Nucleic Acid Polymerases

Author : Katsuhiko S. Murakami,Michael A. Trakselis
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 44,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9783642397967

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Nucleic Acid Polymerases by Katsuhiko S. Murakami,Michael A. Trakselis Pdf

This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.

Author : Anonim
Publisher : World Scientific
Page : 128 pages
File Size : 48,6 Mb
Release : 2010
Category : DNA polymerases
ISBN : 9789814465458

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DNA Polymerases by Anonim Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 40,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Whitney Yin
Publisher : Frontiers Media SA
Page : 118 pages
File Size : 54,7 Mb
Release : 2022-10-04
Category : Science
ISBN : 9782832503829

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Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond by Whitney Yin Pdf

olymerases are the nucleotidyl transferases that are responsible for synthesizing DNA and RNA. They are crucial for essential cellular processes including cellular and viral genome replication, DNA repair and damage tolerance, and transcription. Consistent with their vital roles, polymerases are found in all domains of life. The overall chemistry employed by these enzymes is conserved but there are variations among the different groups of polymerases that confer different substrate specificities and nucleotide incorporation fidelities that allow them to be involved in a wide array of cellular activities. Since polymerases were first isolated more than six decades ago, we have made great progress in understanding how different polymerases have adapted to their specific roles. In this Research Topic we will focus on the enzymatic mechanisms of these enzymes and the relationships between polymerase structure and mechanism, to highlight common themes and unique adaptations.

Author : Ulrich Hbscher
Publisher : World Scientific
Page : 338 pages
File Size : 52,5 Mb
Release : 2010
Category : Science
ISBN : 9789814299169

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DNA Polymerases by Ulrich Hbscher Pdf

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex physiological processes of DNA replication and repair. Besides the tasks in vivo, DNA polymerases are the workhorses in numerous biotechniques such as polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids–based diagnostics, as well as techniques to analyze ancient and otherwise damaged DNA. The authors have recently witnessed the discovery of a plethora of novel DNA polymerases with specialized properties whose physiological functions are only just beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes in viruses, bacteria, archaea and eukaryotes. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes, as well as Hepatitis B and C infections. This book will appeal to a broad audience including basic scientists, diagnostic laboratories, and clinicians who will gain an invaluable understanding of these fascinating enzymes.

Author : Allen I. Laskin,Jerold A. Last
Publisher : Unknown
Page : 296 pages
File Size : 45,5 Mb
Release : 1973
Category : Science
ISBN : UOM:39015000288947

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Nucleic Acid Biosynthesis by Allen I. Laskin,Jerold A. Last Pdf

Author : Samson T. Jacob
Publisher : CRC Press
Page : 203 pages
File Size : 40,7 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351080316

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Enzymes of Nucleic Acid Synthesis and Modification by Samson T. Jacob Pdf

The First volume gives an overview of the enzymes involved in DNA synthesis and modification; the second volume deals with the RNA-enzymes. Although the major emphasis of the book is on eukaryotic enzymes, a separate chapter dealing with prokaryotic DNA repair enzymes has been included to discuss the major advances in this field in recent years. There are two separate chapters on RNA polymerases to provide a comprehensive coverage of the enzymes from lower eukaryotes, plants and higher eukaryotes.

Author : Zvi Kelman,Andrew F Gardner
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 43,7 Mb
Release : 2015-03-18
Category : Biotechnology
ISBN : 9782889194551

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DNA polymerases in Biotechnology by Zvi Kelman,Andrew F Gardner Pdf

DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase engineering for biotechnology. For example, DNA polymerases have been engineered for increased speed and fidelity in PCR while lowering amplification sequence bias. Inhibitor resistant DNA polymerase variants enable PCR directly from tissue (i.e. blood). Design of DNA polymerases that efficiently incorporate modified nucleotide have been critical for development of next generation DNA sequencing, synthetic biology and other labeling and detection technologies. The Frontiers in Microbiology Research Topic on DNA polymerases in Biotechnology aims to capture current research on DNA polymerases and their use in emerging technologies.

