Molecular Mechanisms In The Control Of Gene Expression

Author : Donald P. Nierlich,W.J. Rutter,C. Fred Fox
Publisher : Elsevier
Page : 668 pages
File Size : 45,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483273938

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Molecular Mechanisms in the Control of Gene Expression by Donald P. Nierlich,W.J. Rutter,C. Fred Fox Pdf

Molecular Mechanisms in the Control of Gene Expression documents the proceedings of the ICN-UCLA conference on Molecular Mechanisms in the Control of Gene Expression, organized through the Molecular Biology Institute of UCLA, held in Keystone, Colorado, 21-26 March 1976. The conference focused on three topics: the action of repressors on specific nucleotide sequences in DNA; how DNA and histones are intertwined in eucaryotic chromosomes; and in the development of new techniques that appear to lift genes from complex genomes. The volume contains 65 chapters organized into nine parts. The papers in Part I examine the organization of prokaryotic and eukaryotic chromosomes. Part II presents studies on the interaction of RNA a polymerase and regulatory molecules with defined DNA sites. Parts III and IV focus on RNA polymerases of eukaryotes and the regulation of transcription in eukaryotic systems, respectively. Part V contains papers dealing with nucleic acid sequences, transcription, and processing. Part VI covers cellular aspects in the study of gene expression. Part VII takes up cloning while Part VIII is devoted to genetic analysis through restriction mapping and molecular cloning. Finally, Part IX summarizes the recent progress reported at the conference and also indicates some of the limitations that can be placed upon interpretation of data.

Author : Donald P. Nierlich,C. Fred Fox
Publisher : Unknown
Page : 655 pages
File Size : 41,9 Mb
Release : 1976
Category : Electronic
ISBN : OCLC:397161885

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Molecular Mechanisms in the Control of Gene Expression by Donald P. Nierlich,C. Fred Fox Pdf

Author : Bonald P. Nierlich,W. J. Rutter,C. Fred Fox
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 1976
Category : Electronic
ISBN : OCLC:473474203

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Molecular Mechanisms in the Control of Gene Expression by Bonald P. Nierlich,W. J. Rutter,C. Fred Fox Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 53,8 Mb
Release : 2008-08-17
Category : Science
ISBN : 9781597452281

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Regulation of Gene Expression by Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters Pdf

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Author : Robert O J Weinzierl
Publisher : World Scientific
Page : 436 pages
File Size : 40,6 Mb
Release : 1999-08-10
Category : Science
ISBN : 9781783262250

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Mechanisms of Gene Expression by Robert O J Weinzierl Pdf

A detailed knowledge of the mechanisms underlying the transcriptional control of gene expression is of fundamental importance to many areas of contemporary biomedical research, ranging from understanding basic issues (such as control of embryonic development) to practical applications in industry and medicine. Although elementary concepts of gene expression are described in all general molecular biology textbooks, the depth of coverage is often rather limited and recent discoveries are sometimes not adequately taken into consideration. This book presents much of the current thinking concerning molecular mechanisms of transcriptional control in a form easily accessible to undergraduates with an understanding of basic molecular biology concepts. It contains detailed information about the various pro- and eukaryotic transcriptional machineries that has recently become available through the combined efforts of geneticists, biochemists and structural biologists. The book will thus not only serve as an undergraduate text but also offer something new and interesting to more advanced readers and professional scientists who want to keep up to date with rapid advances in this field. Contents:RNA PolymerasesBasal Factors Recognize Promoters and Assemble the Pre-Initiation Transcription ComplexesGene-Specific Transcription FactorsCoactivators: Interface between Gene-Specific and Basal Transcription FactorsControl of RNA Elongation and TerminationRNAPI and RNAPIII Transcriptional MachineriesChromatinNuclear Matrix, Chromosome Scaffolds and Transcriptional FactoriesGene Expression Dynamics and Global Genome Transcription PatternsAppearing on the Horizon: Medical Applications Focusing on Transcriptional Control Mechanisms Readership: Undergraduate and graduate students in molecular biology, biochemistry and genetics. Keywords:Gene Expression;Genetics;Mechanisms;Basal Transcriptional Machinery

Author : Donald P. Nierlich
Publisher : Unknown
Page : 655 pages
File Size : 47,7 Mb
Release : 1976
Category : Electronic
ISBN : OCLC:476942574

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Molecular Mechanisms in the Control of Gene Expression by Donald P. Nierlich Pdf

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 41,5 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

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Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer Nature
Page : 160 pages
File Size : 47,7 Mb
Release : 2020-10-29
Category : Medical
ISBN : 9783030523213

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Mechanisms of Gene Regulation: How Science Works by Carsten Carlberg,Ferdinand Molnár Pdf

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

Author : Bryan M. Turner
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 42,9 Mb
Release : 2008-04-15
Category : Science
ISBN : 9780470751671

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Chromatin and Gene Regulation by Bryan M. Turner Pdf

Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer
Page : 211 pages
File Size : 43,9 Mb
Release : 2016-06-06
Category : Medical
ISBN : 9789401777414

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Mechanisms of Gene Regulation by Carsten Carlberg,Ferdinand Molnár Pdf

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

Author : Werner Maas
Publisher : Xlibris Corporation
Page : 56 pages
File Size : 52,9 Mb
Release : 2013-03-06
Category : Science
ISBN : 9781479799329

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GENE EXPRESSION AND ITS REGULATION by Werner Maas Pdf

Werner Maas is Professor Emeritus of Microbiology at New York University School of Medicine. Since his student days in 1941 he has been involved in the development of the new science of molecular genetics. His main contributions have been in the discovery of regulatory genes that are essential for the proper functioning of all genes in the maintenance of living cells. In 1955 he discovered that the formation of the amino acid arginine was feedback-regulated by arginine in combination with the product of a regulatory gene. This single gene product controls the formation of the eight enzymes of arginine biosynthesis. The main part of this book deals with the analysis of the molecular mechanism of this regulation.

Author : Jun Ma
Publisher : Springer
Page : 0 pages
File Size : 53,9 Mb
Release : 2010-12-24
Category : Science
ISBN : 1441922032

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Gene Expression and Regulation by Jun Ma Pdf

This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.

Author : Simon Baumberg
Publisher : OUP Oxford
Page : 350 pages
File Size : 47,5 Mb
Release : 1999-05-27
Category : Science
ISBN : 9780191565571

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Prokaryotic Gene Expression by Simon Baumberg Pdf

Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.

Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 45,7 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171

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Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.