Necrotic Cell Death

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Necrotic Cell Death

Han-Ming Shen,Peter Vandenabeele
Necrotic Cell Death Book PDF

Author : Han-Ming Shen,Peter Vandenabeele
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 51,8 Mb
Release : 2014-03-29
Category : Science
ISBN : 9781461482208

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Necrotic Cell Death by Han-Ming Shen,Peter Vandenabeele Pdf

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

Cell Death

Tobias Ntuli
Cell Death Book PDF

Author : Tobias Ntuli
Publisher : BoD – Books on Demand
Page : 448 pages
File Size : 45,7 Mb
Release : 2015-12-16
Category : Science
ISBN : 9789535122364

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Cell Death by Tobias Ntuli Pdf

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Apoptosis and Beyond

James A. Radosevich
Apoptosis and Beyond Book PDF

Author : James A. Radosevich
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 40,8 Mb
Release : 2018-09-18
Category : Science
ISBN : 9781119432357

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Apoptosis and Beyond by James A. Radosevich Pdf

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Mechanisms of Cell Death

Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Mechanisms of Cell Death Book PDF

Author : Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Publisher : Unknown
Page : 236 pages
File Size : 46,8 Mb
Release : 1999
Category : Science
ISBN : STANFORD:36105024897386

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Mechanisms of Cell Death by Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca Pdf

Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Necrosis

Kimberly McCall,Charles Klein
Necrosis Book PDF

Author : Kimberly McCall,Charles Klein
Publisher : Humana
Page : 0 pages
File Size : 41,7 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493960105

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Necrosis by Kimberly McCall,Charles Klein Pdf

Cell death is an essential process in development, and a major contributor to a wide range of human diseases. Three major classifications of cell death, apoptosis, autophagic cell death and necrosis, have been described for years, and the existence of many more forms of cell death is now accepted. In, Necrosis: Methods and Protocols experts in the field provide a wide range of methods and techniques for the study of necrosis in vitro and in vivo. These include methods and techniques for the analysis of necrosis in mammalian cells, characterization of alternative forms of cell death: entosis and pyroptosis, and analysis of cell death in non-mammalian model sytems and mammalian tissues, including chapters on skin, brain, and heart. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Necrosis: Methods and Protocols describes techniques in an easy to follow manner, with details so that beginners can succeed with challenging techniques.

Biochemistry of Apoptosis and Autophagy

Lorrie A. Kirshenbaum
Biochemistry of Apoptosis and Autophagy Book PDF

Author : Lorrie A. Kirshenbaum
Publisher : Springer Nature
Page : 293 pages
File Size : 43,5 Mb
Release : 2021-11-29
Category : Science
ISBN : 9783030787998

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Biochemistry of Apoptosis and Autophagy by Lorrie A. Kirshenbaum Pdf

One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.

Self and Nonself

Carlos López-Larrea
Self and Nonself Book PDF

Author : Carlos López-Larrea
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 51,6 Mb
Release : 2012-03-07
Category : Medical
ISBN : 9781461416807

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Self and Nonself by Carlos López-Larrea Pdf

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Pathologic Basis of Veterinary Disease

M. Donald McGavin
Pathologic Basis of Veterinary Disease Book PDF

Author : M. Donald McGavin
Publisher : Mosby
Page : 0 pages
File Size : 53,6 Mb
Release : 2007
Category : Medical
ISBN : 0323028705

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Pathologic Basis of Veterinary Disease by M. Donald McGavin Pdf

The 4th edition of this textbook, now in full color, presents both general pathology and special pathology in one comprehensive resource. Coverage includes a brief review of basic principles related to anatomy, structure and function, followed by congenital and functional abnormalities and discussions of viral, bacterial, and parasitic infections and neoplasia. Logically organized chapters discuss normal functions of the body system, followed by pathologic conditions found in domestic and companion animals. While focusing primarily on diseases in North America, the text also includes pathologic conditions found in other parts of the world, as well as those being brought into this country, such as West Nile virus, through the importation of cattle, sheep, and other animals. Contributors are recognized in their area of expertise and are well known in research and education. Now in full color throughout with vivid new illustrations that clarify difficult concepts. Includes six new chapters covering general pathology that discuss topics such as cellular and tissue responses to injury, vascular disorders, inflammation, and tumor biology. All chapters emphasize mechanisms of disease (organ, tissue, cell, and molecular injury). Features sequential presentations of disease processes (portal of entry * target cells * cellular injury * visual appearance of injury * resolution of injury * clinical outcomes). Emphasizes portals of entry for microbes and injurious agents. Focuses on defense mechanisms against microbes and injurious agents.

