Author : Ulf Grawunder,Stefan Barth
Publisher : Springer
Page : 181 pages
File Size : 55,8 Mb
Release : 2017-04-07
Category : Medical
ISBN : 9783319468778
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins by Ulf Grawunder,Stefan Barth Pdf
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.