Author : Anonim
Publisher : ScholarlyEditions
Page : 41 pages
File Size : 40,7 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464947087

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DNA-Directed RNA Polymerases: Advances in Research and Application: 2011 Edition by Anonim Pdf

DNA-Directed RNA Polymerases: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about DNA-Directed RNA Polymerases in a compact format. The editors have built DNA-Directed RNA Polymerases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about DNA-Directed RNA Polymerases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of DNA-Directed RNA Polymerases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Sankar Adhya,Susan Garges
Publisher : Elsevier
Page : 674 pages
File Size : 54,6 Mb
Release : 2003-12-18
Category : Science
ISBN : 0080522602

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RNA Polymerase and Associated Factors by Sankar Adhya,Susan Garges Pdf

RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein. * Models and methods for studying polymerase translocation * Assay for movements of RNA polymerase along DNA * Engineering of elongation complexes of bacterial and yeast RNA polymerases

Author : W. Guschlbauer
Publisher : Springer Science & Business Media
Page : 155 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461393979

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Nucleic Acid Structure by W. Guschlbauer Pdf

Teaching a course on nucleic acid structure is a hazardous undertaking, especially if one has no continuous teaching obligations. I still have done it on several occasions in various French universities, when colleagues, suffering from admin istrative overwork and excessive teaching obligations, had asked me to do so. This was generally done with a pile of notes and a dozen slides, and I always regretted that no small, concise, specialized book on nucleic acid structure for students at the senior or beginning graduate level ex isted. Every year, the lecture notes became more and more voluminous, with some key reprints intermingled. Everything changed when, in the spring of 1973, I re ceived an invitation to teach such a course, under the UNESCO-OAS-Molecular Biology Program at the Universi dad de Chile in Santiago during October 1973. I had ac cepted rather enthusiastically, but soon discovered that it would be necessary to produce a photocopied syllabus for the students. This was the fi rst premanuscript of this book. For nonscientific reasons, the course was first canceled and then postponed until December 1973. Nearly a year later, the course, in slightly amended form, was presented at the Lemonossow-State University in Moscow.

Author : Samson T. Jacob
Publisher : CRC Press
Page : 441 pages
File Size : 45,5 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351088756

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Enzymes of Nucleic Acid Synthesis and Modification by Samson T. Jacob Pdf

The First volume gives an overview of the enzymes involved in DNA synthesis and modification; the second volume deals with the RNA-enzymes. Although the major emphasis of the book is on eukaryotic enzymes, a separate chapter dealing with prokaryotic DNA repair enzymes has been included to discuss the major advances in this field in recent years. There are two separate chapters on RNA polymerases to provide a comprehensive coverage of the enzymes from lower eukaryotes, plants and higher eukaryotes.

Author : Michael Fry (Ph.D.),Lawrence A. Loeb
Publisher : Springer
Page : 244 pages
File Size : 47,6 Mb
Release : 1986-05
Category : Science
ISBN : UOM:39015011477414

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ANIMAL CELL DNA POLYMERASES by Michael Fry (Ph.D.),Lawrence A. Loeb Pdf

Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
Publisher : Royal Society of Chemistry
Page : 824 pages
File Size : 43,8 Mb
Release : 2015-11-09
Category : Science
ISBN : 9781782625773

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Nucleic Acids in Chemistry and Biology by G Michael Blackburn,Michael J Gait,David Loakes,David M Williams Pdf

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Author : R.L.P. Adams,J.T. Knowler,D.P. Leader
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 52,7 Mb
Release : 2013-04-18
Category : Science
ISBN : 9789401122900

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The Biochemistry of the Nucleic Acids by R.L.P. Adams,J.T. Knowler,D.P. Leader Pdf

When the first edition of this book was published in 1950, it predated the publication of the double-helical structure of DNA by three years. It is not, therefore, surprizing that nothing of the original book remains in the current edition. Indeed, such is the pace of change in the field of nucleic acids that less than 50% of material incorporated into the 1986 edition has been retained. The book aims at the advanced undergraduate and at graduates that are undertaking course work or requiring an in-depth background for their research. It also aims to provide the established scientist with a single text that permits updating across the whole field from DNA structure, replication and repair, through gene expression and its control to protein synthesis. Every chapter is accompanied by thorough referencing that enables the reader to evaluate personally the data and methodology that cannot be included in the text. In an attempt to keep this list within bounds, references are limited to about ten per page and, to accommodate the more recent literature, many of the older references have been left out in this latest edition.