Neuropeptide Gpcrs In Neuroendocrinology

Author : Jae Young Seong,Hubert Vaudry
Publisher : Frontiers E-books
Page : 826 pages
File Size : 45,7 Mb
Release : 2014-11-07
Category : Diseases of the endocrine glands. Clinical endocrinology
ISBN : 9782889192670

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Neuropeptide GPCRs in neuroendocrinology by Jae Young Seong,Hubert Vaudry Pdf

The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.

Author : Maria Lucia Narducci,Francesco Cellini,Andrea Natale
Publisher : Frontiers Media SA
Page : 397 pages
File Size : 45,9 Mb
Release : 2023-07-07
Category : Medical
ISBN : 9782832529249

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Neuropeptide GPCRs in Neuroendocrinology, Volume II by Maria Lucia Narducci,Francesco Cellini,Andrea Natale Pdf

Author : Dylan Edwards
Publisher : States Academic Press
Page : 250 pages
File Size : 46,6 Mb
Release : 2021-11-16
Category : Medical
ISBN : 1639891129

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Clinical Neuroendocrinology: Neuropeptide Gpcrs by Dylan Edwards Pdf

The branch of biology which focuses on the relationship between the endocrine and the nervous system is termed as neuroendocrinology. The regulation of the activity of the hormones by the brain is studied within this field. The physiological processes in the body are regulated by a process known as neuroendocrine integration, wherein the endocrine and nervous system function together. The major neuroendocrine systems in the body are Hypothalamic-pituitary-adrenal axis (HPA axis), Hypothalamic-pituitary-thyroid axis (HPT axis), Hypothalamic-pituitary-gonadal axis (HPG axis) and Hypothalamic-neurohypophyseal system. GPCRs are G protein-coupled receptors, which can bind to numerous neuropeptides. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the field of neuroendocrinology. It presents the complex subject of neuropeptide GPCRs in the most comprehensible and easy to understand language. The extensive content of this book provides the readers with a thorough understanding of the subject.

Author : Dylan Edwards
Publisher : Unknown
Page : 0 pages
File Size : 42,8 Mb
Release : 2022-09-27
Category : Electronic
ISBN : 1639893717

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Neuroendocrinology: Recent Studies in Neuropeptide Gpcrs by Dylan Edwards Pdf

Neuroendocrinology is the branch of physiology which deals with the study of interactions between the endocrine system and the nervous system. It encompasses the way brain regulates the hormonal activity in the body. To regulate the physiological processes of the human body, the endocrine and nervous systems often act together and the process is known as neuroendocrine integration. Neuroendocrine system is a system by which hypothalamus maintains homeostasis by regulating metabolism, energy utilization, eating and drinking behavior, reproduction, blood pressure and osmolarity. G protein-coupled receptors (GPCRs) are the neuropeptide targets via which the intracellular signaling transduction pathways are activated. This book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of neuroendocrinology. It is an upcoming field of science that has undergone rapid development over the past few decades. This book is a resource guide for experts as well as students.

Author : Olivier Civelli,Qun-Yong Zhou
Publisher : Springer Science & Business Media
Page : 259 pages
File Size : 54,5 Mb
Release : 2008-05-15
Category : Science
ISBN : 9783540783510

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Orphan G Protein-Coupled Receptors and Novel Neuropeptides by Olivier Civelli,Qun-Yong Zhou Pdf

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.

Author : Olivier Civelli,Qun-Yong Zhou
Publisher : Springer
Page : 259 pages
File Size : 41,7 Mb
Release : 2009-08-29
Category : Science
ISBN : 3540849157

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Orphan G Protein-Coupled Receptors and Novel Neuropeptides by Olivier Civelli,Qun-Yong Zhou Pdf

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.

Author : David Murphy,Harold Gainer
Publisher : John Wiley & Sons
Page : 481 pages
File Size : 53,8 Mb
Release : 2016-03-07
Category : Science
ISBN : 9781118760376

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Molecular Neuroendocrinology by David Murphy,Harold Gainer Pdf

Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

Author : Ivone Gomes,Jonathan H. Wardman,Steven D. Stockton Jr.
Publisher : Biota Publishing
Page : 169 pages
File Size : 48,7 Mb
Release : 2013-04-01
Category : Medical
ISBN : 9781615044696

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Neuropeptide Receptors by Ivone Gomes,Jonathan H. Wardman,Steven D. Stockton Jr. Pdf

Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems. Table of Contents: Abbreviations / Overview of Neuropeptide Receptors / G Protein-Coupled Receptors: General Structure & Function / G Protein-Coupled Receptor Signaling / Neuropeptide Processing and Regulation / Neuropeptide Receptors / Perspectives / References

Author : Gilbert Holmes
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2022-09-13
Category : Electronic
ISBN : 1639874968

