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New Treatment Modalities in Rectal Cancer by Fazl Q. Parray,Nisar Ahmad Chowdri Pdf
This book provides an up-to-date and detailed overview of diagnostic and management strategies for rectal cancer. It includes chapters focusing on recent diagnostic modalities such as technical advances, the role of magnetic resonance imaging (MRI), immunology, and histopathology, as well as the latest surgical techniques for the management of rectal cancer. It also discusses the role of adjuvant, neo-adjuvant and non-operative approaches. Further, it presents the recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, clearly and concisely, linking each topic to the therapeutic options arising from the staging. A large part of this multifaceted book is devoted to the in-hospital care of rectal cancer patients, from the fast-track procedures and enhanced recovery systems to detailed descriptions of the available surgical techniques, including salvage situations, accidents, complications and their treatment.
Rectal Cancer Treatment by M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz Pdf
Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.
Modern Management of Cancer of the Rectum by Walter E. Longo,Vikram Reddy,Riccardo A. Audisio Pdf
Modern Management of Cancer of the Rectum is intended to provide a comprehensive overview of all aspects of rectal neoplasms. It addresses epidemiology, biology, screening and chemoprevention, the role of imaging in diagnosis, staging and prognosis, radiation therapy, medical and surgical treatment, as well as new modalities of therapy, including laparoscopy, and transanal endoscopic surgery. A greater understanding of prognostic factors, patterns of spread and natural history has occurred during the past decade; together with new diagnostic modalities this has led to significant changes in the management of patients with rectal cancer. This book will be invaluable for all those who treat rectal cancer.
Rectal Cancer: Modern Approaches to Treatment provides a useful overview of the multidisciplinary treatment of rectal cancer with a deeper dive into clinical challenges faced by treating physicians. Written by the leading experts in the field, it provides a practical management guide with an emphasis on the state-of-the-art that will be of value to both novices and experts engaged in rectal cancer treatment.
Colorectal cancer is the fourth most common type of cancer worldwide yet there continues to be controversy and confusion regarding the best methods and techniques for its diagnosis and management. Colon and Rectal Cancer is a clinician’s guide to major advances, including the tremendous improvements in endorectal ultrasonography, which allow a much more accurate staging of rectal tumors and surrounding lymph nodes. In addition, this comprehensive manual investigates the increasing variety of treatment options for rectal cancers at differing stages. Individual chapters address such topics as: Colon and rectal polyps Screening for colon and rectal cancer Presentation and pretreatment evaluation of patients with adenocarcinoma of the colon Treatment of both colon and rectal cancers and their follow-up after treatment Neoadjuvant and adjuvant therapy for adenocarcinoma of the rectum Treatment for metastatic disease of the colon and rectum Uncommon tumors of the colon and rectum Assembled with the practicing health professional in mind, this clearly written reference will be useful to any practitioner who encounters patients suffering from these malignancies. By fully and objectively evaluating the utility and value of all pretreatment and posttreatment studies, Colon and Rectal Cancer will guide practitioners through the responsible assessment of staging, follow-up studies, and treatment modalities for those suffering from cancers of the colon and rectum.
Recent Advances in the Treatment of Colorectal Cancer by Hideyuki Ishida,Keiji Koda Pdf
This book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.
Colorectal Cancer Diagnosis and Therapeutic Updates by Sankha Bhattacharya,Amit Page,Saurabh Maru,Shilpa Dawre Pdf
Colorectal Cancer is a complex disease caused by the interaction of hereditary and environmental factors that can be classified based on their importance. Colorectal Cancer Diagnosis and Therapeutic Updates provides comprehensive information about the diagnosis and treatment of colorectal cancer. Chapters first cover the fundamentals of colorectal cancer diagnosis, progressing further towards explaining therapeutic modalities and recent advances in the understanding of the disease. Key Features - 11 organized, reader-friendly chapters that provide a complete overview of colorectal cancer - Covers the colorectal cancer diagnosis, screening and histopathology - Covers multimodal treatment of colorectal cancer, including chemotherapy, radiotherapy and robotic surgery - Covers the management and surveillance of colorectal cancer - Explains the key biochemical mechanisms involved in colorectal cancer treatment - Covers recent information about colorectal cancer theranostics and drug delivery - Includes references for further reading in every chapter The book serves as an introductory reference for medical students and residents on the subject of colorectal cancer. It also serves as a quick reference on the disease for the practicing general physician.
Despite lifestyle improvements, the incidence of rectal cancer is increasing in industrialised countries. Rapid advances in technology, growing knowledge of the biological history of the disease and closer attention to patients' quality of life after surgery have led to a less invasive approach. In the last 15 years, the surgical approach has shifted from extended resection to sphincter-saving procedures, featuring a multidisciplinary approach and a high level of specialisation. The experienced surgeon can plan and choose the "right treatment for the right patient" only with the support of the radiologist, endoscopist and pathologist (preoperative staging), oncologist and radiotherapist (neoadjuvant therapy), and psychologist and stomatherapist (rehabilitation). In addition, the difficult problems of salvage procedure and the reconstruction of anal sphincter after abdominal resection are explored. The aim of this book is to clarify the rapid advances and to offer guidelines for doctors dealing with rectal cancer. Taking into account indications, contraindications, risks, benefits and controversies, the authors offer clear and practice-oriented answers for a wide range of specialists and experts, as well as those new to the field.
