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Author : Sandy Bornstein,Jerry Bornstein
Publisher : Julian Messner
Page : 176 pages
File Size : 54,8 Mb
Release : 1984-01-01
Category : Genetic engineering
ISBN : 0671452452
Discusses new advances in genetic science and examines the benefits, risks, and potential problems that these pose for the human community now and in the future.
Author : Lesley Easton
Publisher : States Academic Press
Page : 252 pages
File Size : 54,7 Mb
Release : 2021-11-16
Category : Science
ISBN : 1639893741
Human genetics is concerned with the study of the inheritance of characteristics from parents to children. This inheritance in humans depends upon discrete units called factors or genes. Human genes refer to a set of nucleic acid sequences that are encoded as DNA in the twenty-three chromosome pairs. The field of human genetics attempts to understand the genetics of human life and the development of diseases and its effective treatment. The discipline overlaps with other fields such as cytogenetics, biochemical genetics, population genetics, genetic counseling, developmental genetics, genomics, etc. There has been rapid progress in this field and its applications are finding their way across multiple industries such as medicine and biotechnology. The book studies, analyzes and upholds the pillars of human genetics and its utmost significance in modern times. It contains some path-breaking studies in the field of human genetics. In this book, using case studies and examples, constant effort has been made to make the understanding of the difficult concepts of human genetics as easy and informative as possible, for the readers.
Author : Mark E. Bunnage
Publisher : Royal Society of Chemistry
Page : 329 pages
File Size : 47,9 Mb
Release : 2011
Category : Medical
ISBN : 9781849731256
This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.
Author : Alpo Juhani Vuorio,Uma Ramaswami,Kirsten B. Holven
Publisher : Frontiers Media SA
Page : 190 pages
File Size : 42,9 Mb
Release : 2021-07-02
Category : Science
ISBN : 9782889669738
Author : Yuan-Ming Zhang,Zhenyu Jia,Jim M Dunwell
Publisher : Frontiers Media SA
Page : 236 pages
File Size : 52,6 Mb
Release : 2019-06-19
Category : Electronic
ISBN : 9782889458349
Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.
Author : Aliasghar Tabatabaei Mohammadi,Mohadeseh Taei,Fatemeh Moeini,Erfan Ghanbarzadeh,Mahzad Yousefi,Mohammad mahdi Hanaei
Publisher : Nobel Sciences
Page : 68 pages
File Size : 43,7 Mb
Release : 2024-06-02
Category : Medical
ISBN : 8210379456XXX
Author : Serge Morand,François Beaudeau,Jacques Cabaret
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 52,5 Mb
Release : 2011-09-08
Category : Medical
ISBN : 9789400721142
Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.
Author : Kostas Kampourakis
Publisher : Cambridge University Press
Page : 319 pages
File Size : 42,5 Mb
Release : 2017-03-30
Category : Science
ISBN : 9781107567498
What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.
Author : John Robert Nelson
Publisher : William B. Eerdmans Publishing Company
Page : 232 pages
File Size : 49,8 Mb
Release : 1994
Category : Religion
ISBN : UOM:39015034653033
The Innovative Uses of Genetic Science in Human Medicine and health promotion are now provoking new ethical and religious concerns as well as raising hopes. As the public becomes increasingly aware of the scientific discoveries in the field of genetics - discoveries that appear at once promising and problematic - people are also beginning to ask important fundamental questions: What does this biological revolution have to do with religious beliefs and ethics? How should Christians interpret its significance? Drawing from the work of 260 scientific, medical, and religious professionals who met to discuss genetic research under the auspices of the nation's Human Genome Project in 1990 and 1992, J. Robert Nelson fairly and expertly probes such pressing topics as genetic counseling, prenatal diagnosis, the treatment of inherited diseases, and the temptation to seek eugenic improvements of human nature and capabilities. Religious critiques by leading experts from Jewish, Christian, and other traditions also help to explain the two sides of human genetic science: the possibilities for good and the dangers of abuse.
