Neurochemical Aspects Of Neurotraumatic And Neurodegenerative Diseases

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Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Akhlaq A. Farooqui
Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book PDF

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 50,7 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9781441966520

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Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases by Akhlaq A. Farooqui Pdf

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders

Akhlaq A. Farooqui
Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 404 pages
File Size : 47,8 Mb
Release : 2020-09-07
Category : Medical
ISBN : 9780128217016

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Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders by Akhlaq A. Farooqui Pdf

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Curcumin for Neurological and Psychiatric Disorders

Tahira Farooqui,Akhlaq A. Farooqui
Curcumin for Neurological and Psychiatric Disorders Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 544 pages
File Size : 52,7 Mb
Release : 2019-03-16
Category : Medical
ISBN : 9780128154625

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Curcumin for Neurological and Psychiatric Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium. Identifies molecular mechanisms of curcumin effects in neurological diseases Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin Examines curcumin’s potential in developing new therapeutic drugs

Neurochemical Aspects of Excitotoxicity

Akhlaq A. Farooqui,Wei-Yi Ong,Lloyd A. Horrocks
Neurochemical Aspects of Excitotoxicity Book PDF

Author : Akhlaq A. Farooqui,Wei-Yi Ong,Lloyd A. Horrocks
Publisher : Springer Science & Business Media
Page : 299 pages
File Size : 44,7 Mb
Release : 2007-11-20
Category : Medical
ISBN : 9780387730233

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Neurochemical Aspects of Excitotoxicity by Akhlaq A. Farooqui,Wei-Yi Ong,Lloyd A. Horrocks Pdf

Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases. In addition, the authors discuss the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists.

Neurochemical Aspects of Alzheimer's Disease

Akhlaq A. Farooqui
Neurochemical Aspects of Alzheimer s Disease Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 414 pages
File Size : 46,9 Mb
Release : 2017-05-25
Category : Science
ISBN : 9780128099384

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Neurochemical Aspects of Alzheimer's Disease by Akhlaq A. Farooqui Pdf

Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

Trace Amines and Neurological Disorders

Tahira Farooqui,Akhlaq A. Farooqui
Trace Amines and Neurological Disorders Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 432 pages
File Size : 50,5 Mb
Release : 2016-07-12
Category : Medical
ISBN : 9780128036167

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Trace Amines and Neurological Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Tahira Farooqui,Akhlaq A. Farooqui
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 484 pages
File Size : 48,9 Mb
Release : 2017-10-24
Category : Science
ISBN : 9780128119600

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Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease

Ischemic and Traumatic Brain and Spinal Cord Injuries

Akhlaq A. Farooqui
Ischemic and Traumatic Brain and Spinal Cord Injuries Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 484 pages
File Size : 54,5 Mb
Release : 2018-03-21
Category : Medical
ISBN : 9780128135976

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Ischemic and Traumatic Brain and Spinal Cord Injuries by Akhlaq A. Farooqui Pdf

Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases. Offers a clearly written, logically organized, comprehensive overview on the molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting-edge research information on the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Presents chapters that are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Akhlaq A. Farooqui
Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 498 pages
File Size : 42,6 Mb
Release : 2020-04-10
Category : Medical
ISBN : 9780128196038

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Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders by Akhlaq A. Farooqui Pdf

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help in the early detection of insulin resistance related visceral and neurological disorders, but also promote the discovery of new drugs which may block or delay onset in elderly patients. Understanding these processes is important not only for patients, caregivers and health professionals, but also for health policymakers who must plan for national resources. Presents the first comprehensive book dedicated to insulin resistance as a risk factor for neurological disorders Focuses on the molecular mechanisms and signal transduction processes associated with insulin resistance Discusses insulin resistance to heart disease, obesity, diabetes, stroke, Alzheimer's, Parkinson's, dementia and depression

