Novel Concepts In Ipsc Disease Modeling

Author : Alexander Birbrair
Publisher : Academic Press
Page : 338 pages
File Size : 53,8 Mb
Release : 2022-01-08
Category : Science
ISBN : 9780128238837

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Novel Concepts in iPSC Disease Modeling by Alexander Birbrair Pdf

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Author : Minoru Tomizawa
Publisher : BoD – Books on Demand
Page : 534 pages
File Size : 49,8 Mb
Release : 2016-07-20
Category : Science
ISBN : 9789535124719

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Pluripotent Stem Cells by Minoru Tomizawa Pdf

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Author : ALEXANDER BIRBRAIR
Publisher : Academic Press
Page : 320 pages
File Size : 42,5 Mb
Release : 2020-07-30
Category : Science
ISBN : 9780128222270

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Recent Advances in iPSC Disease Modeling, Volume 1 by ALEXANDER BIRBRAIR Pdf

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Author : Alexander Birbrair
Publisher : Academic Press
Page : 372 pages
File Size : 52,9 Mb
Release : 2021-06-02
Category : Science
ISBN : 9780323856447

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Methods in iPSC Technology by Alexander Birbrair Pdf

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Methods in iPSC Technology, Volume 9 addresses the different methods used for induced pluripotent stem cell (iPSC) formation, maintenance, expansion, and differentiation. The ability to reprogram different cell types to iPSCs offers an opportunity to generate pluripotent patient-specific cell lines that can help in the understanding of multiple human disorders. This volume addresses a variety of current methods used in the generation and manipulation of iPSCs, such as magnetic nanoparticles, piggyBac vectors, lentiviral vectors, bioscaffolds, somatic cell nuclear transfer, CRISPR/Cas9, bacteria, and much more. This volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers the different methods used for iPSC formation, maintenance, expansion, and differentiation Is contributed by world-renowned experts in the field

Author : Keiichi Fukuda
Publisher : Springer
Page : 99 pages
File Size : 47,5 Mb
Release : 2016-03-30
Category : Science
ISBN : 9784431559665

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Human iPS Cells in Disease Modelling by Keiichi Fukuda Pdf

Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to differentiate into multiple cell types. This book focuses on another great potential of human iPS cells, which is the establishment of human disease models using patient-specific iPS cells. Human iPS cells can be easily obtained from a patient’s somatic cells and provide the entire information on the patient’s genome. Accordingly, we can generate disease models for inheritable diseases in cell culture dishes using iPS cells. This is a quite new technique but holds tremendous potential for our increased understanding of pathogenesis, and will then be the basis for novel drug development industries. All the authors are leading researchers in this field and they have reported many kinds of patient-derived iPS cells. In this book, they introduce the aspects that could be recapitulated in terms of disease modelling as well as further innovative findings such as novel pathogenetic insights and novel therapies.

Author : Alexander Birbrair
Publisher : Springer
Page : 225 pages
File Size : 41,8 Mb
Release : 2019-04-23
Category : Science
ISBN : 9783030110963

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Stem Cells Heterogeneity - Novel Concepts by Alexander Birbrair Pdf

This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Author : Kim A. Staats,Kyle David Fink,Dustin R. Wakeman
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 45,5 Mb
Release : 2021-08-17
Category : Science
ISBN : 9782889711826

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Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics by Kim A. Staats,Kyle David Fink,Dustin R. Wakeman Pdf

Author : Christopher R. Cederroth,Marta L. Alves Da Silva,Annemarie Lang,Armand Mensen,Peter Bollen,Benjamin Victor Ineichen,Doris Wilflingseder,Jenny Stina-Maria Sandström,Serban Morosan
Publisher : Frontiers Media SA
Page : 478 pages
File Size : 48,9 Mb
Release : 2024-04-29
Category : Medical
ISBN : 9782832548349

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Towards a New 3Rs Era in Experimental Research by Christopher R. Cederroth,Marta L. Alves Da Silva,Annemarie Lang,Armand Mensen,Peter Bollen,Benjamin Victor Ineichen,Doris Wilflingseder,Jenny Stina-Maria Sandström,Serban Morosan Pdf

With the persisting need of animal experimentation for fundamental and applied research, the relevance and importance of the 3Rs Principle cannot be ignored. The 3Rs Principle was put forward over 50 years ago, providing an essential framework for more humane animal experimentation in research. In this half-century the research landscape within which this principle is applied has dramatically changed and evolved, with ever more emerging venues to explore for 3Rs advancement and implementation.

Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Page : 1202 pages
File Size : 47,6 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123814235

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Principles of Regenerative Medicine by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem Pdf

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Author : Gyan Prakash
Publisher : Springer Nature
Page : 393 pages
File Size : 47,8 Mb
Release : 2024-06-27
Category : Electronic
ISBN : 9789819944361

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Advances in Vision Research, Volume IV by Gyan Prakash Pdf

Author : Rudolf Jaenisch,Feng Zhang,Fred Gage
Publisher : Springer
Page : 0 pages
File Size : 54,8 Mb
Release : 2018-08-11
Category : Medical
ISBN : 3319868012

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Genome Editing in Neurosciences by Rudolf Jaenisch,Feng Zhang,Fred Gage Pdf

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Author : Anonim
Publisher : Academic Press
Page : 301 pages
File Size : 51,8 Mb
Release : 2012-11-27
Category : Medical
ISBN : 9780123983596

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Current Concepts in Drug Metabolism and Toxicology by Anonim Pdf

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity An essential resource for pharmacologists, immunologists and biochemists alike

Author : Alexander Birbrair
Publisher : Academic Press
Page : 336 pages
File Size : 44,8 Mb
Release : 2021-06-02
Category : Science
ISBN : 9780128238851

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Current Progress in iPSC-derived Cell Types by Alexander Birbrair Pdf

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers iPSCs derived cardiomyocytes, skeletal muscles, brown adipocytes, airway epithelial cells, and much more Contributed by world-renown experts in the field

Author : Veerle Baekelandt,Evy Lobbestael
Publisher : Academic Press
Page : 324 pages
File Size : 55,5 Mb
Release : 2017-03-31
Category : Medical
ISBN : 9780128052662

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Disease-Modifying Targets in Neurodegenerative Disorders by Veerle Baekelandt,Evy Lobbestael Pdf

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields

Author : Alexander Birbrair
Publisher : Elsevier
Page : 318 pages
File Size : 48,5 Mb
Release : 2021-11-12
Category : Science
ISBN : 9780323855457

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IPSC Derived Progenitors by Alexander Birbrair Pdf

"[A]ddresses how induced pluripotent stems cells can be differentiated into distinct progenitors. Progenitors are often the first step to making more differentiating cell types. This volume addresses a variety of iPSC-derived progenitors, such as neural stem cells, craniofacial mesenchymal progenitors, astrocyte progenitors, mesothelial progenitors, keratinocyte progenitors, bone progenitors, chondrocyte progenitors, dental pulp stem cells, nephron progenitors, mesenchymal stem cells, hematopoietic stem cells, and cancer stem cells. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field"--Page 4 of cover.