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Nanobiotherapeutic Based Blood Substitutes by Thomas Ming Swi Chang,Leif Bulow,Johnathan S Jahr,Hiromi Sakai,Chengmin Yang Pdf
This definitive volume will provide the reader with up to date information and the most recent science of the fast-evolving area of nanobiotherapeutic-based blood substitutes. Long studied, there are recent updates that make their use in patients more promising, and with one product approved for human use, many more in the pipeline. These include 2nd generations and even third generation ones, the later with enhancement of red blood cell functions. In addition, there are carefully written and referenced updates on the recent history and products in the field, complete with pathophysiologic and pharmacologic studies to validate and verify the efficacy and safety of many of these new products.
Blood Substitutes by Robert M. Winslow,Marcos Intaglietta,Kim D. Vandergriff Pdf
This volume contains a collection of essays by selected authors who are active in the field of blood substitutes research or closely allied disciplines. These essays were delivered as lectures by the authors at the second annual "Current Issues in Blood Substitute Research and Development - 1995" course sponsored jointly by the Departments of Medicine and Bioengineer ing, University of California, San Diego, the National Institutes of Health (NHLBI), and the U.S. Army on March 30, 31, and April 1, 1995 in San Diego. This course had three goals: to present fundaniental discussions of scientific issues critical to further development of artificial oxygen carriers, to provide academicians a forum to discuss their current research, and to provide the companies involved in developing products the opportunity to update the audience on their progress. The organization owes much to the solicited comments of the attendees of the 1994 course. We would like especially to thank the U.S. Army, particularly through the efforts of COL John Hess, who provided significant funding to make publication of this volume possible. In addition, a number of the participating companies provided additional financial support to offset the costs of the course. These include Alliance Pharmaceutical Corp., Hemosol, Nippon Oil and Fat, Northfield Laboratories, and Ortho Biotech.
Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics by Hae Won Kim,A. Gerson Greenburg Pdf
Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
Blood substitutes are solutions designed for use in patients who need blood transfusions, but for whom whole blood is not available, or is not safe. This interest has intensified in the wake of the AIDS and hepatitis C epidemics. Blood Substitutes describes the rationale, current approaches, clinical efficacy, and design issues for all blood substitutes now in clinical trials. The many summary diagrams and tables help make the book accessible to readers such as surgeons and blood bankers, who have less technical expertise than the biochemists and hematologists who are designing and testing blood substitutes. * Includes chapters necessary to the understanding of blood substitutes, including history, toxicity, physiology, and clinical applications* Presents detailed descriptions of the various products that have been developed and have advanced to clinical trials, and some that are in earlier states of development
Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.
Chemistry and Biochemistry of Oxygen Therapeutics by Andrea Mozzarelli,Stefano Bettati Pdf
Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen – the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or “blood substitutes”) which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in β thalassemia and sickle cell disease Finally “old”and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia – industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.
This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. This book includes up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or fluorocarbon-based blood substitutes, and covers issues of hemoglobin toxicity and side effects such as vasoconstriction in more detail using carefully designed in vivo and ex vivo techniques. This book is also a collection of various new types of red cell substitutes such as recombinant Hbs, recombinant albumine-lipidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering.
Author : Henry Liu,Alan D. Kaye,Jonathan S. Jahr Publisher : Springer Nature Page : 441 pages File Size : 51,7 Mb Release : 2022-08-08 Category : Medical ISBN : 9783030959753
Blood Substitutes and Oxygen Biotherapeutics by Henry Liu,Alan D. Kaye,Jonathan S. Jahr Pdf
This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena. The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter. Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.
