Molecular Biology Of Drug Addiction

Author : Rafael Maldonado
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 44,5 Mb
Release : 2002-09-12
Category : Medical
ISBN : 9781592593439

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Molecular Biology of Drug Addiction by Rafael Maldonado Pdf

A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

Author : Anonim
Publisher : Unknown
Page : 76 pages
File Size : 45,7 Mb
Release : 2007
Category : Brain
ISBN : MINN:31951D025861296

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Drugs, Brains, and Behavior by Anonim Pdf

Author : Bertha Madras,Christine M. Colvis,Jonathan D. Pollock
Publisher : CSHL Press
Page : 478 pages
File Size : 45,8 Mb
Release : 2006
Category : Medical
ISBN : 9780879697532

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Cell Biology of Addiction by Bertha Madras,Christine M. Colvis,Jonathan D. Pollock Pdf

This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, stateDSofDStheDSart advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.

Author : Marc Lewis
Publisher : Doubleday Canada
Page : 320 pages
File Size : 54,5 Mb
Release : 2015-08-04
Category : Self-Help
ISBN : 9780385682299

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The Biology of Desire by Marc Lewis Pdf

Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the “disease model” of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease, based on evidence that brains change with drug use. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it’s supposed to do—seek pleasure and relief—in a world that’s not cooperating. Brains are designed to restructure themselves with normal learning and development, but this process is accelerated in addiction when highly attractive rewards are pursued repeatedly. Lewis shows why treatment based on the disease model so often fails, and how treatment can be retooled to achieve lasting recovery, given the realities of brain plasticity. Combining intimate human stories with clearly rendered scientific explanation, The Biology of Desire is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.

Author : Anonim
Publisher : Academic Press
Page : 758 pages
File Size : 42,8 Mb
Release : 2013-05-17
Category : Psychology
ISBN : 9780123983602

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Biological Research on Addiction by Anonim Pdf

Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process. This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individual’s susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence. Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions. Each article provides glossary, full references, suggested readings, and a list of web resources Edited and authored by the leaders in the field around the globe – the broadest, most expert coverage available Discusses the genetic basis of addiction Covers basic science research from a variety of animal studies

Author : Shafiqur Rahman
Publisher : Academic Press
Page : 277 pages
File Size : 43,8 Mb
Release : 2016-01-28
Category : Science
ISBN : 9780128038680

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The Molecular Basis of Drug Addiction by Shafiqur Rahman Pdf

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction. Contains contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Rao S. Rapaka,Wolfgang Sadée
Publisher : Springer Science & Business Media
Page : 791 pages
File Size : 53,9 Mb
Release : 2008-06-19
Category : Medical
ISBN : 9780387766782

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Drug Addiction by Rao S. Rapaka,Wolfgang Sadée Pdf

This book provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain. The volume focuses on the translation of fundamental addiction research to a variety of treatments and brings together scientists with wide ranging expertise.

Author : Judith Grisel
Publisher : Anchor
Page : 258 pages
File Size : 49,9 Mb
Release : 2020-01-14
Category : Psychology
ISBN : 9780525434900

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Never Enough by Judith Grisel Pdf

A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Author : William N. Brownsberger,Philip B Heymann
Publisher : Harvard University Press
Page : 284 pages
File Size : 54,7 Mb
Release : 2009-06-30
Category : Medical
ISBN : 9780674038622

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Drug Addiction and Drug Policy by William N. Brownsberger,Philip B Heymann Pdf

This book is the culmination of five years of debate among distinguished scholars in law, public policy, medicine, and biopsychology, about the most difficult questions in drug policy and the study of addictions. Do drug addicts have an illness, or is the addiction under their control? Should they be treated as patients or as criminals? Challenging the conventional wisdom, the authors show that these standard dichotomies are false.

Author : Avram Goldstein
Publisher : Oxford University Press
Page : 368 pages
File Size : 54,6 Mb
Release : 2001
Category : Medical
ISBN : 9780195146646

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Addiction by Avram Goldstein Pdf

Drug addiction as a brain disease is this book's theme. In clear scientific terms it describes the nature of chemical addiction and addictive behaviour and the muddied effort to develop effective drug control policies and laws.

Author : Sherrel Howard
Publisher : John Wiley & Sons
Page : 208 pages
File Size : 44,8 Mb
Release : 2014-02-27
Category : Medical
ISBN : 9781118850145

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Drugs of Abuse by Sherrel Howard Pdf

Drug abuse has been, and continues to be, a global societalissue with diverse sets of impacts. Drugs of Abuse: Pharmacologyand Molecular Mechanisms introduces the basic principles ofpharmacology and neuroscience of drug abuse. Understanding thechemistry of commonly abused drugs and their impact on brainfunction will provide students and researchers with a more profoundunderstanding of the molecular basis of drug abuse andaddiction. Drugs of Abuse: Pharmacology and Molecular Mechanismsopens with a brief history of drug use and abuse. Subsequentsections look at specific families of drugs, including stimulants,depressants, and hallucinogens among others, and explore how theirchemical make-up interacts with brain function. The final chapterprovides a brief overview of clinical substance abusetreatment. Providing a concise, accessible introductory overview of thetopic, Drugs of Abuse: Pharmacology and Molecular Mechanismswill be a valuable resource for students, researchers, and othersinterested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience andpharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with thebrain and can lead to addiction Includes coverage of a wide array of commonly abused familiesof drugs, including stimulants, depressants, hallucinogens, andothers. Provides an essential introduction to the chemical andmolecular underpinnings of drug use and abuse

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 40,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : David Nutt,Liam J. Nestor
Publisher : Oxford University Press
Page : 102 pages
File Size : 52,6 Mb
Release : 2013-09-26
Category : Medical
ISBN : 9780199685707

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Addiction by David Nutt,Liam J. Nestor Pdf

An essential reference for psychiatrists, clinical psychologists, trainees, and specialist nurses, as well as primary care physicians/GPs with a special interest in mental health conditions and other healthcare professionals.

Author : Marc Lewis
Publisher : Doubleday Canada
Page : 322 pages
File Size : 51,5 Mb
Release : 2011-10-04
Category : Biography & Autobiography
ISBN : 9780385669269

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Memoirs of an Addicted Brain by Marc Lewis Pdf

A gripping, ultimately triumphant memoir that's also the most comprehensive and comprehensible study of the neuroscience of addiction written for the general public. FROM THE INTRODUCTION: "We are prone to a cycle of craving what we don't have, finding it, using it up or losing it, and then craving it all the more. This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?" The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception. Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.

Author : Shafiqur Rahman
Publisher : Academic Press
Page : 0 pages
File Size : 52,7 Mb
Release : 2016-01-12
Category : Science
ISBN : 0128037865

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The Molecular Basis of Drug Addiction by Shafiqur Rahman Pdf

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.