Nano Oncologicals

Author : Maria José Alonso,Marcos Garcia-Fuentes
Publisher : Springer
Page : 473 pages
File Size : 44,6 Mb
Release : 2014-10-15
Category : Medical
ISBN : 9783319080840

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Nano-Oncologicals by Maria José Alonso,Marcos Garcia-Fuentes Pdf

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Author : Sanyog Jain,Kaisar Raza,Ashish Kumar Agrawal,Ankur Vaidya
Publisher : Elsevier
Page : 704 pages
File Size : 42,5 Mb
Release : 2020-09-30
Category : Technology & Engineering
ISBN : 9780128178478

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Nanotechnology Applications for Cancer Chemotherapy by Sanyog Jain,Kaisar Raza,Ashish Kumar Agrawal,Ankur Vaidya Pdf

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics. Discusses how organic and inorganic nanoplatforms are being used in cancer treatment Shows how nanotechnology is being used to create new and more accurate diagnostic tools Surveys the current generation of cancer nanomedicines, assessing their advantages and challenges

Author : Visakh P. M.
Publisher : John Wiley & Sons
Page : 580 pages
File Size : 42,5 Mb
Release : 2022-09-13
Category : Science
ISBN : 9781119558033

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Nanomaterials and Nanotechnology in Medicine by Visakh P. M. Pdf

NANOMATERIALS AND NANOTECHNOLOGY IN MEDICINE A comprehensive introduction to nanomaterials and their application in the field of medicine The use of nanotechnology and nanomaterials more generally is an emerging field that has generated a lot of interest in the last few years. To this point, there have been few books that deal with the recent advances in nanomaterials or nanocomposites in the medical discipline. Intended as a one-stop reference, Nanomaterials and Nanotechnology in Medicine provides the reader with the most-up-to-date and comprehensive exploration of the field of nanomedicine. The scope of the topic is huge, with nano applications in every medical specialization—from diagnostics to pharmaceuticals, from biological therapies to surgical devices, and from regenerative therapies to gene therapy. As such, this volume provides the most comprehensive coverage of this intriguing field of study. Nanomaterials and Nanotechnology in Medicine readers will also find: An application-oriented book dedicated towards helping researchers find solutions to both fundamental and applied problems Chapters written by leading researchers from industry, academy, government, and private research institutions across the globe Nanomaterials and Nanotechnology in Medicine is a useful reference for medical doctors, medical practitioners, post-doctoral research fellows, senior graduate students, and medical libraries.

Author : Prashant Kesharwani,Sebastien Taurin,Khaled Greish
Publisher : Academic Press
Page : 542 pages
File Size : 53,7 Mb
Release : 2020-09-12
Category : Medical
ISBN : 9780128204672

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Theory and Applications of Nonparenteral Nanomedicines by Prashant Kesharwani,Sebastien Taurin,Khaled Greish Pdf

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia

Author : Prashant Kesharwani
Publisher : Elsevier
Page : 570 pages
File Size : 48,7 Mb
Release : 2024-01-19
Category : Technology & Engineering
ISBN : 9780443187711

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Nanomedicine in Cancer Immunotherapy by Prashant Kesharwani Pdf

Nanomedicine in Cancer Immunotherapy bridges the two disciplines of nanotechnology and immunology, summarizing the latest research into novel cancer treatments, often personalized to the patient.This book covers a wide range of nanomaterial types for use in cancer immunotherapy, including hydrogel, lipid, exosome, gold and peptide nanoparticles. The preparation, application, pros and cons of each nanomaterial class is reviewed, helping the reader understand the potential for each and tailor their selection to their needs. Nanovaccines are also covered, along with a clinical evaluation and market analysis of nanomedicines for immunotherapy, offering an important clinical and commercial overview of this rapidly developing field.Nanomedicine in Cancer Immunotherapy is an interesting reference for those working in the fields of nanotechnology, immunology and cancer therapeutics, as well as clinicians with an interest in novel nano-based cancer treatments. Provides a single source for a review of the latest research in the development of nanomaterials for cancer immunotherapy Introduces the reader to basic principles of immunology and immunotherapy to aid our understanding Details a wide range of nanomaterial classes for cancer immunotherapy, with advantages and disadvantages thoroughly analyzed