Author : Lance D. Chambers
Publisher : CRC Press
Page : 464 pages
File Size : 54,5 Mb
Release : 2019-09-17
Category : Mathematics
ISBN : 9781420050073
The mathematics employed by genetic algorithms (GAs)are among the most exciting discoveries of the last few decades. But what exactly is a genetic algorithm? A genetic algorithm is a problem-solving method that uses genetics as its model of problem solving. It applies the rules of reproduction, gene crossover, and mutation to pseudo-organism
Author : Andrew J. Wood,Melvin J. Oliver,David J. Cove
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 42,6 Mb
Release : 2013-03-20
Category : Nature
ISBN : 9780306485688
The mosses (Bryophatea, Musci) are a diverse and widely distributed group of land plants. Mosses are attractive experimental plants because they exhibit the traditional attributes of good model systems (Le. ease of growth & maintenance, fast generation time, and amenable genetics) with the added advantage of a haploid gametophyte that allowed developmental mutants to be recovered with relative ease. In addition, mosses with the ability to tolerate extreme environmental conditions offer realistic models for the analysis of environmental stress-tolerance; particularly when compared to tracheophytes such as Arabidopsis thaliana in which these important plant phenotypes are either not clearly expressed or entirely lacking. And, in one of the most exciting developments in Plant Biology, efficient homologous recombination occurs in the moss Physcomitrella patens. The ability to perform efficient homologous recombination (Le. gene knock-outs) in P. patens is at present unique amongst all plants and represents an extremely powerful technique for the functional analysis of many plant genes. Over the past 5 years, a world-wide community of moss researchers has evolved. A highly successful "Moss" conference has been held annually (l998-Mumbai, India; 1999-Carbondale, IL, USA; 2000-Villars, Switzerland; 200l-0kazaki, Japan; 2002-Ambleside, UK; 2003-St. Louis, MO, USA) with "Moss 2004" planned to be held in Frieburg Germany. These conferences have been instrumental in the creation & development of strong collaborative ties, and the free exchange of both ideas and materials.
Author : Paul Atkinson,Peter Glasner,Margaret Lock
Publisher : Routledge
Page : 566 pages
File Size : 44,6 Mb
Release : 2009-07-02
Category : Science
ISBN : 9781134128778
An authoritative Handbook which offers a discussion of the social, political, ethical and economic consequences and implications of the new bio-sciences. The Handbook takes an interdisciplinary approach providing a synoptic overview of contemporary international social science research on genetics, genomics and the new life sciences. It brings together leading scholars with expertise across a wide-ranging spectrum of research fields related to the production, use, commercialisation and regulation of genetics knowledge. The Handbook is structured into seven cross-cutting themes in contemporary social science research on genetics with introductions written by internationally renowned section editors who take an interdisciplinary approach to offer fresh insights on recent developments and issues in often controversial fields of study. The Handbook explores local and global issues and critically approaches a wide range of public and policy questions, providing an invaluable reference source to a wide variety of researchers, academics and policy makers.
Author : David Sandua
Publisher : Independently Published
Page : 0 pages
File Size : 41,8 Mb
Release : 2023-08-19
Category : Electronic
ISBN : 9798858178422
Enter the fascinating world of genetics, where the boundaries of human understanding are constantly expanding, opening doors to unprecedented breakthroughs. In recent years, gene editing, especially through the revolutionary CRISPR tool, has transformed the field, allowing precise manipulations of the genetic code. This technology promises to transform medicine, cure diseases previously considered incurable, and reshape agriculture, creating resistant crops and reducing dependence on pesticides. But beyond its applications, CRISPR has the potential to alter entire ecosystems, engineer organisms for extreme conditions, and revolutionize the production of biofuels and renewable materials. However, with great powers come great responsibilities. The ethical and social implications of gene editing are profound. How do we ensure the ethical use of this technology? How do we ensure that its benefits are not limited to a privileged few? These and other crucial questions are explored in this insightful essay, which not only illuminates the possibilities of genetics, but also highlights the need for responsible and ethical application.
Author : Roger A. Dixon,Lars Bäckman,Lars-Göran Nilsson
Publisher : Oxford : Oxford University Press
Page : 390 pages
File Size : 50,7 Mb
Release : 2004
Category : Medical
ISBN : 0198525699
With an ever increasing population of aging people in the western world, it is more crucial than ever that we try to understand how and why cognitive competence breaks down with advancing age; why do some people follow normal patterns of cognitive change, while others follow a path of progressive decline, with neurodegenerative diseases such as Alzheimer's. What can be done to prevent cognitive decline - or to avoid neurodegenerative diseases? The answers, if they come, will not emerge from research within one discipline, but from work being done across a range of scientific and medical specialities. This volume brings together leading experts from a range of fields studying cognitive aging, including neuroscience, pharmacology, health, genetics, sensory biology, and epidemiology. Unlike other books in this area, this book is more about 'new frontiers' than past research and accomplishments. Recently cognitive aging research has taken several new directions, linking with, and benefiting from, rapid technological and theoretical advances in these neighbouring disciplines. This book provides unique interdisciplinary coverage of the topic. With each chapter including commentaries from specialists in related fields, the book provides an integrative study of the topic. For those within the fields of psychology, cognitive neuroscience, and geriatrics, this volume will make an important contribution in furthering our understanding of a problem that affects us all.
Author : Lance D. Chambers
Publisher : CRC Press
Page : 442 pages
File Size : 49,6 Mb
Release : 2019-09-17
Category : Mathematics
ISBN : 1420050079
The mathematics employed by genetic algorithms (GAs)are among the most exciting discoveries of the last few decades. But what exactly is a genetic algorithm? A genetic algorithm is a problem-solving method that uses genetics as its model of problem solving. It applies the rules of reproduction, gene crossover, and mutation to pseudo-organism