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Author : June R. Wyman
Publisher : Unknown
Page : 2 pages
File Size : 45,5 Mb
Release : 1987
Category : Multiple sclerosis
ISBN : MINN:20000004580284
Author : Judy Graham
Publisher : Simon and Schuster
Page : 192 pages
File Size : 48,7 Mb
Release : 1999-06-01
Category : Health & Fitness
ISBN : 9781594775246
An essential resource for anyone with MS who is considering having a child. • Firsthand advice from a woman with multiple sclerosis who has successfully borne and raised a child. • Contains information that can change the lives of many of the 250,000 women in the United States suffering from MS. • Highly readable format puts the facts at your fingertips. Diagnosed with MS at twenty-eight, author Judy Graham gave birth for the first time at the age of thirty-eight. Her new book Multiple Sclerosis and Having a Baby provides other women who are considering starting a family with the kind of genuine and useful insight that comes only from firsthand experience. Multiple Sclerosis and Having a Baby makes available not only the medical answers prospective parents need, but also the practical suggestions and sound advice that will help them meet the many unique and sometimes difficult challenges that face couples living with MS. In this highly informative and readable book, Graham asks and provides answers for nearly every question a woman with multiple sclerosis might want to consider before having a baby. With the latest medical facts and valuable data culled from hundreds of interviews with women who have multiple sclerosis and are currently raising a child, Graham straightforwardly addresses such issues as the possibility of relapse, genetic predisposition to MS, sexuality and fertility, pregnancy, postnatal care, and breastfeeding as they relate to women with MS.
Author : Alireza Minagar
Publisher : Elsevier
Page : 218 pages
File Size : 50,6 Mb
Release : 2010-12-08
Category : Psychology
ISBN : 0123849128
Timely diagnosis and management of neurological diseases during pregnancy poses major therapeutic challenges to neurologists and other non-neurologist health care providers. Pregnancy is a unique period in life associated with significant hormonal and other physiologic changes in female patients, which may trigger or alter the course of neurological and psychiatric disorders. In addition, many diagnostic procedures that can be performed in non-pregnant women are prohibited during pregnancy for safety reasons. Therapeutic decisions and management of a pregnant patient with neurological disorders heavily depends on the issue of the reasonable balance between the risks of no treatment versus active treatment for the mother and her fetus. This book provides a review of the latest findings in this field, giving the neurologist and non-neurologist the information they need to determine the best treatment. Neurological disorders covered include multiple sclerosis, stroke and epilepsy. Discusses how neurological disorders should be managed in a pregnant patient Includes contributions from leading authorities
Author : Mary Rensel,Orla Gray
Publisher : Karger Medical and Scientific Publishers
Page : 146 pages
File Size : 52,8 Mb
Release : 2016-08-29
Category : Medical
ISBN : 9781910797235
Since the last edition of this book, 'no evidence of disease activity' (NEDA) has been proposed as a new treatment target, early data on the first pharmacological treatments for progressive MS have emerged, and the first remyelination trial has shown positive effects on nerve repair. It is with this sense of optimism that the authors of 'Fast Facts: Multiple Sclerosis' have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team, including: • a concise overview of investigations and modern diagnostic criteria • a holistic approach to all signs and symptoms, and proactive relapse management • the latest disease-modifying drugs, including when to treat, choice of drug and risk versus benefit. With case histories that will help to guide treatment decisions, discussion of the special considerations for MS during pregnancy, and in children and the elderly, and a detailed outline of emerging therapies, this book will benefit all healthcare professionals involved in the care of patients with this complex disease.