Selected Topics in Nanomedicine by Thomas Ming Swi Chang Pdf
Nanomedicine consists of the use of nanotechnology and nanobiotechnology in medicine. There have been extensive developments in the area of nanomedicine. The scope of this book is first to discuss the origin of nanomedicine. Following this, instead of a general overview of the whole area, 24 chapters on selected topics of important areas are described in detail. Authors are selected from around the world to give a representative and international view of the activities in the area of nanomedicine. Contents:Artificial Cells: The Beginning of Nanomedicine (Thomas Ming Swi Chang)The Clinical Development of Hemopure®: A Selective Commentary (A Gerson Greenburg)Glutaraldehyde Polymerized Porcine Hemoglobin: Preparation, Safety Evaluation and Pharmacodynamics Study (Chao Chen, Hongli Zhu and Kunping Yan)Evidence Regarding Some Pharmacologic Characteristics of Hemoglobin-Based Oxygen Carriers (Enrico Bucci)EAF PEG Hemoglobins: Novel Class of Nonhypertensive Resuscitation Fluids: Simplicity and Advantages of Extension Arm Chemistry for PEGylation (Seetharama A Acharya, Amy G Tsai and Marcos Intaglietta)Biocompatibility of a Highly Concentrated Fluid of Hemoglobin-Vesicles as a Transfusion Alternative (Hiromi Sakai)Molecular Basis of Haptoglobin and Hemoglobin Complex Formation and Protection against Oxidative Stress and Damage (Yiping Jia and Abdu I Alayash)Polynitroxylated Hemoglobin as a Multifunctional Therapeutic for Critical Care and Transfusion Medicine (Li Ma and Carleton Jen Chang Hsia)Surface-Mediated Drug Delivery (Benjamin M Wohl, Betina Fejerskov, Siow-Feng Chong and Alexander N Zelikin)Use of Tunable Pores for Accurate Characterization of Micro- and Nanoparticle Systems in Nanomedicine (James Eldridge, Aaron H Colby, Geoff R Willmott, Sam Yu and Mark W Grinstaff)Microfluidic Probes to Process Surfaces, Cells, and Tissues (Mohammad A Qasaimeh, Sebastien G Ricoult and David Juncker)Subcompartmentalized Systems Towards Therapeutic Cell Mimics (Leticia Hosta-Rigau and Brigitte Städler)Soft Magnetic Nanomaterials Towards Nanomedicine: Magnetism Principles, Preparation, Characterization and Potential Applications (G W Qin, S Li, Y P Ren, F Darain and K Dimitrov)GoldMag Composite Particles and Their Applications in Nanomedicine (Mingli Peng, Xu Chao, Chao Chen and Yali Cui)Nanoparticles for Imaging and Therapy: Functionalization, Endocytosis and Characterization (Yu Zhang, Yi Li, Gürer Budak, Mihrimah Ozkan and Cengiz S Ozkan)Noscapines: Novel Carrier Systems to Target Tumor Cells (Ramesh Chandra, J Madan, Prashant Singh, Pradeep Kumar, V Tomar, Sujata K Dass and Ankush Chandra)High-Throughput Methods for Miniaturization of Implantable Artificial Cells (Maryam Mobed-Miremadi)Amphiphilic Core–Shell Nanoparticles Containing Hairy Polyethyleneimine Shells as Effective Nanocarriers for Gene and siRNA Delivery (Pei Li, Yuen Shan Siu, Kin Man Ho and Wei Li)Nano-Chaperones: Nanoparticles Acting as Artificial Chaperones (S Boridy and D Maysinger)Bio-Functional Polymer Vesicles for Applications in Nanomedicine (Hans-Peter M de Hoog, Bo Liedberg and Madhavan Nallani)Carbon Nanotubes in Cancer and Stem Cell Therapeutics (Wei Shao, Arghya Paul and Satya Prakash)Chitosan-Based Nanocarriers for Efficient and Targeted siRNA Delivery (Surendra Nimesh and Ramesh Chandra)Application of Polyethylenimine-Based Nanoparticles for RNA Therapeutics (Surendra Nimesh and Ramesh Chandra)Nanosilver System Technology for Applications in Nanomedicine (Helmut Schmid) Readership: Graduate students and researchers in nanomedicine, nanobiotechnology, nanotechnology, biotechnology and biomedical engineering. Keywords:Nanomedicine;Nanobiotechnology;Nanotechnology;Blood Substitutes;Polyhemoglobin;Oxygen Therapeutics;Antioxidant;Oxygen Radicals;Regenerative Medicine;Nanocapsules;Nanoparticles;Bioencapsulation;Drug Delivery;Magnetic;Conjugated Hemoglobin;Enzymes;Cancer Therapy;Carbon Nanotubule;Microfluidics;Blood;Transfusion;Polyethylene Glycol;Liposome;Polymersomes;Oxidative Stress;Artificial Cells
Nanostructured Materials and their Applications by Bibhu Prasad Swain Pdf
The book provides an introduction to nanostructured materials and guides the reader through their different engineering applications. It gives an overview of nanostructured materials applied in the fields of physics, chemistry, biology, medicine, and materials science. Materials for different applications in engineering such as those used in opto-electronics, energy, tribology, bio-applications, catalysis, reinforcement and many more have been described in this book. The book will be of interest to researchers and students who want to learn about applications of nanostructured materials in engineering.
