Modern Nmr Approaches To The Structure Elucidation Of Natural Products

Author : Antony J. Williams,Gary E. Martin,David Rovnyak
Publisher : Royal Society of Chemistry
Page : 344 pages
File Size : 50,9 Mb
Release : 2016
Category : Science
ISBN : 9781849733830

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony J. Williams,Gary E. Martin,David Rovnyak Pdf

Modern NMR Approaches for the Structure Elucidation of Natural Products is part of a two-volume set focusing on the structure elucidation of natural products. Volume 1 discusses contemporary NMR approaches including optimized hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. It also discusses data processing and algorithmic-based analysis of the data to establish molecular structures. This meshing of details regarding data acquisition, software and hardware approaches to the elucidation of natural products will bring together contributions from leading experts in the field. Volume 2 reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, anti-cancer agents, alkaloids, terpenes, steroids, antibiotics, carbohydrates, peptides and venoms. There are no books on the market that are focused on the unique combination of experimental approaches and modern hardware and software approaches to the structure elucidation of natural products. These books will, spread over 2 volumes, bring together acknowledged experts in the field of structure elucidation and be attractive to those with a specific interest in the characterisation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterisation of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

Author : Antony Williams,Gary Martin,David Rovnyak
Publisher : Royal Society of Chemistry
Page : 516 pages
File Size : 54,5 Mb
Release : 2016-12-12
Category : Science
ISBN : 9781849734684

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony Williams,Gary Martin,David Rovnyak Pdf

The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 μg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.

Author : Antony J. Williams,Gary E. Martin,David Rovnyak
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 2016
Category : Science
ISBN : 1849734593

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony J. Williams,Gary E. Martin,David Rovnyak Pdf

This two volume set focuses on the structure elucidation of natural products forming an essential resource for spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products.

Author : Antony J. Williams,Gary E. Martin,David Rovnyak
Publisher : Unknown
Page : 329 pages
File Size : 50,5 Mb
Release : 2016
Category : Electronic book
ISBN : 184973383X

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Modern NMR Approaches to the Structure Elucidation of Natural Products: Data Acquisition and Applications to Compound Classes by Antony J. Williams,Gary E. Martin,David Rovnyak Pdf

The first volume in a two-part set that discusses contemporary NMR approaches for the structure elucidation of natural products. It covers optimized hardware and experimental approaches

Author : Razvan Teodorescu
Publisher : Unknown
Page : 344 pages
File Size : 48,9 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:990603531

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Razvan Teodorescu Pdf

The first volume in a two part set that discusses NMR analysis for the structure elucidation of natural products. It covers instrumentation for a contemporary laboratory and software.

Author : Darcy C Burns,William F Reynolds
Publisher : Royal Society of Chemistry
Page : 254 pages
File Size : 45,8 Mb
Release : 2018-09-26
Category : Science
ISBN : 9781788015356

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Optimizing NMR Methods for Structure Elucidation by Darcy C Burns,William F Reynolds Pdf

This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the minimum possible time. It covers the latest pulse sequences, acquisition and processing methods, practical areas not covered in most texts e.g. detailed consideration of the relative advantages and disadvantages of different pulse sequences, choosing acquisition and processing parameters to get the best possible data in the least possible time, pitfalls to avoid and how to minimize the risks of getting wrong structures. Useful in industrial, pharma or research environments, this reference book is for anyone involved with organic chemistry research and, in particular, natural products research requiring advice for getting the best results from the NMR facilities.

Author : H. Duddeck,W. Dietrich
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642977817

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Structure Elucidation by Modern NMR by H. Duddeck,W. Dietrich Pdf

For several years we have been organizing seminars and workshops on the application of modem one and two-dimensional NMR methods at the faculty of chemistry in the Ruhr-University Bochum, FRG, and elsewhere, addressing researchers and graduate students who work in the field of organic and natural products chemistry. In 1987, we wrote a workbook (StrukturaufkUirung mit modemer NMR-Spektroskopie, Steinkopff, Darmstadt, FRG, 1988) in German language based on our experience in these courses. Many of the exercises described therein have been used in such courses and some of them have been shaped by the participants to a great extent. The response of readers and discussions with colleagues from many countries encouraged us to produce an English translation in order to make the book accessible to a wider audience. Moreover, the content has been increased from 20 exercise examples in the German, to 23 in the English version. This book could not have been written in the present form without the help of a number of col leagues and, therefore, we acknowledge gratefully the generous supply of samples from and useful discussions with B. Abegaz (Addis Ababa, Ethiopia), U.H. Brinker (Bingham, New York, USA), E.

