Molecular Pharming

Author : Allison R. Kermode,Liwen Jiang
Publisher : John Wiley & Sons
Page : 495 pages
File Size : 42,7 Mb
Release : 2018-05-08
Category : Science
ISBN : 9781118801284

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Molecular Pharming by Allison R. Kermode,Liwen Jiang Pdf

A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Author : Muhammad Sarwar Khan
Publisher : Bentham Science Publishers
Page : 413 pages
File Size : 54,5 Mb
Release : 2021-12-09
Category : Science
ISBN : 9789815036671

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Frontiers in Molecular Pharming by Muhammad Sarwar Khan Pdf

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Author : Muhammad Sarwar Khan
Publisher : Bentham Science Publishers
Page : 415 pages
File Size : 50,5 Mb
Release : 2021-12-09
Category : Electronic
ISBN : 9815036688

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Frontiers in Molecular Pharming by Muhammad Sarwar Khan Pdf

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Author : Rainer Fischer,Stefan Schillberg
Publisher : John Wiley & Sons
Page : 338 pages
File Size : 47,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605811

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Molecular Farming by Rainer Fischer,Stefan Schillberg Pdf

Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

Author : Allison R. Kermode
Publisher : John Wiley & Sons
Page : 496 pages
File Size : 41,8 Mb
Release : 2018-03-12
Category : Science
ISBN : 9781118801505

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Molecular Pharming by Allison R. Kermode Pdf

A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Author : Aiming Wang,Shengwu Ma
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 46,7 Mb
Release : 2011-10-14
Category : Science
ISBN : 9400722176

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Molecular Farming in Plants: Recent Advances and Future Prospects by Aiming Wang,Shengwu Ma Pdf

Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Author : Chittaranjan Kole,Anurag Chaurasia,Kathleen L. Hefferon,Jogeswar Panigrahi
Publisher : Springer Nature
Page : 421 pages
File Size : 46,8 Mb
Release : 2023-11-22
Category : Science
ISBN : 9789819948598

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Tools & Techniques of Plant Molecular Farming by Chittaranjan Kole,Anurag Chaurasia,Kathleen L. Hefferon,Jogeswar Panigrahi Pdf

This edited book is an in-depth compilation of recent tools and techniques, concepts and strategies used globally in plant molecular farming (PMF) for the cost-effective bulk production of recombinant proteins, secondary metabolites, and other biomolecules. The book presents an overview of success stories of PMF applications from developing countries to address poverty, achieve zero hunger, good health and well-being, thus achieving the UN SDGs 1, 2, and 3. The book deep dives into recent extraction and downstream processing methodologies, its co-existence with conventional agriculture, global governance and finally opportunities, challenges, and future perspectives in plant molecular farming. It focuses on plastid/chloroplast transformation (transplastomics) and its application in plant molecular farming. The books highlight recent advances in genome editing, synthetic biology, glycosylation and glyco-engineering for improved plant molecular farming by marker-free and tissue-specific systems via cisgenic and transgenic crops. In depth discussions on biosafety issues and bio-containment strategies have also been included. The book has 15 chapters authored by globally leading experts on the subject, presenting opportunities & challenges for bio-industrial researchers and entrepreneurs. It is useful to researchers, industrialists, entrepreneurs, policy planners, academician, and students across the disciplines.

Author : Anneli Ritala,Heiko Rischer,Suvi Tuulikki Häkkinen,Jussi Joonas Joensuu,Kirsi-Marja Oksman-Caldentey
Publisher : Frontiers Media SA
Page : 312 pages
File Size : 40,5 Mb
Release : 2020-06-16
Category : Electronic
ISBN : 9782889637942

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Proceedings of ISPMF 2018 - Plant Molecular Farming by Anneli Ritala,Heiko Rischer,Suvi Tuulikki Häkkinen,Jussi Joonas Joensuu,Kirsi-Marja Oksman-Caldentey Pdf

Author : Anonim
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 40,9 Mb
Release : 2024-03-11
Category : Science
ISBN : 9782832545669

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Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges by Anonim Pdf

