Mosquito Gene Drives And The Malaria Eradication Agenda

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Mosquito Gene Drives and the Malaria Eradication Agenda

Rebeca Carballar-Lejarazú

Author : Rebeca Carballar-Lejarazú
Publisher : CRC Press
Page : 373 pages
File Size : 42,8 Mb
Release : 2023-02-24
Category : Medical
ISBN : 9781000625929

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Mosquito Gene Drives and the Malaria Eradication Agenda by Rebeca Carballar-Lejarazú Pdf

Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Mosquito Gene Drives and the Malaria Eradication Agenda

Rebeca Carballar-Lejarazu

Author : Rebeca Carballar-Lejarazu
Publisher : Unknown
Page : 0 pages
File Size : 46,8 Mb
Release : 2023
Category : MEDICAL
ISBN : 1003308775

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Mosquito Gene Drives and the Malaria Eradication Agenda by Rebeca Carballar-Lejarazu Pdf

This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Gene Drives on the Horizon

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct
Publisher : National Academies Press
Page : 231 pages
File Size : 51,5 Mb
Release : 2016-08-28
Category : Science
ISBN : 9780309437875

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Gene Drives on the Horizon by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Pdf

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Disease Control Priorities, Third Edition (Volume 6)

King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha

Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 55,6 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257

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Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Genetic Control of Malaria and Dengue

Zach N. Adelman

Author : Zach N. Adelman
Publisher : Academic Press
Page : 486 pages
File Size : 43,8 Mb
Release : 2015-10-15
Category : Medical
ISBN : 9780128004050

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Genetic Control of Malaria and Dengue by Zach N. Adelman Pdf

Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Genetically Modified Mosquitoes for Malaria Control

Christophe Boete

Author : Christophe Boete
Publisher : CRC Press
Page : 174 pages
File Size : 53,6 Mb
Release : 2006-07-15
Category : Science
ISBN : 9781498712866

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Genetically Modified Mosquitoes for Malaria Control by Christophe Boete Pdf

Despite a century of research and attempts to control one of the deadliest foes of mankind, the malaria situation remains a major public health problem. Obviously biological explanations (the resistance of parasites and mosquitoes against available drugs and insecticides respectively) are often given, but they remain partial and incomplete. Indeed,

Cancer Cell Lines Part 1

John Masters,Bernhard Ø Palsson

Author : John Masters,Bernhard Ø Palsson
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 50,9 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468728

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Cancer Cell Lines Part 1 by John Masters,Bernhard Ø Palsson Pdf

Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Investing to Overcome the Global Impact of Neglected Tropical Diseases

World Health Organization

Author : World Health Organization
Publisher : World Health Organization
Page : 211 pages
File Size : 41,8 Mb
Release : 2015-08-05
Category : Medical
ISBN : 9789241564861

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Investing to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization Pdf

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Towards Malaria Elimination

Sylvie Manguin,Vas Dev

Author : Sylvie Manguin,Vas Dev
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 50,9 Mb
Release : 2018-07-18
Category : Medical
ISBN : 9781789235500

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Towards Malaria Elimination by Sylvie Manguin,Vas Dev Pdf

Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.

Global Health Impacts of Vector-Borne Diseases

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 397 pages
File Size : 40,6 Mb
Release : 2016-10-21
Category : Medical
ISBN : 9780309377591

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Global Health Impacts of Vector-Borne Diseases by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.

Transgenesis and the Management of Vector-Borne Disease

Serap Aksoy

Author : Serap Aksoy
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 54,5 Mb
Release : 2008-08-21
Category : Science
ISBN : 9780387782256

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Transgenesis and the Management of Vector-Borne Disease by Serap Aksoy Pdf

Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies.

