Molecular Targeted Radiosensitizers

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Molecular Targeted Radiosensitizers

Henning Willers,Iris Eke
Molecular Targeted Radiosensitizers Book PDF

Author : Henning Willers,Iris Eke
Publisher : Springer Nature
Page : 370 pages
File Size : 46,6 Mb
Release : 2020-08-10
Category : Medical
ISBN : 9783030497019

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Molecular Targeted Radiosensitizers by Henning Willers,Iris Eke Pdf

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer

Shirley Lehnert
Radiosensitizers and Radiochemotherapy in the Treatment of Cancer Book PDF

Author : Shirley Lehnert
Publisher : CRC Press
Page : 552 pages
File Size : 42,5 Mb
Release : 2014-12-08
Category : Medical
ISBN : 9781439829028

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Radiosensitizers and Radiochemotherapy in the Treatment of Cancer by Shirley Lehnert Pdf

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease Book PDF

Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 54,6 Mb
Release : 2007-08-06
Category : Medical
ISBN : 9780387464015

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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia Pdf

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Medicinal Chemistry of Anticancer Drugs

Carmen Avendaño,J. Carlos Menéndez
Medicinal Chemistry of Anticancer Drugs Book PDF

Author : Carmen Avendaño,J. Carlos Menéndez
Publisher : Elsevier
Page : 767 pages
File Size : 55,7 Mb
Release : 2015-06-11
Category : Science
ISBN : 9780444626677

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Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Mitotic Inhibitors—Advances in Research and Application: 2012 Edition

Anonim
Mitotic Inhibitors Advances in Research and Application 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 164 pages
File Size : 53,9 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481603744

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Mitotic Inhibitors—Advances in Research and Application: 2012 Edition by Anonim Pdf

Mitotic Inhibitors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mitotic Inhibitors. The editors have built Mitotic Inhibitors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mitotic Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mitotic Inhibitors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

DNA Repair in Cancer Therapy

Mark R. Kelley,Melissa L. Fishel
DNA Repair in Cancer Therapy Book PDF

Author : Mark R. Kelley,Melissa L. Fishel
Publisher : Academic Press
Page : 464 pages
File Size : 53,9 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9780128035993

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DNA Repair in Cancer Therapy by Mark R. Kelley,Melissa L. Fishel Pdf

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Textbook of Radiation Oncology

Steven A. Leibel,Theodore L. Phillips
Textbook of Radiation Oncology Book PDF

Author : Steven A. Leibel,Theodore L. Phillips
Publisher : Unknown
Page : 0 pages
File Size : 46,6 Mb
Release : 2004
Category : Medical
ISBN : 0721600263

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Textbook of Radiation Oncology by Steven A. Leibel,Theodore L. Phillips Pdf

Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.

Biomolecular Action of Ionizing Radiation

Shirley Lehnert
Biomolecular Action of Ionizing Radiation Book PDF

Author : Shirley Lehnert
Publisher : CRC Press
Page : 560 pages
File Size : 41,6 Mb
Release : 2007-10-24
Category : Science
ISBN : 9781420011920

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Biomolecular Action of Ionizing Radiation by Shirley Lehnert Pdf

Embracing the transformation of radiation sciences by the recent surge of developments in molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo molecular responses in the body induced by ionizing radiation. With a unique emphasis on medical physics applications, Biomolecular Action of Ionizing Radiation also presents a much needed, in-depth perspective on clinical applications for the treatment of cancer and radiation injuries. Based on a popular course given by the author at McGill University,the bookplaces the traditional tenets of radiation biology in the context of contemporary cell and molecular biology. Using terms that non-experts in molecular biology can understand, it clarifies the underlying mechanisms of radiation effects on molecular interactions including signal transduction pathways, modes of cell killing, and non-targeted effects. The author subsequently associates key principles and advances with potential applications, including the use of ionizing radiation as a cytotoxic and cytostatic agent, and radiosensitization by targeting molecular intermediates or signaling molecules involved in radiation-induced processes. Raising the standard for radiation biology texts that are currently available, Biomolecular Action of Ionizing Radiation is an outstanding resource for advanced undergraduate and graduate students in medical physics, radiation oncology, radiation biology, and those who have an interest in the radiation sciences and in cancer treatment.