Author : Rajput, Vishnu D.,Singh, Abhishek,Ghazaryan, Karen,Alexiou, Athanasios,Said Al-Tawaha, Abdel Rahman Mohammad
Publisher : IGI Global
Page : 557 pages
File Size : 46,8 Mb
Release : 2024-05-01
Category : Technology & Engineering
ISBN : 9798369318911

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Harnessing NanoOmics and Nanozymes for Sustainable Agriculture by Rajput, Vishnu D.,Singh, Abhishek,Ghazaryan, Karen,Alexiou, Athanasios,Said Al-Tawaha, Abdel Rahman Mohammad Pdf

In an era overshadowed by pressing global challenges such as climate change, burgeoning populations, and the depletion of natural resources, the agricultural landscape is at a critical juncture. The need for sustainable practices has never been more urgent, with conventional methods struggling to meet the demands of a growing population while grappling with environmental degradation. Harnessing NanoOmics and Nanozymes for Sustainable Agriculture delves into the heart of the problem, navigating the intricate web of challenges facing agriculture today. From dwindling crop yields to the environmental repercussions of conventional farming practices, the urgency to find innovative, sustainable solutions is paramount. Harnessing NanoOmics and Nanozymes for Sustainable Agriculture offers a comprehensive exploration of nanotechnology's potential to revolutionize agriculture, presenting a promising pathway toward enhanced productivity, minimizing environmental impact, and optimal resource utilization.

Author : Muthupandian Saravanan,Hamed Barabadi
Publisher : Springer Nature
Page : 379 pages
File Size : 41,5 Mb
Release : 2021-10-05
Category : Medical
ISBN : 9783030762636

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Cancer Nanotheranostics by Muthupandian Saravanan,Hamed Barabadi Pdf

Cancer Nanotheranostics, Volume 2 continues the discussion of the important work being done in this field of cancer nanotechnology. The contents of these two volumes are explained in detail as follows. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials, and nano-antibodies. This important second volume discusses nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nanoerythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, safety of nanobiomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics. Volume 2 is a vital continuation of this two-volume set. Together, these two volumes create a comprehensive and unique examination of this important area of research.

Author : Wolfgang Parak,Neus Feliu
Publisher : Elsevier
Page : 398 pages
File Size : 54,7 Mb
Release : 2020-05-13
Category : Technology & Engineering
ISBN : 9780081028285

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Colloids for Nanobiotechnology by Wolfgang Parak,Neus Feliu Pdf

Colloids for Nanobiotechnology: Synthesis, Characterization and Potential Applications, Volume 17, offers a range of perspectives on emerging nano-inspired colloidal applications. With an emphasis on biomedical and environmental opportunities and challenges, the book outlines how nanotechnology is being used to increase the uses and impact of colloid science. Nanotechnology offers new horizons for colloidal research and synthesis routes that allow for the production of highly reproducible and defined materials. This book presents new characterization methods and a fundamental understanding of basic physicochemical, physical and chemical properties. Explores the use of nanotechnology in enhancing colloidal characterization techniques Explains how colloids are being used in a range of nanomedical applications Demonstrates how nanotechnology is being used to create more efficient colloidal synthesis techniques

Author : Alexandru Grumezescu
Publisher : William Andrew
Page : 518 pages
File Size : 49,6 Mb
Release : 2016-04-13
Category : Medical
ISBN : 9780323417389

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Nanobiomaterials in Medical Imaging by Alexandru Grumezescu Pdf

Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A valuable resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A detailed guide to recent scientific progress, along with the latest application methods Presents innovative opportunities and ideas for developing or improving technologies in nanomedicine and medical imaging

Author : Lara Scheherazade Milane,Mansoor M. Amiji
Publisher : CRC Press
Page : 510 pages
File Size : 53,9 Mb
Release : 2021-12-29
Category : Science
ISBN : 9781000505931

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Organelle and Molecular Targeting by Lara Scheherazade Milane,Mansoor M. Amiji Pdf