Author : Mikhail E Elyashberg,Antony Williams,Kirill Blinov
Publisher : Royal Society of Chemistry
Page : 504 pages
File Size : 44,5 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781782625766

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Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation by Mikhail E Elyashberg,Antony Williams,Kirill Blinov Pdf

Computer-Assisted Structure Elucidation (CASE) systems are a combination of software algorithms and tools to support and enable chemists and spectroscopists engaged in the process of molecular structure elucidation via the analysis of spectroscopic data. These expert systems dramatically reduce the time associated with structure elucidation and improve the reliability of the results. Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation describes the principles on which these expert systems for spectroscopic structure elucidation are based and concisely explains the algorithmic concepts behind the programs. The authors use their own personal experiences in the development of the Structure Elucidator (StrucEluc) CASE software system to discuss the present state-of-the-art in computer-assisted structure elucidation. Scientists that are presently using CASE systems will be interested in the algorithms and modern approaches and for organizations that are currently using the StrucEluc platform the book is designed to help researchers understand the strategies behind CASE as well as details regarding the StrucEluc platform. For scientists that have never used CASE systems they will now have access to all necessary information to understand CASE systems for mastering this new and very effective approach to structure elucidation. The authors overall goal is writing this book is to produce the 'must read' definitive text that will represent the results of decades of work to develop computer-assisted structure elucidation software systems. CASE systems are now powerful software tools commonly outperforming and correcting human interpretations of data. This book will also provide an historical perspective of the work of the founding fathers of the technique and identify the challenges that have been overcome to produce modern CASE systems.

Author : Antony Williams,Gary Martin,David Rovnyak
Publisher : Royal Society of Chemistry
Page : 532 pages
File Size : 41,7 Mb
Release : 2016-12-14
Category : Science
ISBN : 9781849733939

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Modern NMR Approaches to the Structure Elucidation of Natural Products by Antony Williams,Gary Martin,David Rovnyak Pdf

The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.

Author : Helmut Duddeck,Wolfgang Dietrich,Gabor Toth
Publisher : Springer Science & Business Media
Page : 214 pages
File Size : 53,9 Mb
Release : 2013-04-18
Category : Science
ISBN : 9783642883101

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Structure Elucidation by Modern NMR by Helmut Duddeck,Wolfgang Dietrich,Gabor Toth Pdf

During the last few years, routine applications of NMR (Nuclear Magnetic Resonance) techniques have developed at a tremendous pace. The latest generation of spectrometers have enabled chemists to perform new types of experiments, such as spinlock and inverse-detected methods. This third, revised and expanded edition introduces the latest methodologies and incorporates them into new exercises.

Author : Julie Fisher
Publisher : CRC Press
Page : 364 pages
File Size : 50,9 Mb
Release : 2014-10-13
Category : Science
ISBN : 9781466592247

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Modern NMR Techniques for Synthetic Chemistry by Julie Fisher Pdf

A blend of theory and practical advice, Modern NMR Techniques for Synthetic Chemistry illustrates how NMR spectroscopy can be used to determine the abundance, size, shape, and function of organic molecules. It provides you with a description the NMR technique used (more pictorial than mathematical), indicating the most common pulse sequences, some practical information as appropriate, followed by illustrative examples. This format is followed for each chapter so you can skip the more theoretical details if the practical aspects are what interest you. Following a discussion of basic parameters, the book describes the utility of NMR in detecting and quantifying dynamic processes, with particular emphasis on the usefulness of saturation-transfer (STD) techniques. It details pulsed–field gradient approaches to diffusion measurement, diffusion models, and approaches to ‘inorganic’ nuclei detection, important as many synthetic pathways to new organics involve heavier elements. The text concludes with coverage of applications of NMR to the analysis of complex mixtures, natural products, carbohydrates, and nucleic acids—all areas of activity for researchers working at the chemistry-life sciences interface. The book’s unique format provides some theoretical insight into the NMR technique used, indicating the most common pulse sequences. The book draws upon several NMR methods that are resurging or currently hot in the field and indicates the specific pulse sequence used by various spectrometer manufacturers for each technique. It examines the analysis of complex mixtures, a feature not found in most books on this topic.