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Role of Neuropeptide Receptors in Neuroendocrinology by Gilbert Holmes Pdf

Neuroendocrinology is a branch of biology which is concerned with the functional and anatomical interactions between the endocrine system and the nervous system. Major neuroendocrine systems are hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis, hypothalamic-pituitary-gonadal axis and hypothalamic-neurohypophyseal system. Neuropeptide receptors are the G-protein coupled class that comprises of seven transmembrane receptors. Peptides are released into the synaptic cleft and they activate these receptors through high affinity binding and also mediate internal signaling events through cytoplasmic G-protein coupled effector. When these receptors are activated, this inhibits and activates a variety of second messenger systems which results in cell firing, phosphorylation and dephosphorylation events, modulation of membrane threshold and alteration of gene expression. This book covers in detail some existent theories about the role of neuropeptide receptors in neuroendocrinology. It presents researches and studies performed by experts across the globe. Students, researchers, experts and all associated with this field will benefit alike from this book.

Author : Michael Wilkinson,S. Ali Imran
Publisher : Cambridge University Press
Page : 207 pages
File Size : 47,7 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9781316645192

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Clinical Neuroendocrinology by Michael Wilkinson,S. Ali Imran Pdf

A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Author : Chandraleka Saravanan,Bhaskar Biswas
Publisher : BoD – Books on Demand
Page : 122 pages
File Size : 51,8 Mb
Release : 2018-05-23
Category : Science
ISBN : 9781789231823

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Ligand by Chandraleka Saravanan,Bhaskar Biswas Pdf

The book Ligand describes the diversity and versatility of ligands, covering structural features, donor-acceptor properties and secondary functions like molecular recognition. Moreover, this book also provides a comprehensive account on the applicability like catalysis, sensors, supramolecular assembly, photochemical property, bioinorganic chemistry, and so on. The advancement of fundamentals in ligand design and the control of physicochemical properties of coordination compounds has largely increased emphasis on understanding the structural and electronic features toward different perspectives in materials science. In this regard, this book has a special appeal to chemists, biologists and others. This book will be beneficial for the graduate students, teachers, researchers and other professionals who are interested to fortify and expand their knowledge in chemistry, biology, microbiology, biotechnology, materials science, environmental science and so on.

Author : Hubert Vaudry,Marie-Christine Tonon,David Vaudry
Publisher : Frontiers Media SA
Page : 282 pages
File Size : 53,5 Mb
Release : 2018-07-24
Category : Electronic
ISBN : 9782889455379

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Trends in Regulatory Peptides by Hubert Vaudry,Marie-Christine Tonon,David Vaudry Pdf

Regulatory peptides represent the most diverse and versatile family of messenger molecules. They are produced by all living organisms from bacteria to mammals. They are involved in a wide variety of biological functions. Biologically active peptides and their receptors thus constitute an unlimited source of inspiration for the development of innovative drugs and cosmetics. The present eBook is a unique collection of research articles and reviews that provide a representative examplification of the latest progress in regulatory peptide research.

Author : George Fink,Donald W. Pfaff,Jon Levine
Publisher : Academic Press
Page : 895 pages
File Size : 50,9 Mb
Release : 2012
Category : Medical
ISBN : 9780123750976

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Handbook of Neuroendocrinology by George Fink,Donald W. Pfaff,Jon Levine Pdf

Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.

Author : Saber Saleuddin,Angela B. Lange,Ian Orchard
Publisher : CRC Press
Page : 1055 pages
File Size : 49,5 Mb
Release : 2020-03-15
Category : Science
ISBN : 9780429555008

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Advances in Invertebrate (Neuro)Endocrinology (2-volume set) by Saber Saleuddin,Angela B. Lange,Ian Orchard Pdf

Advances in Invertebrate (Neuro)Endocrinology: A Collection of Reviews in the Post-Genomic Era (2-volume set) provides an informative series of reviews from expert scientists who are at the forefront of their research into the endocrinology of invertebrates. These two volumes are timely and appropriate in this post-genomic era because of the rapid pace of change brought about by genome projects, functional genomics, and genetics (omics technologies). The volume shows the rich history and strong tradition of cutting-edge research using invertebrates that has opened up our broader understanding of comparative endocrinology and the evolution of regulatory pathways and systems. These reviews set the scene and context for this exciting new era of understanding that has come from this post-genomic revolution. This book undertakes the daunting task of covering most of the diverse endocrine systems that exist among invertebrates. The papers in this book will advance our knowledge of invertebrate endocrinology but also of endocrinology in general, making the book will be valuable to researchers and students.

Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Academic Press
Page : 488 pages
File Size : 40,5 Mb
Release : 2021-02-02
Category : Science
ISBN : 9780128198025

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Cellular Endocrinology in Health and Disease by Alfredo Ulloa-Aguirre,Ya-Xiong Tao Pdf

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field