Molecular Basis Of Pulmonary Disease

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Molecular Basis of Pulmonary Disease

Author : Francis X. McCormack,Ralph J. Panos,Bruce C. Trapnell
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 53,6 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781597453844

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Molecular Basis of Pulmonary Disease by Francis X. McCormack,Ralph J. Panos,Bruce C. Trapnell Pdf

The study of rare lung disorders enhances our understanding of common pulmonary diseases such as fibrosis and emphysema. Molecular Basis of Lung Disease: Insights from Rare Disorders brings together a panel of distinguished clinicians and molecular scientists who are experts in a range of rare lung diseases and their underlying molecular defects. Each chapter focuses on the pathogenic mechanisms and therapeutic targets suggested by basic research and follows an easy to read format: brief introduction followed by discussion of epidemiology, genetic basis and molecular pathogenesis, animal models, clinical presentation, diagnostic approaches, conventional management and treatment strategies, as well as future therapeutic targets and directions. Disorders ranging from the Marfan and Goodpasture’s syndromes to Sarcoidosis and alpha one titrypsin deficiency are treated in detail. Written for pulmonary clinicians and scientists alike, Molecular Basis of Lung Disease: Insights from Rare Disorders is a comprehensive and invaluable nesource that sheds new light on the molecular mechanisms influencing the clinical presentation and treatment strategies for these debilitating disorders.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author : Venkataramana K Sidhaye,Michael Koval
Publisher : Academic Press
Page : 276 pages
File Size : 41,6 Mb
Release : 2017-03-09
Category : Medical
ISBN : 9780128038819

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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by Venkataramana K Sidhaye,Michael Koval Pdf

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Essential Concepts in Molecular Pathology

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 634 pages
File Size : 45,7 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9780128132586

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Essential Concepts in Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

The Lung

Author : Jerome S. Brody
Publisher : Saunders
Page : 248 pages
File Size : 48,6 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015040049770

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The Lung by Jerome S. Brody Pdf

This user-friendly reference provides a basic understanding of the molecular biology underlying pulmonary diseases. Presents the background information necessary to understand the impact that molecular biology has on pulmonary medicine. Chapters begin with a list of basic concepts and a summary of the state-of-the-art information for each disease, starting with a clinical-molecular point of view and concluding with an annotated bibliography. Features excellent color illustrations and a thorough appendix!

Targeting Cellular Signalling Pathways in Lung Diseases

Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Page : 926 pages
File Size : 48,5 Mb
Release : 2021-07-02
Category : Medical
ISBN : 9789813368279

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Targeting Cellular Signalling Pathways in Lung Diseases by Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija Pdf

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Molecular Pathology

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 54,9 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

How Tobacco Smoke Causes Disease

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 46,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Clinical Relevance of Genetic Factors in Pulmonary Diseases

Author : Takeshi Kaneko
Publisher : Springer
Page : 344 pages
File Size : 54,5 Mb
Release : 2018-07-12
Category : Medical
ISBN : 9789811081446

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Clinical Relevance of Genetic Factors in Pulmonary Diseases by Takeshi Kaneko Pdf

This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.

Genetics for Pulmonologists

Author : Jordan Prutkin,Joel Moss
Publisher : Remedica
Page : 207 pages
File Size : 55,9 Mb
Release : 2002
Category : Lung Diseases
ISBN : 9781901346459

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Genetics for Pulmonologists by Jordan Prutkin,Joel Moss Pdf

Our understanding of the relationship between genetics and pulmonary disorders is still evolving. In 1989 cloning of the gene that, when mutated, causes cystic fibrosis marked a great advance in the study of genetic diseases. Yet, over a decade later, understanding of how this genetic defect leads to colonization by bacteria and inflammation in the lung remains elusive.