Author : Sandra Hellberg
Publisher : Linköping University Electronic Press
Page : 118 pages
File Size : 47,6 Mb
Release : 2019-10-22
Category : Electronic
ISBN : 9789179299934
Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
Author : Maria K. Houtchens,A. Dessa Sadovnick
Publisher : Springer
Page : 131 pages
File Size : 50,5 Mb
Release : 2017-03-15
Category : Medical
ISBN : 9783709148587
This book addresses specific concerns of females affected by multiple sclerosis, where women are disproportionally impacted by the disease. MS is an autoimmune disease of the central nervous system affecting young adults of reproductive age. This book presents the current understanding of genetic variables, hormonal influences, immunological milieu and neurological outcomes, discussing issues such as fertility, pregnancy management, and menopause, as well as end of life care and mortality in women with MS. With contributions by international experts, this interdisciplinary book will serve as a useful reference and guide for MS specialists, general neurologists, obstetricians/gynecologists, physicians in training, family practice doctors, clinical nurse specialists in multiple sclerosis, and all other healthcare professionals involved in the care and treatment of women affected by MS.
Author : Hiroshi Mitoma,Mario Manto
Publisher : Springer
Page : 822 pages
File Size : 52,6 Mb
Release : 2019-08-13
Category : Medical
ISBN : 9783030195151
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Author : Rosalind C. Kalb, MD
Publisher : Demos Medical Publishing
Page : 496 pages
File Size : 53,9 Mb
Release : 2011-11-11
Category : Health & Fitness
ISBN : 9781617050763
Multiple Sclerosis: The Questions You Have, The Answers You Need, 5th Edition is the definitive guide for everyone concerned with the disease - those who have MS and those who share their lives with someone who has it. It covers a wide range of topics in an accessible question and answer format that allows people to easily find the information they need while providing a model of successful communication with healthcare providers. The contributors are leading authorities in all areas of multiple sclerosis management, who proffer expert answers to the most common questions about living with MS-medical, emotional, social, and economic - and represents a interdisciplinary approach to the disease. The book's goal is to help those living with MS live the lives they aspire to lead. The chapters cover everything from treatment to emotional, sexual, and employment issues. The new edition has been thoroughly revised and updated throughout. The book provides the most current information on multiple sclerosis including a review of the controversy surrounding CCVSI, discussion of the first two pills in development for the disease, new information on the drug Tysabri, emotional issues, and the family. The thoroughly revised and updated fifth edition of the classic Multiple Sclerosis: The Questions You Have, The Answers You Need answers even more of your questions about how to live and thrive with MS. What are the current drug therapies for MS? What about alternative medicine? Should I exercise? How common is depression with MS?
Author : Anjani Chandra,Casey E. Copen,Elizabeth H. Stephen
Publisher : Unknown
Page : 24 pages
File Size : 49,6 Mb
Release : 2013
Category : Fertility, Human
ISBN : UCR:31210024293399
Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2015
Category : Health & Fitness
ISBN : 9241549351
Intended to provide evidence-based recommendations to guide health care professionals in the management of women during pregnancy, childbirth and postpartum, and newborns, and the post abortion, including management of endemic deseases like malaria, HIV/AIDS, TB and anaemia. This edition has been updated to include recommendations from recently approved WHO guidelines relevant to maternal and perinatal health. These include pre-eclampsia & eclampsia; postpartum haemorrhage; postnatal care for the mother and baby; newborn resuscitation; prevention of mother-to- child transmission of HIV; HIV and infant feeding; malaria in pregnancy, interventions to improve preterm birth outcomes, tobacco use and second-hand exposure in pregnancy, post-partum depression, post-partum family planning and post abortion care.