Precision Radiation Oncology

Bruce G. Haffty,Sharad Goyal
Precision Radiation Oncology Book PDF

Author : Bruce G. Haffty,Sharad Goyal
Publisher : Rutgers University Press
Page : 255 pages
File Size : 50,9 Mb
Release : 2018-05-24
Category : Medical
ISBN : 9780813592541

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Precision Radiation Oncology by Bruce G. Haffty,Sharad Goyal Pdf

Precision medicine is a rapidly-evolving field in the management of cancer. The use of novel molecular or genetic signatures in local-regional management is still in its infancy. Precision Radiation Oncology demystifies this state-of-the-art research and technology. By describing current existing clinical and pathologic features, and focusing on the ability to improve outcomes in cancer using radiation therapy, this book discusses incorporating novel genomic- or biology-based biomarkers in the treatment of patients moving radiation oncology into precision/personalized medicine. Precision Radiation Oncology provides readers with an overview of the new developments of precision medicine in radiation oncology, further advancing the integration of new research findings into individualized radiation therapy and its clinical applications.

Cancer Targeted Drug Delivery

You Han Bae,Randall J. Mrsny,Kinam Park
Cancer Targeted Drug Delivery Book PDF

Author : You Han Bae,Randall J. Mrsny,Kinam Park
Publisher : Springer Science & Business Media
Page : 720 pages
File Size : 55,5 Mb
Release : 2013-08-31
Category : Medical
ISBN : 9781461478768

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Cancer Targeted Drug Delivery by You Han Bae,Randall J. Mrsny,Kinam Park Pdf

This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer

Shirley Lehnert
Radiosensitizers and Radiochemotherapy in the Treatment of Cancer Book PDF

Author : Shirley Lehnert
Publisher : CRC Press
Page : 548 pages
File Size : 43,5 Mb
Release : 2014-12-08
Category : Medical
ISBN : 9781439829035

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Radiosensitizers and Radiochemotherapy in the Treatment of Cancer by Shirley Lehnert Pdf

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.

Targeted Molecular Imaging in Oncology

E. Edmund Kim,David J. Yang
Targeted Molecular Imaging in Oncology Book PDF

Author : E. Edmund Kim,David J. Yang
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 52,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475735055

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Targeted Molecular Imaging in Oncology by E. Edmund Kim,David J. Yang Pdf

This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Radioprotectors

Edward A. Bump,Kamal Malaker
Radioprotectors Book PDF

Author : Edward A. Bump,Kamal Malaker
Publisher : CRC Press
Page : 450 pages
File Size : 53,6 Mb
Release : 1997-12-29
Category : Medical
ISBN : 0849347564

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Radioprotectors by Edward A. Bump,Kamal Malaker Pdf

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.

Metal-based Anticancer Agents

Angela Casini,Anne Vessières,Samuel M Meier-Menches
Metal based Anticancer Agents Book PDF

Author : Angela Casini,Anne Vessières,Samuel M Meier-Menches
Publisher : Royal Society of Chemistry
Page : 370 pages
File Size : 47,8 Mb
Release : 2019-04-05
Category : Science
ISBN : 9781788017671

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Metal-based Anticancer Agents by Angela Casini,Anne Vessières,Samuel M Meier-Menches Pdf

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

Multimodal Concepts for Integration of Cytotoxic Drugs

Martin J. Brown,M.P. Mehta,Carsten Nieder
Multimodal Concepts for Integration of Cytotoxic Drugs Book PDF

Author : Martin J. Brown,M.P. Mehta,Carsten Nieder
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 48,5 Mb
Release : 2006-08-06
Category : Medical
ISBN : 9783540356622

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Multimodal Concepts for Integration of Cytotoxic Drugs by Martin J. Brown,M.P. Mehta,Carsten Nieder Pdf

The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.