Molecular Biology of the Lung

Author : Robert Stockley
Publisher : Birkhäuser
Page : 216 pages
File Size : 55,9 Mb
Release : 1998-12-01
Category : Medical
ISBN : 3764359692

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Molecular Biology of the Lung by Robert Stockley Pdf

The techniques and knowledge in molecular biology are advancing rapidly. The basic mechanisms involved in the pathogenesis of various lung conditions including asthma, COPD and lung cancer are being clarified by the application of this powerful technology. Genetic causes of single gene disorders such as cystic fibrosis and alpha-1 antitrypsin deficiency have now been well delineated. This progress leads to an understanding of the pathogenic process that result in disease. The purpose of Volumes I and II of "Molecular Biology of the Lung" is to provide an update on the use of this powerful technology. As such, the books provide an insight into the techniques for the non-specialist. Scientists embarking upon studies in chronic lung disease will find a review of the current status of research. At the same time, the books are useful to clinicians, both specialist and academic, and to scientists already involved in the basic aspects of the pathogenesis of lung disease. Both volumes deal with basic mechanisms of cell biology, receptors and cell activation and provides an insight as to how the technology influences our concepts of pathogenesis and vice versa.

Biochemical and Molecular Basis of Pediatric Disease

Author : Edward C.C. Wong,Dennis J. Dietzen,Michael J. Bennett,Shannon Haymond
Publisher : Academic Press
Page : 1172 pages
File Size : 43,6 Mb
Release : 2021-05-13
Category : Science
ISBN : 9780128179635

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Biochemical and Molecular Basis of Pediatric Disease by Edward C.C. Wong,Dennis J. Dietzen,Michael J. Bennett,Shannon Haymond Pdf

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult

Physiologic Basis of Respiratory Disease

Author : Qutayba Hamid
Publisher : PMPH-USA
Page : 824 pages
File Size : 42,5 Mb
Release : 2005
Category : Lung diseases
ISBN : 1550092367

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Physiologic Basis of Respiratory Disease by Qutayba Hamid Pdf

Accompanying CD-ROM contains ... "the complete text and illustrations ... in fully searchable PDF files."--Page 4 of cover.

Lung Development

Author : Claude Gaultier,Jacques R Bourbon,Martin Post
Publisher : Springer
Page : 464 pages
File Size : 50,7 Mb
Release : 2013-05-27
Category : Medical
ISBN : 9781461475378

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Lung Development by Claude Gaultier,Jacques R Bourbon,Martin Post Pdf

Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.

Treatment of Cystic Fibrosis and Other Rare Lung Diseases

Author : Arata Azuma,Michael S. Schechter
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2017-02-09
Category : Medical
ISBN : 3034809751

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Treatment of Cystic Fibrosis and Other Rare Lung Diseases by Arata Azuma,Michael S. Schechter Pdf

This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions. It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug therapies that augment airway surface liquid as well as anti-inflammatory and anti-infective therapies. Further topics include long-term, low-dose macrolide therapy for diffuse panbronchiolitis; novel agents for previously untreatable idiopathic pulmonary fibrosis; possible new treatments for pulmonary alveolar proteinosis (PAP); and multiple novel therapeutic targets for treating lymphangiomyomatosis. Research into these conditions has led to major advances in our understanding of the underlying genetic and molecular basis of this disease, and to dramatic improvements in survival and quality of life for affected individuals.

Chronic Obstructive Pulmonary Disease (COPD)

Author : Onn Min Kon,Trevor T. Hansel,Peter J. Barnes
Publisher : Oxford University Press, USA
Page : 128 pages
File Size : 53,9 Mb
Release : 2008
Category : Medical
ISBN : 9780199549146

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Chronic Obstructive Pulmonary Disease (COPD) by Onn Min Kon,Trevor T. Hansel,Peter J. Barnes Pdf

Chronic Obstructive Pulmonary Disease (COPD) is growing in reocnition as a major chronic disease, and a key cause of acute medical admissions. It kills approximately 30,000 patients each year in England and Wales alone, and is set to be the third commonest cause of death by 2020 globally. This pocketbook is a concise companion for all health care professionals who come into contact with patients wtih COPD. It covers the full spectrum of COPD management, ranging from smoking cessation to advanced COPD, bridging both the primary and secondary care aspects of treatment and discussing the latest advances in our understanding of the pathophysiology and new drug treatments of this disease. This compact volume of the Oxford Respiratory Medicine Library summarizes up-to-date literature in a style that will have direct clinical application to busy health care professionals.