Author : Wendy Jones
Publisher : Routledge
Page : 362 pages
File Size : 40,8 Mb
Release : 2018-05-11
Category : Medical
ISBN : 9781351580991
Sadly, women often feel they have no alternative but to give up breastfeeding, having been prescribed or purchased medication. In many cases, however, this is unnecessary. This book outlines the evidence base for the use of medication during breastfeeding. Breastfeeding and Medication presents a comprehensive A to Z guide to the most frequently prescribed drugs and their safety for breastfeeding mothers. Evaluating the evidence for interventions and using a simple format for quickly identifying medications that are safe or unsafe to use, it also highlights those drugs where there is inconclusive evidence. Additional contextual information makes this the most complete text for those practitioners who support and treat breastfeeding women. It: provides an overview of the anatomy and physiology of the breast together with hormonal influences to better understand how complications, such as mastitis, arise and inform the approach to their treatment; includes a section on conditions that affect women specifically when they are lactating where prescription of medication may be necessary; discusses the importance of breastfeeding and its advantages, as well as its disadvantages; and explores how to support breastfeeding mothers, and presents a counselling model approach. This new edition contains information on more drugs and a chapter on the management of some chronic conditions which may affect breastfeeding mothers. In most cases there are options to support the mother’s optimal care whilst allowing her to continue to breastfeed her baby as long as she wishes. This is a topic which raises many questions on social media, which informed the choice of conditions to consider. This is an invaluable reference for all health practitioners and volunteers who work with, support and treat breastfeeding women, including lactation consultants, breastfeeding support workers, health visitors, GPs, practice nurses, pharmacists and midwives.
Author : George Jelinek,Sandra Neate,Michelle O'Donoghue
Publisher : Allen & Unwin
Page : 490 pages
File Size : 46,6 Mb
Release : 2022-02-01
Category : Health & Fitness
ISBN : 9781761063688
A complete guide to a healthy and active life with MS on the Overcoming Multiple Sclerosis Program, with chapters from a team of international experts and personal stories from around the world. A long, healthy, happy life is possible after a diagnosis of multiple sclerosis. Around the world, thousands of people are living active and fulfilling lives on the Overcoming Multiple Sclerosis Program. The Overcoming Multiple Sclerosis Handbook explains what MS is, and outlines the scientifically credible and evidence-based 7 step self-management program originally devised by Professor George Jelinek. It covers all aspects of living on the program, from first diagnosis to later life, with chapters from medical specialists and other experts on choosing your healthcare team, improving resilience, work, pregnancy and progressive MS. The book taps into the wealth of knowledge and experience in the community of people following the Overcoming Multiple Sclerosis Program, with personal stories from across the world. If you have recently been diagnosed with MS, if you have been living with MS for years, or if you have a family member with MS, the Overcoming Multiple Sclerosis Handbook is your best companion. It is also an invaluable resource for doctors treating people with MS. 'If you or someone that you love is impacted by MS this book is a must-read.' - Dr Aaron Boster, The Boster Center for Multiple Sclerosis, Columbus, Ohio 'This highly recommended book highlights the importance of a holistic approach to MS management.' - Professor Richard Nicholas, Imperial College London 'Overcoming MS is now the essential mainstay of MS management, before or alongside drug therapy, offering the best chance of a full and healthy life for people with MS.' - Dr Peter Silbert, Clinical Professor of Neurology, University of Western Australia Medical School
Author : John T. Queenan,Catherine Y. Spong,Charles J. Lockwood
Publisher : Wiley-Blackwell
Page : 488 pages
File Size : 52,6 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470691182
This book is a must-have for all health professionals involved in the care of women with high risk pregnancies. It is a concise and practical resource for all perinatal care and a reference for the diagnosis and management of high risk pregnancy. The fifth edition of this classic, focuses on factors affecting pregnancy, genetics, practical diagnostic techniques, maternal diseases in pregnancy and pregnancy complications, labor, anesthesia, and neonatal considerations. Dr Queenan is joined in the fifth edition by a new editor, Catherine Spong. The book will take an explicitly evidence-based approach this time around and will expand upon several important areas; genetics, doppler ultrasound, prevention, AIDS, group B streptococcus, preeclampsia, and prematurity.
Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Publisher : National Academies Press
Page : 457 pages
File Size : 42,7 Mb
Release : 2001-08-10
Category : Medical
ISBN : 9780309072854
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.