williams,Gary E. Martin,David Rovnyak
Modern NMR Approaches to the Structure Elucidation of Natural Products Book PDF

Author : Antony J. Williams,Gary E. Martin,David Rovnyak
Publisher : Royal Society of Chemistry
Page : 344 pages
File Size : 46,5 Mb
Release : 2016
Category : Science
ISBN : 9781849733830

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony J. Williams,Gary E. Martin,David Rovnyak Pdf

Modern NMR Approaches for the Structure Elucidation of Natural Products is part of a two-volume set focusing on the structure elucidation of natural products. Volume 1 discusses contemporary NMR approaches including optimized hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. It also discusses data processing and algorithmic-based analysis of the data to establish molecular structures. This meshing of details regarding data acquisition, software and hardware approaches to the elucidation of natural products will bring together contributions from leading experts in the field. Volume 2 reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, anti-cancer agents, alkaloids, terpenes, steroids, antibiotics, carbohydrates, peptides and venoms. There are no books on the market that are focused on the unique combination of experimental approaches and modern hardware and software approaches to the structure elucidation of natural products. These books will, spread over 2 volumes, bring together acknowledged experts in the field of structure elucidation and be attractive to those with a specific interest in the characterisation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterisation of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

Optimizing NMR Methods for Structure Elucidation

Darcy C. Burns,William F. Reynolds
Optimizing NMR Methods for Structure Elucidation Book PDF

Author : Darcy C. Burns,William F. Reynolds
Publisher : Royal Society of Chemistry
Page : 238 pages
File Size : 48,5 Mb
Release : 2018-09-26
Category : Science
ISBN : 9781782625391

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Optimizing NMR Methods for Structure Elucidation by Darcy C. Burns,William F. Reynolds Pdf

This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the minimum possible time. It covers the latest pulse sequences, acquisition and processing methods, practical areas not covered in most texts e.g. detailed consideration of the relative advantages and disadvantages of different pulse sequences, choosing acquisition and processing parameters to get the best possible data in the least possible time, pitfalls to avoid and how to minimize the risks of getting wrong structures. Useful in industrial, pharma or research environments, this reference book is for anyone involved with organic chemistry research and, in particular, natural products research requiring advice for getting the best results from the NMR facilities.

Encyclopedia of Analytical Science

Anonim
Encyclopedia of Analytical Science Book PDF

Author : Anonim
Publisher : Elsevier
Page : 5142 pages
File Size : 54,8 Mb
Release : 2019-04-02
Category : Science
ISBN : 9780081019849

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Encyclopedia of Analytical Science by Anonim Pdf

The third edition of the Encyclopedia of Analytical Science, Ten Volume Set is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science, Ten Volume Set provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Pharmacognosy

Simone Badal McCreath,Yuri N. Clement
Pharmacognosy Book PDF

Author : Simone Badal McCreath,Yuri N. Clement
Publisher : Elsevier
Page : 847 pages
File Size : 43,8 Mb
Release : 2023-10-13
Category : Medical
ISBN : 9780443186585

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Pharmacognosy by Simone Badal McCreath,Yuri N. Clement Pdf

Pharmacognosy: Fundamentals, Applications and Strategies, Second Edition represents a comprehensive compilation of the philosophical, scientific and technological aspects of contemporary pharmacognosy. The book examines the impact of the advanced techniques of pharmacognosy on improving the quality, safety and effectiveness of traditional medicines, and how pharmacokinetics and pharmacodynamics have a crucial role to play in discerning the relationships of active metabolites to bioavailability and function at the active sites, as well as the metabolism of plant constituents. Structured in seven parts, the book covers the foundational aspects of Pharmacognosy, the chemistry of plant metabolites, their effects, other sources of metabolites, crude drugs from animals, basic animal anatomy and physiology, technological applications and biotechnology, and the current trends in research. New to this edition is a chapter on plant metabolites and SARS-Cov-2, extensive updates on existing chapters and the development of a Laboratory Guide to support instructors execute practical activities on the laboratory setting. Covers the main sources of natural bioactive substances Contains practice questions and laboratory exercises at the end of every chapter to test learning and retention Describes how pharmacokinetics and pharmacodynamics play a crucial role in discerning the relationships of active metabolites to bioavailability and function at active sites Includes a dedicated chapter on the effect of plant metabolites on SARS-CoV-2

