Neuroscience Trials Of The Future

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Neuroscience Trials of the Future

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Neuroscience Trials of the Future Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 111 pages
File Size : 43,5 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9780309442589

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Neuroscience Trials of the Future by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Neuroscience Trials of the Future

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Neuroscience Trials of the Future Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 111 pages
File Size : 46,9 Mb
Release : 2016-12-07
Category : Medical
ISBN : 9780309442558

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Neuroscience Trials of the Future by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Multiple Sclerosis

Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Multiple Sclerosis Book PDF

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Publisher : National Academies Press
Page : 457 pages
File Size : 45,9 Mb
Release : 2001-08-10
Category : Medical
ISBN : 9780309072854

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Multiple Sclerosis by Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future Pdf

Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Sharing Clinical Trial Data

Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data
Sharing Clinical Trial Data Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data
Publisher : National Academies Press
Page : 304 pages
File Size : 49,5 Mb
Release : 2015-04-20
Category : Medical
ISBN : 9780309316323

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Sharing Clinical Trial Data by Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data Pdf

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Improving and Accelerating Therapeutic Development for Nervous System Disorders Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 118 pages
File Size : 41,5 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Parkinson's Disease: Current and Future Therapeutics and Clinical Trials

Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox
Parkinson s Disease Current and Future Therapeutics and Clinical Trials Book PDF

Author : Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox
Publisher : Cambridge University Press
Page : 385 pages
File Size : 49,8 Mb
Release : 2016-03-24
Category : Medical
ISBN : 9781107053861

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Parkinson's Disease: Current and Future Therapeutics and Clinical Trials by Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox Pdf

This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.

Opportunities in Neuroscience for Future Army Applications

National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Neuroscience for Future Army Applications
Opportunities in Neuroscience for Future Army Applications Book PDF

Author : National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Neuroscience for Future Army Applications
Publisher : National Academies Press
Page : 136 pages
File Size : 49,9 Mb
Release : 2009-07-16
Category : Social Science
ISBN : 9780309127400

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Opportunities in Neuroscience for Future Army Applications by National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Neuroscience for Future Army Applications Pdf

Advances and major investments in the field of neuroscience can enhance traditional behavioral science approaches to training, learning, and other applications of value to the Army. Neural-behavioral indicators offer new ways to evaluate how well an individual trainee has assimilated mission critical knowledge and skills, and can also be used to provide feedback on the readiness of soldiers for combat. Current methods for matching individual capabilities with the requirements for performing high-value Army assignments do not include neuropsychological, psychophysiological, neurochemical or neurogenetic components; simple neuropsychological testing could greatly improve training success rates for these assignments. Opportunities in Neuroscience for Future Army Applications makes 17 recommendations that focus on utilizing current scientific research and development initiatives to improve performance and efficiency, collaborating with pharmaceutical companies to employ neuropharmaceuticals for general sustainment or enhancement of soldier performance, and improving cognitive and behavioral performance using interdisciplinary approaches and technological investments. An essential guide for the Army, this book will also be of interest to other branches of military, national security and intelligence agencies, academic and commercial researchers, pharmaceutical companies, and others interested in applying the rapid advances in neuroscience to the performance of individual and group tasks.

Transforming Clinical Research in the United States

Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Transforming Clinical Research in the United States Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 151 pages
File Size : 47,8 Mb
Release : 2010-10-22
Category : Medical
ISBN : 9780309163354

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Transforming Clinical Research in the United States by Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Pdf

An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise.

International Animal Research Regulations

National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
International Animal Research Regulations Book PDF

Author : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 102 pages
File Size : 48,8 Mb
Release : 2012-06-26
Category : Science
ISBN : 9780309252119

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International Animal Research Regulations by National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

Organizational Neuroscience

David A. Waldman,Pierre A. Balthazard
Organizational Neuroscience Book PDF

Author : David A. Waldman,Pierre A. Balthazard
Publisher : Emerald Group Publishing Limited
Page : 0 pages
File Size : 42,9 Mb
Release : 2015-12-14
Category : Business & Economics
ISBN : 1785604317

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Organizational Neuroscience by David A. Waldman,Pierre A. Balthazard Pdf

This volume aims to introduce organizational researchers and practitioners to the role of neuroscience in building theory, research methodologies and practical applications. The volume introduces the field of organizational neuroscience and explores its influence on topics such as leadership, ethics and moral reasoning.

Gene Therapy of the Central Nervous System: From Bench to Bedside

Michael G. Kaplitt,Matthew During
Gene Therapy of the Central Nervous System From Bench to Bedside Book PDF

Author : Michael G. Kaplitt,Matthew During
Publisher : Gulf Professional Publishing
Page : 380 pages
File Size : 49,8 Mb
Release : 2006
Category : Medical
ISBN : 0123976324

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Gene Therapy of the Central Nervous System: From Bench to Bedside by Michael G. Kaplitt,Matthew During Pdf

Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.

