Oxford Textbook Of Clinical And Biochemical Disorders Of The Skeleton

Author : Roger Smith,Paul Wordsworth
Publisher : Oxford University Press
Page : 449 pages
File Size : 53,6 Mb
Release : 2016-01-05
Category : Medical
ISBN : 9780191503603

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Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton by Roger Smith,Paul Wordsworth Pdf

Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton 2 is a definitive reference providing comprehensive coverage of common polygenic and rare monogenic disorders, emphasizing new advances in bone cell biology and human skeletal disease. With an up-to-date account of common and rare metabolic disorders of the skeleton, including their causes, clinical aspects, and treatment, this book offers the reader clarity in the complex field of the molecular biology of the skeleton. Topics covered include bone biology and investigation, osteoporosis, osteomalacia and rickets, parathyroid bone disease, Paget disease, and the effects of malignancy on the skeleton. Newer metabolic bone disorders are also included, along with chapters on osteogenesis imperfecta, skeletal dysplasias, osteopetrosis and osteosclerosis, Marfan syndrome, Ehlers-Danlos syndrome, fibrous dysplasia, and ectopic mineralisation. Essential for postgraduates and clinicians, this accessible and highly illustrated book provides a clear authoritative account of metabolic bone diseases in their widest sense. Bringing together considerable advances in the field, it discusses molecular causes and personal experiences of all disorders, ensuring a comprehensive and didactic reference. Enriched with over 100 new illustrations and revised chapters to reflect a rapidly developing field, this second edition will be indispensable for those who look after patients with metabolic bone disease, including general physicians, rheumatologists, endocrinologists, and orthopaedic surgeons, along with paediatricians and geneticists. This print edition of The Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Author : Roger Smith
Publisher : Unknown
Page : 153 pages
File Size : 40,8 Mb
Release : 2007
Category : Electronic
ISBN : 0199235236

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Clinical and biochemical disorders of the skeleton by Roger Smith Pdf

Author : Roger Smith (M.D.),B. Paul Wordsworth
Publisher : Oxford University Press, USA
Page : 471 pages
File Size : 54,8 Mb
Release : 2005
Category : Medical
ISBN : 0192617400

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Clinical and Biochemical Disorders of the Skeleton by Roger Smith (M.D.),B. Paul Wordsworth Pdf

This book is the definitive guide on the subject. It comprehensively covers common polygenic and rare monogenic disorders and emphasizes the new advances which have been made in bone cell biology and in human skeletal disease, particularly as a result of molecular medicine. This accessible and well-illustrated book is written for postgraduates and clinicians who find disorders of the skeleton mysterious, and for whom an understandable explanation has been hard to find. It will be of particular interest to those who look after patients with a wide variety of metabolic bone diseases, including general physicians, rheumatologists, endocrinologists and orthopaedic surgeons, and contains new information of interest to paediatricians and geneticists.

Author : Michael Benson,John Fixsen,Malcolm Macnicol,Klausdieter Parsch
Publisher : Springer Science & Business Media
Page : 868 pages
File Size : 46,5 Mb
Release : 2010-01-23
Category : Medical
ISBN : 9781848826113

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Children’s Orthopaedics and Fractures by Michael Benson,John Fixsen,Malcolm Macnicol,Klausdieter Parsch Pdf

Con?rming the British genetic trait for writing and publishing (as well as acting), two English (Oxford and London) and a Scottish orthopaedic surgeon (Edinburgh) have produced a third edition of their comprehensive text, joined, as in the second edition by an editor from Germany, recognizing its part in the European community. The 62 physician contributors are drawn from pink-colored countries in our childhood geography books—the old British Empire from Australia to Zambia and two from the former colony, the USA. The original purpose of the book was to give residents or registrars an easily accessible and concise description of diseases and conditions encountered in the practice of paediatric orthopaedic surgery and to prepare for their examinations. But the practicing orthopaedic s- geon will ?nd an update of current practice that can be read for clarity and constraint—enough but not too much. A foreword might be a preview of things to come, but a “back word” of what was thought to be the ?nal say on the subject is needed for a perspective in progress. A “back word” look reveals the tremendous progress in medical diagnosis and treatment of which paediatric orthopaedics and fracture care is a component. Clubfoot treatment based on the dictums of Hiram Kite has had a revolutionary change by Ponseti. The chapter by Eastwood has the details on cast application and orthotics follow-up to obtain the 95% correction without the extensive surgery many of us thought was needed.

