Ocular Circulation And Neovascularization

Author : D. Benezra,N. Ryan,B.M. Glaser,R.P. Murphy
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400933378

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Ocular Circulation and Neovascularization by D. Benezra,N. Ryan,B.M. Glaser,R.P. Murphy Pdf

Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif·ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand & upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook

Author : Jeffrey W. Kiel
Publisher : Morgan & Claypool Publishers
Page : 82 pages
File Size : 54,9 Mb
Release : 2011
Category : Medical
ISBN : 9781615041688

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The Ocular Circulation by Jeffrey W. Kiel Pdf

This presentation describes the unique anatomy and physiology of the vascular beds that serve the eye. The needs for an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures pose significant challenges for the vasculature to provide nutrients and remove metabolic waste. To meet these needs, the ocular vascular beds are confined to the periphery of the posterior two thirds of the eye and a surrogate circulation provides a continuous flow of aqueous humor to nourish the avascular cornea, lens and vitreous compartment. The production of aqueous humor (and its ease of egress from the eye) also generates the intraocular pressure (IOP), which maintains the shape of the eye. However, the IOP also exerts a compressing force on the ocular blood vessels that is higher than elsewhere in the body. This is particularly true for the intraocular veins, which must have a pressure higher than IOP to remain patent, and so the IOP is the effective venous pressure for the intraocular vascular beds. Consequently, the ocular circulation operates at a lower perfusion pressure gradient than elsewhere in the body and is more at risk for ischemic damage when faced with low arterial pressure, particularly if IOP is elevated. This risk and the specialized tissues of the eye give rise to the fascinating physiology of the ocular circulations. Table of Contents: Introduction / Anatomy / Blood flow measuring techniques / Ocular perfusion pressure, IOP and the ocular Starling resistor effect / Ocular blood flow effects on IOP / Local control of ocular blood flow / Neural control of ocular blood flow / Summary

Author : Alon Harris
Publisher : Butterworth-Heinemann
Page : 150 pages
File Size : 50,8 Mb
Release : 2003
Category : Blood flow
ISBN : UOM:39015056919791

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Atlas of Ocular Blood Flow by Alon Harris Pdf

This text examines the vascular anatomy and physiology of the eye as well as the assessment of ocular circulation in health and disease. It offers a cutting-edge analysis of the eye's blood supply and how it is affected by conditions such as glaucoma, age-related macular degeneration, and diabetic retinopathy. 425 illustrations -- including 250 in full color -- detail anatomy, techniques, the results of imaging studies, and more.

Author : Leopold Schmetterer,Jeffrey Kiel
Publisher : Springer
Page : 0 pages
File Size : 52,6 Mb
Release : 2012-06-15
Category : Medical
ISBN : 3540694684

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Ocular Blood Flow by Leopold Schmetterer,Jeffrey Kiel Pdf

Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.

Author : George N. Wise,Colin T. Dollery,Paul Henkind
Publisher : HarperCollins Publishers
Page : 584 pages
File Size : 45,7 Mb
Release : 1971
Category : Blood
ISBN : UOM:39015011780544

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The Retinal Circulation by George N. Wise,Colin T. Dollery,Paul Henkind Pdf

Author : Leopold Schmetterer,Jeffrey Kiel
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 52,9 Mb
Release : 2012-06-14
Category : Medical
ISBN : 9783540694694

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Ocular Blood Flow by Leopold Schmetterer,Jeffrey Kiel Pdf

Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.