Chiral Separations and Stereochemical Elucidation

Quezia Bezerra Cass,Maria Elizabeth Tiritan,João Marcos Batista Junior,Juliana Cristina Barreiro
Chiral Separations and Stereochemical Elucidation Book PDF

Author : Quezia Bezerra Cass,Maria Elizabeth Tiritan,João Marcos Batista Junior,Juliana Cristina Barreiro
Publisher : John Wiley & Sons
Page : 644 pages
File Size : 47,9 Mb
Release : 2023-05-09
Category : Science
ISBN : 9781119802259

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Chiral Separations and Stereochemical Elucidation by Quezia Bezerra Cass,Maria Elizabeth Tiritan,João Marcos Batista Junior,Juliana Cristina Barreiro Pdf

An expert resource for chemists using stereochemical analysis methods In Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications, a team of distinguished researchers delivers a robust and authoritative discussion of the theoretical fundamentals of chiral separation, the most commonly used chiral selectors, and stereochemical elucidation methods. The book offers expert discussions of a variety of chiral separation methods by gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), and liquid chromatography (LC). The authors also describe several methods for stereochemical elucidation, including X-ray crystallography, nuclear magnetic resonance spectroscopy, and chiroptical methods. The explored material is ideal for practicing chemists seeking a resource to help them guide method development and optimization or to explain quality control-complements during target compound production. Readers will also find: A thorough introduction to the most important advances and applications in LC, GC, CE, SFC, and preparative chromatography Comprehensive explorations of the role of 2D-LC for chiral separation methods development and applications Practical discussions of the design, mechanisms, and applications of the most commonly used chiral selectors Fulsome treatments of the theoretical backgrounds, advantages, limitations, and applications of stereochemical elucidation methods Perfect for academic and industrial chemists specially in organic, analytical chemistry and pharmaceutical analysis. Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications will also benefit biochemists, environmental analysts, forensic and medicinal chemists as well as natural product chemists and those involved with stereochemistry or structural elucidation.

Advances in Chemical Biology- An Insight to New Applications and Developments Volume – 1

Dr. Sharangouda J. Patil,,Dr. Sadashiv S. O.,Dr. Nandeshwarappa B.
Advances in Chemical Biology An Insight to New Applications and Developments Volume 1 Book PDF

Author : Dr. Sharangouda J. Patil,,Dr. Sadashiv S. O.,Dr. Nandeshwarappa B.
Publisher : Shineeks Publishers
Page : 194 pages
File Size : 47,8 Mb
Release : 2023-06-21
Category : Education
ISBN : 9798889400530

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Advances in Chemical Biology- An Insight to New Applications and Developments Volume – 1 by Dr. Sharangouda J. Patil,,Dr. Sadashiv S. O.,Dr. Nandeshwarappa B. Pdf

Advancesin chemical and biological sciences are together contributing as organic molecules by the natural or synthetic sources with the research insight of scientific touch to make it as innovative ideas, process, protocols, products, and technologies for industrial applications. These conceptualapplications are useful to determine the next generation organic molecules againstcardiovascular, degenerative, infectious, neurological diseases with the valid dataneeded to prove its technical efficiency by the comparing standard drugs. Emerging any drugs from the origin of organic drugs are having more importance in the industries due to their efficacyand target to regulate or recover the health issues, these novel drugs may be inthe form of enzymes, metabolites, proteins, hormones or call it as biologicallyderived organic molecules. Most of the organic molecule findings are used toanalyze their hypotheses, mechanism of action, experimental design and theirbiological properties to derive functional aspects. To know these molecules structuralconfiguration various techniques and technology used and it is essential to becharacterizing the molecule by the chromatography, spectroscopy, etc., to confirmand further biological studies to know the properties. In this context this editedcomprehensive book brings the current innovation in the organic molecules withthe updates of various biological applications and covering the area of agriculture,biotechnology, microbiology, neutraceutics, nanotechnology, pharmacology, synthetic medicinal chemistry etc., based applicative research data to reviewed extensivelyin narrative loom. Highlights of the chapters are novel experimental protocol, methodology, techniques, study concepts, used advanced tools and statistical analysisfor the use of organic molecules to know their biological properties. The book possessing 9 chapters covering chemistry and biological investigations on theorganic molecules with the updated innovative findings, principles of the molecules,molecular targets, also interactions with cell lines, microorganisms and animalmodels which persuade remedial measures as preclinical and clinical studies. Book also focused on types of synthesis, advanced extractions, use of analyticaltools, purification schemes, characterization methods and data analytics.It is a designed as comprehensive reference book for all the grade &level of researchersto use it as experimental handbook or manual to work on the similar areas, it isalso useful for the creative scholars to obtain research experience and enhancethe skills by updating themselves as need of hour, also know the timely outbreaksto combat by such organic molecules as emerging drugs to be in a bio-innovationforum.

