Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers

Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers book. This book definitely worth reading, it is an incredibly well-written.

Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers

Andrea Necchi,Philippe E. Spiess
Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers Book PDF

Author : Andrea Necchi,Philippe E. Spiess
Publisher : Springer Nature
Page : 312 pages
File Size : 49,6 Mb
Release : 2022-01-03
Category : Medical
ISBN : 9783030805463

Get Book

Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers by Andrea Necchi,Philippe E. Spiess Pdf

This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.

Genitourinary Cancers

Siamak Daneshmand,Kevin G. Chan
Genitourinary Cancers Book PDF

Author : Siamak Daneshmand,Kevin G. Chan
Publisher : Springer
Page : 308 pages
File Size : 49,9 Mb
Release : 2018-08-31
Category : Medical
ISBN : 9783319933399

Get Book

Genitourinary Cancers by Siamak Daneshmand,Kevin G. Chan Pdf

This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.

Chemotherapy and Immunotherapy in Urologic Oncology

Edouard J. Trabulsi,Costas D. Lallas,Anne E. Lizardi-Calvaresi
Chemotherapy and Immunotherapy in Urologic Oncology Book PDF

Author : Edouard J. Trabulsi,Costas D. Lallas,Anne E. Lizardi-Calvaresi
Publisher : Springer Nature
Page : 303 pages
File Size : 53,5 Mb
Release : 2020-09-29
Category : Medical
ISBN : 9783030520212

Get Book

Chemotherapy and Immunotherapy in Urologic Oncology by Edouard J. Trabulsi,Costas D. Lallas,Anne E. Lizardi-Calvaresi Pdf

This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects.

Comprehensive Textbook of Genitourinary Oncology

Nicholas Vogelzang
Comprehensive Textbook of Genitourinary Oncology Book PDF

Author : Nicholas Vogelzang
Publisher : Lippincott Williams & Wilkins
Page : 936 pages
File Size : 49,8 Mb
Release : 2006
Category : Medical
ISBN : 9780781749848

Get Book

Comprehensive Textbook of Genitourinary Oncology by Nicholas Vogelzang Pdf

Thoroughly revised for its Third Edition, this volume is the most comprehensive, multidisciplinary text on genitourinary cancers. This edition has two new editors—Frans M.J. Debruyne and W. Marston Linehan—and more than 50% new contributors. Seventeen new chapters cover familial prostate cancer, biology of bone metastases, molecular pathology and biologic determinants, PSA and related kallikreins, needle biopsy, laparoscopic surgical procedures, 3D conformal radiotherapy, hormones and radiotherapy, integration of chemotherapy and other modalities, quality of life after treatment of localized prostate cancer, management of rising PSA after local therapy, the role of surgery in advanced bladder cancer, post-chemotherapy node dissections and resection of metastatic disease, and stem cell transplantation.

Cancer Immunotherapy in Urology, An Issue of Urologic Clinics, E-Book

Sujit S Nair,Ashutosh Tewari
Cancer Immunotherapy in Urology An Issue of Urologic Clinics E Book Book PDF

Author : Sujit S Nair,Ashutosh Tewari
Publisher : Elsevier Health Sciences
Page : 145 pages
File Size : 55,8 Mb
Release : 2020-10-15
Category : Medical
ISBN : 9780323754996

Get Book

Cancer Immunotherapy in Urology, An Issue of Urologic Clinics, E-Book by Sujit S Nair,Ashutosh Tewari Pdf

The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

Rare Genitourinary Tumors

Lance Pagliaro
Rare Genitourinary Tumors Book PDF

Author : Lance Pagliaro
Publisher : Springer
Page : 367 pages
File Size : 43,5 Mb
Release : 2016-06-28
Category : Medical
ISBN : 9783319300467

Get Book

Rare Genitourinary Tumors by Lance Pagliaro Pdf

Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.

Kidney Cancer

Primo N. Lara,Eric Jonasch
Kidney Cancer Book PDF

Author : Primo N. Lara,Eric Jonasch
Publisher : Springer
Page : 402 pages
File Size : 44,7 Mb
Release : 2015-06-10
Category : Medical
ISBN : 9783319179032

Get Book

Kidney Cancer by Primo N. Lara,Eric Jonasch Pdf

Kidney Cancer: Principles and Practice is a comprehensive and interdisciplinary textbook that encompasses all clinically relevant aspects of the disease. This new edition has been extensively updated and includes brand new material covering the most recent developments in kidney cancer diagnosis and therapy. The user-friendly and clinically oriented content of the book guarantees that it will be of great interest to a wide range of medical professionals, and every effort has been made to ensure that contributions are both easy to understand and directly related to patient care. Content presentation departs from the usual dense chapter format featuring a lengthy series of paragraphs. Instead, each chapter contains several boxed sections, including one that summarizes essential "take home points" for the busy clinician and another that presents a patient-oriented case highlighting the clinical application of elements discussed in that chapter. In addition, accessible original images, illustrations, and diagrams (some in full color) are used to simplify particularly complex material. This book will be of value for clinicians, researchers, residents, fellows, students, and knowledgeable lay people. The contributors comprise an international group of authors with expertise in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others.

