Organ Crosstalk In Acute Kidney Injury

Author : Carlos Guido Musso,Adrian Covic
Publisher : Springer Nature
Page : 219 pages
File Size : 40,7 Mb
Release : 2023-10-14
Category : Medical
ISBN : 9783031367892

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Organ Crosstalk in Acute Kidney Injury by Carlos Guido Musso,Adrian Covic Pdf

This is an original work dedicated to an important and current topic in nephrology: organ crosstalk in acute renal injury. Acute kidney injury is a prevalent and serious syndrome. The related mortality to this syndrome has not been significantly reduced in the last decades despite the advances in renal replacement therapy technology. For this reason, a new approach to obtain an effective treatment is urgently needed. The organ crosstalk perspective could be useful in order to achieve this objective since it implies a very early acute kidney injury diagnose and treatment. This book includes a comprehensive review of the organ crosstalk perspective in acute kidney injury. Organized in two parts, the chapters in the first part present general subjects as an introduction to analysing the crosstalk concept. These chapters give an overview of the concepts of biosemiotics, hormones, neurotransmitters, cytokines, signalling and adhesion molecules, organ intercommunication, and epigenetics. The second part gathers chapters on the different kidney crosstalk, such as brain, lung, heart, liver, gut, and placenta. Finally, there is a chapter dedicated to the influence of renal replacement treatment on kidney crosstalk. Since acute kidney injury is a topic of interest to many health professionals, this work will be a useful resource to general practitioners, internal medicine physicians, geriatricians, nephrologists, critical care therapists, immunologists, and also biologists and bioengineers.

Author : Jonatan Barrera-Chimal,Frederic Jaisser,Natalia Lopez-Andres
Publisher : Frontiers Media SA
Page : 164 pages
File Size : 55,9 Mb
Release : 2021-09-08
Category : Science
ISBN : 9782889712694

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Kidney and Distant Organ Crosstalk in Health and Disease by Jonatan Barrera-Chimal,Frederic Jaisser,Natalia Lopez-Andres Pdf

Author : J.A. Kellum,P.A. McCullough,R.L. Mehta,P.T. Murray,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Page : 218 pages
File Size : 51,9 Mb
Release : 2013-05-14
Category : Medical
ISBN : 9783318024074

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ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes by J.A. Kellum,P.A. McCullough,R.L. Mehta,P.T. Murray,C. Ronco Pdf

Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.

Author : John A. Kellum,C. Ronco,J. L. Vincent
Publisher : Karger Medical and Scientific Publishers
Page : 267 pages
File Size : 48,9 Mb
Release : 2011
Category : Medical
ISBN : 9783805598101

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Controversies in Acute Kidney Injury by John A. Kellum,C. Ronco,J. L. Vincent Pdf

A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.

Author : Yoshio Terada,Takashi Wada,Kent Doi
Publisher : Springer Nature
Page : 390 pages
File Size : 54,9 Mb
Release : 2020-05-14
Category : Medical
ISBN : 9789811511080

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Acute Kidney Injury and Regenerative Medicine by Yoshio Terada,Takashi Wada,Kent Doi Pdf

This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Author : Claudio Ronco,Rinaldo Bellomo,John A. Kellum
Publisher : Karger Medical and Scientific Publishers
Page : 477 pages
File Size : 53,8 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582711

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Acute Kidney Injury by Claudio Ronco,Rinaldo Bellomo,John A. Kellum Pdf

Acute kidney injury is defined as an abrupt change in serum creatinine and/or urine output, and a majority of patients admitted to the ICU have some evidence of the disorder. Unfortunately, treatment for this complex syndrome is as yet lacking and understanding is limited. An interdisciplinary panel of experts has contributed to this volume, illuminating some of the fundamental and complex aspects of the disorder ranging from pathophysiology to treatment, from emerging biomarkers to genetic polymorphisms. Other contributions focus on immunological issues or the many complications of acute kidney injury and co-morbid conditions encountered, covering the fundamentals as well as the latest developments. Moreover, important technical aspects of extracorporeal therapies including vascular access, anticoagulation or fluid composition are introduced, and different approaches to renal support from intermittent dialysis to continuous therapies and hybrid techniques are discussed. A description of advanced extracorporeal techniques of organ support and their role in the management of sepsis and acute kidney injury in the context of an overall strategy of multi-organ failure management concludes the discussions. This volume not only provides a practical and up-to-date summary of current knowledge and technology, but also imparts a fundamental understanding of the pathogenesis and likely future developments in this field. It also serves to challenge and re-examine the fundamental underlying assumptions we hold regarding critical illness in general and acute kidney injury in particular.

Author : Sushrut S. Waikar,Patrick T. Murray,Ajay K. Singh
Publisher : Springer
Page : 373 pages
File Size : 49,9 Mb
Release : 2018-09-14
Category : Medical
ISBN : 9781493986286

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Core Concepts in Acute Kidney Injury by Sushrut S. Waikar,Patrick T. Murray,Ajay K. Singh Pdf

This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis of AKI. This is followed by sections on pathophysiology, clinical syndromes and patient management. Authored by leading clinicians, epidemiologists, basic scientists, and clinical trialists, this book captures the latest evidence and best practices for treating patients with AKI.