Computational Phytochemistry

Satyajit Dey Sarker,Lutfun Nahar
Computational Phytochemistry Book PDF

Author : Satyajit Dey Sarker,Lutfun Nahar
Publisher : Elsevier
Page : 532 pages
File Size : 44,9 Mb
Release : 2024-03-15
Category : Science
ISBN : 9780443161032

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Computational Phytochemistry by Satyajit Dey Sarker,Lutfun Nahar Pdf

Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research Features clearly illustrated chapters contributed by highly reputable researchers Covers all key areas in phytochemical research, including virtual screening and metabolomics

NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces

Anirban Bhunia,Hanudatta S Atreya,Neeraj Sinha
NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces Book PDF

Author : Anirban Bhunia,Hanudatta S Atreya,Neeraj Sinha
Publisher : Royal Society of Chemistry
Page : 733 pages
File Size : 49,7 Mb
Release : 2022-08-17
Category : Science
ISBN : 9781839162091

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NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces by Anirban Bhunia,Hanudatta S Atreya,Neeraj Sinha Pdf

Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies.

Drug Design with an Ethnobotanical Concept, Volume 1

Stefan Dahl
Drug Design with an Ethnobotanical Concept Volume 1 Book PDF

Author : Stefan Dahl
Publisher : IPS Intelligentsia Publishing Services
Page : 569 pages
File Size : 47,9 Mb
Release : 2023-08-02
Category : Antiques & Collectibles
ISBN : 9789787982884

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Drug Design with an Ethnobotanical Concept, Volume 1 by Stefan Dahl Pdf

This handbook comprises huge data amounts considering the areas of world-wide Ethnopharmacology, Pharmacognosy together with modern identification tools within Phytochemistry. In recent years, modern drug design has its return back to nature, rather applying guidance achieved from herb remedies valid during centuries. The handbook established on information of 100 medicinal plants from all parts of the globe, encloses now over 4700 chemical components, their structural formulas and so far, over 500 identification spectra (EI-MS 85%, NMR 15%). It facilitates the rapid survey on medicinal plants as well as search for remedies, where the possibility exists in searching at Portuguese and Russian besides English. Why have I chosen those languages? Because geographically you will be understood on almost of the entire globe! From Western Europe to Hawaii using English, from Minsk to Vladivostok at Russian and because of many Portuguese colonies throughout the world with that language. The names of 100 specimens are provided in Portuguese, English, French, German, Russian, Swedish, Finnish and Hungarian out of Latin (scientific name). Included is a chapter that deals on preparations made for household remedies as well as procedures for industrial upscale for medicine production. The main idea is to provide a structure-based knowledge of synergisms between physiological activities of plant compounds originating from 2nd metabolic pathways and their approved beneficial curing power of “common” diseases (flue, cough, nausea, insomnia) until severe complications like virus diseases, pandemics, cancer and alike.

Genetic Manipulation of Secondary Metabolites in Medicinal Plant

Ravi Singh,Nitish Kumar
Genetic Manipulation of Secondary Metabolites in Medicinal Plant Book PDF

Author : Ravi Singh,Nitish Kumar
Publisher : Springer Nature
Page : 382 pages
File Size : 48,6 Mb
Release : 2023-11-21
Category : Science
ISBN : 9789819949397

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Genetic Manipulation of Secondary Metabolites in Medicinal Plant by Ravi Singh,Nitish Kumar Pdf