Author : F. Kreuzer,S. M. Cain,Z. Turek,T. K. Goldstick Publisher : Springer Science & Business Media Page : 942 pages File Size : 48,6 Mb Release : 2013-11-11 Category : Medical ISBN : 9781468432916
Oxygen Transport to Tissue VII by F. Kreuzer,S. M. Cain,Z. Turek,T. K. Goldstick Pdf
Since there are many different tissues and organs in the body, a study of oxygen transport to tissue necessarily involves a great diversity of bodily functions. Furthermore, these tissue functions can be approached from the viewpoint of several disciplines. Even tually, however, all of these approaches must be combined to arrive at a comprehensive picture. This multidisciplinary effort, though imperative, has been implemented slowly because traditional biologi cal science has been largely organ- or discipline oriented. Initia tives to realize an effective international multidisciplinary collab oration have assumed increasing momentum for the past 20 years. These include meetings held in Bad Oeynhausen in 1965 (book in 1968, edited by D. W. Lubbers, U. C. Luft, G. Thews and E. Witzleb), in Nijmegen in 1968 (book in 1969, edited by F. Kreuzer), in Vancouver in 1970 (J. Strauss), and in Dortmund in 1971; this last was in connection with the 25th International Physiological Congress in Munich (book in 1973, edited by M. Kessler, D. F. Bruley, L. C. Clark, Jr. , D. W. Lubbers, I. A. Silver and J. Strauss). This increasing international cooperation called for a more formal organization of these individual initiatives. The credit for taking this decisive step goes to H. I. Bicher and D. F. Bruley from the U. S. A. and D. W. Lubbers and M. Kessler from Germany, who got together in 1972 to plan a large-scale inter national meeting and to organize an international society.
Author : Thomas Ming Swi Chang,Binglan Yu Publisher : Frontiers Media SA Page : 148 pages File Size : 42,7 Mb Release : 2023-11-28 Category : Medical ISBN : 9782832540022
Innovative Medical Technology Based on Artificial Cells, Including its Different Configurations by Thomas Ming Swi Chang,Binglan Yu Pdf
Artificial Cells are not to reproduce biological cells but to prepare an artificial system for possible uses in medicine and other areas. Many of the ideas on artificial cells are being extensively applied and extended by researchers worldwide, resulting in rapid and exciting progress and discoveries. Different configurations include using emulsion methods and microfluidizers to form microscopic or nano dimension cells called artificial cells, synthetic cells, microcapsules, nanocapsules, liposomes, microparticles, nanoparticles, polymersomes, etc. Macro dimensions artificial cells are used for bioencapsulated cells. Soluble nanobiotherapeutics can be formed by crosslinking proteins and enzymes or by PEG conjugation. The principle of artificial cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation, biosorbent/immunosorbent hemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, COVID_19 vaccine, COVID_19 therapy, nanobiotechnology, nanotechnology and other areas.
Author : Karl H. Krieger,O. Wayne Isom Publisher : Springer Science & Business Media Page : 678 pages File Size : 46,9 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461221807
Blood Conservation in Cardiac Surgery by Karl H. Krieger,O. Wayne Isom Pdf
Here, two of the foremost cardiothoracic surgeons have brought together many of the top cardiologists and haematologists to produce the most current reference source on all aspects of blood conservation, from an overall clinical approach to the use of erythropoietin and the benefits of post-operative blood salvage. The subject matter covers numerous areas involved in the preoperative considerations in cardiac surgery, the intraoperative decision-making in cardiac surgery, postoperative bleeding and management and a section on the algorithm for bloodless surgery used at the New York Hospital-Cornell Medical Center.