Molecular Mechanisms In Pulmonary Hypertension And Right Ventricle Dysfunction

Author : Harry Karmouty-Quintana,Christophe Guignabert,Grazyna Kwapiszewska,Mark L. Ormiston
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 44,9 Mb
Release : 2019-03-20
Category : Electronic
ISBN : 9782889457731

Get Book

Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction by Harry Karmouty-Quintana,Christophe Guignabert,Grazyna Kwapiszewska,Mark L. Ormiston Pdf

Pulmonary hypertension (PH) is a disorder of the pulmonary vasculature defined by increased mean pulmonary arterial pressure (mPAP) leading to right ventricle (RV) hypertrophy and dysfunction, right-sided heart failure and ultimately death. PH is a common complication of chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) where it is classified as Group 3 PH by the WHO. It can also be associated with cardiovascular conditions such as left-heart disease (classified as Group 2 PH) or appear on its own as pulmonary arterial hypertension (PAH) and classified as Group1 PH. In all of these cases the diagnosis of pulmonary hypertension is strongly associated with increased morbidity and mortality. The focus of this Research Topic is to enhance our understanding of the mechanisms that contribute to the pathophysiology of pulmonary hypertension and right ventricle hypertrophy.

Author : Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Publisher : Springer Nature
Page : 374 pages
File Size : 47,8 Mb
Release : 2020-02-28
Category : Medical
ISBN : 9789811511851

Get Book

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi Pdf

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Author : Toshio Nakanishi,H Scott Baldwin,Jeffrey R Fineman
Publisher : Unknown
Page : 374 pages
File Size : 54,8 Mb
Release : 2020-10-09
Category : Medical
ISBN : 1013277414

Get Book

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by Toshio Nakanishi,H Scott Baldwin,Jeffrey R Fineman Pdf

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author : Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Publisher : Springer
Page : 405 pages
File Size : 45,9 Mb
Release : 2020-02-29
Category : Medical
ISBN : 9811511845

Get Book

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi Pdf

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Author : Bradley A. Maron,Roham T. Zamanian,Aaron B. Waxman
Publisher : Springer
Page : 371 pages
File Size : 44,7 Mb
Release : 2015-11-02
Category : Medical
ISBN : 9783319235943

Get Book

Pulmonary Hypertension by Bradley A. Maron,Roham T. Zamanian,Aaron B. Waxman Pdf

This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles that increases pulmonary vascular resistance to affect cardiopulmonary hemodynamic and right ventricular function adversely, resulting in a clinical syndrome of diminished exercise tolerance, shortness of breath, and heart failure-associated morbidity and mortality. Owing to the availability of novel pulmonary circulation-selective pharmacotherapies over the previous decade, the number of pulmonary hypertension patients eligible for treatment has increased substantially. Despite this progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. Taken together, a key educational opportunity is exposed to bridge this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension.

Author : Jason X. -J Yuan
Publisher : Unknown
Page : 612 pages
File Size : 48,7 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475779917

Get Book

Hypoxic Pulmonary Vasoconstriction by Jason X. -J Yuan Pdf

Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Page : 926 pages
File Size : 44,5 Mb
Release : 2021-07-02
Category : Medical
ISBN : 9789813368279

Get Book

Targeting Cellular Signalling Pathways in Lung Diseases by Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija Pdf

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Author : Peter Lanzer
Publisher : Springer
Page : 5004 pages
File Size : 50,8 Mb
Release : 2015-03-30
Category : Medical
ISBN : 3642370772

Get Book

PanVascular Medicine by Peter Lanzer Pdf

​Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

Author : Robert P. Baughman,Roberto G. Carbone,Giovanni Bottino
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 48,7 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9781603270748

Get Book

Pulmonary Arterial Hypertension and Interstitial Lung Diseases by Robert P. Baughman,Roberto G. Carbone,Giovanni Bottino Pdf

Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease and associated pulmonary hypertension. A detailed analysis of the pathology of the various interstitial lung diseases is also provided. The second part addresses specific categories of disease. Bronchiolitis, hypersensitivity pneumonitis, and other conditions are covered, and the use of inspiratory and expiratory high resolution CT scan is discussed as well. This important new text is an invaluable resource for the practicing physician who must be aware of the broad and troubling manifestations of interstitial lung disease.

