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Author : Anupam Bishayee,Mukerrem Betul Yerer-Aycan
Publisher : MDPI
Page : 285 pages
File Size : 45,9 Mb
Release : 2018-11-07
Category : Electronic books
ISBN : 9783038973102
This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients
Author : Frank E. Koehn
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 55,6 Mb
Release : 2012-11-09
Category : Medical
ISBN : 9781461446545
This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.
Author : Motamarri Venkata Naga Lalitha Chaitanya,Galvina Pereira,Heyam Saad Ali
Publisher : Bentham Science Publishers
Page : 325 pages
File Size : 51,5 Mb
Release : 2023-11-02
Category : Medical
ISBN : 9789815124705
This book provides a holistic view of natural products and remedies that have been used to treat cancer. The editors aim to educate readers about the importance of the translational role of natural products in cancer treatment by compiling 14 chapters. The book emphasizes an integrative approach to the topic by blending traditional knowledge that supports alternative therapies with the science of phytochemicals and drug discovery technologies as a means to manage the disease. Key topics include alternative therapies (such as aromatherapy and immune boosting herbal medications), cytotoxic and anti-cancer phytochemicals, drug delivery and discovery technologies (including high-throughput screening) and some drug targets of interest for cancer treatment (such as topoisomerases and caspases). Readers will be able to learn about natural sources of ant-cancer compounds, and the methods used by research and development experts in pharmaceutical and nutraceutical industries to isolate and formulate these compounds. This book will be a handy resource for a wide range of readers. This includes researchers, traditional medical practitioners, PG students, Ph.D. scholars and general readers to understand the role of natural products in cancer treatment. key features - Explains the importance of alternative therapies in the management of cancer - Emphasizes the ethnopharmacological approaches to cancer - Explores natural anticancer drug libraries - Discusses the role of modern cancer targets and the importance of in-silico tools in anticancer drug discovery - Addresses modern drug discovery tools and drug delivery technologies concerning their applications in cancer treatment. - Includes references for further reading
Author : Jiang-Jiang Qin,Wei-Dong Zhang,Huizi Jin,Sanjay K. Srivastava
Publisher : Frontiers Media SA
Page : 699 pages
File Size : 53,6 Mb
Release : 2024-01-11
Category : Medical
ISBN : 9782832541982
This Research Topic is part of a series with: Multi-targeted Natural Products as Cancer Therapeutics: Challenges and Opportunities, Volume II Cancer remains a leading cause of disease-related deaths worldwide, despite recent advances in our understanding of cancer initiation, progression, and metastasis. Chemotherapy and radiotherapy have been used as standard non-surgical treatments of human cancer for decades, however, the survival rates of patients with cancer, especially those with advanced diseases are still very low due to the high toxicities of these treatments as well as the severe side effects. This fact has motivated researchers to discover new cancer therapeutics with minimum side effects, which intensively promotes the rapid development of single specific molecule-targeted therapies (SSMTT). Many efforts have been made in world-wide cancer drug discovery research and several single molecule-targeted therapies have been successfully developed. Unfortunately, most of the investments failed because cancer is a genetic disease and always harbors multiple alternations of molecules or genes at the genomic, genetic and epigenetic levels. The inhibition of a single molecule or signaling pathway by SSMTT frequently results in a hyperactive compensation of other cancer-related molecules and signaling pathways as well as the subsequent development of drug resistance. Therefore, identifying multi-targeted therapies, i.e. drugs that are able to target multiple cancer-related genes, proteins, or signaling pathways is a more promising way to success in developing new cancer therapeutics. Natural products, especially those from traditional Chinese medicine and folk remedies in other countries are an extraordinarily important source for new drug discovery over the past decades. Of note, many natural products have often been demonstrated to target several crucial genes or proteins in cancer-related signaling networks and exert synergistic effects. For example, Japonicone A, a dimeric sesquiterpenoid from the medicinal plant Inula japonica, has been found to inhibit tumor growth and metastasis by dually targeting the TNF-α/NF-κB and p53/MDM2 signaling pathways. Traditionally, researchers have believed that the multi-targeting mechanisms of natural products have limited their use in cancer treatment due to the low specificity and potential side effects. The growing interest in developing multi-targeted cancer therapies may provide another golden opportunity to develop natural products as new cancer therapeutics. Nevertheless, critical investigations for a comprehensive understanding of the molecular mechanisms of natural products also mean more challenges. Our long-term goals are to fully understand the molecular targets and mechanisms of action of anticancer natural products and develop them as novel cancer preventive and therapeutic agents. The specific goal of this Research Topic is to bring together the recent findings of newly identified anticancer natural products, especially those with multiple molecular targets. Papers (Original Research articles or Reviews) which discuss the in vitro and in vivo efficacy and pharmacological and toxicological properties of natural products are also welcome to be submitted. Guidelines for the conception and review of submissions As many anticancer drugs working as cytotoxic compounds have non-selective effects annihilating their potential therapeutic benefits, manuscripts are advised to provide evidence of a significant selectivity towards cancer cells (vs. healthy cells). Specifically, if the studied anticancer drug or modality does not target an oncogenic pathway, the authors should make every effort possible to prove that the cytotoxic or cytostatic effects they have identified exhibit selectivity for cancer cells (ideally 1 log difference in EC50 or IC50) vs. non-malignant cells (eg, fibroblasts or primary culture of cells). The authors should also demonstrate the applicability of their anticancer modalities on a minimum of two well-authenticated cancer cell lines (ideally originating from distinct organs/tissues). For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.