When Cells Die

Richard A. Lockshin
When Cells Die Book PDF

Author : Richard A. Lockshin
Publisher : Wiley-Liss
Page : 536 pages
File Size : 54,5 Mb
Release : 1998-04-13
Category : Science
ISBN : IND:30000121255743

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When Cells Die by Richard A. Lockshin Pdf

When Cells Die A Comprehensive Evaluation of Apoptosis and Programmed Cell Death Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field. When Cells Die establishes a coherent framework for the study of cell death -cutting across viewpoints and disciplines and consolidating disparate research efforts. Leading international researchers describe a wide range of topics, including evaluation methods for programmed cell death and apoptosis in numerous tissues and circumstances; genetic mechanism, signal transduction, and observed manifestations of physiological cell death; model systems ranging from nematodes to humans; relevant work in cancer research, AIDS, immune disorders, fertility, eye disease, and Alzheimer's disease; and more. Written to provide an in-depth overview of cell death, the book is divided into five major parts: * The phenomenon of cell death * Themes and approaches to cell death * Cell death where mitosis is high and evanescence is desirable * Cell death in long-lived cells * The clinical relevance of apoptosis. When Cells Die offers a comprehensive introduction to an intriguing discipline, insight into areas in need of exploration, and information on new techniques and therapeutic applications -all supported with diagrams and flowcharts and a fully cross-referenced and indexed text. It is important reading for anyone working in cell and developmental biology, neuroscience, immunology, cancer research, and virology. It is also useful for advanced undergraduate and graduate-level students, postdoctoral fellows, and researchers just entering the field.

Pulmonary Pathology E-Book

Dani S. Zander,Carol F. Farver
Pulmonary Pathology E Book Book PDF

Author : Dani S. Zander,Carol F. Farver
Publisher : Elsevier Health Sciences
Page : 853 pages
File Size : 53,6 Mb
Release : 2008-07-02
Category : Medical
ISBN : 9781437720488

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Pulmonary Pathology E-Book by Dani S. Zander,Carol F. Farver Pdf

This volume in the Foundations in Diagnostic Pathology Series packs today's most essential pulmonary pathology into a compact, high-yield format! It covers both common and rare neoplastic and non-neoplastic diseases of the lung and pleura and focuses primarily on diagnosis with correlations to clinical and radiographic characteristics. Its pragmatic, well-organized approach, abundant full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Detailed discussions on today’s technologies help you select the best test for case evaluation. Chapters devoted to the techniques used in the assessment of pulmonary diseases, including immunohistochemistry, immunofluorescnece, and certain clinical laboratory tests offer you a better understanding of techniques and their application for the diagnosis of lung disease. Internationally recognized pathologists convey the most current information, keeping you on the cusp of your field. More than 800 photomicrographs and gross photographs—most in full color—present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Pharmacokinetics and Toxicokinetic Considerations - Vol II

Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II Book PDF

Author : Rakesh Kumar Tekade
Publisher : Academic Press
Page : 816 pages
File Size : 44,8 Mb
Release : 2022-02-05
Category : Business & Economics
ISBN : 9780323913164

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Pharmacokinetics and Toxicokinetic Considerations - Vol II by Rakesh Kumar Tekade Pdf

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts

Autophagy Networks in Inflammation

Maria Chiara Maiuri,Daniela De Stefano
Autophagy Networks in Inflammation Book PDF

Author : Maria Chiara Maiuri,Daniela De Stefano
Publisher : Springer
Page : 403 pages
File Size : 43,8 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319300795

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Autophagy Networks in Inflammation by Maria Chiara Maiuri,Daniela De Stefano Pdf

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Calcium Signalling and Disease

Ernesto Carafoli,Marisa Brini
Calcium Signalling and Disease Book PDF

Author : Ernesto Carafoli,Marisa Brini
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 40,6 Mb
Release : 2007-09-29
Category : Medical
ISBN : 9781402061912

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Calcium Signalling and Disease by Ernesto Carafoli,Marisa Brini Pdf

Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Cell Volume Regulation

Florian Lang
Cell Volume Regulation Book PDF

Author : Florian Lang
Publisher : S. Karger AG (Switzerland)
Page : 280 pages
File Size : 51,7 Mb
Release : 1998
Category : Cell Size
ISBN : UOM:39015043125916

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Cell Volume Regulation by Florian Lang Pdf

This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

M. A. Hayat
Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book PDF

Author : M. A. Hayat
Publisher : Academic Press
Page : 430 pages
File Size : 48,6 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9780128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available