Author : G. Batta,K. Kövér,C. Szántay, Jr.
Publisher : Elsevier
Page : 356 pages
File Size : 49,9 Mb
Release : 1997-12-04
Category : Science
ISBN : 0080536506

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Methods for Structure Elucidation by High-Resolution NMR by G. Batta,K. Kövér,C. Szántay, Jr. Pdf

Nuclear Magnetic Resonance Spectroscopy (NMR) is now widely regarded as having evolved into a subscience. The field has become immensely diverse, ranging from medical use through solid state NMR to liquid state applications, with countless books and scientific journals devoted to these topics. Theoretical as well as experimental advance continues to be rapid, and has in fact accelerated by many novel innovations. This multi-authored book focuses on the latest developments in the rapidly evolving field of high resolution NMR, specifically with a view to applications on the structure elucidation of organic molecules of moderate molecular weight. Conceptually it differs from basic educational texts, hard-core scientific papers and regular review articles in that each chapter may be regarded as the authors' personal account of their special insights and results that crystallised after several years of research into a given topic. The book revolves around several themes and offers a handful of scientific "gems" of various colors, reflecting the great diversity of NMR. It contains 16 loosely connected chapters written by some of today's most accomplished NMR scientists in the world. Each chapter is a unique synthesis of the authors' previous research results in the given field, and thus projects special insights. Much emphasis has been given to the latest developments in NMR, in particular to selective pulses and pulsed field gradients. As a part of the series "Analytical Spectroscopy Library", with subsequent editions coming along this book should provide a platform for future research accounts of similar flavor. The material is presented in a mostly non-mathematical fashion, and is intended mainly for chemists, application NMR scientists and students with already some background in NMR. Some of the chapters slightly overlap in the discussed topics, which is particularly exciting in terms of gaining insight into the same area from different angles.

Author : Dieter Sicker,Klaus-Peter Zeller,Hans Ullrich Siehl,Stefan Berger
Publisher : Unknown
Page : 128 pages
File Size : 52,8 Mb
Release : 2019
Category : Electronic
ISBN : 3527806504

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Natural Products by Dieter Sicker,Klaus-Peter Zeller,Hans Ullrich Siehl,Stefan Berger Pdf

Author : Vladimir Havlicek,Jaroslav Spizek
Publisher : John Wiley & Sons
Page : 634 pages
File Size : 47,8 Mb
Release : 2014-10-13
Category : Science
ISBN : 9781118466612

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Natural Products Analysis by Vladimir Havlicek,Jaroslav Spizek Pdf

This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. • Applies analytical techniques to natural products research – an area of critical importance to drug discovery • Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics • Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail for both current practitioners and beginning researchers

Author : Stefan Berger,Dieter Sicker
Publisher : Wiley-VCH Verlag GmbH
Page : 645 pages
File Size : 46,5 Mb
Release : 2009
Category : Chemical structure
ISBN : 9783527627356

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Classics in Spectroscopy by Stefan Berger,Dieter Sicker Pdf

"Classics in Spectroscopy: Isolation and Structure Elucidation of Natural Products" is the first book of its kind to describe the art of NMR using everyday examples. This textbook will not only fascinate students wanting to learn about the topic, but also those experienced analytical chemists who are still inspired by their profession. The contents provide for easy reading by using natural products that everyone knows, such as caffeine, backed by an attractive layout with many pictures to visualize the topics. In addition, an in-depth analytical part makes the book a valuable teaching tool, or for self-learning using the questions and answers at the end of each chapter.