Neurotransmitter Receptors

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Neurotransmitter Receptors

Sam J. Enna
Neurotransmitter Receptors Book PDF

Author : Sam J. Enna
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 53,5 Mb
Release : 2013-12-12
Category : Science
ISBN : 9789400959286

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Neurotransmitter Receptors by Sam J. Enna Pdf

Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electro physiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 74 pages
File Size : 40,6 Mb
Release : 2011-08-05
Category : Medical
ISBN : 9780309212212

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Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Neurotransmitter Release

Hugo J. Bellen
Neurotransmitter Release Book PDF

Author : Hugo J. Bellen
Publisher : Unknown
Page : 466 pages
File Size : 54,9 Mb
Release : 1999
Category : Cellular signal transduction
ISBN : UOM:39015048547338

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Neurotransmitter Release by Hugo J. Bellen Pdf

Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.

Neurotransmitter Receptors

F. Hucho
Neurotransmitter Receptors Book PDF

Author : F. Hucho
Publisher : Elsevier
Page : 366 pages
File Size : 55,8 Mb
Release : 1994-03-17
Category : Science
ISBN : 0080860842

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Neurotransmitter Receptors by F. Hucho Pdf

This comprehensive compilation provides a wealth of information on receptor sequences produced by recombinant DNA techniques used in combination with classical biochemistry. To minimize redundancies in this wealth of information, only a few receptors (some of which are typical for a whole group of similar receptors, others which are presently of special interest) are dealt with in a full-size chapter. Others are represented in the TIPS Receptor Nomenclature Supplement which is included as a special feature in this book, making this volume more useful as a receptor handbook.

Pharmacology of Neurotransmitter Release

Thomas C. Südhof,Klaus Starke
Pharmacology of Neurotransmitter Release Book PDF

Author : Thomas C. Südhof,Klaus Starke
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 44,5 Mb
Release : 2007-12-07
Category : Medical
ISBN : 9783540748052

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Pharmacology of Neurotransmitter Release by Thomas C. Südhof,Klaus Starke Pdf

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.

Neurotransmitter Receptors

Sam J. Enna
Neurotransmitter Receptors Book PDF

Author : Sam J. Enna
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 54,9 Mb
Release : 2013-12-11
Category : Science
ISBN : 9789401095471

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Neurotransmitter Receptors by Sam J. Enna Pdf

Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electrophysiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Neurotransmitter Receptors: Advances in Research and Application: 2011 Edition

Anonim
Neurotransmitter Receptors Advances in Research and Application 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 87 pages
File Size : 50,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464931857

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Neurotransmitter Receptors: Advances in Research and Application: 2011 Edition by Anonim Pdf

Neurotransmitter Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Neurotransmitter Receptors in a concise format. The editors have built Neurotransmitter Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurotransmitter Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurotransmitter Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Neurotransmitters, Drugs and Brain Function

Roy Webster
Neurotransmitters Drugs and Brain Function Book PDF

Author : Roy Webster
Publisher : John Wiley & Sons
Page : 550 pages
File Size : 47,9 Mb
Release : 2001-11-28
Category : Medical
ISBN : 0471978191

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Neurotransmitters, Drugs and Brain Function by Roy Webster Pdf

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Neurotransmitters and Neuromodulators

Oliver von Bohlen und Halbach,Rolf Dermietzel
Neurotransmitters and Neuromodulators Book PDF

Author : Oliver von Bohlen und Halbach,Rolf Dermietzel
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 54,8 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9783527609079

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Neurotransmitters and Neuromodulators by Oliver von Bohlen und Halbach,Rolf Dermietzel Pdf

A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

Neurotransmitter Receptors

Shozo Kito
Neurotransmitter Receptors Book PDF

Author : Shozo Kito
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 55,6 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781468448054

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Neurotransmitter Receptors by Shozo Kito Pdf

This meeting was held commemorating Dr. Kito's 10th Anniversary as Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito was born in 1927 in Nagoya, graduated from Tokyo University School of Medicine and received his M. D. in 1951. He spent his first academic years as a research associate (1952 - 1968) at the Third Department of Internal Medi cine, Tokyo University School of Medicine. During this period he studied for one year (1952 - 1953) at Illinois University School of Medicine, and acquired his Ph. D. in 1959. In 1968 he became Instructor and in 1971 he was appointed as Assistant Professor of Tokyo Women's Medical College. In 1973, he became Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito is a clinician but he is always enthusiastic about basic medicine. His major research field concerns neurotrans mitters and their receptors in the central nervous system. He prefers a combination of neurotransmitter immunohistochemistry and receptor autoradiography as research techniques. He is also engaged in biochemical studies on amyloid proteins. When the Eighth Inter national Congress of Pharmacology was held in Tokyo in 1981, Dr. Segawa, Dr. Yamamura, and Dr. Kuriyama organized a Satellite Symposium on Neurotransmitter Receptors in Hiroshima. Dr. Kito attended this meeting and was deeply impressed by the active presentations and discussions. In order to make some contribution to the progress of neuro sciences, Dr.

An Introduction to Neuroendocrinology

Richard E. Brown
An Introduction to Neuroendocrinology Book PDF

Author : Richard E. Brown
Publisher : Cambridge University Press
Page : 434 pages
File Size : 46,5 Mb
Release : 1994-01-27
Category : Science
ISBN : 0521426650

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An Introduction to Neuroendocrinology by Richard E. Brown Pdf

This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Receptors in the Developing Nervous System

Ian S. Zagon,Patricia J. McLaughlin
Receptors in the Developing Nervous System Book PDF

Author : Ian S. Zagon,Patricia J. McLaughlin
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401115445

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Receptors in the Developing Nervous System by Ian S. Zagon,Patricia J. McLaughlin Pdf

Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.

Neurotransmitters, Drugs and Brain Function

Roy Webster
Neurotransmitters Drugs and Brain Function Book PDF

Author : Roy Webster
Publisher : John Wiley & Sons
Page : 550 pages
File Size : 51,5 Mb
Release : 2001-11-28
Category : Medical
ISBN : 9780471978190

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Neurotransmitters, Drugs and Brain Function by Roy Webster Pdf

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

The GABA Receptors

Salvatore J. Enna,Hanns Möhler
The GABA Receptors Book PDF

Author : Salvatore J. Enna,Hanns Möhler
Publisher : Humana Press
Page : 325 pages
File Size : 51,5 Mb
Release : 2007-07-19
Category : Medical
ISBN : 1588298132

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The GABA Receptors by Salvatore J. Enna,Hanns Möhler Pdf

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

Receptors in the Human Nervous System

F. A. O. Mendelsohn,George Paxinos
Receptors in the Human Nervous System Book PDF

Author : F. A. O. Mendelsohn,George Paxinos
Publisher : Academic Press
Page : 273 pages
File Size : 42,9 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483258621

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Receptors in the Human Nervous System by F. A. O. Mendelsohn,George Paxinos Pdf

Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.