Molecular Modelling Of Vitamin B12 And Its Analogues

Author : Penny Govender,Francis Opoku,Olaide Wahab,Ephraim Kiarii
Publisher : CRC Press
Page : 177 pages
File Size : 42,9 Mb
Release : 2021-09-23
Category : Medical
ISBN : 9781000452303

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Molecular Modelling of Vitamin B12 and Its Analogues by Penny Govender,Francis Opoku,Olaide Wahab,Ephraim Kiarii Pdf

For many years, the chemistry of vitamin B12 and its derivatives has been investigated for their inherent eco-friendly and nontoxic nature. This vitamin, also known as cobalamin, is an organic complex that contains a cobalt ion in its structure. Its derivatives are vital bio-inorganic cofactors and possess complex and rich photolytic properties, facilitated by their excited states. This book compiles and details cutting-edge research in the application of vitamin B12 as an environmentally benign catalyst for several organic reactions. It discusses the recent advances and current understanding of the photolytic properties of vitamin B12 derivatives from the perspective of the density functional theory (DFT). The book is of interest for anyone involved in nanotechnology, macromolecular science, cancer, and drug-delivery research.

Author : Penny Govender,Taylor & Francis Group,Francis Opoku,Olaide Wahab,Ephraim Kiarii
Publisher : Unknown
Page : 164 pages
File Size : 53,8 Mb
Release : 2021-09-29
Category : Electronic
ISBN : 9814877581

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Molecular Modelling of Vitamin B12 and Its Analogues by Penny Govender,Taylor & Francis Group,Francis Opoku,Olaide Wahab,Ephraim Kiarii Pdf

For many years, the chemistry of vitamin B12 and its derivatives has been investigated for their inherent eco-friendly and nontoxic nature. This vitamin, also known as cobalamin, is an organic complex that contains a cobalt ion in its structure. Its derivatives are vital bio-inorganic cofactors and possess complex and rich photolytic properties, facilitated by their excited states. Several studies in the field of organic chemistry have effectively applied vitamin B12 as a catalyst in various organic reactions such as 1,4-additions to activated double bonds, alkyl and aryl halide dimerization, dehalogenation, and hydrogenation of double bonds. The story of vitamin B12 analogues has opened doors for exploring other large ring-type structures that can be used for designing drug delivery systems and synthesising smart biological materials. This book compiles and details cutting-edge research in the application of vitamin B12 as an environmentally benign catalyst for several organic reactions. It discusses the recent advances and current understanding of the photolytic properties of vitamin B12 derivatives from the perspective of the density functional theory. The book is of interest for anyone involved in nanotechnology, macromolecular science, cancer, and drug-delivery research.

Author : Anonim
Publisher : Unknown
Page : 1268 pages
File Size : 54,9 Mb
Release : 2024-06-30
Category : Medicine
ISBN : UOM:39015072175105

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Research Awards Index by Anonim Pdf

Author : T. D. H. Bugg
Publisher : John Wiley & Sons
Page : 310 pages
File Size : 41,7 Mb
Release : 2012-05-29
Category : Science
ISBN : 9781118348994

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Introduction to Enzyme and Coenzyme Chemistry by T. D. H. Bugg Pdf

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1264 pages
File Size : 53,9 Mb
Release : 1966
Category : Medicine
ISBN : IND:30000090423835

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Peter J. Cragg
Publisher : Springer Science & Business Media
Page : 267 pages
File Size : 47,7 Mb
Release : 2010-08-26
Category : Science
ISBN : 9789048125821

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Supramolecular Chemistry by Peter J. Cragg Pdf

The aim of this book is to return to the biomimicry and medicinal potential that inspired many of the early supramolecular chemists and to set it in the context of current advances in the field. Following an overview of supramolecular chemistry, the first section considers the efforts made to synthesize artificial systems that mimic biological entities. The second section addresses the application of supramolecular principles to molecular diagnostics with a particular emphasis on the ‘receptor-relayreporter’ motif. Many of the examples chosen have clinical importance. The third section takes the clinical diagnostic theme further and demonstrates the therapeutic applications of supramolecular chemistry through photodynamic therapy, drug delivery, and the potential for synthetic peptides to form antibiotic tubes. The short epilogue considers the potential for supramolecular solutions to be found for further challenges in biomimetic and therapeutic chemistry.

Author : Anonim
Publisher : Unknown
Page : 588 pages
File Size : 49,9 Mb
Release : 1999
Category : Agriculture
ISBN : UOM:39015055285053

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Bibliography of Agriculture by Anonim Pdf

Author : National Cancer Institute (U.S.)
Publisher : Unknown
Page : 456 pages
File Size : 50,8 Mb
Release : 1974
Category : Cancer
ISBN : UOM:39015010012691

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Subject Index of Current Extramural Research Administered by the National Cancer Institute by National Cancer Institute (U.S.) Pdf

Provides information concerning research grants and contracts supported by the National Cancer Institute.

Author : Jerry L. Atwood
Publisher : CRC Press
Page : 1745 pages
File Size : 53,7 Mb
Release : 2013-10-09
Category : Science
ISBN : 9781482258165

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Encyclopedia of Supramolecular Chemistry - Two-Volume Set (Print) by Jerry L. Atwood Pdf

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized information on a rapidly expanding interdisciplinary field. User-friendly and high-quality articles parse the latest supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics. Designed for specialists and students alike, the set covers the fundamentals of supramolecular chemistry and sets the standard for relevant future research.

Author : Anonim
Publisher : Unknown
Page : 1060 pages
File Size : 45,8 Mb
Release : 1990
Category : Medicine
ISBN : MINN:31951P00079212D

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Biomedical Index to PHS-supported Research by Anonim Pdf

Author : J. L. Atwood,Jonathan W. Steed
Publisher : CRC Press
Page : 1002 pages
File Size : 51,5 Mb
Release : 2004
Category : Science
ISBN : 0824747240

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Encyclopedia of Supramolecular Chemistry by J. L. Atwood,Jonathan W. Steed Pdf

Covers the fundamentals of supramolecular chemistry; supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics.

Author : Anonim
Publisher : Unknown
Page : 1384 pages
File Size : 48,6 Mb
Release : 1991
Category : Medicine
ISBN : OSU:32436010178877

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Cumulated Index Medicus by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 1192 pages
File Size : 53,6 Mb
Release : 1992
Category : Medicine
ISBN : MINN:31951P00216726J

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Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by Anonim Pdf

Author : Anonim
Publisher : Academic Press
Page : 395 pages
File Size : 47,7 Mb
Release : 1989-02-01
Category : Science
ISBN : 0080576311

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Advances in Heterocyclic Chemistry by Anonim Pdf

Advances in Heterocyclic Chemistry

Author : National Institutes of Health (U.S.)
Publisher : Unknown
Page : 264 pages
File Size : 54,9 Mb
Release : 1969
Category : Neurology
ISBN : STANFORD:36105216538632

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Neurological Research Supported by the National Institute of Neurological Diseases and Stroke by National Institutes of Health (U.S.) Pdf