Author : Sohan Singh Hayreh
Publisher : Springer
Page : 851 pages
File Size : 55,6 Mb
Release : 2015-02-18
Category : Medical
ISBN : 9783319127811

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Ocular Vascular Occlusive Disorders by Sohan Singh Hayreh Pdf

This book provides a comprehensive account of the pathogenesis, clinical features, and management of ocular vascular occlusive disorders, with the focus very much on the scientific evidence. This offers a sound basis for addressing the many controversies that surround these disorders, which collectively constitute the most common cause of visual impairment or blindness. The book is divided into two sections, the first of which addresses the basic science and encompasses vascular anatomy, blood supply and flow, and retinal tolerance time to acute ischemia. The second, clinical, section covers the presentation, clinical features, diagnosis, and treatment of the full range of vascular occlusive disorders of the retina, the choroid, the anterior segment of the eye, ophthalmic manifestations of carotid artery disease and the optic nerve. Ocular Vascular Occlusive Disorders, written by a distinguished world leader in the field, will be invaluable for general ophthalmologists, and particularly for retina specialists, neuro-ophthalmologists, and researchers.

Author : Amresh Chopdar
Publisher : Butterworth-Heinemann
Page : 168 pages
File Size : 47,6 Mb
Release : 1996
Category : Fluorescence angiography
ISBN : UOM:39015037322768

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Fundus Fluorescein Angiography by Amresh Chopdar Pdf

Fluorescein angiography provides the ophthalmologist with valuable diagnostics information on retinal blood flow, and permits diagnosis of a wide range of eye disorders including macular disease, diabetes, tumours and retinal detachment. This book, now retitled, has been completely updated, revised and redesigned to give more details on techniques and the interpretation of results obtained. New to this book: * the existing text has been expanded and updated * there is a new chapter on digital and video angiography * there is a new section on pitfalls * the layout has been redesigned for greater clarity * the book contains more information on fundus angiography in clinical practice * there is more information on the anatomy of the ocular vascular system * there are two new chapters on diabetes and age related macular degeneration The book will continue to be an indispensible guide for the practising and trainee ophthalmologist.

Author : Josef F. Bille
Publisher : Springer
Page : 407 pages
File Size : 54,9 Mb
Release : 2019-08-13
Category : Medical
ISBN : 9783030166380

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High Resolution Imaging in Microscopy and Ophthalmology by Josef F. Bille Pdf

This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Author : Michael S. Lee,KATHLEEN B. DIGRE
Publisher : Springer
Page : 286 pages
File Size : 47,5 Mb
Release : 2017-11-15
Category : Medical
ISBN : 9783319651217

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A Case-Based Guide to Eye Pain by Michael S. Lee,KATHLEEN B. DIGRE Pdf

Diagnosing a patient with unexplained ocular pain can be time-consuming and difficult, but taking an anatomic approach and excluding causes along the way can aid in the diagnosis. This book provides the reader with a systematic evaluation plan for these cases, written and edited by leaders in the field. A Case-Based Guide to Eye Pain is written for both ophthalmologists and neuro-ophthalmologists since there are not enough neuro-ophthalmologists to treat the number of patients with unexplained ocular pain and general ophthalmologists are having to take on the diagnosis and treatment of these patients. Organized in an easy-to-use manner, each case covers the following key elements: the chief complaint, history of the present illness, the examination, assessment and plan, follow-up, alternate perspective, summary points, and key references. Tables are also available to help the reader rapidly sort through cases that may apply to a sign, symptom, historical feature, diagnostic test or treatment option. This allows the practitioner who has a patient with a particular concern to use the tables to identify a case discussion. Additionally, A Case-based Guide to Eye Pain includes an appendices with the general approach to eye pain and anatomy of the trigeminal pathway and its relation to eye pain.

Author : Simon E. Skalicky
Publisher : Springer
Page : 366 pages
File Size : 48,7 Mb
Release : 2015-11-03
Category : Medical
ISBN : 9789812878465

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Ocular and Visual Physiology by Simon E. Skalicky Pdf

This book meets the growing demand among ophthalmologists, optometrists and orthoptists, in training and in practice, as well as visual neuroscientists, to have a clear, succinct and well-written textbook to objectively cover the subject of ocular and visual physiology. Ocular and visual physiology is a core knowledge component for these disciplines, and yet is often difficult to understand. However, this book clearly conveys the simple elegance of the relationship between structure and function that is the hallmark of understanding the physiology of the eye and visual system. Ocular and Visual Physiology – Clinical Application is essential reading for any one hoping to have a clear understanding of the subject. Students will find it a great resource to pass their exams. Each of the chapters has been independently reviewed and edited by an expert in the field with a clinical or visual scientific academic background. The text is based on the latest publications in peer-reviewed journals that are closely referenced within the body of the text.