Invasive Bladder Cancer

PierFrancesco Bassi,Francesco Pagano
Invasive Bladder Cancer Book PDF

Author : PierFrancesco Bassi,Francesco Pagano
Publisher : Springer
Page : 303 pages
File Size : 47,9 Mb
Release : 2007-04-16
Category : Medical
ISBN : 1846283760

Get Book

Invasive Bladder Cancer by PierFrancesco Bassi,Francesco Pagano Pdf

Invasive bladder tumors affect the muscle wall, and have a propensity to metastasize and spread to other areas of the body, and are more likely to be fatal. This book presents state-of-the-art diagnoses and treatments available for bladder cancer that has metastasised into the body. A thorough review of current practice is presented in a full color volume with more than 40 tables and 50 illustrations. The book offers a comprehensive review of the subject, covering epidemiology, screening, diagnostic factors, surgery, chemotherapy and post-operative monitoring. Most chapters are jointly written by a basic researcher and a clinician.

Immunotherapy

Aung Naing,Joud Hajjar
Immunotherapy Book PDF

Author : Aung Naing,Joud Hajjar
Publisher : Springer Nature
Page : 445 pages
File Size : 42,8 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030793081

Get Book

Immunotherapy by Aung Naing,Joud Hajjar Pdf

The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.

Urologic Oncology

Kelly L. Stratton,Alicia K. Morgans
Urologic Oncology Book PDF

Author : Kelly L. Stratton,Alicia K. Morgans
Publisher : Springer
Page : 0 pages
File Size : 46,5 Mb
Release : 2023-01-31
Category : Medical
ISBN : 3030898938

Get Book

Urologic Oncology by Kelly L. Stratton,Alicia K. Morgans Pdf

Urologists and medical oncologists have witnessed a rapid growth in systemic therapeutic options for treating genitourinary malignancies that increasingly integrates radiation therapy to primary cancers, nodal beds, and even metastatic sites. The culmination of these advances has been the creation of multidisciplinary teams that expertly provide comprehensive care to patients with urologic cancers. This book provides the framework to create such a multidisciplinary clinical team focused on the treatment of urologic malignancies with representation from urologists, medical oncologists, and additional specialists who work together to provide optimal team-based care. The book integrates advanced systemic therapeutics including immune-based and targeted therapies. Readers gain a better understanding of the benefit of multidisciplinary co-management through specific examples such as hormone sensitive metastatic prostate cancer, neoadjuvant chemotherapy for muscle invasive bladder cancer, and immunotherapy approaches to advanced bladder and kidney cancer. The book also discusses the integration of genomic tumor characterization and personalized medicine into surgical planning, tumor biopsies, and chemo-immunotherapy selection, emphasizing the expansion of new therapeutics for urologic malignancies and the changing definitions of disease progression. Urologic Oncology: Multidisciplinary Care for Patients is a comprehensive resource for urologists, medical oncologists, radiation oncologists, genetic counselors, fellows in urologic oncology and medical oncology, residents in urology and radiation oncology, advanced practice providers, practice managers, and pharmaceutical representatives.

Biomarkers and Immunotherapy for Genitourinary Tumors

Hui Dai,Jun Pang,Yu Fan,Jianzhong Ai,Youqiang Ke,Lu Yang
Biomarkers and Immunotherapy for Genitourinary Tumors Book PDF

Author : Hui Dai,Jun Pang,Yu Fan,Jianzhong Ai,Youqiang Ke,Lu Yang
Publisher : Frontiers Media SA
Page : 374 pages
File Size : 40,8 Mb
Release : 2024-04-02
Category : Medical
ISBN : 9782832547106

Get Book

Biomarkers and Immunotherapy for Genitourinary Tumors by Hui Dai,Jun Pang,Yu Fan,Jianzhong Ai,Youqiang Ke,Lu Yang Pdf

Genitourinary tumors consist of a large variety of malignancies located in the urinary and the reproductive systems, mainly including prostate cancer, bladder cancer, and renal tumors. Apart from surgeries, various systemic treatments have been used for the whole-course management of genitourinary tumors, including radiation therapy, chemotherapy, and hormonal therapy. However, the characteristics of progression, metastasis, and drug resistance deriving from tumors require and breed novel treatments. Furthermore, exploring biomarkers of genitourinary tumors at the early stage is also beneficial to strengthen the management of patients with tumors. Additionally, the diagnostic and prognostic value of the potential biomarkers for immunotherapy and combined therapy of genitourinary tumors are underexplored. On the basis of precision treatments, the advent of immune-based therapies, including immune checkpoint inhibitors (ICIs, antibodies targeting PD-L1 /PD-1 and CTLA-4 pathways), tumor vaccines, and other therapies, has extended the scope of treatment modalities. FDA has until now approved the clinical application of immune checkpoint inhibitors in a wide range of diseases including some types of genitourinary tumors, whereas not all patients with genitourinary tumors are suitable for immune-based therapies, therefore, the understanding of its underlying mechanism is key to develop effective treatments based on current ICI-based immunotherapy.

