Nmda Antagonists As Potential Analgesic Drugs

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NMDA Antagonists as Potential Analgesic Drugs

Dalip J.S. Sirinathsinghji,Ray G. Hill
NMDA Antagonists as Potential Analgesic Drugs Book PDF

Author : Dalip J.S. Sirinathsinghji,Ray G. Hill
Publisher : Birkhäuser
Page : 212 pages
File Size : 50,5 Mb
Release : 2012-11-28
Category : Medical
ISBN : 9783034881395

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NMDA Antagonists as Potential Analgesic Drugs by Dalip J.S. Sirinathsinghji,Ray G. Hill Pdf

There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. Leading scientists in excitatory amino acid and analgesia research have compiled in this volume the most recent information on molecular biology, physiology and pharmacology of NMDA receptors, their neuroanatomical localisation within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states.

The Essence of Analgesia and Analgesics

Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford
The Essence of Analgesia and Analgesics Book PDF

Author : Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford
Publisher : Cambridge University Press
Page : 551 pages
File Size : 45,9 Mb
Release : 2010-10-14
Category : Medical
ISBN : 9781139491983

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The Essence of Analgesia and Analgesics by Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford Pdf

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

Magnesium in the Central Nervous System

Robert Vink,Mihai Nechifor
Magnesium in the Central Nervous System Book PDF

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 54,7 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Biology of the NMDA Receptor

Antonius M. VanDongen
Biology of the NMDA Receptor Book PDF

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 368 pages
File Size : 52,7 Mb
Release : 2008-10-29
Category : Medical
ISBN : 9781420044157

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Fundamentals of Anaesthesia

Colin Pinnock,Ted Lin,Robert Jones,Tim Smith
Fundamentals of Anaesthesia Book PDF

Author : Colin Pinnock,Ted Lin,Robert Jones,Tim Smith
Publisher : Cambridge University Press
Page : 990 pages
File Size : 54,5 Mb
Release : 2002-12
Category : Medical
ISBN : 052169079X

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Fundamentals of Anaesthesia by Colin Pinnock,Ted Lin,Robert Jones,Tim Smith Pdf

The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Anesthesiology In-Training Exam Review

Ratan K. Banik
Anesthesiology In Training Exam Review Book PDF

Author : Ratan K. Banik
Publisher : Springer
Page : 395 pages
File Size : 54,9 Mb
Release : 2022-01-18
Category : Medical
ISBN : 3030872653

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Anesthesiology In-Training Exam Review by Ratan K. Banik Pdf

Focused on rotations in regional anesthesia and chronic pain, this book provides a structured review of the concepts covered in the American Board of Anesthesiology in-training exam. The first section of the book covers regional anesthesia with dedicated chapters on basic science, acute postoperative pain, and nerve blocks for neuraxial, lower and upper extremity blocks, and head and neck. The second section on chronic pain includes chapters on basic science and common pain conditions - including craniofacial pain, CRPS, neuropathic pain, and cancer pain. This section closes on multimodal analgesia and other treatment approaches. Each chapter presents a common clinical topic and is organized by indications, preparation, technique, complication, prevention, clinical pearls, and related ABA key points. Highlights must-know information in bold throughout the text. Concise, practical, and easy-to-read, this book will aid anesthesiology residents, certified nurse anesthetists, and medical students in their study regarding patient care practices on regional anesthesia and chronic pain. The book will also be useful to residents going into regional anesthesia and pain medicine subspecialties during the year of their anesthesiology training.

Pain Management and the Opioid Epidemic

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Pain Management and the Opioid Epidemic Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Publisher : National Academies Press
Page : 483 pages
File Size : 44,9 Mb
Release : 2017-09-28
Category : Medical
ISBN : 9780309459570

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Pain Management and the Opioid Epidemic by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse Pdf

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 40,5 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Oxford Textbook of Palliative Medicine

Nathan I. Cherny,Marie Fallon,Stein Kaasa,Russell K. Portenoy,David Currow
Oxford Textbook of Palliative Medicine Book PDF

Author : Nathan I. Cherny,Marie Fallon,Stein Kaasa,Russell K. Portenoy,David Currow
Publisher : Oxford University Press, USA
Page : 1281 pages
File Size : 51,9 Mb
Release : 2015
Category : Medical
ISBN : 9780199656097

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Oxford Textbook of Palliative Medicine by Nathan I. Cherny,Marie Fallon,Stein Kaasa,Russell K. Portenoy,David Currow Pdf

Emphasising the multi-disciplinary nature of palliative care the fourth edition of this text also looks at the individual professional roles that contribute to the best-quality palliative care.

Annual Reports in Medicinal Chemistry

Annette M. Doherty
Annual Reports in Medicinal Chemistry Book PDF

Author : Annette M. Doherty
Publisher : Academic Press
Page : 484 pages
File Size : 41,9 Mb
Release : 2003-09-10
Category : Medical
ISBN : 0120405385

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Annual Reports in Medicinal Chemistry by Annette M. Doherty Pdf

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease-orientated and generally report on specific medicinal agents. Sections V-VI continue to emphasize important topics in medicinal chemistry, biology and drug design. In addition to the chapter reviews, a comprehensive set of indices has been included to enable the reader to easily locate topics in Volumes 1-38 of this series.

Mechanisms of Vascular Disease

Robert Fitridge,M. M. Thompson
Mechanisms of Vascular Disease Book PDF

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 48,7 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Acute Pain Management

Raymond S. Sinatra
Acute Pain Management Book PDF

Author : Raymond S. Sinatra
Publisher : Cambridge University Press
Page : 729 pages
File Size : 42,5 Mb
Release : 2009-04-27
Category : Medical
ISBN : 9780521874915

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Acute Pain Management by Raymond S. Sinatra Pdf

This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Toxicology Cases for the Clinical and Forensic Laboratory

Hema Ketha,Uttam Garg
Toxicology Cases for the Clinical and Forensic Laboratory Book PDF

Author : Hema Ketha,Uttam Garg
Publisher : Academic Press
Page : 542 pages
File Size : 41,9 Mb
Release : 2020-06-20
Category : Medical
ISBN : 9780128163733

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Toxicology Cases for the Clinical and Forensic Laboratory by Hema Ketha,Uttam Garg Pdf

Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions

Pharmacology of Pain

Pierre Beaulieu,David Lussier,Frank Porreca,Anthony Dickenson
Pharmacology of Pain Book PDF

Author : Pierre Beaulieu,David Lussier,Frank Porreca,Anthony Dickenson
Publisher : Lippincott Williams & Wilkins
Page : 1338 pages
File Size : 46,7 Mb
Release : 2015-06-01
Category : Medical
ISBN : 9781496331915

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Pharmacology of Pain by Pierre Beaulieu,David Lussier,Frank Porreca,Anthony Dickenson Pdf

Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees

Boorman's Pathology of the Rat

Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
Boorman s Pathology of the Rat Book PDF

Author : Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
Publisher : Academic Press
Page : 748 pages
File Size : 50,6 Mb
Release : 2017-12-18
Category : Medical
ISBN : 9780123914897

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Boorman's Pathology of the Rat by Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley Pdf

Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research