Author : F. Bandello,L. Mastropasqua,G. Querques
Publisher : Karger Medical and Scientific Publishers
Page : 146 pages
File Size : 48,5 Mb
Release : 2020-12-07
Category : Medical
ISBN : 9783318066432

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Clinical Applications of Optical Coherence Tomography Angiography by F. Bandello,L. Mastropasqua,G. Querques Pdf

The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded the knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often used as a routine exam in clinical practice, which has significantly modified the approach to patients, granting the opportunity to easily and noninvasively investigate the retinal and choroidal circulation. Major experts in posterior eye imaging share in this publication their experiences, images and ideas using OCTA in various contexts including age-related macular degeneration, diabetic retinopathy and retinal dystrophies, thus providing an in-depth overview of the latest knowledge in this field.

Author : John Penn
Publisher : Springer Science & Business Media
Page : 557 pages
File Size : 40,8 Mb
Release : 2008-01-19
Category : Medical
ISBN : 9781402067808

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Retinal and Choroidal Angiogenesis by John Penn Pdf

This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.

Author : Myron Yanoff,Ben S. Fine
Publisher : Unknown
Page : 792 pages
File Size : 43,9 Mb
Release : 2002
Category : Eye
ISBN : UOM:39015055207065

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Ocular Pathology by Myron Yanoff,Ben S. Fine Pdf

The new, 5th Edition of the premier ocular pathology resource offers the latest information in the field. Over 2095 illustrations *1800 in full color* from the authors' collections represent one of the finest compilations of rare and unusual ocular conditions available. Comprehensive, yet concise, it explores new topics such as complications of corneal surgery, vascular disorders, secondary cataracts, bone-marrow transplant retinopathy, neural retinal detachment, ocular melanotic tumors, and more. Plus, a companion CD-ROM and text/CD-ROM package are available! Explores new topics such as complications of corneal surgery, vascular disorders, secondary cataracts, bone-marrow transplant retinopathy, neural retinal detachment, and ocular melanotic tumors (including diabetes). Offers expanded coverage of entities such as chromosome 17 deletion syndrome, necrobiotic xanthogranuloma, climatic protoglycan stromal keratopathy, unilateral acute idiopathic maculopathy, acute mutifocal retinitis, idiopathic polypoidal choroidal vasculopathy, North Carolina macular dystrophy, familial internal limiting membrane dystrophy, clumped pigmentary retinal dystrophy (clumped pigmentary retinal degeneration), vasoproliferative retinal tumors, Schwartz's syndrome, familial amyloidotic polyneuropathy, familial atypical mole and melanoma (FAM-M) syndrome, and more! Features specific genetic profiles for many existing entities.

Author : Jay Chhablani
Publisher : Springer Nature
Page : 428 pages
File Size : 48,6 Mb
Release : 2020-07-31
Category : Medical
ISBN : 9789811522130

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Choroidal Neovascularization by Jay Chhablani Pdf

The book discusses all aspects of choroidal neovascularization (CNV), including the basics, clinical conditions associated with CNV, clinical trials related to CNV, future directions and rehabilitation. The first section covers the pathogenesis, proposed mechanisms, disease models, histopathology and electronmicroscopy. The next section explores CNV secondary to various clinical conditions, such as age-related macular degeneration (AMD), myopia, and less common conditions like choroidal osteoma. The book also covers clinical features, imaging characteristics, and treatment approaches, as well as clinical trials in CNV conditions with recent updates. Lastly, it features chapters on stem cell therapy, gene therapy, new molecules, and lasers, as well as a section on rehabilitation, which addresses home monitoring and low vision aids. This book is intended for retina specialists, retina fellows and general ophthalmologists.