Molecular Mechanisms And Models Of Aging

Author : Christian Behl,Christine Ziegler
Publisher : Springer Science & Business Media
Page : 113 pages
File Size : 44,6 Mb
Release : 2013-12-18
Category : Science
ISBN : 9783642451799

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Cell Aging: Molecular Mechanisms and Implications for Disease by Christian Behl,Christine Ziegler Pdf

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Author : Pramod C. Rath
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2019
Category : Aging
ISBN : 9811335869

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Models, Molecules and Mechanisms in Biogerontology by Pramod C. Rath Pdf

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Author : Efstathios S. Gonos,Ioannis P. Trougakos,Niki Chondrogianni
Publisher : Wiley-Blackwell
Page : 0 pages
File Size : 50,5 Mb
Release : 2008-01-14
Category : Science
ISBN : 1573316865

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Molecular Mechanisms and Models of Aging, Volume 1119 by Efstathios S. Gonos,Ioannis P. Trougakos,Niki Chondrogianni Pdf

Aging is an inevitable consequence of life for nearly all organisms. It mostly reflects the outcome of complicated interactions between genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive process, not caused by a single factor or process, but it is rather a multifactorial procedure modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. This volume gathers together contributions from the top scientists and covers the whole range of modern research on aging. More specifically, the following topics are included: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, Immunity, neurodegeneration, model organisms, intervention as well as evolutional and epidemiological aspects. Overall, increasing our understanding of the aging process at the molecular level and applying available interventions will help to protect and preserve healthy aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Author : Vladimir Titorenko
Publisher : MDPI
Page : 322 pages
File Size : 42,9 Mb
Release : 2019-08-19
Category : Science
ISBN : 9783039213559

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Aging and Age-Related Disorders From Molecular Mechanisms to Therapies by Vladimir Titorenko Pdf

Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

Author : International Association of Biomedical Gerontology. International Congress
Publisher : Unknown
Page : 328 pages
File Size : 46,9 Mb
Release : 2007
Category : Aging
ISBN : PSU:000062892193

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Molecular Mechanisms and Models of Aging by International Association of Biomedical Gerontology. International Congress Pdf

Author : Olivier Toussaint
Publisher : Unknown
Page : 0 pages
File Size : 42,5 Mb
Release : 2000
Category : Aging
ISBN : 1573312711

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Molecular and Cellular Gerontology by Olivier Toussaint Pdf

This work covers a number of relevant aspects of the molecular and cellular biology of ageing, a timely general topic highlighted by the United Nations' having declared 1999 the Year of the Elderly. The papers published here represent a wide range of complementary research areas: molecular and cellular aspects; theories of ageing; molecular basis of the loss of homeostatic maintenance mechanisms; lower and higher model organisms including transgenic animal models; the genetics of human longevity; clinical and molecular aspects of age-related diseases; and integrated systems like brain and immune system aging. It is hoped that the additions to knowledge of the molecular mechanisms of ageing provided by this volume may ultimately lead to the prevention of age-related diseases.

Author : Naofumi Shiomi
Publisher : BoD – Books on Demand
Page : 128 pages
File Size : 55,7 Mb
Release : 2016-08-31
Category : Medical
ISBN : 9789535125686

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Molecular Mechanisms of the Aging Process and Rejuvenation by Naofumi Shiomi Pdf

Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.

Author : Konrad Beyreuther
Publisher : Springer
Page : 220 pages
File Size : 41,7 Mb
Release : 1990-07-23
Category : Medical
ISBN : UCAL:B5036134

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Molecular Mechanisms of Aging by Konrad Beyreuther Pdf

A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases."

Author : Syed Ibrahim Rizvi,Ufuk Çakatay
Publisher : Springer
Page : 386 pages
File Size : 44,8 Mb
Release : 2018-11-02
Category : Medical
ISBN : 9789811316999

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Molecular Basis and Emerging Strategies for Anti-aging Interventions by Syed Ibrahim Rizvi,Ufuk Çakatay Pdf

This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Author : Taihao Quan
Publisher : CRC Press
Page : 0 pages
File Size : 40,5 Mb
Release : 2016
Category : Older people
ISBN : 1498704646

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Molecular Mechanisms of Skin Aging and Age-related Diseases by Taihao Quan Pdf

Chapter 5: CCN Family Proteins in Skin Connective Tissue Aging

Author : Taihao Quan
Publisher : CRC Press
Page : 263 pages
File Size : 40,7 Mb
Release : 2016-04-21
Category : Medical
ISBN : 9781498704656

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Molecular Mechanisms of Skin Aging and Age-Related Diseases by Taihao Quan Pdf

Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 51,7 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

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Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 50,5 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441906397

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Epigenetics of Aging by Trygve O. Tollefsbol Pdf

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Author : Pramod C. Rath
Publisher : Springer Nature
Page : 497 pages
File Size : 40,9 Mb
Release : 2020-06-26
Category : Medical
ISBN : 9789813290051

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Models, Molecules and Mechanisms in Biogerontology by Pramod C. Rath Pdf

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Author : Alex 1920- Comfort
Publisher : Hassell Street Press
Page : 282 pages
File Size : 44,9 Mb
Release : 2021-09-09
Category : Electronic
ISBN : 1014542405

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The Biology of Senescence by Alex 1920- Comfort Pdf

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.