Rectal Cancer Treatment

M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz
Rectal Cancer Treatment Book PDF

Author : M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 51,6 Mb
Release : 2005-10-11
Category : Medical
ISBN : 9783540274490

Get Book

Rectal Cancer Treatment by M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz Pdf

Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.

Absolute Clinical Radiation Oncology Review

Daniel M. Trifiletti,Nicholas G. Zaorsky
Absolute Clinical Radiation Oncology Review Book PDF

Author : Daniel M. Trifiletti,Nicholas G. Zaorsky
Publisher : Springer
Page : 492 pages
File Size : 48,8 Mb
Release : 2019-01-22
Category : Medical
ISBN : 9783319968094

Get Book

Absolute Clinical Radiation Oncology Review by Daniel M. Trifiletti,Nicholas G. Zaorsky Pdf

This book provides a quick reference guide for clinicians in radiation oncology. It is designed to be an intuitive and easily reviewed study guide for board or maintenance of certification examinations, as well as a quick reference for residents and established radiation oncologists who need a refresher. The text begins with a general pearls chapter that radiation oncologists should consider in all aspects of their practice, including cancer visibility, dosing, counseling recommendations, and toxicity management. The subsequent chapters then delve into different cancer disease sites, including pediatrics, central nervous system, head and neck, thoracic, breast, gastrointestinal, gynecologic, genitourinary, hematologic, soft tissue, palliative, and radiophysics/radiobiology. Within each chapter, each disease and its recommended approach is then summarized in only a few pages, allowing a focus on the most essential information. Bullet points, figures, tables, and images make for an intuitive reader experience. Recommendations are taken from the American Society for Radiation Oncology (ASTRO), the European Society for Radiation Oncology (ESTRO), and the National Comprehensive Cancer Network (NCCN). Planning guides for imaging, diagnosis, and staging offer readers a starting point in approaching each patient based on disease origin, and dosing guidelines then detail consideration for treatment methods. Each chapter additionally includes disease-specific pearls and key points to test the knowledge reviewed in the chapters. Experts in the disease sites from the United States serve as senior authors on each chapter. The authors include all diseases associated with radiation oncology training to ensure a comprehensive resource for exam studying and clinical care. Residents, trainees, and established radiation oncologists find this an ideal study resource for both board and certification exams, as well as an easily accessible aid during practice.

Cancer Neurology in Clinical Practice

David Schiff,Santosh Kesari,Patrick C. Y. Wen
Cancer Neurology in Clinical Practice Book PDF

Author : David Schiff,Santosh Kesari,Patrick C. Y. Wen
Publisher : Springer Science & Business Media
Page : 636 pages
File Size : 41,6 Mb
Release : 2008-07-11
Category : Medical
ISBN : 9781597454124

Get Book

Cancer Neurology in Clinical Practice by David Schiff,Santosh Kesari,Patrick C. Y. Wen Pdf

Neuro-oncology has evolved substantially as a clinical and research discipline over the past few decades. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition provides clinicians from various backgrounds and levels of training with a reference to help focus the differential diagnosis, treatment strategy, and management plan for the cancer patient with neurologic symptoms and findings. The volume begins with an overview of the field of neuro-oncology and a review of the role of neuroimaging in the diagnosis of neuro-oncologic disease. Several chapters on interpretation and management of common neuro-oncologic symptoms follow. Subsequent sections contain chapters on the direct and indirect neurologic complications of cancer as well as complications of therapy. The final section focuses on the spectrum and management of neurologic disease in patients with cancer of specific organs. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition is an important new work that aims to broaden and deepen the familiarity of clinicians with the range and management of neuro-oncologic diseases in order to improve the quality of care for cancer patients.

Predictive Biomarkers in Oncology

Sunil Badve,George Louis Kumar
Predictive Biomarkers in Oncology Book PDF

Author : Sunil Badve,George Louis Kumar
Publisher : Springer
Page : 642 pages
File Size : 45,5 Mb
Release : 2018-12-06
Category : Medical
ISBN : 9783319952284

Get Book

Predictive Biomarkers in Oncology by Sunil Badve,George Louis Kumar Pdf

“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.