This book provides a comprehensive introduction and review of state-of-the-art biotechnological tools in enhancement of bioactive compounds in medicinal and aromatic plants. Plant bioactive compounds are plant-based natural products that display a variety of pharmacological applications. These bioactive compounds are important as medicines, pigments, flavorings and drugs because most of the pharmaceutical industries are highly dependent on medicinal plants and their extraction. The book introduces a systematic overview of state-of-the-art biotechnological techniques such as Omics, Crisper /Cas9 and RNAi to enhance the plant bioactive contents as well as enlists various in vitro techniques, hairy root culture and transgenic technology to enhance plant bioactive contents using plant tissue culture approaches. The book also provides an overview of the role of induced mutation, biotic and abiotic stress to increase the bioactive contents in plants and discusses the significant role of endophytes to enhance the contents of plant bioactive compound. The book also opens discussions related to standard operating procedures using hydroponics system of cultivation for significant enhancement of bioactive compound(s) and much more. This book serves as an excellent reference book for the researchers working in the field of plant secondary metabolites and pharmaceutical industries at global level.

Modern NMR Approaches to the Structure Elucidation of Natural Products

Antony J. Williams,Gary E. Martin,David Rovnyak
Modern NMR Approaches to the Structure Elucidation of Natural Products Book PDF

Author : Antony J. Williams,Gary E. Martin,David Rovnyak
Publisher : Unknown
Page : 0 pages
File Size : 50,7 Mb
Release : 2016
Category : Science
ISBN : 1849734593

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony J. Williams,Gary E. Martin,David Rovnyak Pdf

This two volume set focuses on the structure elucidation of natural products forming an essential resource for spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products.

Modern NMR Approaches to the Structure Elucidation of Natural Products

Razvan Teodorescu
Modern NMR Approaches to the Structure Elucidation of Natural Products Book PDF

Author : Razvan Teodorescu
Publisher : Unknown
Page : 344 pages
File Size : 48,9 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:990603531

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Razvan Teodorescu Pdf

The first volume in a two part set that discusses NMR analysis for the structure elucidation of natural products. It covers instrumentation for a contemporary laboratory and software.

Biological Water

Gertz I. Likhtenshtein
Biological Water Book PDF

Author : Gertz I. Likhtenshtein
Publisher : Springer Nature
Page : 523 pages
File Size : 53,6 Mb
Release : 2021-10-21
Category : Science
ISBN : 9783030825034

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Biological Water by Gertz I. Likhtenshtein Pdf

This book embraces all physiochemical aspects of the structure and molecular dynamics of water, focusing on its role in biological objects, e.g. living cells and tissue, and in the formation of functionally active structures of biological molecules and their ensembles. Water is the single most abundant chemical found in all living things. It offers a detailed look into the latest modern physical methods for studying the molecular structure and dynamics of the water and provides a critical analysis of the existing literature data on the properties of water in biological objects. Water as a chemical reagent and as a medium for the formation of conditions for enzymatic catalysis is a core focus of this book. Although well suited for active researchers, the book as a whole, as well as each chapter on its own, can be used as fundamental reference material for graduate and undergraduate students throughout chemistry, physics, biophysics and biomedicine.

Fast NMR Data Acquisition

Mehdi Mobli,Jeffrey C Hoch
Fast NMR Data Acquisition Book PDF

Author : Mehdi Mobli,Jeffrey C Hoch
Publisher : Royal Society of Chemistry
Page : 308 pages
File Size : 49,8 Mb
Release : 2017-05-18
Category : Science
ISBN : 9781782628361

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Fast NMR Data Acquisition by Mehdi Mobli,Jeffrey C Hoch Pdf

Providing a definitive reference source on novel methods in NMR acquisition and processing, this book will highlight similarities and differences between emerging approaches and focus on identifying which methods are best suited for different applications. The highly qualified editors have conducted extensive research into the fundamentals of fast methods of data acquisition in NMR, including applications of non-Fourier methods of spectrum analysis. With contributions from additional distinguished experts in allied fields, clear explanations are provided on methods that speed up NMR experiments using different ways to manipulate the nuclei in the sample, modern methods for estimating the spectrum from the time domain response recorded during an NMR experiment, and finally how the data is sampled. Starting with a historical overview of Fourier Transformation and its role in modern NMR spectroscopy, this volume will clarify and demystify this important emerging field for spectroscopists and analytical chemists in industry and academia.