Author : Danielle Elise Soranno,Katja Michelle Gist,Michael Zappitelli,Akash Deep
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 51,7 Mb
Release : 2022-01-07
Category : Medical
ISBN : 9782889719983

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Acute Kidney Injury: It’s Not Just Acute, and It’s Not Just the Kidneys by Danielle Elise Soranno,Katja Michelle Gist,Michael Zappitelli,Akash Deep Pdf

Author : Peter A. McCullough,Claudio Ronco
Publisher : Springer Nature
Page : 381 pages
File Size : 54,5 Mb
Release : 2020-11-24
Category : Medical
ISBN : 9783030574604

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Textbook of Cardiorenal Medicine by Peter A. McCullough,Claudio Ronco Pdf

This textbook provides a practical and board-driven resource to describe and define the emerging field of cardiorenal medicine. Covering all aspects of the topic with depth and relevance, this groundbreaking reference brings together experts at the nexus between cardiovascular and renal medicine to provide an exception reference to educate in this critical area of modern medicine. It describes how the heart and kidneys are inextricably linked via hemodynamic, neural, hormonal and cellular signaling systems and, concentrating on disease-based coverage, goes on to review emerging concepts in epidemiology, pathogenesis, screening, diagnosis and the management of cardiorenal syndromes, all extensively illustrated and containing features to support scholarship in the field. Textbook of Cardiorenal Medicine provides consistent chapter organization, clear design and engaging text to define the diagnosis, treatment, intervention and surgical aspects of the full range of conditions encountered within this area of medicine. It is therefore an essential resource to all involved in the management of cardiorenal disease.

Author : Derek S. Wheeler,Hector R. Wong
Publisher : Springer Science & Business Media
Page : 1854 pages
File Size : 42,9 Mb
Release : 2007
Category : Children
ISBN : 1846284635

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Pediatric Critical Care Medicine by Derek S. Wheeler,Hector R. Wong Pdf

This new textbook is the definitive evidence-based resource for pediatric critical care. It is the first ostensibly evidence-based pediatric critical care textbook and will prove an invaluable resource for critical care professionals across the globe.

Author : Giuseppe Castellano,Vincenzo Cantaluppi,Claudio Ronco
Publisher : Frontiers Media SA
Page : 255 pages
File Size : 47,5 Mb
Release : 2022-07-14
Category : Medical
ISBN : 9782889765485

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Dysfunction of the Immune System During Acute Kidney Injury by Giuseppe Castellano,Vincenzo Cantaluppi,Claudio Ronco Pdf

Author : Hemanshu Prabhakar,Nidhi Gupta
Publisher : Springer Nature
Page : 126 pages
File Size : 43,5 Mb
Release : 2020-06-27
Category : Medical
ISBN : 9789811523250

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Brain and Kidney Crosstalk by Hemanshu Prabhakar,Nidhi Gupta Pdf

This book discusses normal brain physiology and renal physiology, as well as the interactions between the two. The physiology of the brain can easily be affected by any changes to the physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together the brain and the renal system help our body systems to function automatically. The book addresses the basic aspects of neurophysiology and renal physiology in three broad sections, the first of which covers the basic principles of cerebral physiology and neural regulation of the renal system. The second part reviews the normal physiology of the renal system, including the mechanism of action, while the last section summarizes the correlation between the brain and kidney. Highly informative and clearly structured, the book provides essential insights for anyone with an interest in physiology and medicine.

Author : C. Ronco,R. Bellomo,P.A. McCullough
Publisher : Karger Medical and Scientific Publishers
Page : 377 pages
File Size : 47,6 Mb
Release : 2010-05-04
Category : Medical
ISBN : 9783805594738

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Cardiorenal Syndromes in Critical Care by C. Ronco,R. Bellomo,P.A. McCullough Pdf

Critical care nephrology is an emerging multidisciplinary science in which the competences of different specialists are merged to provide a unified diagnostic and therapeutic approach to the critically ill patient. The volume at hand places great emphasis on cardiorenal syndromes and the multidisciplinary collaboration between cardiology and nephrology. Several contributions describe the cardiorenal syndrome in its different varieties and subtypes and report the results from the most recent Acute Dialysis Quality Initiative Consensus Conference, as well as proposing new diagnostic approaches based on early biomarkers of AKI. Other papers discuss advances in technology for renal replacement therapy and multiple organ support therapy. Moreover, special emphasis is placed on the potential role of extracorporeal therapies in patients affected by H1N1 influenza, and a summary of the most recent trials in the field is included.Containing the proceedings of the 2010 International Vicenza Course on Critical Care Nephrology, this publication is a state-of-the-art appraisal of today’s technology and current issues related to cardiorenal syndromes.

Author : Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi
Publisher : Oxford University Press
Page : 3045 pages
File Size : 53,6 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780191017650

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Oxford Textbook of Clinical Nephrology by Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi Pdf

This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Author : J.A. Kellum,C. Ronco,J.-L. Vincent
Publisher : Karger Medical and Scientific Publishers
Page : 267 pages
File Size : 51,6 Mb
Release : 2011-09-15
Category : Science
ISBN : 9783805598118

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Controversies in Acute Kidney Injury by J.A. Kellum,C. Ronco,J.-L. Vincent Pdf

Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy.The publication at hand contains sections on prerenal azotemia syndromes, dying ‘of’ or ‘with’ AKI, pathophysiology of sepsis-induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.