Molecular Diagnosis And Targeting For Thoracic And Gastrointestinal Malignancy

Author : Yutaka Shimada,Katsuhiko Yanaga
Publisher : Springer
Page : 156 pages
File Size : 41,9 Mb
Release : 2017-11-29
Category : Medical
ISBN : 9789811064692

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Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy by Yutaka Shimada,Katsuhiko Yanaga Pdf

This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise treatment of cancer, analysis of the molecular background of the tumor is indispensable. However, there are both tumor-specific and comprehensive mechanisms involved in these processes. Accordingly, a firm grasp of molecular diagnosis and targeted therapies for different tumors is vital for clinicians and basic researchers alike. This book provides essential information and the latest findings on molecular diagnosis and targeted therapy for thoracic and gastrointestinal malignancies. Though primarily intended for clinical and basic oncologists, it also offers a useful guide for clinicians who are interested in this field and are considering getting started in molecular diagnosis and targeted therapy.

Author : Takashi Nakano,Takashi Kijima
Publisher : Springer Nature
Page : 352 pages
File Size : 47,9 Mb
Release : 2021-02-05
Category : Medical
ISBN : 9789811591587

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Malignant Pleural Mesothelioma by Takashi Nakano,Takashi Kijima Pdf

This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions. The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meant a paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions. Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

Author : Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu
Publisher : Frontiers Media SA
Page : 682 pages
File Size : 43,6 Mb
Release : 2023-06-05
Category : Medical
ISBN : 9782832526378

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Advanced Molecular Targets in the Diagnosis and Treatment of Gastrointestinal Cancers by Zsolt Kovacs,Simona Gurzu,Raluca Ioana Stefan-van Staden,Cornelia Braicu Pdf

Gastrointestinal cancers are among the most common cancer types, based on the Cancer Genome Atlas. GI cancers are within the most frequent malignancy, with almost 150.000 new cases in 2020. On one hand a big number of researches are focused on the diagnosis, new diagnostic approaches in upper and lower gastrointestinal tract cancers. On the other hand in the last 10 years several papers had been published about the possible therapeutic targets, pointing to precision and personalized medicine.

Author : Wataru Walter Sutow
Publisher : Unknown
Page : 982 pages
File Size : 47,6 Mb
Release : 1984
Category : Medical
ISBN : UOM:39015004443621

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Clinical Pediatric Oncology by Wataru Walter Sutow Pdf

Author : Aejaz Nasir,Domenico Coppola
Publisher : Springer
Page : 543 pages
File Size : 47,5 Mb
Release : 2016-08-31
Category : Medical
ISBN : 9781493934263

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Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances by Aejaz Nasir,Domenico Coppola Pdf

This comprehensive subspecialty reference book on NeuroEndocrine Tumor (NET) pathology brings together the diagnostic and clinical expertise of an outstanding team of practicing neuroendocrine pathologists and oncologists. In addition to in-depth coverage of clinico-pathologic aspects of NETs of the various organ systems, the recent histological grading and staging schemes proposed by the North American and European NeuroEndocrine Tumor Societies (NANETS, ENETS), the World Health Organization (WHO) and the American Joint Committee on Cancer (AJCC), this book also focuses on the recent molecular and therapeutic advances in the field of NET pathology and oncology. Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances will be an essential reference book for anatomic pathology (histopathology) residents, fellows, surgical pathologists, researchers, oncologists, surgeons and other medical professionals practicing advanced NET Pathology and Oncology in academia, community, private practice and research settings.

Author : Prateek Sharma,Richard Sampliner
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 54,9 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405171533

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Barrett's Esophagus and Esophageal Adenocarcinoma by Prateek Sharma,Richard Sampliner Pdf

The leading reference text entirely devoted to this increasinglysignificant condition This text is dedicated to Barrett’s esophagus and providesrecent evidence and current approaches to patient management. Ithas been completely revised, updated and extended to include thelatest research findings and describes how these affect day-to-dayclinical practice. It includes seven new chapters and even more color images thanthe last edition. Each chapter, written by the leadinginternational experts in the field, provides clear, didacticguidance on diagnosis, treatment and management of thiscondition. Barrett’s Espohagus gives an extensive overviewcovering epidemiology, screening, pathology, gastroenterology andsurgery. It looks at the precursor lesions leading to thedevelopment of Barrett’s epithelium, the uniquecharacteristics of Barrett’s esophagus, and the consequencesof malignant degeneration. All aspects of diagnosis, secondaryprevention, multimodality, and medical and surgical treatment areclearly explained. This is a complete guide on the latest thinking on diagnosis andtreatment of Barrett’s esophagus which can be referred toover and over again.