Although attempts at radical removal of cancers of the rectum had been performed earlier, it was not until W. E. Miles in 1908 re ported his experience in the management of cancer in this ana tomic part, that the combined abdominoperineal resection be came the recognized and accepted approach for the treatment of this cancer. Miles reasoned that proctectomy removed the cancer, bearing a segment oflarge bowel but also the regional lymphatics into which the cancer spread, not only proximally, but laterally and distally as well. In his monograph in 1926 he stated: . . . There are, I hold, two main principles to be observed in the surgical treatment of cancer of the rectum and indeed of all cancers wherever they are found, first, ope ration should be based on a knowledge of the demonstrable facts of pathology, and, second, the most extensive operation possible in conformity with that knowl edge should be performed on all patients no matter how small or early the local manifestation of the disease may seem to be . . . This philosophy was appropriate in his time but today, with increased knowledge regarding the biological behavior of cancer of the rectum, the recognition of the importance of the extent of the primary lesion and staging of cancer, and the availability of multiple modalities in the management of neoplastic disease, the philosophy has appropriately changed.
Surgical Techniques in Rectal Cancer by Giovanni Dapri,John H Marks Pdf
This book describes the various procedures, including surgery through the abdominal wall, through a transanal access or by the union of both, using an open, laparoscopic, or robotic approach. Worldwide pioneers for each technique are invited as authors and portray in step-by-step detail about each procedure. Of the 32 chapters, 23 are dedicated only for the surgical procedures. Each chapter is enriched by numerous figures, which complement the text, permitting the understanding of each surgical technique from its beginning until the last step. Eight additional chapters are dedicated to the clinical and anatomical aspects of rectal cancer. In the last decade there has been an impressive evolution in the treatment of patients with rectal cancer, with a focus not only on the preservation of a cancer-free life, but the quality of that life. This book has been written to be useful for everyone involved in rectal cancer management. From internists, gastroenterologists, endoscopists, oncologists, radiotherapists and radiologists involved in the treatment of rectal cancer during their daily practice, to surgeons specialized in colorectal surgery, to junior faculty to trainees, all interested in new and innovative techniques.
Colorectal cancer, a formidable adversary within the landscape of oncology, remains a significant global health challenge. Afflicting millions worldwide, its impact reverberates through communities, families, and healthcare systems alike. Yet, amidst the complexity and gravity of this disease, there exists a beacon of hope rooted in understanding, prevention, and treatment. At its core, colorectal cancer arises from the malignant transformation of cells lining the colon or rectum, typically progressing from benign polyps to invasive tumors over time. While its exact etiology remains multifaceted, a culmination of genetic predispositions, lifestyle factors, and environmental influences underscores its pathogenesis. Understanding these intricacies is pivotal in our quest to combat this disease effectively. Exploring the epidemiology of colorectal cancer unveils a sobering reality. Globally, it ranks as the third most commonly diagnosed cancer in men and the second in women, with over 1.9 million new cases reported annually. Within this statistical narrative lies a tale of disparities, with incidence rates varying widely across regions and populations. From the bustling cities of developed nations to the remote villages of underserved communities, no corner of the world is untouched by its reach. Yet, amidst this daunting landscape, lies a beacon of hope: prevention. Research has illuminated the profound impact of lifestyle modifications and early detection strategies in mitigating the burden of colorectal cancer. From dietary interventions promoting fiber-rich foods and the reduction of processed meats to the implementation of robust screening programs, opportunities abound to shift the tide in our favor. Indeed, the cornerstone of our defense against colorectal cancer lies in our ability to arm ourselves with knowledge and awareness. Through public health initiatives, advocacy campaigns, and educational outreach, we empower individuals to take proactive steps in safeguarding their health. From the corridors of research institutions to the halls of community centers, collaboration emerges as our greatest ally in this endeavor. As we delve deeper into the labyrinth of colorectal cancer, we uncover a myriad of treatment modalities aimed at eradicating the disease and improving patient outcomes. From surgical interventions offering curative intent to the advent of targeted therapies and immunomodulatory agents, innovation propels us forward on the frontlines of battle. Yet, amidst these triumphs, challenges persist, underscoring the need for continued research, advocacy, and investment in cancer care.
Colorectal Cancer Liver Metastases by Mauro Monteiro Correia,Michael A. Choti,Flavio G. Rocha,Go Wakabayashi Pdf
Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.
Textbook of Gastrointestinal Oncology by Suayib Yalcin,Philip A. Philip Pdf
This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.
With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.