Neglected Tropical Diseases And Phytochemicals In Drug Discovery

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje
Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book PDF

Author : Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje
Publisher : John Wiley & Sons
Page : 628 pages
File Size : 40,9 Mb
Release : 2021-11-09
Category : Science
ISBN : 9781119616603

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery by Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje Pdf

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Neglected Tropical Diseases

David C. Swinney,Michael P. Pollastri
Neglected Tropical Diseases Book PDF

Author : David C. Swinney,Michael P. Pollastri
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 52,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9783527808625

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Neglected Tropical Diseases by David C. Swinney,Michael P. Pollastri Pdf

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Medicinal Chemistry of Neglected and Tropical Diseases

Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay
Medicinal Chemistry of Neglected and Tropical Diseases Book PDF

Author : Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay
Publisher : CRC Press
Page : 374 pages
File Size : 46,7 Mb
Release : 2019-08-15
Category : Medical
ISBN : 9781351011648

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Medicinal Chemistry of Neglected and Tropical Diseases by Venkatesan Jayaprakash,Daniele Castagnolo,Yusuf Özkay Pdf

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

Neglected Diseases and Drug Discovery

Michael J. Palmer,Timothy N. C. Wells
Neglected Diseases and Drug Discovery Book PDF

Author : Michael J. Palmer,Timothy N. C. Wells
Publisher : Drug Discovery
Page : 0 pages
File Size : 54,6 Mb
Release : 2012
Category : Science
ISBN : 1849731926

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Neglected Diseases and Drug Discovery by Michael J. Palmer,Timothy N. C. Wells Pdf

An invaluable guide to successful practice in neglected tropical diseases (NTDs) and highlights best practice to guide the ongoing drug discovery effort.

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Goutam Brahmachari
Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 458 pages
File Size : 40,6 Mb
Release : 2019-04-15
Category : Medical
ISBN : 9780128157244

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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases by Goutam Brahmachari Pdf

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje
Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book PDF

Author : Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje
Publisher : John Wiley & Sons
Page : 624 pages
File Size : 42,7 Mb
Release : 2021-10-25
Category : Science
ISBN : 9781119617150

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery by Muhammad Akram,Chukwuebuka Egbuna,Jonathan Chinenye Ifemeje Pdf

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Neglected Diseases: Extensive Space for Modern Drug Discovery

Anonim
Neglected Diseases Extensive Space for Modern Drug Discovery Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 49,5 Mb
Release : 2018-10-30
Category : Medical
ISBN : 0128151439

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Neglected Diseases: Extensive Space for Modern Drug Discovery by Anonim Pdf

Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

Blockchain Technology in Healthcare - Concepts, Methodologies, and Applications

Nilayam Kumar Kamila
Blockchain Technology in Healthcare Concepts Methodologies and Applications Book PDF

Author : Nilayam Kumar Kamila
Publisher : Bentham Science Publishers
Page : 286 pages
File Size : 44,5 Mb
Release : 2023-11-28
Category : Computers
ISBN : 9789815165203

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Blockchain Technology in Healthcare - Concepts, Methodologies, and Applications by Nilayam Kumar Kamila Pdf

This volume reviews cutting-edge innovations in blockchain technology that are propelling the healthcare industry into a new era of efficiency and security. It brings 14 reviews contributed by experts in blockchain and Web3 technologies into a single volume. Each contribution includes a summary for easy understanding and scientific references for advanced readers. Key Themes: Empowering Decentralized Healthcare: Learn about the future of decentralized healthcare, powered by blockchain, ensuring a seamless and patient-centric experience. Clinical Trials: Discover how blockchain is reshaping clinical trials, offering a glimpse into a future of optimized medical research. Data Security: Uncover the strategic use of blockchain in securing vital clinical trials data, ensuring confidentiality and integrity at every step. Blockchain-based Healthcare delivery: Delve into a comprehensive review of blockchain technology in the health sector, revealing its potential to transform healthcare systems with efficient and precise solutions. Predict, Prevent, and Protect: Understand how blockchain technology serves as a predictive tool, aiding in the prevention and control of the spread of COVID-19. This volume is a must-read for healthcare practitioners and administrators seeking to harness the power of blockchain in medicine and healthcare. It also provides information for researchers and business professionals who want to understand the innovative role of blockchain technology in the healthcare sector.

