New Advances On Disease Biomarkers And Molecular Targets In Biomedicine

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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine

Nikki P. Lee,C.Y. Cheng,John M. Luk
New Advances on Disease Biomarkers and Molecular Targets in Biomedicine Book PDF

Author : Nikki P. Lee,C.Y. Cheng,John M. Luk
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 40,8 Mb
Release : 2013-06-22
Category : Science
ISBN : 9781627034562

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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine by Nikki P. Lee,C.Y. Cheng,John M. Luk Pdf

Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includes concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. This book renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

Ion Channels as Therapeutic Targets

Anonim
Ion Channels as Therapeutic Targets Book PDF

Author : Anonim
Publisher : Academic Press
Page : 466 pages
File Size : 54,6 Mb
Release : 2016-03-31
Category : Science
ISBN : 9780128052426

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Ion Channels as Therapeutic Targets by Anonim Pdf

This volume is the second part of the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students

Current Advances in Breast Cancer Research: A Molecular Approach

Shankar Suman,Garima Suman,Sanjay Mishra
Current Advances in Breast Cancer Research A Molecular Approach Book PDF

Author : Shankar Suman,Garima Suman,Sanjay Mishra
Publisher : Bentham Science Publishers
Page : 401 pages
File Size : 48,9 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9789811451423

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Current Advances in Breast Cancer Research: A Molecular Approach by Shankar Suman,Garima Suman,Sanjay Mishra Pdf

Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.

Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

Arpad Szallasi,Susan M. Huang
Transient Receptor Potential TRP Channels in Drug Discovery Old Concepts New Thoughts Book PDF

Author : Arpad Szallasi,Susan M. Huang
Publisher : MDPI
Page : 247 pages
File Size : 40,9 Mb
Release : 2018-06-22
Category : Electronic books
ISBN : 9783038426387

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Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts by Arpad Szallasi,Susan M. Huang Pdf

This book is a printed edition of the Special Issue "Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts" that was published in Pharmaceuticals

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Improving and Accelerating Therapeutic Development for Nervous System Disorders Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 107 pages
File Size : 46,9 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

New Trends in Cancer for the 21st Century

Antonio Llombart-Bosch,José A. López-Guerrero,Vicente Felipo
New Trends in Cancer for the 21st Century Book PDF

Author : Antonio Llombart-Bosch,José A. López-Guerrero,Vicente Felipo
Publisher : Springer
Page : 0 pages
File Size : 48,8 Mb
Release : 2010-11-18
Category : Medical
ISBN : 904817239X

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New Trends in Cancer for the 21st Century by Antonio Llombart-Bosch,José A. López-Guerrero,Vicente Felipo Pdf

This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view.

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease Book PDF

Author : Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Publisher : National Academies Press
Page : 335 pages
File Size : 47,5 Mb
Release : 2010-06-25
Category : Medical
ISBN : 9780309157278

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Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease Pdf

Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Spermatogenesis

C. Yan Cheng
Spermatogenesis Book PDF

Author : C. Yan Cheng
Publisher : CRC Press
Page : 278 pages
File Size : 55,6 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9780429949494

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Spermatogenesis by C. Yan Cheng Pdf

Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.

Fundamentals of Clinical Trials

Lawrence M. Friedman,Curt Furberg,David L. DeMets
Fundamentals of Clinical Trials Book PDF

Author : Lawrence M. Friedman,Curt Furberg,David L. DeMets
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 53,8 Mb
Release : 1998
Category : Clinical trials
ISBN : 0387985867

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Fundamentals of Clinical Trials by Lawrence M. Friedman,Curt Furberg,David L. DeMets Pdf

This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.

Evolution of Translational Omics

Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Evolution of Translational Omics Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 50,6 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Stem Cell Genetics for Biomedical Research

Raul Delgado-Morales
Stem Cell Genetics for Biomedical Research Book PDF

Author : Raul Delgado-Morales
Publisher : Springer
Page : 426 pages
File Size : 46,8 Mb
Release : 2018-06-27
Category : Science
ISBN : 9783319906959

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Stem Cell Genetics for Biomedical Research by Raul Delgado-Morales Pdf

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

Advancing Nuclear Medicine Through Innovation

National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
Advancing Nuclear Medicine Through Innovation Book PDF

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
Publisher : National Academies Press
Page : 173 pages
File Size : 52,6 Mb
Release : 2007-09-11
Category : Medical
ISBN : 9780309134156

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Advancing Nuclear Medicine Through Innovation by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine Pdf

Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 55,9 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

ADDRESSING GLOBAL ISSUES WITH COLLECTIVE AND CONCERTED ACTIONS: Indonesian Scholar Perspectives for the G20 Forum

Wahyudi Kumorotomo,Muhammad Baiquni
ADDRESSING GLOBAL ISSUES WITH COLLECTIVE AND CONCERTED ACTIONS Indonesian Scholar Perspectives for the G20 Forum Book PDF

Author : Wahyudi Kumorotomo,Muhammad Baiquni
Publisher : UGM PRESS
Page : 451 pages
File Size : 51,7 Mb
Release : 2023-01-12
Category : Political Science
ISBN : 9786233591102

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ADDRESSING GLOBAL ISSUES WITH COLLECTIVE AND CONCERTED ACTIONS: Indonesian Scholar Perspectives for the G20 Forum by Wahyudi Kumorotomo,Muhammad Baiquni Pdf

As a compilation of research and scholarly articles under the auspices of Dewan Guru Besot (Board of Professors) of U niversitas Gadjah Mada, this volume is expected to contribute for the Sherpa Track of G20 forum. We believe that multi-disciplinary approach among university scholars would provide a comprehensive understanding on what to be considered by the G20 country leaders who are scheduled to meet in Bali, Indonesia, in 2022. Parallel to the three prioritized agendas for G20, critical reviews on health system after the Covid-19 global pandemic, changing activities and lifestyle under digitalized economy, and transition towards sustainable energy are presented. Cases are mostly taken from the Indonesian experience. We would argue that interdependency and partnership among countries are inevitable and that we must understand and acknowledge it more than ever. All the critical global issues—health, poverty, climate change—can only be addressed with collective actions of all individuals in developed as well as developing countries. The collective awareness of the new world order for healthy, smart, and green lifestyle is essential to the future living in the planet. The G20 forum is crucial as it represents 65 percent of the world population and 80 percent of the world economy. We hope that G20 leaders have a full commitment and capacity to conduct an orchestra of global community which enable and empower citizens while acknowledging cultural diversity in their respected countries. It is a high time for all of collective and concerted actions.

Recent Advances in Stem Cells

Essam M. Abdelalim
Recent Advances in Stem Cells Book PDF

Author : Essam M. Abdelalim
Publisher : Springer
Page : 269 pages
File Size : 47,7 Mb
Release : 2016-09-14
Category : Medical
ISBN : 9783319332703

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Recent Advances in Stem Cells by Essam M. Abdelalim Pdf

This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.