Author : Marvin A. Konstam,Jeffrey M. Isner
Publisher : Springer Science & Business Media
Page : 345 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317739

Get Book

The Right Ventricle by Marvin A. Konstam,Jeffrey M. Isner Pdf

It is quite natural that literature related to car heart disease, cardiomyopathy, pulmonary and diac structure, function, pathology, and patho pulmonary vascular disease, trauma, acquired valvular disease, congenital disease, and surgi physiology has emphasized the left heart and systemic circulation. The relative lack of im cal considerations. The pathologic and clinical relevance of myocardial infarction of the right portance of the right ventricle was supported by studies performed in the 1940s and 1950s ventricle has only been documented over the which suggested that the right ventricular free last 15 years. The chapter on right ventricular wall could be effectively destroyed in an animal infarction integrates clinical, functional, patho model without detectable untoward hemody physiologic, and pathologic observations to pro namic consequences. The relative inadequacy vide the reader with a thorough review, equally of noninvasive tools to study right ventricular relevant to the clinician and investigator. The contribution on dilated cardiomyopathy pro structure and function obviated detailed and systematic investigation. However, over the vides novel insight into the impact of right ventricular performance on the functional in past 15 years there has been a resurgence of interest in the right ventricle by a variety of capacity accompanying left heart failure. A book dealing with the right ventricle would investigators. The skeptic would argue that this renewed interest resulted from an exhaustion be incomplete without at least cursory reference we have of clinically-related observations that could be to the pulmonary circulation.

Author : Sean P. Gaine,Robert Naeije,Andrew John Peacock
Publisher : Springer
Page : 326 pages
File Size : 45,9 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9781447123989

Get Book

The Right Heart by Sean P. Gaine,Robert Naeije,Andrew John Peacock Pdf

The heart and lung are intricately linked. When the heart is affected by disease, the lungs will often show some related pathological or clinical conditions and vice versa. Pulmonary heart disease is by definition a condition when the lungs cause the heart to fail. The left ventricle in combination with the other structures in the “left heart” pumps blood throughout the body. The right ventricle (and structures of the “right heart”) pumps blood to the lungs where it is oxygenated and returned to the left heart for distribution. In normal circumstances, the right heart pumps blood into the lungs without any resistance. The lungs usually have minimal pressure and the right heart easily pumps blood through. However when there is lung disease present, like emphysema, chronic obstructive lung disease (COPD) or pulmonary hypertension- the small blood vessels become very stiff and rigid. The right ventricle is no longer able to push blood into the lungs and eventually fails. This is known as pulmonary heart disease. Pulmonary heart disease is also known as right heart failure or cor pulmonale. The chief cause of right heart failure is the increase in blood pressure in the lungs (pulmonary artery).

Author : Norbert F. Voelkel,Dietmar Schranz
Publisher : Springer
Page : 488 pages
File Size : 49,5 Mb
Release : 2014-10-29
Category : Medical
ISBN : 9781493910656

Get Book

The Right Ventricle in Health and Disease by Norbert F. Voelkel,Dietmar Schranz Pdf

The Right Ventricle in Health and Disease provides a comprehensive and up-to-date database and collection of the available information which describes the structure and function of the normal right ventricle. The right ventricular performance and function reserve has now finally moved to the center of the stage as clinicians recognize that the drugs presently used to treat patients with severe pulmonary hypertension do not necessarily improve the performance of the right ventricle and because the survival depends on the right ventricular function that treatment strategies need to be developed to primarily protect the right ventricle from failing. In-depth chapters discuss right heart function and failure in patients with congenital heart diseases, review modern imaging techniques used to describe right ventricular form and function in patients with right heart failure (including cardiac MRI and PET scanning), describe ventricular interdependence: the left ventricle in pulmonary hypertension and discuss the concept of the sick lung circulation and its contribution to right heart failure. Treatment strategies of chronic right heart failure including drugs and mechanical devices are also discussed.