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Author : João Conde,Pedro Viana Baptista,Jesús M De La Fuente,Furong Tian
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 43,7 Mb
Release : 2016-03-17
Category : Cancer
ISBN : 9782889197767

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Cancer Nanotheranostics: What Have We Learned So Far? by João Conde,Pedro Viana Baptista,Jesús M De La Fuente,Furong Tian Pdf

After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

Author : Gil Goncalves,Paula A.A.P. Marques,Joao F. Mano
Publisher : Elsevier
Page : 442 pages
File Size : 55,9 Mb
Release : 2022-10-07
Category : Medical
ISBN : 9780323885669

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New Trends in Smart Nanostructured Biomaterials in Health Sciences by Gil Goncalves,Paula A.A.P. Marques,Joao F. Mano Pdf

New Trends in Smart Nanostructured Biomaterials in Health Sciences provides guidance on the design and synthesis of nanostructured smart biomaterials, as well as the resultant therapeutic effects and associated biomedical applications of these novel materials. The book provides readers with a deeper understanding of these novel biomaterials and aids them in making informed decisions when selecting appropriate materials for tissue engineering and cancer therapy applications. It will be of specific interest to materials scientists, biomedical engineers, oncological scientists, tissue engineers and those working in regenerative medicine. Nanostructured smart materials have the special ability to respond to changes in the cell microenvironment, allowing for robust, biocompatible and rapidly adaptable, therapeutic and restorative action against a range of ailments. These materials are thus ideal candidates for use in tissue engineering and cancer therapy due to the varying nature of the cell microenvironment between persons, tissues and cancers. This book covers the design, synthesis, unique properties and application of smart biomaterials in these two key topic areas of tissue engineering and cancer therapeutics. Presents an overview of how smart biomaterials respond to changes in physiological factors and exogeneous stimuli and their impact in modern medicine Provides readers with the basis for designing, processing and characterizing advanced smart biomaterials Guides the reader through the mechanisms of tissue repair and cancer therapeutics by exploring the most relevant features of smart nanostructured materials

Author : Raghvendra Ashok Bohara,Nanasaheb D. Thorat
Publisher : Elsevier
Page : 276 pages
File Size : 45,8 Mb
Release : 2018-11-19
Category : Science
ISBN : 9780128139073

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Hybrid Nanostructures for Cancer Theranostics by Raghvendra Ashok Bohara,Nanasaheb D. Thorat Pdf

Hybrid nanostructures are nanoparticles which incorporate two or more structures. These structures may represent organic or inorganic material, but they synergistically improve the application of the material for end users. Hybrid Nanostructures for Cancer Theranostics explores how hybrid nanostructures are used in cancer treatment. Focusing on the properties of hybrid nanostructures, the book demonstrates how their unique characteristics can be used to create more effective treatment techniques. In the second half of the book, the chapters examine how hybrid nanostructures are currently being used in practice, assessing the pros and cons of using different types of nanostructures for different treatments. This valuable resource will allow readers to understand the core and emerging concept of functionalization, bioconjugation, hyperthermia and phototherapy of nanoparticles which allows for the greater use of hybrid nanomaterials in cancer theranostics. Shows how the use of novel hybrid nanostructures can lead to more effective cancer treatments. Explores how hybrid nanostructures are used for different treatment types, including photo thermal therapy and drug delivery. Explains how the use of hybrid nanostructures can lead to more rapid cancer diagnosis.

Author : Weifeng Lin,Long Bai
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 48,5 Mb
Release : 2023-09-08
Category : Science
ISBN : 9782832533765

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Exploration of innovative strategies focusing on advanced nanobiomaterials for optimizing oncological treatment and tissue restoration by Weifeng Lin,Long Bai Pdf

Author : Amit Kumar Nayak,Md Saquib Hasnain,Tejraj M. Aminabhavi,Vladimir P. Torchilin
Publisher : Academic Press
Page : 525 pages
File Size : 53,8 Mb
Release : 2022-07-22
Category : Medical
ISBN : 9780323919531

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Applications of Nanovesicular Drug Delivery by Amit Kumar Nayak,Md Saquib Hasnain,Tejraj M. Aminabhavi,Vladimir P. Torchilin Pdf

Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables