Novel Developments In Stem Cell Mobilization

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Novel Developments in Stem Cell Mobilization

Stefan Fruehauf,W. Jens Zeller,Gary Calandra
Novel Developments in Stem Cell Mobilization Book PDF

Author : Stefan Fruehauf,W. Jens Zeller,Gary Calandra
Publisher : Springer Science & Business Media
Page : 493 pages
File Size : 44,7 Mb
Release : 2012-02-15
Category : Medical
ISBN : 9781461419600

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Novel Developments in Stem Cell Mobilization by Stefan Fruehauf,W. Jens Zeller,Gary Calandra Pdf

Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.

Novel Developments in Stem Cell Mobilization

Stefan Fruehauf,W. Jens Zeller,Gary Calandra
Novel Developments in Stem Cell Mobilization Book PDF

Author : Stefan Fruehauf,W. Jens Zeller,Gary Calandra
Publisher : Springer
Page : 498 pages
File Size : 55,7 Mb
Release : 2012-02-15
Category : Medical
ISBN : 1461419611

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Novel Developments in Stem Cell Mobilization by Stefan Fruehauf,W. Jens Zeller,Gary Calandra Pdf

Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.

Stem Cell Mobilization

Gerd Klein
Stem Cell Mobilization Book PDF

Author : Gerd Klein
Publisher : Unknown
Page : 248 pages
File Size : 41,5 Mb
Release : 2019
Category : Stem cells
ISBN : 149399574X

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Stem Cell Mobilization by Gerd Klein Pdf

This book provides detailed state-of-the-art protocols for analyzing individual aspects of stem cell mobilization at the molecular and cellular level with contributions encompassing the most recent technological developments. Specifically, the volume covers cell adhesion and migration assays in three-dimensional models, imaging techniques for the determination of blood flow or hypoxic status, innovative biomechanical studies of stem cells, and assays to determine the involvement of proteases or complement factors, as well as other key topics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Mobilization: Methods and Protocols is an ideal guide for all laboratories in their endeavors to decipher the mechanisms of stem cell mobilization, ultimately helping stem cell donors and patients around the world.

New Developments in Stem Cell Research

Erik V. Greer
New Developments in Stem Cell Research Book PDF

Author : Erik V. Greer
Publisher : Nova Publishers
Page : 214 pages
File Size : 46,9 Mb
Release : 2007
Category : Stem cells
ISBN : 1594548471

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New Developments in Stem Cell Research by Erik V. Greer Pdf

New Developments In Stem Cell Research

New Advances in Stem Cell Transplantation

Taner Demirer
New Advances in Stem Cell Transplantation Book PDF

Author : Taner Demirer
Publisher : BoD – Books on Demand
Page : 598 pages
File Size : 50,6 Mb
Release : 2012-02-24
Category : Science
ISBN : 9789535100133

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New Advances in Stem Cell Transplantation by Taner Demirer Pdf

This book documents the increased number of stem cell-related research, clinical applications, and views for the future. The book covers a wide range of issues in cell-based therapy and regenerative medicine, and includes clinical and preclinical chapters from the respected authors involved with stem cell studies and research from around the world. It complements and extends the basics of stem cell physiology, hematopoietic stem cells, issues related to clinical problems, tissue typing, cryopreservation, dendritic cells, mesenchymal cells, neuroscience, endovascular cells and other tissues. In addition, tissue engineering that employs novel methods with stem cells is explored. Clearly, the continued use of biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.

Stem Cell Mobilization

Gerd Klein
Stem Cell Mobilization Book PDF

Author : Gerd Klein
Publisher : Unknown
Page : 250 pages
File Size : 52,6 Mb
Release : 2019
Category : Stem cells
ISBN : 1493995758

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Stem Cell Mobilization by Gerd Klein Pdf

This book provides detailed state-of-the-art protocols for analyzing individual aspects of stem cell mobilization at the molecular and cellular level with contributions encompassing the most recent technological developments. Specifically, the volume covers cell adhesion and migration assays in three-dimensional models, imaging techniques for the determination of blood flow or hypoxic status, innovative biomechanical studies of stem cells, and assays to determine the involvement of proteases or complement factors, as well as other key topics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Mobilization: Methods and Protocols is an ideal guide for all laboratories in their endeavors to decipher the mechanisms of stem cell mobilization, ultimately helping stem cell donors and patients around the world.

Advances in Hematopoietic Stem Cell Research

Rosana Pelayo
Advances in Hematopoietic Stem Cell Research Book PDF

Author : Rosana Pelayo
Publisher : IntechOpen
Page : 478 pages
File Size : 45,7 Mb
Release : 2012-01-27
Category : Science
ISBN : 9533079304

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Advances in Hematopoietic Stem Cell Research by Rosana Pelayo Pdf

This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Novel Perspectives of Stem Cell Manufacturing and Therapies

Diana Kitala,Ana Colette Maurício
Novel Perspectives of Stem Cell Manufacturing and Therapies Book PDF

Author : Diana Kitala,Ana Colette Maurício
Publisher : BoD – Books on Demand
Page : 180 pages
File Size : 47,9 Mb
Release : 2021-04-14
Category : Technology & Engineering
ISBN : 9781839625039

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Novel Perspectives of Stem Cell Manufacturing and Therapies by Diana Kitala,Ana Colette Maurício Pdf

In the 1950s, Nobel Prize winner Dr. E. Donnall Thomas was the first to successfully transplant hematopoietic stem cells. Since then, studies on stem cells have evolved and expanded worldwide. There are more than 650,000 scientific publications on stem cells and more than 8000 stem cell clinical trials. This book summarizes types of stem cells, key studies, ongoing trials, and future perspectives. It also includes ethical, formal, and legal aspects to give the reader a comprehensive view of the field.

Stem Cells and Tissue Engineering

Mirjana Pavlovic,Bela Balint
Stem Cells and Tissue Engineering Book PDF

Author : Mirjana Pavlovic,Bela Balint
Publisher : Springer Science & Business Media
Page : 159 pages
File Size : 45,8 Mb
Release : 2012-11-07
Category : Technology & Engineering
ISBN : 9781461455059

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Stem Cells and Tissue Engineering by Mirjana Pavlovic,Bela Balint Pdf

Stem cells are the building blocks for all other cells in an organism. The human body has about 200 different types of cells and any of those cells can be produced by a stem cell. This fact emphasizes the significance of stem cells in transplantational medicine, regenerative therapy and bioengineering. Whether embryonic or adult, these cells can be used for the successful treatment of a wide range of diseases that were not treatable before, such as osteogenesis imperfecta in children, different forms of leukemias, acute myocardial infarction, some neural damages and diseases, etc. Bioengineering, e.g. successful manipulation of these cells with multipotential capacity of differentiation toward appropriate patterns and precise quantity, are the prerequisites for successful outcome and treatment. By combining in vivo and in vitro techniques, it is now possible to manage the wide spectrum of tissue damages and organ diseases. Although the stem-cell therapy is not a response to all the questions, it provides more and more answers every day. Stem Cells and Tissue Engineering is a concise review on the functional, phenotypic, regenerative, transplantational and curative aspects of a stem cell’s entity. It is critical and encouraging at the same time, providing truthful and appropriate samples from the practice and research that can lead toward optimal use of this immense source of adjuvant and curative therapy in human pathology. Written by a clinician and a researcher, who are currently teaching what they are doing, it is recommended as a teaching tool along with an original textbook.

Advances in Tissue Engineering

Julia M. Polak,Sakis Mantalaris,Sian E. Harding
Advances in Tissue Engineering Book PDF

Author : Julia M. Polak,Sakis Mantalaris,Sian E. Harding
Publisher : World Scientific
Page : 947 pages
File Size : 47,7 Mb
Release : 2008
Category : Medical
ISBN : 9781848161825

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Advances in Tissue Engineering by Julia M. Polak,Sakis Mantalaris,Sian E. Harding Pdf

Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field.

The European Blood and Marrow Transplantation Textbook for Nurses

Michelle Kenyon,Aleksandra Babic
The European Blood and Marrow Transplantation Textbook for Nurses Book PDF

Author : Michelle Kenyon,Aleksandra Babic
Publisher : Springer
Page : 311 pages
File Size : 44,8 Mb
Release : 2018-03-14
Category : Medical
ISBN : 9783319500263

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The European Blood and Marrow Transplantation Textbook for Nurses by Michelle Kenyon,Aleksandra Babic Pdf

This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

The EBMT Handbook

Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
The EBMT Handbook Book PDF

Author : Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
Publisher : Unknown
Page : 688 pages
File Size : 50,5 Mb
Release : 2020-10-08
Category : Medical
ISBN : 1013273672

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The EBMT Handbook by Nicolaus Kröger,Mohamad Mohty,Carlo Dufour Pdf

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Stem Cells Handbook

Stewart Sell
Stem Cells Handbook Book PDF

Author : Stewart Sell
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 55,7 Mb
Release : 2003-10-22
Category : Medical
ISBN : 9781592594115

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Stem Cells Handbook by Stewart Sell Pdf

The power of stem cells for tissue development, regeneration, and renewal has been well known by embryologists and developmental biologists for many years. Those presently active in research in the stem cell field owe much to previous work by embryologists and cancer researchers for their insights into what stem cells can do. In the last 4- 5 years, the rapid expansion of the concept of adult tissue stem cells as pluripotent progenitors for various tissues has led to an even greater appreciation of the power of stem cells. The demonstration that both embryonic and adult tissue stem cells have the ability to produce progenitor cells for tissue renewal has opened vast possibilities for treatment of congenital deficiency diseases as well as for regeneration of damaged tissues. Older concepts of determination leading to loss of potential during differentiation of adult tissues are being replaced by newer ideas that cells with multiple potential exist in different forms in various adult organs and that cells thought to be restricted to differentiation to one cell type may be able to "transdifferentiate" into other tissue cell types. Thus, the concept of "embryonic rests" in adult tissues, hypothesized to be the cellular origin of cancer by Durante and Conheim in the 1870s, now can be expanded to include survival of pluripotential embryonic-like stem cells in adult tissues.

Hematopoietic Stem Cell Transplantation

Anthony D. Ho,Rainer Haas,Richard E. Champlin
Hematopoietic Stem Cell Transplantation Book PDF

Author : Anthony D. Ho,Rainer Haas,Richard E. Champlin
Publisher : CRC Press
Page : 610 pages
File Size : 43,5 Mb
Release : 2000-07-25
Category : Medical
ISBN : 9780824741815

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Hematopoietic Stem Cell Transplantation by Anthony D. Ho,Rainer Haas,Richard E. Champlin Pdf

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion

Stem Cells

C. Potten
Stem Cells Book PDF

Author : C. Potten
Publisher : Elsevier
Page : 497 pages
File Size : 49,9 Mb
Release : 1996-10-09
Category : Science
ISBN : 9780080541761

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Stem Cells by C. Potten Pdf

Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. Provides reviews of stem cell systems by world experts Covers stem cell biology in plants, invertebrates, and mammals Presents clinical implications of stem cell differentiation