Morphological Mouse Phenotyping

Author : Jesus Ruberte,Ana Carretero,Marc Navarro
Publisher : Academic Press
Page : 600 pages
File Size : 53,6 Mb
Release : 2016-12-15
Category : Medical
ISBN : 0128128054

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MORPHOLOGICAL MOUSE PHENOTYPIN by Jesus Ruberte,Ana Carretero,Marc Navarro Pdf

Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypothesis has encouraged the development of massive global projects making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans. However, a mouse is not a man. Here we present a complete and integrative description of mouse normal morphology. This book, basically an atlas, but also containing explanatory diagrams and text, guides the reader through normal mouse anatomy, histology and imaging, and is aimed for mouse researchers as well as veterinarian and human pathologists. More than 2,200 original images showing the anatomy, histology and cellular structure of mouse organs have been specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona) In addition, correlative X-ray, Computed Tomography, Magnetic Resonance and Ultrasound images complete this integrative vision of the mouse morphology Classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, as well as histological, immunohistochemical and electron microscopy techniques have been employed to characterize the mouse morphology "

Author : Jesus Ruberte,Ana Carretero,Marc Navarro
Publisher : Elsevier
Page : 602 pages
File Size : 51,8 Mb
Release : 2017-01-27
Category : Medical
ISBN : 9780128128770

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Morphological Mouse Phenotyping by Jesus Ruberte,Ana Carretero,Marc Navarro Pdf

Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona) Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology

Author : Anonim
Publisher : Unknown
Page : 600 pages
File Size : 45,7 Mb
Release : 2024-06-07
Category : Medical
ISBN : 8479035005

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Morphological Mouse Phenotyping:: Anatomy, Histology and Imaging by Anonim Pdf

Author : Piper M. Treuting,Suzanne M. Dintzis,Charles W. Frevert,Denny Liggitt,Kathleen S. Montine
Publisher : Academic Press
Page : 475 pages
File Size : 52,6 Mb
Release : 2012
Category : Medical
ISBN : 9780123813619

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Comparative Anatomy and Histology by Piper M. Treuting,Suzanne M. Dintzis,Charles W. Frevert,Denny Liggitt,Kathleen S. Montine Pdf

1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.

Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
Publisher : Academic Press
Page : 343 pages
File Size : 49,5 Mb
Release : 2015-09-23
Category : Science
ISBN : 9780128009130

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Kaufman’s Atlas of Mouse Development Supplement by Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay Pdf

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Author : Pottumarthi V. Prasad
Publisher : Springer Science & Business Media
Page : 446 pages
File Size : 41,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781597450102

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Magnetic Resonance Imaging by Pottumarthi V. Prasad Pdf

Leading experts in the use of MRI explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous cantrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.

Author : Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine
Publisher : Academic Press
Page : 570 pages
File Size : 44,5 Mb
Release : 2017-08-29
Category : Science
ISBN : 9780128029190

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Comparative Anatomy and Histology by Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine Pdf

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Author : Sara Anna Bonini,Susanna Pietropaolo
Publisher : Frontiers Media SA
Page : 166 pages
File Size : 53,9 Mb
Release : 2022-09-13
Category : Science
ISBN : 9782889769469

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Acoustic Communication Analysis for Understanding Animal Behavior by Sara Anna Bonini,Susanna Pietropaolo Pdf

Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 43,7 Mb
Release : 2022-01-26
Category : Medical
ISBN : 9781119624578

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Pathology of Genetically Engineered and Other Mutant Mice by John P. Sundberg,Peter Vogel,Jerrold M. Ward Pdf

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Author : Andreas Deutsch,Rafael Bravo de la Parra,Rob J. de Boer,Odo Diekmann,Peter Jagers,Eva Kisdi,Mirjam Kretzschmar,Petr Lansky,Hans Metz
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 54,9 Mb
Release : 2007-10-12
Category : Mathematics
ISBN : 9780817645564

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Mathematical Modeling of Biological Systems, Volume II by Andreas Deutsch,Rafael Bravo de la Parra,Rob J. de Boer,Odo Diekmann,Peter Jagers,Eva Kisdi,Mirjam Kretzschmar,Petr Lansky,Hans Metz Pdf

Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.

Author : Brad Bolon
Publisher : CRC Press
Page : 446 pages
File Size : 54,6 Mb
Release : 2015-04-24
Category : Medical
ISBN : 9781420070095

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Pathology of the Developing Mouse by Brad Bolon Pdf

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Author : Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
Publisher : Springer Nature
Page : 353 pages
File Size : 42,5 Mb
Release : 2020-02-28
Category : Medical
ISBN : 9783030198985

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Neuroanatomy of the Mouse by Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger Pdf

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

Author : Martin Hrabé de Angelis,Pierre Chambon,Steve Brown
Publisher : John Wiley & Sons
Page : 358 pages
File Size : 54,8 Mb
Release : 2009-09-03
Category : Science
ISBN : 9783527608706

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Standards of Mouse Model Phenotyping by Martin Hrabé de Angelis,Pierre Chambon,Steve Brown Pdf

This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.

Author : Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler
Publisher : Oxford University Press
Page : 1259 pages
File Size : 49,7 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9780199934959

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Neurobiology of Mental Illness by Dennis S. Charney,Joseph D. Buxbaum,Pamela Sklar,Eric J. Nestler Pdf

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Author : Cord Brakebusch,Taina Pihlajaniemi
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 40,6 Mb
Release : 2011-03-29
Category : Medical
ISBN : 9789400707504

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Mouse as a Model Organism by Cord Brakebusch,Taina Pihlajaniemi Pdf

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.