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Neuroscience Methods in Drug Abuse Research by Roger M. Brown,David P. Friedman,Yuth Nimit Pdf
This monograph is based upon papers presented at a technical review which took place on September 10-11, 1984, at Bethesda, Maryland. The conference was sponsored by the Division of Preclinical Research, National Institute on Drug Abuse.
Methods in Drug Abuse Research by Barry D. Waterhouse Pdf
The field of drug addiction and substance abuse, which was initially confined to behavioral studies, has broadened dramatically. It now includes a vast array of cellular and molecular approaches as well as sophisticated electrophysiological and neurochemical methodologies that bridge the gap between cellular/molecular events and behavior. In many cases, these techniques are used to clarify and characterize specific dimensions of the addictive process or actions of potential abuse. Methods of Drug Abuse Research: Cellular and Circuit Level Analyses assembles this information in one volume. It bridges the gap between cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book presents state-of-the-art technical information and critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level. Chapters provide examples of the use of neurochemical and delectrophysiological the techniques in drug studies, as well as insight into the pros and cons of these various experimental strategies. Focusing on neurochemical and neurophysiological techniques that assess drug actions on neural circuits and neural networks in intact animals, this state-of-the-art reference provides detailed descriptions of procedures as well as methods and equipment used in experiments that often employ multiple technical approaches. Methods of Drug Abuse Research brings together pertinent issues in drug abuse research and systems level investigative techniques, thus allowing you to effectively grasp the critical conceptual and technical issues associated with modern drug abuse studies.
Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions by Anonim Pdf
Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions is the latest volume from Progress in Brain Research focusing on new trends and developments in addiction research. This established international series examines major areas of basic and clinical research within neuroscience, as well as popular emerging subfields such as addiction. This volume takes an integrated approach to review and summarize some of the most recent progress from the subfield of addiction research, with particular emphasis on potential applications in a clinical setting. Explores new trends and developments in basic and clinical research in the addiction subfield of neuroscience Uses an integrated approach to review and summarize recent progress Emphasizes potential applications in a clinical setting Enhances the literature of neuroscience by further expanding the established international series Progress in Brain Research
Neuroscience Methods in Drug Abuse Research by Roger M. Brown,David P. Friedman,Yuth Nimit Pdf
This monograph is based upon papers presented at a technical review which took place on September 10-11, 1984, at Bethesda, Maryland. The conference was sponsored by the Division of Preclinical Research, National Institute on Drug Abuse.
Author : Stephen J. Wilson Publisher : John Wiley & Sons Page : 552 pages File Size : 45,9 Mb Release : 2015-04-28 Category : Psychology ISBN : 9781118472439
The Wiley Handbook on the Cognitive Neuroscience of Addiction by Stephen J. Wilson Pdf
This volume provides a thorough and up-to-date synthesis of the expansive and highly influential literature from the last 30 years by bringing together contributions from leading authorities in the field, with emphasis placed on the most commonly investigated drugs of abuse. Emphasises the most commonly investigated drugs of abuse, including alcohol, cocaine, nicotine, and opiates Brings together the work of the leading authorities in all major areas of the field Provides novel coverage of cutting-edge methods for using cognitive neuroscience to advance the treatment of addiction, including real-time neurofeedback and brain stimulation methods Includes new material on emerging themes and future directions in the use of cognitive neuroscience to advance addiction science
Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research Publisher : National Academies Press Page : 330 pages File Size : 46,9 Mb Release : 1996-11-01 Category : Medical ISBN : 9780309055338
Pathways of Addiction by Institute of Medicine,Committee on Opportunities in Drug Abuse Research Pdf
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
This Is Your Brain: Teaching About Neuroscience and Addiction Research by Terra Nova Learning Systems Pdf
The need for studentsOCO understanding of the value of the neurosciencesOCoand the damaging effects of illicit drug use, the mechanisms of addiction, and the scientific and ethical basis of animal-based drug abuse researchOCois critical to creating a better future for our children (from the Introduction). This innovative middle school curriculum presents 10 comprehensive, ready-to-use lessons about contemporary real-world issues involved in drug use and abuse."
Drug Addiction and Its Treatment by Bankole A. Johnson,John D. Roache Pdf
Provides a basic understanding of the behavioral and biological processes involved in drug addiction with 19 contributions by specialists in various disciplines writing specifically for readers who are not. They explain the procedures, results, and significance of research in their field, emphasizing the commonality of actions between drugs of abuse rather than discussing addictive substances by drug class. Annotation copyrighted by Book News, Inc., Portland, OR.