Biodiversity and Health in the Face of Climate Change

Melissa R. Marselle,Jutta Stadler,Horst Korn,Katherine N. Irvine,Aletta Bonn

Author : Melissa R. Marselle,Jutta Stadler,Horst Korn,Katherine N. Irvine,Aletta Bonn
Publisher : Springer
Page : 494 pages
File Size : 40,5 Mb
Release : 2019-06-11
Category : Medical
ISBN : 9783030023188

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Biodiversity and Health in the Face of Climate Change by Melissa R. Marselle,Jutta Stadler,Horst Korn,Katherine N. Irvine,Aletta Bonn Pdf

This open access book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdisciplinary book will attract a wide audience interested in biodiversity, ecology, resource management, public health, psychology, urban planning, and landscape architecture. The emphasis is on multiple human health benefits from biodiversity - in particular with respect to the increasing challenge of climate change. This makes the book unique to other books that focus either on biodiversity and physical health or natural environments and mental wellbeing. The book is written as a definitive ‘go-to’ book for those who are new to the field of biodiversity and health.

Vector-Borne Diseases

Institute of Medicine,Board on Global Health,Forum on Microbial Threats

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 350 pages
File Size : 40,5 Mb
Release : 2008-03-18
Category : Medical
ISBN : 9780309177702

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Vector-Borne Diseases by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world's population is infected with at least one type of vector-borne pathogen (CIESIN, 2007; WHO, 2004a). Vector-borne plant and animal diseases, including several newly recognized pathogens, reduce agricultural productivity and disrupt ecosystems throughout the world. These diseases profoundly restrict socioeconomic status and development in countries with the highest rates of infection, many of which are located in the tropics and subtropics. Although this workshop summary provides an account of the individual presentations, it also reflects an important aspect of the Forum philosophy. The workshop functions as a dialogue among representatives from different sectors and allows them to present their beliefs about which areas may merit further attention. These proceedings summarize only the statements of participants in the workshop and are not intended to be an exhaustive exploration of the subject matter or a representation of consensus evaluation. Vector-Borne Diseases : Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary (Forum on Microbial Threats) summarizes this workshop.

Vector-Borne Diseases

David Claborn,Sujit Bhattacharya,Syamal Roy

Author : David Claborn,Sujit Bhattacharya,Syamal Roy
Publisher : BoD – Books on Demand
Page : 168 pages
File Size : 44,7 Mb
Release : 2020-06-03
Category : Medical
ISBN : 9781838800215

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Vector-Borne Diseases by David Claborn,Sujit Bhattacharya,Syamal Roy Pdf

Vector-Borne Diseases - Recent Developments in Epidemiology and Control utilizes the unique capabilities of open-access publishing to share exciting developments in the biology, diagnosis, and treatment of diseases spread by arthropods. From malaria to dengue to leishmaniasis, the diseases addressed in this book continue to present threats to the life and well-being of millions around the world. The international cast of writers published here provide specific insight into a full spectrum of diseases spread by insects and their close relatives.

The Handy Bug Answer Book

Gilbert Waldbauer

Author : Gilbert Waldbauer
Publisher : Unknown
Page : 308 pages
File Size : 50,6 Mb
Release : 1998
Category : Nature
ISBN : 1578590493

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The Handy Bug Answer Book by Gilbert Waldbauer Pdf

Answers questions about bugs and insects, including insect anatomy, growth, reproduction, care of offspring, insect behavior, social insects, predators, beneficial insects, insect pests, and pest control

Mosquito Gene Drives And The Malaria Eradication Agenda

Mosquito Gene Drives and the Malaria Eradication Agenda by Rebeca Carballar-Lejarazú Pdf

Mosquito Gene Drives and the Malaria Eradication Agenda by Rebeca Carballar-Lejarazu Pdf

Gene Drives on the Horizon by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Pdf

Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Genetic Control of Malaria and Dengue by Zach N. Adelman Pdf

Genetically Modified Mosquitoes for Malaria Control by Christophe Boete Pdf

Cancer Cell Lines Part 1 by John Masters,Bernhard Ø Palsson Pdf

Investing to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization Pdf

Towards Malaria Elimination by Sylvie Manguin,Vas Dev Pdf

Global Health Impacts of Vector-Borne Diseases by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

Transgenesis and the Management of Vector-Borne Disease by Serap Aksoy Pdf

Biodiversity and Health in the Face of Climate Change by Melissa R. Marselle,Jutta Stadler,Horst Korn,Katherine N. Irvine,Aletta Bonn Pdf

Vector-Borne Diseases by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Vector-Borne Diseases by David Claborn,Sujit Bhattacharya,Syamal Roy Pdf

The Handy Bug Answer Book by Gilbert Waldbauer Pdf

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