Molecular Mechanisms of Dementia

Akhlaq A. Farooqui
Molecular Mechanisms of Dementia Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 386 pages
File Size : 45,8 Mb
Release : 2019-04-15
Category : Medical
ISBN : 9780128167311

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Molecular Mechanisms of Dementia by Akhlaq A. Farooqui Pdf

Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

Therapeutic Potentials of Curcumin for Alzheimer Disease

Akhlaq A Farooqui
Therapeutic Potentials of Curcumin for Alzheimer Disease Book PDF

Author : Akhlaq A Farooqui
Publisher : Springer
Page : 402 pages
File Size : 48,5 Mb
Release : 2016-03-05
Category : Medical
ISBN : 9783319158891

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Therapeutic Potentials of Curcumin for Alzheimer Disease by Akhlaq A Farooqui Pdf

This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer’s disease (AD) is the leading cause of dementia and is present in 60%–70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

Inflammation and Oxidative Stress in Neurological Disorders

Akhlaq A. Farooqui
Inflammation and Oxidative Stress in Neurological Disorders Book PDF

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 43,6 Mb
Release : 2014-01-27
Category : Medical
ISBN : 9783319041117

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Inflammation and Oxidative Stress in Neurological Disorders by Akhlaq A. Farooqui Pdf

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Neuroinflammation, Resolution, and Neuroprotection in the Brain

Akhlaq A. Farooqui
Neuroinflammation Resolution and Neuroprotection in the Brain Book PDF

Author : Akhlaq A. Farooqui
Publisher : Academic Press
Page : 334 pages
File Size : 48,5 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9780323884617

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Neuroinflammation, Resolution, and Neuroprotection in the Brain by Akhlaq A. Farooqui Pdf

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation

Phytochemicals, Signal Transduction, and Neurological Disorders

Akhlaq A. Farooqui
Phytochemicals Signal Transduction and Neurological Disorders Book PDF

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 48,6 Mb
Release : 2012-07-10
Category : Medical
ISBN : 9781461438045

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Phytochemicals, Signal Transduction, and Neurological Disorders by Akhlaq A. Farooqui Pdf

Phytochemicals Signal Transduction and Neurological Disorders Phytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases. Unlike vitamins and minerals, phytochemicals are not required for sustaining cell viability, but they play an important role in protecting tissues and cells from the harmful effects of oxidative stress and inflammation. Examples of phytochemicals include catechins, resveratrol, ginkgo biloba, curcumin, and sulfur compounds found in garlic. Although, the precise molecular mechanisms associated with beneficial effects of phytochemicals still remain the subject of intense investigations, but it is becoming increasingly evident that phytochemicals mediate their effects by counteracting, reducing, and repairing the damage caused by oxidative stress and neuroinflammation. In addition, phytochemicals also stimulate the synthesis of adaptive enzymes and proteins through the stimulation of a transcription factor called Nrf2 and induction of phase II detoxifying enzymes. Consumption of phytochemicals induces neurohormetic response that results in the expression of adaptive stress-resistance genes that are responsible for encoding antioxidant enzymes, protein chaperones, and neurotrophic factor (BDNF). Based on the stimulation of signal transduction network and adaptive stress-resistance genes, it is proposed that the use of phytochemicals from childhood to old age along with regular exercise is an important strategy for maintaining normal aging and delaying onset of age-related neurological disorders (stroke, Alzheimer disease, and Parkinson disease). Phytochemicals Signal Transduction and Neurological Disorders presents readers with cutting edge and comprehensive information not only on bioavailability, and mechanism of action of phytochemicals in the brain, but also provides the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic (stroke, spinal cord trauma, and traumatic brain injury) and neurodegenerative (Alzheimers disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis) diseases.

Metabolic Syndrome

Akhlaq A. Farooqui
Metabolic Syndrome Book PDF

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 52,7 Mb
Release : 2013-06-14
Category : Medical
ISBN : 9781461473183

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Metabolic Syndrome by Akhlaq A. Farooqui Pdf

Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.