Author : Mahdi Rezai,Mehmet Ali Kocdor,Nuh Zafer Canturk
Publisher : Springer Nature
Page : 665 pages
File Size : 45,6 Mb
Release : 2021-08-27
Category : Medical
ISBN : 9783030731472

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Breast Cancer Essentials by Mahdi Rezai,Mehmet Ali Kocdor,Nuh Zafer Canturk Pdf

Breast cancer is a disease requiring multidisciplinary management including surgery, medical and radiation oncology, radiology, pathology, nuclear medicine, genetic counseling, and psychological support. Each member of the team needs to be updated continuously on breast cancer treatment because of its rapidly changing nature. From the diagnostic procedures to operations and even in metastatic stages of breast cancer, surgeons play an essential part in multidisciplinary teams. After standard surgical options, oncoplastic breast surgery is rapidly becoming one of the most important surgical topics that should be learned by attending surgeons. The idea of writing this book stemmed from a collaboration between the European Academy of Senology (EAoS), European Institute of Oncology (IEO), Euro-Asian Society of Mastology (ESOMA), and SENATURK (Turkish Academy of Senology), which have been working together to promote better training in breast care for professionals. The book offers invaluable support for breast surgeons by covering critical and essential information in senology. It will also greatly benefit the other members of multidisciplinary teams, surgery residents, gynecologists, and plastic and reconstructive surgeons.

Author : J. Verweij,H.M. Pinedo
Publisher : Springer Science & Business Media
Page : 185 pages
File Size : 47,7 Mb
Release : 2006-04-18
Category : Medical
ISBN : 9781402078569

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Targeting Treatment of Soft Tissue Sarcomas by J. Verweij,H.M. Pinedo Pdf

- Discusses the latest drug treatments in the field - Gleevec arranged a bulk sale for this title - Written by leaders in the industry

Author : S.E. Monaco,W.E. Khalbuss,L. Pantanowitz
Publisher : Karger Medical and Scientific Publishers
Page : 147 pages
File Size : 41,7 Mb
Release : 2014-05-22
Category : Medical
ISBN : 9783318023961

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Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): A Practical Approach by S.E. Monaco,W.E. Khalbuss,L. Pantanowitz Pdf

This high-yield reference book focuses on the clinical, technical, and pathological aspects of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Its reviews cover all aspects of EBUS-TBNA, including the clinical perspective, technical aspects of the procedure, and cytomorphology of common and uncommon entities, as well as highlights diagnostic challenges. Each chapter features a multitude of full-color high-resolution images and includes key references to the current literature in the field. Additionally, reference tables and informative figures highlight the salient points. The book is unique in that it is written by experienced thoracic surgeons, pulmonary medicine physicians, and cytopathologists who use EBUS-TBNA in a large medical center. This publication is of interest to individuals learning and practicing cytopathology, in addition to clinicians practicing pulmonary/thoracic medicine or surgery. In short, it provides important pearls of wisdom to create a comprehensive reference for all physicians involved with EBUS-TBNA.

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
Page : 331 pages
File Size : 54,8 Mb
Release : 2006-04-18
Category : Medical
ISBN : 9781402078477

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Molecular Targeting and Signal Transduction by Rakesh Kumar Pdf

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Author : Leonard Weiss,Harvey A. Gilbert
Publisher : Macmillan Reference USA
Page : 362 pages
File Size : 48,6 Mb
Release : 1978
Category : Medical
ISBN : UOM:39015003796250

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Pulmonary Metastasis by Leonard Weiss,Harvey A. Gilbert Pdf

Author : Dong-Hua Yang, Zhi Shi,Pascale Cohen,Huiqin Guo
Publisher : Frontiers Media SA
Page : 285 pages
File Size : 41,9 Mb
Release : 2020-07-16
Category : Electronic
ISBN : 9782889638796

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Novel Targets and Biomarkers in Solid Tumors, 2nd Edition by Dong-Hua Yang, Zhi Shi,Pascale Cohen,Huiqin Guo Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : International Agency for Research on Cancer
Publisher : World Health Organization
Page : 410 pages
File Size : 40,9 Mb
Release : 2015-03-16
Category : Health & Fitness
ISBN : 9283224361

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Who Classification of Tumours of the Lung, Pleura, Thymus and Heart by International Agency for Research on Cancer Pdf

WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart is the seventh volume in the Fourth Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

Author : Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley
Publisher : CRC Press
Page : 266 pages
File Size : 49,5 Mb
Release : 2012-05-09
Category : Mathematics
ISBN : 9781439814482

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Clinical Trials in Oncology, Third Edition by Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley Pdf

The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.

Author : Muin S. A. Tuffaha
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 43,8 Mb
Release : 2008-05-06
Category : Science
ISBN : 352731881X

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Phenotypic and Genotypic Diagnosis of Malignancies by Muin S. A. Tuffaha Pdf

Carefully designed as an easy and quick reference, this desktop manual is for working pathologists who need to determine the particular type of cancer they are dealing with in a patient. To this end, the book contains many large tables of information to allow a fast analysis of results, providing all the relevant information to diagnose the full range of different tumors in humans. Must-have content for all cancer pathologists.