Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition

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Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition)

Markus Rudin
Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition Book PDF

Author : Markus Rudin
Publisher : World Scientific
Page : 801 pages
File Size : 43,6 Mb
Release : 2020-04-04
Category : Technology & Engineering
ISBN : 9781786346865

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Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) by Markus Rudin Pdf

The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.

Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition)

Rudin Markus
Molecular Imaging Basic Principles And Applications In Biomedical Research 2nd Edition Book PDF

Author : Rudin Markus
Publisher : World Scientific
Page : 620 pages
File Size : 45,6 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9781783263172

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Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition) by Rudin Markus Pdf

The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Molecular Imaging

Jie Tian
Molecular Imaging Book PDF

Author : Jie Tian
Publisher : Springer Science & Business Media
Page : 699 pages
File Size : 48,8 Mb
Release : 2013-07-23
Category : Science
ISBN : 9783642343032

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Molecular Imaging by Jie Tian Pdf

"Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Molecular Imaging

Ralph Weissleder
Molecular Imaging Book PDF

Author : Ralph Weissleder
Publisher : PMPH-USA
Page : 1384 pages
File Size : 45,9 Mb
Release : 2010
Category : Diagnostic imaging
ISBN : 1607950057

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Molecular Imaging by Ralph Weissleder Pdf

The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Molecular Imaging

Jie Tian
Molecular Imaging Book PDF

Author : Jie Tian
Publisher : Springer
Page : 699 pages
File Size : 48,7 Mb
Release : 2014-06-11
Category : Science
ISBN : 364234304X

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Molecular Imaging by Jie Tian Pdf

"Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Molecular Imaging

Brian D. Ross,Sanjiv S. Gambhir
Molecular Imaging Book PDF

Author : Brian D. Ross,Sanjiv S. Gambhir
Publisher : Academic Press
Page : 1872 pages
File Size : 41,7 Mb
Release : 2021-08-03
Category : Science
ISBN : 9780128163870

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Molecular Imaging by Brian D. Ross,Sanjiv S. Gambhir Pdf

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data Concepts illustrated with over 600 color figures and molecular-imaging examples Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Biomedical Imaging Instrumentation

Mrutyunjay Suar,Namrata Misra,Neel Sarovar Bhavesh
Biomedical Imaging Instrumentation Book PDF

Author : Mrutyunjay Suar,Namrata Misra,Neel Sarovar Bhavesh
Publisher : Academic Press
Page : 240 pages
File Size : 52,9 Mb
Release : 2021-11-26
Category : Technology & Engineering
ISBN : 9780323899918

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Biomedical Imaging Instrumentation by Mrutyunjay Suar,Namrata Misra,Neel Sarovar Bhavesh Pdf

Biomedical Imaging Instrumentation: Applications in Tissue, Cellular and Molecular Diagnostics provides foundational information about imaging modalities, reconstruction and processing, and their applications. The book provides insights into the fundamental of the important techniques in the biomedical imaging field and also discusses the various applications in the area of human health. Each chapter summarizes the overview of the technique, the various applications, and the challenges and recent innovations occurring to further improve the technique. Chapters include Biomedical Techniques in Cellular and Molecular Diagnostics, The Role of CT Scan in Medical and Dental Imaging, Ultrasonography - Technology & Applications in Clinical Radiology, Magnetic Resonance Imaging, Instrumentation and Utilization of PET-CT Scan in Oncology, Gamma Camera and SPECT, Sentinel of Breast Cancer Screening; Hyperspectral Imaging; PA Imaging; NIR Spectroscopy, and The Advances in Optical Microscopy and its Applications in Biomedical Research. This book is ideal for supporting learning, and is a key resource for students and early career researchers in fields such as medical imaging and biomedical instrumentation. A basic, fundamental, easy to understand introduction to medical imaging techniques Each technique is accompanied with detailed discussion on the application in the biomedical field in an accessible and easy to understand way Provides insights into the limitations of each technology and innovations that are occurring related to that technology

Molecular Imaging

Shankar Vallabhajosula
Molecular Imaging Book PDF

Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
Page : 379 pages
File Size : 52,7 Mb
Release : 2009-07-13
Category : Medical
ISBN : 9783540767350

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Molecular Imaging by Shankar Vallabhajosula Pdf

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Medical Imaging

Yongxia Zhou
Medical Imaging Book PDF

Author : Yongxia Zhou
Publisher : BoD – Books on Demand
Page : 110 pages
File Size : 47,7 Mb
Release : 2019-11-27
Category : Medical
ISBN : 9781789238716

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Medical Imaging by Yongxia Zhou Pdf

Several distinct medical imaging perspectives such as cutting-edge imaging methods, data analysis, better correlation with neurocognitive function, as well as detailed examples and summaries of disease monitoring, may help convey the methodological, technical, and developmental information of medical imaging principles and applications. The aim of this book is to provide beginners and experts in the medical imaging field with general pictures and detailed descriptions of imaging principles and clinical applications. With forefront applications and up-to-date analytical methods, this book will hopefully capture the interests of colleagues in the medical imaging research field. Precise illustrations and thorough reviews in many research topics such as neuroimaging quantification and correlation, as well as cancer diagnoses, are the advantages of this book.