Infectious diseases are still a major threat to public health. The vaccine remains the most important and safer way of combating infectious diseases. Therefore, there is an urgent need to look for new ways of vaccine generation that can cut down production costs and processing time. The development of rDNA technology allows the expression and purification of proteins in unlimited quantity, thus opening an avenue for the development of protein-based vaccines as a prophylactic measure against infectious diseases. Recombinant therapeutic proteins derived from biological sources, including mammalian cells, microorganisms, suspension cultures, or genetically modified organisms by employing biotechnological processes, are widely used in clinical applications, especially for the treatment and prevention of human or veterinary infections. Since the development of human insulin by utilizing recombinant DNA technology in E. coli in the 1980s, the recombinant therapeutic protein production field has significantly grown and gained major attention. Plant molecular farming, the production of biologics in plant cells or transgenic plants, could offer a cost-effective adaptable strategy to produce biologics, particularly in low-resource settings. Molecular farming-based strategies could provide an alternative strategy to traditional biologics or vaccine production, enabling rapid development, effective deployment, and safe administration of vaccines. The concept of PMF was initially documented three decades back when recombinant growth hormone was produced in tobacco and sunflower plants. Even with such a long history of significant advantages and several proof-of-concept studies, very few plant-derived therapeutic products have been clinically translated. However, the recent progress around the approval of the plant-based biopharmaceutical ZMapp by the FDA, Medicago’s COVID-19 vaccine by Health Canada, and the safety of a few plant-derived vaccines in clinical trials have displayed the potential of a plant platform for biopharmaceutical production. Furthermore, constant efforts are being made with respect to the optimization of expression techniques, downstream processing, and defining standard guidelines for plant products to make an impact of plant-derived products on an array of applications.

Author : Aiming Wang,Shengwu Ma
Publisher : Springer
Page : 280 pages
File Size : 43,6 Mb
Release : 2011-10-21
Category : Science
ISBN : 9400722184

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Molecular Farming in Plants: Recent Advances and Future Prospects by Aiming Wang,Shengwu Ma Pdf

Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Author : Eckard Rehbinder,Margret Engelhard,Kristin Hagen,R. B. Jørgensen,Rafael Pardo Avellaneda,Angelika Schnieke,Felix Thiele
Publisher : Springer Science & Business Media
Page : 341 pages
File Size : 55,8 Mb
Release : 2008-09-27
Category : Medical
ISBN : 9783540857938

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Pharming by Eckard Rehbinder,Margret Engelhard,Kristin Hagen,R. B. Jørgensen,Rafael Pardo Avellaneda,Angelika Schnieke,Felix Thiele Pdf

A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present interdisciplinary study comprises an extended overview of the state of the art of pharming, as well as in depth analyses of the environmental risks and other ethical and legal issues of pharming. Public attitudes to pharming are investigated on the basis of an original survey in 15 countries worldwide. The study concludes with specific recommendations addressed towards science, industry and politics.

Author : Kaiser Iqbal Wani,Tariq Aftab
Publisher : Springer Nature
Page : 83 pages
File Size : 55,8 Mb
Release : 2022-08-23
Category : Science
ISBN : 9783031127946

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Plant Molecular Farming by Kaiser Iqbal Wani,Tariq Aftab Pdf

Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.

Author : Chittaranjan Kole
Publisher : Springer Nature
Page : 704 pages
File Size : 46,6 Mb
Release : 2024-06-03
Category : Electronic
ISBN : 9789819701766

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Applications of Plant Molecular Farming by Chittaranjan Kole Pdf

Author : Rainer Fischer,Stefan Schillberg
Publisher : John Wiley & Sons
Page : 342 pages
File Size : 41,6 Mb
Release : 2004-10-25
Category : Gardening
ISBN : 3527307869

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Molecular Farming by Rainer Fischer,Stefan Schillberg Pdf

Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

Author : Abdullah Makhzoum,Kathleen Hefferon
Publisher : CRC Press
Page : 364 pages
File Size : 43,7 Mb
Release : 2022-12-23
Category : Science
ISBN : 9781000818383

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Applications in Plant Biotechnology by Abdullah Makhzoum,Kathleen Hefferon Pdf

The book focuses on interesting topics in plant biotechnology and its applications. The first section covers a number of specific medicinal plants and their secondary metabolites using genetic and metabolic engineering. The pharmaceutical uses of these plant bioactive compounds and their applications in treating a variety of diseases including cancer, as well as recent works on in silico and bioinformatic analysis are described. The second section deals with innovative plant molecular pharming approaches and reviews the potential for using various plant host systems to design and produce effective new drugs to treat different illnesses and diseases such as HIV, infectious diseases, and other human and livestock diseases.