The Neuroscience of Empathy, Compassion, and Self-Compassion

Larry Charles Stevens,C. Chad Woodruff
The Neuroscience of Empathy Compassion and Self Compassion Book PDF

Author : Larry Charles Stevens,C. Chad Woodruff
Publisher : Academic Press
Page : 353 pages
File Size : 53,8 Mb
Release : 2018-06-19
Category : Psychology
ISBN : 9780128098387

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The Neuroscience of Empathy, Compassion, and Self-Compassion by Larry Charles Stevens,C. Chad Woodruff Pdf

The Neuroscience of Empathy, Compassion, and Self-Compassion provides contemporary perspectives on the three related domains of empathy, compassion and self-compassion (ECS). It informs current research, stimulates further research endeavors, and encourages continued and creative philosophical and scientific inquiry into the critical societal constructs of ECS. Examining the growing number of electrocortical (EEG Power Spectral, Coherence, Evoked Potential, etc.) studies and the sizeable body of exciting neuroendocrine research (e.g., oxytocin, dopamine, etc.) that have accumulated over decades, this reference is a unique and comprehensive approach to empathy, compassion and self-compassion. Provides perspectives on empathy, compassion and self-compassion (ECS), including discussions of cruelty, torture, killings, homicides, suicides, terrorism and other examples of empathy/compassion erosion Addresses autonomic nervous system (vagal) reflections of ECS Discusses recent findings and understanding of ECS from mirror neuron research Covers neuroendocrine manifestations of ECS and self-compassion and the neuroendocrine enhancement Examines the neuroscience research on the enhancement of ECS Includes directed-meditations (mindfulness, mantra, Metta, etc.) and their effects on ECS and the brain

The Science of Fate

Hannah Critchlow
The Science of Fate Book PDF

Author : Hannah Critchlow
Publisher : Hodder & Stoughton
Page : 256 pages
File Size : 50,7 Mb
Release : 2019-05-02
Category : Psychology
ISBN : 9781473659308

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The Science of Fate by Hannah Critchlow Pdf

**THE SUNDAY TIMES BESTSELLER** 'A truly fascinating - if unnerving - read' DAILY TELEGRAPH 'Acute, mind-opening, highly accessible - this book doesn't just explain how our lives might pan out, it helps us live better' BETTANY HUGHES 'A humane and highly readable account of the neuroscience that underpins our ideas of free will and fate' PROFESSOR DAVID RUNCIMAN *** So many of us believe that we are free to shape our own destiny. But what if free will doesn't exist? What if our lives are largely predetermined, hardwired in our brains - and our choices over what we eat, who we fall in love with, even what we believe are not real choices at all? Neuroscience is challenging everything we think we know about ourselves, revealing how we make decisions and form our own reality, unaware of the role of our unconscious minds. Did you know, for example, that: * You can carry anxieties and phobias across generations of your family? * Your genes and pleasure and reward receptors in your brain will determine how much you eat? * We can sniff out ideal partners with genes that give our offspring the best chance of survival? Leading neuroscientist Hannah Critchlow draws vividly from everyday life and other experts in their field to show the extraordinary potential, as well as dangers, which come with being able to predict our likely futures - and looking at how we can alter what's in store for us. Lucid, illuminating, awe-inspiring The Science of Fate revolutionises our understanding of who we are - and empowers us to help shape a better future for ourselves and the wider world.

Clinical Recovery from CNS Damage

Hiroaki Naritomi,D. W. Krieger
Clinical Recovery from CNS Damage Book PDF

Author : Hiroaki Naritomi,D. W. Krieger
Publisher : Karger Medical and Scientific Publishers
Page : 162 pages
File Size : 43,5 Mb
Release : 2013
Category : Medical
ISBN : 9783318023084

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Clinical Recovery from CNS Damage by Hiroaki Naritomi,D. W. Krieger Pdf

A compilation of innovative findings and new directions in neurological recovery After decades of focusing on how to alleviate and prevent recurrence of acute CNS injuries, the emphasis has finally shifted towards repairing such devastating events and rehabilitation. This development has been made possible by substantial progress in understanding the scientific underpinnings of recovery as well as by novel diagnostic tools, and most importantly, by emerging therapies awaiting clinical trials. In this publication, several international experts introduce novel areas of neurological reorganization and repair following CNS damage. Principles and methods to monitor and augment neuroplasticity are explored in depth and supplemented by a critical appraisal of neurological repair mechanisms and possibilities to curtail disability using computer or robotic interfaces. Rather than providing a textbook approach of CNS restoration, the editors selected topics where progress is most imminent in this labyrinthine domain of medicine. Moreover, the varied background and origins of the contributors lend this book a truly global perspective on the current state of affairs in neurological recovery.

Present and Future of EMDR in Clinical Psychology and Psychotherapy

Benedikt L. Amann,Isabel Fernandez,Gianluca Castelnuovo
Present and Future of EMDR in Clinical Psychology and Psychotherapy Book PDF

Author : Benedikt L. Amann,Isabel Fernandez,Gianluca Castelnuovo
Publisher : Frontiers Media SA
Page : 230 pages
File Size : 53,9 Mb
Release : 2019-11-22
Category : Electronic
ISBN : 9782889632091

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Present and Future of EMDR in Clinical Psychology and Psychotherapy by Benedikt L. Amann,Isabel Fernandez,Gianluca Castelnuovo Pdf

Eye Movement Desensitization Reprocessing (EMDR) therapy is an evidence-based psychotherapy which has been recognized by the World Health Organization (WHO) as a first-choice treatment for Posttraumatic Stress Disorder (PTSD). Beyond PTSD, there has been increasing research into its mechanism of action and in the efficacy of EMDR in other psychiatric and somatic disorders with comorbid psychological trauma. The motivation of this research topic was to offer new and innovative research on EMDR across the globe to an increasing number of clinicians and researchers with an interest in this trauma-focused intervention.