Author : Nico Westerhof,Nikos Stergiopulos,Mark I.M. Noble
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 52,8 Mb
Release : 2006-01-12
Category : Medical
ISBN : 9780387233468

Get Book

Snapshots of Hemodynamics by Nico Westerhof,Nikos Stergiopulos,Mark I.M. Noble Pdf

Hemodynamics makes it possible to characterize in a quantitative way, the function of the heart and arterial system, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education by Nico Westerhof, Nikos Stergiopulos and Mark I. M. Noble is a quick reference guide designed to help basic and clinical researchers as well as graduate students to understand hemodynamics. The layout of the book provides short and independent chapters that provide teaching diagrams as well as clear descriptions of the essentials of basic and applied principles of hemodynamics. References are provided at the end of each chapter for further reading and reference.

Author : M. Zamir
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 43,8 Mb
Release : 2006-06-18
Category : Science
ISBN : 9780387260198

Get Book

The Physics of Coronary Blood Flow by M. Zamir Pdf

The fields of biological and medical physics and biomedical engineering are broad, multidisciplinary and dyanmic. They lie at the crossroads of frontier - search in physics, biology, chemistry, and medicine. The Biological & Me- cal Physics/Biomedical Engineering Series is intended to be comprehensive, covering a broad range of topics important to the study of the physical, che- cal and biological sciences. Its goal is to provide scientists and engineers with textbooks, monographs, and reference works to address the growing need for information. Books in the series emphasize established and emergent areas of science - cluding molecular, membrane, and mathematical biophysics; photosynthetic - ergy harvesting and conversion; information processing; physical principles of genetics; sensory communications; automata networks, neural networks, and cellular automata. Equally important will be coverage of applied aspects of b- logical and medical physics and biomedical engineering such as molecular el- tronic components and devices, biosensors, medicine, imaging, physical prin- ples of renewable energy production, advanced prostheses, and environmental control and engineering. Elias Greenbaum Oak Ridge, TN M. Zamir Department of Applied Mathematics University of Western Ontario London, Ontario, N6A 5B7 CANADA [email protected] Library of Congress Cataloging-in-Publication Data Zamir, M. (Mair) The physics of coronary blood flow / M. Zamir. p. cm. — (Biological and medical physics, biomedical engineering) Includes bibliographical references and index. 1. Coronary circulation. 2. Hemodynamics. 3. Blood flow. I. Title. II. Series. QP108.Z36 2005 612.1?7—dc22 2005042502 ISBN-10: 0-387-25297-5 e-ISBN: 0-387-26019-6 Printed on acid-free paper.

Author : Lewis J. Rubin,Stuart Rich
Publisher : CRC Press
Page : 384 pages
File Size : 48,9 Mb
Release : 1996-11-06
Category : Medical
ISBN : 0824795059

Get Book

Primary Pulmonary Hypertension by Lewis J. Rubin,Stuart Rich Pdf

Detailing state-of-the-art developments in the various aspects of primary pulmonary hypertension (PPH), this practical reference explores the history, most current scientific concepts, and treatments of this disease. Includes new advances not yet formally published! Written by nearly 30 of the top international experts in the field, Primary Pulmonary Hypertension addresses the general histological features of the normal and hypertensive pulmonary vasculature and the pathology of PPH discusses etiological possibilities of pathogenesis, common morphological features, and findings in experimental models examines risks factors for PPH and looks separately at familial PPH and PPH in children presents an approach to the differential diagnosis of pulmonary hypertension, emphasizing the recognition of PPH elucidates the invasive and noninvasive modalities available for obtaining qualitative and quantitative hemodynamic data for the diagnosis of PPH covers a variety of therapeutic options and much more!