Molecular Imaging of Small Animals

Habib Zaidi
Molecular Imaging of Small Animals Book PDF

Author : Habib Zaidi
Publisher : Springer
Page : 760 pages
File Size : 43,5 Mb
Release : 2014-05-27
Category : Medical
ISBN : 9781493908943

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Molecular Imaging of Small Animals by Habib Zaidi Pdf

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.

The Chemistry of Molecular Imaging

Nicholas Long,Wing-Tak Wong
The Chemistry of Molecular Imaging Book PDF

Author : Nicholas Long,Wing-Tak Wong
Publisher : John Wiley & Sons
Page : 408 pages
File Size : 42,9 Mb
Release : 2014-12-01
Category : Technology & Engineering
ISBN : 9781118854778

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The Chemistry of Molecular Imaging by Nicholas Long,Wing-Tak Wong Pdf

Molecular imaging is primarily about the chemistry of novelbiological probes, yet the vast majority of practitioners are notchemists or biochemists. This is the first book, written from achemist's point of view, to address the nature of the chemicalinteraction between probe and environment to help elucidatebiochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies,including their techniques and application within medicine andindustry Focuses primarily on the chemistry of probes and imagingagents, and chemical methodology for labelling andbioconjugation First book to investigate the chemistry of molecularimaging Aimed at students as well as researchers involved in the areaof molecular imaging

Molecular Imaging

Alexei Bogdanov,Kai Licha
Molecular Imaging Book PDF

Author : Alexei Bogdanov,Kai Licha
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 45,6 Mb
Release : 2007-01-19
Category : Medical
ISBN : 9783540268093

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Molecular Imaging by Alexei Bogdanov,Kai Licha Pdf

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Targeted Molecular Imaging

Michael J. Welch,William C. Eckelman
Targeted Molecular Imaging Book PDF

Author : Michael J. Welch,William C. Eckelman
Publisher : CRC Press
Page : 390 pages
File Size : 55,5 Mb
Release : 2012-02-24
Category : Science
ISBN : 9781439841952

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Targeted Molecular Imaging by Michael J. Welch,William C. Eckelman Pdf

Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Bioimaging

Shoogo Ueno
Bioimaging Book PDF

Author : Shoogo Ueno
Publisher : CRC Press
Page : 273 pages
File Size : 41,6 Mb
Release : 2020-05-26
Category : Medical
ISBN : 9780429536564

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Bioimaging by Shoogo Ueno Pdf

Bioimaging: Imaging by Light and Electromagnetics in Medicine and Biology explores new horizons in biomedical imaging and sensing technologies, from the molecular level to the human brain. It explores the most up-to-date information on new medical imaging techniques, such as the detection and imaging of cancer and brain diseases. This book also provides new tools for brain research and cognitive neurosciences based on new imaging techniques. Edited by Professor Shoogo Ueno, who has been leading the field of biomedical imaging for 40 years, it is an ideal reference book for graduate and undergraduate students and researchers in medicine and medical physics who are looking for an authoritative treatise on this expanding discipline of imaging and sensing in medicine and biology. Features: Provides step-by-step explanations of biochemical and physical principles in biomedical imaging Covers state-of-the art equipment and cutting-edge methodologies used in biomedical imaging Serves a broad spectrum of readers due to the interdisciplinary topic and approach Shoogo Ueno, Ph.D, is a professor emeritus of the University of Tokyo, Tokyo, Japan. His research interests include biomedical imaging and bioelectromagnetics, particularly in brain mapping and neuroimaging, transcranial magnetic stimulation (TMS), and magnetic resonance imaging (MRI). He was the President of the Bioelectromagnetics Society, BEMS (2003-2004) and the Chairman of the Commission K on Electromagnetics in Biology and Medicine of the International Union of Radio Science, URSI (2000-2003). He was named the IEEE Magnetics Society Distinguished Lecturer during 2010 and received the d’Arsonval Medal from the Bioelectromagnetics Society in 2010.

Comprehensive Systems Biomedicine

Pietro Lio,Enrico Capobianco
Comprehensive Systems Biomedicine Book PDF

Author : Pietro Lio,Enrico Capobianco
Publisher : Frontiers E-books
Page : 114 pages
File Size : 41,6 Mb
Release : 2014-12-03
Category : Genetics
ISBN : 9782889193745

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Comprehensive Systems Biomedicine by Pietro Lio,Enrico Capobianco Pdf

Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.