Author : Markus J. Tamás,Enrico Martinoia
Publisher : Springer Science & Business Media
Page : 519 pages
File Size : 55,7 Mb
Release : 2006-07-07
Category : Science
ISBN : 9783540317197
Molecular Biology of Metal Homeostasis and Detoxification by Markus J. Tamás,Enrico Martinoia Pdf
One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.