Non Coding Rna And The Reproductive System

Author : Dagmar Wilhelm,Pascal Bernard
Publisher : Springer
Page : 198 pages
File Size : 48,6 Mb
Release : 2015-12-11
Category : Medical
ISBN : 9789401774178

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Non-coding RNA and the Reproductive System by Dagmar Wilhelm,Pascal Bernard Pdf

This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Author : Linjun Hong,Katja Teerds,Tang Zhonglin,Zuo Bo,Li Meng
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 45,5 Mb
Release : 2021-08-25
Category : Science
ISBN : 9782889712274

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Non-Coding RNAs in Reproductive Biology by Linjun Hong,Katja Teerds,Tang Zhonglin,Zuo Bo,Li Meng Pdf

Author : Joanna Sztuba-Solinska
Publisher : Elsevier
Page : 450 pages
File Size : 47,9 Mb
Release : 2023-06-17
Category : Science
ISBN : 9780323907002

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Navigating Non-coding RNA by Joanna Sztuba-Solinska Pdf

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies Explores the molecular mechanisms and intermolecular interactions of ncRNA

Author : Santosh Kumar Upadhyay
Publisher : Academic Press
Page : 390 pages
File Size : 49,8 Mb
Release : 2020-11-13
Category : Science
ISBN : 9780128214633

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Long Noncoding RNAs in Plants by Santosh Kumar Upadhyay Pdf

The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. Includes the latest advances and research in long noncoding RNAs in plants Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops Focuses on the application and uses of long noncoding RNAs

Author : Junjie Xiao
Publisher : Springer
Page : 0 pages
File Size : 50,5 Mb
Release : 2018-12-29
Category : Medical
ISBN : 9811346321

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Circular RNAs by Junjie Xiao Pdf

This book provides an essential overview of the rapidly advancing field of circular RNAs – newly discovered RNAs that are generated by back-splicing precursor mRNA and perform regulatory functions in many biological processes. Although many aspects of circular RNAs’ biology and mechanisms of gene regulation remain unclear, they have been found to be abundant, evolutionally conserved, and stable in cells; further, they have numerous potential functions. The book consists of eight parts:1) An overview of circular RNAs, 2) Bioinformatics for circular RNAs, 3) Biogenesis of circular RNAs, 4) Molecular mechanisms and gene regulation of circular RNAs, 5) Circular RNAs as potential disease biomarkers, 6) Circular RNAs and human diseases, 7) Circular RNAs in Plants and in Archaea, and 8) Future prospects. Given its focus, the book will be especially useful for researchers and students in the fields of biochemistry, molecular biology, cell biology, and medicine.

Author : Bibekanand Mallick
Publisher : Academic Press
Page : 387 pages
File Size : 47,5 Mb
Release : 2019-01-20
Category : Science
ISBN : 9780128156704

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AGO-Driven Non-Coding RNAs by Bibekanand Mallick Pdf

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

Author : Rafael A. Fissore,Adam Burton,Karin Lykke-Hartmann
Publisher : Frontiers Media SA
Page : 145 pages
File Size : 47,6 Mb
Release : 2019-08-20
Category : Electronic
ISBN : 9782889459445

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Molecular and Cellular Mechanisms in Reproduction and Early Development by Rafael A. Fissore,Adam Burton,Karin Lykke-Hartmann Pdf

The Research Topic aims to support progress towards understanding the different sets of developmental processes that are absolutely required to complete all the steps essential for successful embryonic development, under physiological conditions. We sought contributions that dealt with single cells, interaction between cells as well as intra- and extracellular signal transduction. The Research Topic presents original studies covering experimental and theoretical approaches, descriptions of new methodologies, reviews and opinions.

Author : Shaveta Kanoria,Santosh Kumar,Florent Hubé
Publisher : Frontiers Media SA
Page : 133 pages
File Size : 46,6 Mb
Release : 2022-05-27
Category : Science
ISBN : 9782889762484

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Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases by Shaveta Kanoria,Santosh Kumar,Florent Hubé Pdf

Author : Jing Zhang,Jingmin Ou,Tao Zeng,Xiang Zhang,Song Zhao,Jinshui Zhu
Publisher : Frontiers Media SA
Page : 325 pages
File Size : 51,6 Mb
Release : 2023-04-14
Category : Science
ISBN : 9782832520802

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RNA modification and non-coding RNAs in human disease by Jing Zhang,Jingmin Ou,Tao Zeng,Xiang Zhang,Song Zhao,Jinshui Zhu Pdf

Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 514 pages
File Size : 50,8 Mb
Release : 2011-07-20
Category : Science
ISBN : 9783642194542

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Non Coding RNAs in Plants by Volker A. Erdmann,Jan Barciszewski Pdf

In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognized to carry critical developmental, stress-response and bodyguard functions be coordinating the expression, protection, stability and inheritance of virtually all eukaryotic genomes. Thus, the ncRNAs encompass a wide set of mechanisms that achieve specialized functions.

Author : Debmalya Barh
Publisher : Academic Press
Page : 292 pages
File Size : 44,8 Mb
Release : 2022-03-30
Category : Medical
ISBN : 9780323898782

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Biotechnology in Healthcare, Volume 1 by Debmalya Barh Pdf

Biotechnology in Healthcare, Technologies and Innovations, Volume One presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Sections cover 3D printing, tissue engineering, synthetic biology, nano-biotechnology, omics, precision medicine, gene therapy, vaccine development, predictive healthcare, entrepreneurship, financing, business models, product development and marketing in the sector. This is a valuable source for biotechnologists, bioinformaticians, clinicians and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare. Presents the progress and innovations that biotechnology has accomplished in the field of healthcare Discusses the impact of healthcare biotechnology in global economics and business prospects Explains how biotechnology revolutionizes future healthcare approaches

Author : Yongye Huang,Yun Dai,Peng Qu,Yue Hou
Publisher : Frontiers Media SA
Page : 273 pages
File Size : 47,5 Mb
Release : 2023-03-15
Category : Science
ISBN : 9782832517505

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Combating cancer with natural products: Non-coding RNA and RNA modification by Yongye Huang,Yun Dai,Peng Qu,Yue Hou Pdf

Author : Julia A. Chekanova,Hsiao-Lin V. Wang
Publisher : Humana Press
Page : 480 pages
File Size : 48,5 Mb
Release : 2019-04-20
Category : Science
ISBN : 1493990446

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Plant Long Non-Coding RNAs by Julia A. Chekanova,Hsiao-Lin V. Wang Pdf

This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and innovative, Plant Long Non-Coding RNAs: Methods and Protocols is a valuable resource that aids researchers in understanding the functions of lncRNAs in different plant species, and helps them explore currently uncharted facets of plant biology.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 42,8 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Francesco Fazi,Alessandro Rosa,Constance Ciaudo,Pavel Sumazin
Publisher : Frontiers Media SA
Page : 229 pages
File Size : 51,7 Mb
Release : 2021-11-02
Category : Science
ISBN : 9782889715718

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The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease by Francesco Fazi,Alessandro Rosa,Constance Ciaudo,Pavel Sumazin Pdf