Opioids And Their Receptors

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Opioids and Their Receptors

Mariana Spetea,Helmut Schmidhammer
Opioids and Their Receptors Book PDF

Author : Mariana Spetea,Helmut Schmidhammer
Publisher : MDPI
Page : 358 pages
File Size : 55,7 Mb
Release : 2020-12-18
Category : Medical
ISBN : 9783036500461

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Opioids and Their Receptors by Mariana Spetea,Helmut Schmidhammer Pdf

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

The Essence of Analgesia and Analgesics

Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford
The Essence of Analgesia and Analgesics Book PDF

Author : Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford
Publisher : Cambridge University Press
Page : 551 pages
File Size : 41,8 Mb
Release : 2010-10-14
Category : Medical
ISBN : 9781139491983

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The Essence of Analgesia and Analgesics by Raymond S. Sinatra,Jonathan S. Jahr,J. Michael Watkins-Pitchford Pdf

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

Opioids in Non-Cancer Pain

Cathy Stannard,Michael Coupe,Tony Pickering
Opioids in Non Cancer Pain Book PDF

Author : Cathy Stannard,Michael Coupe,Tony Pickering
Publisher : Oxford University Press
Page : 121 pages
File Size : 49,7 Mb
Release : 2013-03-21
Category : Medical
ISBN : 9780199678075

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Opioids in Non-Cancer Pain by Cathy Stannard,Michael Coupe,Tony Pickering Pdf

This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.

Opiate Receptors and Antagonists

Reginald Dean,Edward J. Bilsky,S. Stevens Negus
Opiate Receptors and Antagonists Book PDF

Author : Reginald Dean,Edward J. Bilsky,S. Stevens Negus
Publisher : Springer Science & Business Media
Page : 757 pages
File Size : 46,9 Mb
Release : 2009-03-12
Category : Medical
ISBN : 9781597451970

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Opiate Receptors and Antagonists by Reginald Dean,Edward J. Bilsky,S. Stevens Negus Pdf

Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

Opioid Analgesics

A.F. Casy,R.T. Parfitt
Opioid Analgesics Book PDF

Author : A.F. Casy,R.T. Parfitt
Publisher : Springer Science & Business Media
Page : 526 pages
File Size : 44,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489905857

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Opioid Analgesics by A.F. Casy,R.T. Parfitt Pdf

The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

The Opiate Receptors

Gavril Pasternak
The Opiate Receptors Book PDF

Author : Gavril Pasternak
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 47,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781607619901

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The Opiate Receptors by Gavril Pasternak Pdf

The growth of the opiate field over the past decade has been enor mous. Initial interest focused upon the strategic clinical impor tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi gators in almost all areas of neuroscience as well as pharmacol ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo lecular and classical pharmacology of opiates and the opioid pep tides. The issue of multiple classes of opiate and opioid peptide re ceptors and their importance in understanding mechanisms of ac tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.

Opioid Receptors: Advances in Research and Application: 2011 Edition

Anonim
Opioid Receptors Advances in Research and Application 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 104 pages
File Size : 48,7 Mb
Release : 2012-01-09
Category : Psychology
ISBN : 9781464930676

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Opioid Receptors: Advances in Research and Application: 2011 Edition by Anonim Pdf

Opioid Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Opioid Receptors. The editors have built Opioid Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Opioid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Opioid Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Itch

E. Carstens,Tasuku Akiyama
Itch Book PDF

Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Page : 482 pages
File Size : 49,9 Mb
Release : 2014-02-25
Category : Science
ISBN : 9781466505438

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Itch by E. Carstens,Tasuku Akiyama Pdf

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Encyclopedia of Pain

G.F. Gebhart,Robert F. Schmidt
Encyclopedia of Pain Book PDF

Author : G.F. Gebhart,Robert F. Schmidt
Publisher : Springer
Page : 0 pages
File Size : 54,8 Mb
Release : 2013-11-18
Category : Medical
ISBN : 3642287522

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Encyclopedia of Pain by G.F. Gebhart,Robert F. Schmidt Pdf

The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.

Opioids and Their Receptors

Mariana Spetea,Helmut Schmidhammer
Opioids and Their Receptors Book PDF

Author : Mariana Spetea,Helmut Schmidhammer
Publisher : Unknown
Page : 358 pages
File Size : 41,5 Mb
Release : 2020
Category : Electronic
ISBN : 3036500472

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Opioids and Their Receptors by Mariana Spetea,Helmut Schmidhammer Pdf

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Opiate Receptors and Antagonists

Reginald Dean,Edward J. Bilsky,S. Stevens Negus
Opiate Receptors and Antagonists Book PDF

Author : Reginald Dean,Edward J. Bilsky,S. Stevens Negus
Publisher : Humana Press
Page : 757 pages
File Size : 44,8 Mb
Release : 2009-05-04
Category : Medical
ISBN : 1607612283

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Opiate Receptors and Antagonists by Reginald Dean,Edward J. Bilsky,S. Stevens Negus Pdf

Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

Frontiers in Pharmacology of Neurotransmitters

Puneet Kumar,Pran Kishore Deb
Frontiers in Pharmacology of Neurotransmitters Book PDF

Author : Puneet Kumar,Pran Kishore Deb
Publisher : Springer Nature
Page : 729 pages
File Size : 49,8 Mb
Release : 2020-10-29
Category : Medical
ISBN : 9789811535567

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Frontiers in Pharmacology of Neurotransmitters by Puneet Kumar,Pran Kishore Deb Pdf

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

Opioid Sensitivity of Chronic Noncancer Pain

Eija Kalso,Henry J. McQuay
Opioid Sensitivity of Chronic Noncancer Pain Book PDF

Author : Eija Kalso,Henry J. McQuay
Publisher : Progress in Pain Research and
Page : 424 pages
File Size : 41,8 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015041889646

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Opioid Sensitivity of Chronic Noncancer Pain by Eija Kalso,Henry J. McQuay Pdf

Contains papers from the first international research symposium of the International Association for the Study of Pain, held in Helsinki, Finland, Fall 1998. Focus is on opioid responsiveness to neuropathic pain. Papers are arranged in sections on function and dysfunction of opioid receptors, clinical pharmacology of opioids, understanding and improving opioid sensitivity, and opioid sensitivity of different chronic pain states. Specific topics include targeting of opioid receptors to presynaptic sites, route of opioid administration, phenotypic changes induced in dorsal root ganglion neurons by nerve injury, and opioids in headache. Kalso is currently affiliated with the Karolinska Institute in Sweden. IASP member price, $44.85. Annotation copyrighted by Book News, Inc., Portland, OR.

Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence

World Health Organization. Department of Mental Health and Substance Abuse,World Health Organization
Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence Book PDF

Author : World Health Organization. Department of Mental Health and Substance Abuse,World Health Organization
Publisher : World Health Organization
Page : 133 pages
File Size : 48,5 Mb
Release : 2009
Category : Medical
ISBN : 9789241547543

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Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence by World Health Organization. Department of Mental Health and Substance Abuse,World Health Organization Pdf

"These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv

The Opiate Receptors

Gavril W. Pasternak
The Opiate Receptors Book PDF

Author : Gavril W. Pasternak
Publisher : Springer Science & Business Media
Page : 519 pages
File Size : 54,5 Mb
Release : 2010-11-30
Category : Medical
ISBN : 9781607619932

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The Opiate Receptors by Gavril W. Pasternak Pdf

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.