Novel Concepts In Cardiac Energy Metabolism From Biology To Disease
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Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cardiac Energy Metabolism in Health and Disease by Gary D. Lopaschuk,Naranjan S. Dhalla Pdf
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
The Scientist's Guide to Cardiac Metabolism by Michael Schwarzer,Torsten Doenst Pdf
The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field
Biology of Cardiovascular and Metabolic Diseases by Chaya Gopalan,Erik Kirk Pdf
Biology of Cardiovascular and Metabolic Diseases combines physiology and pathophysiology of selected metabolic and cardiovascular diseases with health relevance. Written in a concise and easy to read manner, the book allows readers to gain an understanding on a number of topics, including cardiovascular physiology and pathophysiology and how it relates to the development of insulin resistance, diabetes and other metabolic diseases. The book also highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure and way to treat underlying conditions. Focuses succinctly on the physiology and pathophysiology of cardiovascular and metabolic diseases Written in a concise and easy to read manner, allowing readers to quickly understand concepts Highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure
Cancer as a Metabolic Disease by Thomas Seyfried Pdf
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.
Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Biology of Cardiovascular and Metabolic Diseases by Chaya Gopalan,Erik Kirk Pdf
Biology of Cardiovascular and Metabolic Diseases combines physiology and pathophysiology of selected metabolic and cardiovascular diseases with health relevance. Written in a concise and easy to read manner, the book allows readers to gain an understanding on a number of topics, including cardiovascular physiology and pathophysiology and how it relates to the development of insulin resistance, diabetes and other metabolic diseases. The book also highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure and way to treat underlying conditions. Focuses succinctly on the physiology and pathophysiology of cardiovascular and metabolic diseases Written in a concise and easy to read manner, allowing readers to quickly understand concepts Highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure
Textbook of Cardiovascular Medicine by Eric J. Topol,Robert M. Califf Pdf
The Topol Solution gives you a complete print and multimedia package consisting of Textbook of Cardiovascular Medicine, Third Edition, a DVD, and access to a wealth of online resources. Updated throughout by renowned international authorities, Dr. Topol's best-selling text provides a comprehensive, contemporary view of every area of cardiovascular medicine--preventive cardiology; clinical cardiology; cardiovascular imaging; electrophysiology and pacing; invasive cardiology and surgical techniques; heart failure and transplantation; molecular cardiology; and vascular biology and medicine. The bound-in DVD contains the full text, plus heart sounds, an image/chart/table bank, and videos of procedures--catheterization, CT/MRI, echocardiography, electrophysiology and pacing, intravascular ultrasonography, nuclear cardiology, and surgery. The Topol Solution Website includes the fully searchable text, heart sounds, and an image/chart/table bank downloadable to PowerPoint--plus questions and answers from The Cleveland Clinic Cardiology Board Review; a PDA download of cardiology drug facts; quarterly articles from Critical Pathways in Cardiology, and links to other cardiology Websites.FEATURES: - Thoroughly updated Third Edition of best-selling Textbook of Cardiovascular Medicine, plus DVD and instant access to a wealth of online resources- THE TEXT: - Renowned international contributors- A comprehensive, contemporary view of every area of cardiovascular medicine-preventive cardiology; clinical cardiology; cardiovascular imaging; electrophysiology and pacing; invasive cardiology and surgical techniques; heart failure and transplantation; molecular cardiology; and vascular biology and medicine- Focus on clinical material, particularly the application of clinical research to practice- Each chapter includes comments on current controversies and pioneering insights into future developments- THE BOUND-IN DVD: - Full content of book- Heart sounds-a
Douglas L. Mann,Douglas P. Zipes,Peter Libby,Robert O. Bonow
Author : Douglas L. Mann,Douglas P. Zipes,Peter Libby,Robert O. Bonow Publisher : Elsevier Health Sciences Page : 2376 pages File Size : 49,6 Mb Release : 2014-07-30 Category : Medical ISBN : 9780323290647
Braunwald's Heart Disease E-Book by Douglas L. Mann,Douglas P. Zipes,Peter Libby,Robert O. Bonow Pdf
Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more! Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine. Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease. Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
Robert O. Bonow,Douglas L. Mann,Douglas P. Zipes,Peter Libby
Author : Robert O. Bonow,Douglas L. Mann,Douglas P. Zipes,Peter Libby Publisher : Elsevier Health Sciences Page : 2049 pages File Size : 44,8 Mb Release : 2011-02-25 Category : Medical ISBN : 9781437727708
Braunwald's Heart Disease E-Book by Robert O. Bonow,Douglas L. Mann,Douglas P. Zipes,Peter Libby Pdf
Braunwald’s Heart Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, and Peter Libby, this dynamic, multimedia reference helps you apply the most recent knowledge in molecular biology and genetics, imaging, pharmacology, interventional cardiology, electrophysiology, and much more. Weekly updates online, personally selected by Dr. Braunwald, continuously keep you current on the most important new developments affecting your practice. Enhanced premium online content includes new dynamic cardiac imaging videos, heart sound recordings, and podcasts. With sweeping updates throughout, and contributions from a "who’s who" of global cardiology, Braunwald’s is the cornerstone of effective practice. Continuously access the most important new developments affecting your practice with weekly updates personally selected by Dr. Braunwald, including focused reviews, "hot off the press" commentaries, and late-breaking clinical trials. Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Search the complete contents online at www.expertconsult.com. Stay on top of the latest advances in molecular imaging, intravascular ultrasound, cardiovascular regeneration and tissue engineering, device therapy for advanced heart failure, atrial fibrillation management, structural heart disease, Chagasic heart disease, ethics in cardiovascular medicine, the design and conduct of clinical trials, and many other timely topics. Hone your clinical skills with new dynamic cardiac imaging videos, heart sound recordings, and podcasts at www.expertconsult.com.
Author : Douglas L. Mann Publisher : Elsevier Health Sciences Page : 923 pages File Size : 54,7 Mb Release : 2010-11-11 Category : Medical ISBN : 9781437703634
Heart Failure: A Companion to Braunwald's Heart Disease E-book by Douglas L. Mann Pdf
Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care
Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf
Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Douglas P. Zipes,Peter Libby,Robert O. Bonow,Douglas L. Mann,Gordon F. Tomaselli
Author : Douglas P. Zipes,Peter Libby,Robert O. Bonow,Douglas L. Mann,Gordon F. Tomaselli Publisher : Elsevier Health Sciences Page : 2040 pages File Size : 47,9 Mb Release : 2018-01-09 Category : Medical ISBN : 9780323555937
Braunwald's Heart Disease E-Book by Douglas P. Zipes,Peter Libby,Robert O. Bonow,Douglas L. Mann,Gordon F. Tomaselli Pdf
Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology.