Phytochemistry, Computational Tools, and Databases in Drug Discovery

Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani
Phytochemistry Computational Tools and Databases in Drug Discovery Book PDF

Author : Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani
Publisher : Elsevier
Page : 494 pages
File Size : 50,6 Mb
Release : 2022-11-30
Category : Science
ISBN : 9780323907163

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Phytochemistry, Computational Tools, and Databases in Drug Discovery by Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani Pdf

Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research. Provides the various databases, methods and procedures for computational drug discovery in plants Includes insights into the predictors for properties of phytochemicals against different diseases Discusses the applications of computational tools and their databases

Sensing and Artificial Intelligence Solutions for Food Manufacturing

Daniel Hefft,Charles Oluwaseun Adetunji
Sensing and Artificial Intelligence Solutions for Food Manufacturing Book PDF

Author : Daniel Hefft,Charles Oluwaseun Adetunji
Publisher : CRC Press
Page : 194 pages
File Size : 48,8 Mb
Release : 2023-03-31
Category : Computers
ISBN : 9781000844498

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Sensing and Artificial Intelligence Solutions for Food Manufacturing by Daniel Hefft,Charles Oluwaseun Adetunji Pdf

This book gives readers a practical introduction into machine learning and sensing techniques, their design and ultimately specific applications that could improve food production. It shows how these sensing and computing systems are suitable for process implementation in food factories. This book starts by giving the reader an overview of the historic structures of food manufacturing standards and how they defined today’s manufacturing. It is followed by a topical introduction for professionals in the food industries in topics such as AI, machine learning, and neural networks. It also includes an explanation of the different sensor systems and their basic principles. It shows how these sensing and computing systems are suitable for process implementation in food factories and what types of sensing systems have already been proven to deliver benefit to the food manufacturing industries. The authors also discuss issues around food safety, labelling, and traceability and how sensing and AI can help to resolve issues. They also use case studies and specific examples that can show the benefit of such technologies compared to current approaches. This book is a practical introduction and handbook for students, food engineers, technologists and process engineers on the benefits and challenges around modern manufacturing systems following Industry 4.0 approaches.

Functional Foods and Nutraceuticals

Chukwuebuka Egbuna,Genevieve Dable Tupas
Functional Foods and Nutraceuticals Book PDF

Author : Chukwuebuka Egbuna,Genevieve Dable Tupas
Publisher : Springer Nature
Page : 644 pages
File Size : 51,7 Mb
Release : 2020-08-24
Category : Technology & Engineering
ISBN : 9783030423193

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Functional Foods and Nutraceuticals by Chukwuebuka Egbuna,Genevieve Dable Tupas Pdf

Functional foods and nutraceuticals are food products that naturally offer or have been modified to offer additional health benefits beyond basic nutrition. As such products have surged in popularity in recent years, it is crucial that researchers and manufacturers understand the concepts underpinning functional foods and the opportunity they represent to improve human health, reduce healthcare costs, and support economic development worldwide. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations presents a guide to functional foods from experienced professionals in key institutions around the world. The text provides background information on the health benefits, bioavailability, and safety measurements of functional foods and nutraceuticals. Subsequent chapters detail the bioactive components in functional foods responsible for these health benefits, as well as the different formulations of these products and recent innovations spurred by consumer demands. Authors emphasize product development for increased marketability, taking into account safety issues associated with functional food adulteration and solutions to be found in GMP adherence. Various food preservation methods aimed at enhancing the quality and shelf life of functional food are also highlighted. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations is the first of its kind, designed to be useful to students, teachers, nutritionists, food scientists, food technologists and public health regulators alike.

Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I

Swarnlata Saraf,Ram Kumar Sahu,Vivek Dave
Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I Book PDF

Author : Swarnlata Saraf,Ram Kumar Sahu,Vivek Dave
Publisher : Bentham Science Publishers
Page : 325 pages
File Size : 43,5 Mb
Release : 2022-05-26
Category : Medical
ISBN : 9789815036527

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Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I by Swarnlata Saraf,Ram Kumar Sahu,Vivek Dave Pdf

This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery. Part I covers the following topics: - Introduction to nanotechnology and herbal-based nanoparticulate systems - Nucleic acid-based therapeutic drug delivery systems - Herbal bioactives: a booster dose for advanced pharmaceutical nanoscience - Pulmonary nano-drug delivery systems - Application of nano-drug delivery systems in improving the therapeutic efficacy of bioactive natural products - PEGylated liposomes - Insulin liposomes - Aquasomes: a promising novel drug carrier - Nanoparticle-aided herbal drugs: therapeutic implications on cholinergic dysfunction with relevance to Alzheimer’s disease - Vitamins based nanomedicine approach - Recent advances in tumor targeting drug delivery systems: fundamentals of advanced pharmaceutical nanoscience - Niosomes: a revolutionary progress in the field of pharmaceutical sciences - Infectious diseases: pharmaceutical nanoscience for targeted drug delivery This reference is a valuable resource for scholars that creates awareness of novel drug delivery systems as well as their promising applications in drug targeting, and nanotherapeutics for specific diseases.

Natural Product Based Drug Discovery Against Human Parasites

Archana Singh,Brijesh Rathi,Anita K. Verma,Indrakant K. Singh
Natural Product Based Drug Discovery Against Human Parasites Book PDF

Author : Archana Singh,Brijesh Rathi,Anita K. Verma,Indrakant K. Singh
Publisher : Springer Nature
Page : 602 pages
File Size : 54,7 Mb
Release : 2024-01-01
Category : Medical
ISBN : 9789811996054

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Natural Product Based Drug Discovery Against Human Parasites by Archana Singh,Brijesh Rathi,Anita K. Verma,Indrakant K. Singh Pdf

This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural products. The initial chapters summarize the conventional treatment strategies and natural-product based therapeutics against these parasites. It discusses biochemical tools and techniques for the discovery of natural product based drugs against human parasites. The book also covers the ingenious and innovative mechanisms to achieve drug resistance by the protozoan parasites and strategies to overcome the resistance. It entails mechanistic insight into the modulation of host immune responses to delay or inhibit parasite clearance and explores host-pathogen interactions that mediate immunity against subsequent parasite challenge. In turn, the volume helps in understanding the immunobiology of the parasites and tools to identify candidate vaccine antigens and novel delivery systems against the protozoan parasites. Lastly, it explores the role of advanced methods, including nanotechnology, marine bioprospecting, and microorganisms-derived biochemicals against the protozoan parasites. This book is useful for students and researchers of pharmacology, parasitology, zoology and other allied fields.​

Molecular Advancements in Tropical Diseases Drug Discovery

Gauri Misra,Vijay Kumar Srivastava
Molecular Advancements in Tropical Diseases Drug Discovery Book PDF

Author : Gauri Misra,Vijay Kumar Srivastava
Publisher : Academic Press
Page : 156 pages
File Size : 52,9 Mb
Release : 2020-05-12
Category : Science
ISBN : 9780128213971

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Molecular Advancements in Tropical Diseases Drug Discovery by Gauri Misra,Vijay Kumar Srivastava Pdf

Molecular Advancements in Tropical Diseases Drug Discovery presents in-depth knowledge relating to the detection of infection, epidemiology, drugs against various tropical diseases, new target sites for drug discovery and multidrug resistance issues using bioinformatics tools and approaches. The book's chapters are written by experts in their respective fields so that each disease is covered in a rational manner and with a solid foundation on existing facts and prospective research ideas. Updates knowledge about tropical diseases with recent advancements in the field Presents an overview of new research covering detection, infection, epidemiology and risk factors of the most common tropical diseases using bioinformatics tools Encompasses a detailed description of developments in drug discovery, new drugs and their molecular mechanisms of action

Phytopharmaceuticals and Herbal Drugs

Manju Rawat Singh,Deependra Singh
Phytopharmaceuticals and Herbal Drugs Book PDF

Author : Manju Rawat Singh,Deependra Singh
Publisher : Elsevier
Page : 488 pages
File Size : 51,9 Mb
Release : 2023-07-15
Category : Medical
ISBN : 9780323993692

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Phytopharmaceuticals and Herbal Drugs by Manju Rawat Singh,Deependra Singh Pdf

Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource. This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity. Includes perspectives from academic and industry research Provides information on the safety, regulatory aspects and clinical aspects related to plant-based drugs Introduces developments of new targeted drug delivery systems