Author : Farid A. Badria
Publisher : BoD – Books on Demand
Page : 318 pages
File Size : 45,6 Mb
Release : 2017-07-05
Category : Medical
ISBN : 9789535133131
This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.
Author : Radhakrishnan, Narayanaswamy,Vasantha, Srinivasan,Pandurangan, Ashok Kumar
Publisher : IGI Global
Page : 409 pages
File Size : 49,9 Mb
Release : 2023-08-18
Category : Medical
ISBN : 9798369307052
The field of cancer therapeutics faces challenges like limited treatment options, adverse side effects, and drug resistance, leaving a critical gap in addressing this disease. Natural Products as Cancer Therapeutics explores the untapped potential of bioactive compounds derived from nature, providing a fresh perspective on cancer treatment. Authored by esteemed scholars, this book comprehensively examines these compounds and their diverse pharmacological benefits. With cutting-edge research, this book has the potential to revolutionize oncology by expanding treatment options and emphasizing the safety and efficacy of natural compounds. It empowers researchers, practitioners, and scholars to explore new avenues in cancer therapeutics, contributing to improved patient outcomes in the ongoing battle against cancer. Embracing the potential of natural products, this book offers a comprehensive and effective approach to combatting cancer.
Author : Pandurangan, Ashok Kumar,Anandasadagopan, Suresh Kumar,Alhumaydhi, Fahad A.
Publisher : IGI Global
Page : 643 pages
File Size : 43,5 Mb
Release : 2022-03-18
Category : Medical
ISBN : 9781799892601
Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
Author : Jiang-Jiang Qin,Wei-Dong Zhang,Huizi Jin,Sanjay K. Srivastava
Publisher : Frontiers Media SA
Page : 714 pages
File Size : 47,5 Mb
Release : 2021-11-30
Category : Science
ISBN : 9782889717286
Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 51,7 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315
The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.
Author : John Boik
Publisher : Unknown
Page : 548 pages
File Size : 42,5 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015053511682
Natural Compounds in Cancer Therapy is a classic reference work for patients and medical professionals interested in use of nontoxic botanical compounds in the treatment of cancer. It offers a snapshot of the field circa 2001, and its insights are still pertinent today. Natural Compounds in Cancer Therapy is among the first books to discuss the use of natural products against cancer from a systems biology perspective.
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 19??
Category : Electronic
ISBN : 9535133144
Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 51,6 Mb
Release : 2008-10-13
Category : Science
ISBN : 9780470697030
Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.
Author : Ho John Wing Shing
Publisher : World Scientific
Page : 172 pages
File Size : 42,7 Mb
Release : 2019-04-23
Category : Medical
ISBN : 9789814525640
Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.
Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Page : 786 pages
File Size : 52,8 Mb
Release : 2011-10-10
Category : Science
ISBN : 9781439813829
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Author : Sahdeo Prasad,Amit Kumar Tyagi
Publisher : Bentham Science Publishers
Page : 213 pages
File Size : 45,9 Mb
Release : 2017-05-11
Category : Medical
ISBN : 9781681084916
Cancer is a major cause of deaths all around the globe. Although numerous anticancer drugs are available, most of them are expensive and have serious side effects. Natural compounds are usually non-toxic and inexpensive. Many such compounds have been identified and explored for their health benefits for centuries, and several nutritional factors derived from natural products have attracted considerable attention as therapeutic agents for the prevention and treatment of cancer. Based on current available research, this ebook focuses on chemopreventive and anti-cancer activities of different natural/dietary compounds present in fruits, vegetable, spices, legumes, nuts, grains, and cereals. Contributions from authors around the world highlight the potential use of such derivatives against cancer treatment by presenting updated information of their biochemical mechanisms. Information in this book is intended for researchers, clinicians, patients, academicians, industrialists, and students seeking updated and critical information for their experimental plans (including clinical trials). The book also creates awareness among cancer patients, nutritionists and laymen about cost effective therapeutic alternatives available for cancer therapy.
