Molecular Mechanisms In Cancer

Author : Georg F. Weber
Publisher : Springer Science & Business Media
Page : 643 pages
File Size : 46,7 Mb
Release : 2007-09-12
Category : Medical
ISBN : 9781402060168

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Molecular Mechanisms of Cancer by Georg F. Weber Pdf

This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.

Author : Metin Budak,Rajamanickam Rajkumar
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 50,6 Mb
Release : 2022-08-17
Category : Science
ISBN : 9781839698422

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Molecular Mechanisms in Cancer by Metin Budak,Rajamanickam Rajkumar Pdf

Cancer is a major public health problem and much research is being conducted to develop effective treatments for various types of malignancies. In doing so, researchers must have comprehensive knowledge about what causes cancer. This book explains the mechanisms of different types of cancers in twelve chapters organized into three sections on oncogenes, tumor suppressor genes, and viral oncogenes.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Lauren Pecorino
Publisher : Oxford University Press
Page : 365 pages
File Size : 54,7 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780199577170

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Molecular Biology of Cancer by Lauren Pecorino Pdf

Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 51,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Georg F. Weber
Publisher : Springer
Page : 488 pages
File Size : 49,9 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319132785

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Molecular Therapies of Cancer by Georg F. Weber Pdf

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Author : Neil F. Sullivan,Anne E. Willis
Publisher : R G Landes Company
Page : 203 pages
File Size : 53,7 Mb
Release : 1994-01-01
Category : Medical
ISBN : 1570591938

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The Molecular Mechanisms of Cancer Predisposition by Neil F. Sullivan,Anne E. Willis Pdf

Author : Antonella Zannetti,Gennaro Ilardi,Wolfgang Link
Publisher : Frontiers Media SA
Page : 566 pages
File Size : 49,9 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9782889714483

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Tumor Microenvironment: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression by Antonella Zannetti,Gennaro Ilardi,Wolfgang Link Pdf

Author : Maryce M. Jacobs
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 50,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489909497

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Diet and Cancer by Maryce M. Jacobs Pdf

The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu 3 3 3 lar tone, and growth inhibition and differentiation.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 53,7 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Ramasamy Paulmurugan,Tarik F. Massoud
Publisher : Elsevier
Page : 830 pages
File Size : 51,9 Mb
Release : 2021-06-25
Category : Science
ISBN : 9780128215678

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Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies by Ramasamy Paulmurugan,Tarik F. Massoud Pdf

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Author : Mohd Sayeed Akhtar,Mallappa Kumara Swamy
Publisher : Springer
Page : 360 pages
File Size : 52,7 Mb
Release : 2018-07-03
Category : Science
ISBN : 9789811084171

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Anticancer Plants: Mechanisms and Molecular Interactions by Mohd Sayeed Akhtar,Mallappa Kumara Swamy Pdf

This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. The book provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research.

Author : Chi Hin Cho,Tao Hu
Publisher : Academic Press
Page : 242 pages
File Size : 43,9 Mb
Release : 2020-05-24
Category : Science
ISBN : 9780128199381

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Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies by Chi Hin Cho,Tao Hu Pdf

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Author : Elena Adinolfi,Lin-Hua Jiang,Sébastien Roger
Publisher : Frontiers Media SA
Page : 261 pages
File Size : 46,7 Mb
Release : 2021-08-02
Category : Science
ISBN : 9782889711246

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Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics by Elena Adinolfi,Lin-Hua Jiang,Sébastien Roger Pdf

Author : Stella Pelengaris,Michael Khan
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 54,9 Mb
Release : 2009-03-12
Category : Science
ISBN : 9781444309089

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The Molecular Biology of Cancer by Stella Pelengaris,Michael Khan Pdf

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field