Drug Abuse in the Decade of the Brain by Gabriel G. Nahas,Thomas F. Burks Pdf
Life scientists have declared the 1990s to be the "Decade of the Brain." Undoubtedly the most important organ, the brain is perhaps the least understood. Until recently, the proper methodology for exploring the basic functions of the brain were not available. However, the new era of computer technology brain imaging and molecular biology have given scientists the tools for studying previously hidden mechanisms of the brain which control thinking, emotions, and behavior. Along with this new knowledge, scientists have observed that drugs of abuse can alter these same brain functions in a profound and persistent manner. Drugs of abuse are widely used substances that differ in chemical nature but have a common property-creating dependence. Dependence is characterized by a stereotypical pattern of behavior oriented toward the search, acquisition, and ingestion of drugs of abuse with such frequency and in such quantity as to be harmful. This behavior is beyond the control of reason and will. Studies conducted during the "decade of the brain" or before, show that the clinically observed, dependent behavior induced by drugs of abuse result from neurophysiological and chemical alterations of complex brain mechanisms. These mechanisms involve the production and turnover of the brain neurotransmitters that carry information in the brain neurocircuitry, changes in brain metabolism and circulation, and alterations in the expression of DNA which programs the functions or the neuronal cell. This book describes a number of newly discovered basic brain mechanisms and the alterations caused by drugs of abuse. Contributions by top researchers in fields of radian biology, biochemistry, genetics, and pharmacology examine the new technological improvements for the measurement of brain function, metabolism, blood flow and drug elimination and report changes in brain biochemistry, including DNA expression, as they occur during drug abuse. Physicians and health professionals will benefit from a better understanding of the effects of drugs on the brain which will lead to more effective interventions for prevention and treatment. Highlights include: New knowledge about the brain New methods of investigation Opiates and the brain Marijuana and the brain Cocaine and the brain This book will be of interest to health professionals and program administrators involved in the education and treatment of substance abuse disorders, as well as physicians, nurses, psychiatric social workers, neuroscientists, and pharmacologists.
Author : Michael T. Bardo,Diana H. Fishbein,Richard Milich Publisher : Springer Science & Business Media Page : 337 pages File Size : 41,7 Mb Release : 2011-03-30 Category : Medical ISBN : 9781441912688
Inhibitory Control and Drug Abuse Prevention by Michael T. Bardo,Diana H. Fishbein,Richard Milich Pdf
The purpose of this book is to review our state of knowledge about the neurobehavioral and psychosocial processes involved in behavioral inhibitory processes and to provide an insight into how these basic research findings may be translated into the practice of drug abuse prevention interventions. Over the last decade, there has been a wealth of information indicating that substance use disorders do not simply reflect an exaggeration of reward seeking behavior, but that they also represent a dysfunction of behavioral inhibitory processes that are critical in exercising self-control. A number of studies have determined that individuals with substance use disorders have poor inhibitory control compared to non-abusing individuals. In addition, the fact that the adolescent period is often characterized by a lack of inhibitory control may be one important reason for the heightened vulnerability for the initiation of drug use during this time. Controlled experiments utilizing neuroscience techniques in laboratory animals or neuroimaging techniques in humans have revealed that individual differences in prefrontal cortical regions may underlie, at least in part, these differences in inhibitory control. Although a few excellent journal reviews have been published on the role of inhibitory deficits in drug abuse, there has been relatively little attention paid to the potential applications of this work for drug abuse prevention. The current book will provide both basic and applied researchers with an overview of this important health-relevant topic. Since translational research cuts across multiple disciplines and most readers are not familiar with all of these disciplines, the reading level will be geared to be accessible to graduate students, as well as to faculty and researchers in the field. The book will be organized around three general themes, encased within introductory and concluding chapters. The first theme will review basic neurobehavioral research findings on inhibition and drug abuse. Chapters in this theme will emphasize laboratory studies using human volunteers or laboratory animals that document the latest research implicating a relation between inhibition and drug abuse at both the neural and behavioral levels of analysis. The second theme will move the topic to at-risk populations that have impulse control problems, including children, adolescents and young adults. The third theme will concentrate on prevention science as it relates to inhibitory control. Chapters in this theme will be written by experts attempting to develop and improve prevention interventions by integrating evidence-based knowledge about inhibitory control processes. In all of the chapters, writers will be asked to speculate about innovative approaches that may be useful for the practice of prevention.
Neurobiology of Addiction by George F. Koob,Michel Le Moal Pdf
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Richard Muscat,Co-operation Group to Combat Drug Abuse and Illicit Trafficking in Drugs (Pompidou Group)
Author : Richard Muscat,Co-operation Group to Combat Drug Abuse and Illicit Trafficking in Drugs (Pompidou Group) Publisher : Council of Europe Page : 114 pages File Size : 49,9 Mb Release : 2006-01-01 Category : Science ISBN : 9789287160171
Biomedical Research in the Drugs Field by Richard Muscat,Co-operation Group to Combat Drug Abuse and Illicit Trafficking in Drugs (Pompidou Group) Pdf
Why is it that certain people use drugs in the first place and then why do some become dependent following repeated use while others do not? What are the possible implications of the current state of affairs of research from a biomedical or more aptly put, a Neuroscience perspective, including an ethical point of view? These are questions the author attempts to answer as the biomedical or neuroscience research in the drug field is a fast moving area with ethical implications that have arisen as a result of the conduct of such research.
Behavioral Neuroscience of Drug Addiction by David W. Self,Julie K. Staley Gottschalk Pdf
Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain's natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.
Behavioral Neuroscience of Drug Addiction by David W. Self,Julie K. Staley Gottschalk Pdf
Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.