Author : Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
Publisher : Oxford University Press
Page : 976 pages
File Size : 43,5 Mb
Release : 2018-10-25
Category : Medical
ISBN : 9780190626662

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Bone Dysplasias by Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger Pdf

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Identifying Disabling Medical Conditions Likely to Improve with Treatment
Publisher : National Academies Press
Page : 319 pages
File Size : 41,7 Mb
Release : 2020-07-12
Category : Medical
ISBN : 9780309670951

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Selected Health Conditions and Likelihood of Improvement with Treatment by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Identifying Disabling Medical Conditions Likely to Improve with Treatment Pdf

The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.

Author : Philip Conaghan,Chris Denton,Helen Foster,John Isaacs
Publisher : Oxford University Press
Page : 1553 pages
File Size : 49,7 Mb
Release : 2013-10
Category : Medical
ISBN : 9780199642489

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Oxford Textbook of Rheumatology by Philip Conaghan,Chris Denton,Helen Foster,John Isaacs Pdf

A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.

Author : John A.H. Wass,Paul M. Stewart
Publisher : Oxford University Press, USA
Page : 2158 pages
File Size : 40,9 Mb
Release : 2011-07-28
Category : Medical
ISBN : 9780199235292

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Oxford Textbook of Endocrinology and Diabetes by John A.H. Wass,Paul M. Stewart Pdf

Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.

Author : William H. Harris
Publisher : Oxford University Press
Page : 249 pages
File Size : 48,9 Mb
Release : 2018
Category : Medical
ISBN : 9780190687762

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Vanishing Bone by William H. Harris Pdf

When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as periprosthetic osteolysis, this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone: Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation.

Author : Edward F. McCarthy,Frank J. Frassica
Publisher : Cambridge University Press
Page : 385 pages
File Size : 42,9 Mb
Release : 2014-11-20
Category : Medical
ISBN : 9781107041233

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Pathology of Bone and Joint Disorders Print and Online Bundle by Edward F. McCarthy,Frank J. Frassica Pdf

Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.

Author : Klaus Olgaard,Isidro B. Salusky,Justin Silver
Publisher : Oxford University Press
Page : 617 pages
File Size : 54,7 Mb
Release : 2010-06-10
Category : Medical
ISBN : 9780199559176

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The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease by Klaus Olgaard,Isidro B. Salusky,Justin Silver Pdf

Rev. ed. of: Spectrum of renal osteodystrophy / edited by Tilman Drueke, Isidro B. Salusky. 1st. 2001.

Author : David J. Weatherall,J. G. G. Ledingham,D. A. Warrell
Publisher : Unknown
Page : 1690 pages
File Size : 40,6 Mb
Release : 1996
Category : Internal medicine
ISBN : STANFORD:36105019248405

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Oxford Textbook of Medicine by David J. Weatherall,J. G. G. Ledingham,D. A. Warrell Pdf

Author : Ronald J. Korthuis
Publisher : Morgan & Claypool Publishers
Page : 147 pages
File Size : 52,8 Mb
Release : 2011
Category : Medical
ISBN : 9781615041831

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Skeletal Muscle Circulation by Ronald J. Korthuis Pdf

The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

Author : Michael K. D. Benson
Publisher : Unknown
Page : 744 pages
File Size : 41,9 Mb
Release : 2002
Category : Bone Diseases
ISBN : UOM:39015053510957

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Children's Orthopaedics and Fractures by Michael K. D. Benson Pdf

This comprehensive book on all aspects of the clinical management of pediatric orthopedic disorders and fractures contains sections on common disorders of the skeletal, hematopoietic and neuromuscular systems, inherited and acquired conditions, and diagnosis and management of pediatric fractures. Aimed at both the practicing orthopaedic surgeon and residents preparing for board certification, Children's Orthopaedics and Fractures, 2/e will provide the reader with a complete and detailed review of the field of pediatric orthopedics and trauma. Every paediatric orthopaedic condition discussed in detail, with diagnosis and clinical management. Details on complications and their avoidance in each chapter. Surgical techniques and non-surgical orthopaedic clinical management. Additional material on genetics, anaesthesia and other aspects of the care of the child with an orthopaedic condition. Renowned editors and the expertise of an international list of contributors. Superb illustrations with over 700 black and white prints and over 200 surgical line illustrations. New section on imaging in orthopaedic surgery Many advances in diagnosis and surgical techniques. Greatly expanded chapter on gait analysis. Expanded coverage of trauma, arthroplasty in JCA, pelvic osteotomies, and pre- and post-operative care. Extensively revised chapters on genetic disorders, neural tube defects and infections.

Author : Elizabeth J Price,Anwar R Tappuni
Publisher : Oxford University Press
Page : 432 pages
File Size : 49,7 Mb
Release : 2021-03-11
Category : Medical
ISBN : 9780192529459

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Oxford Textbook of Sjögren's Syndrome by Elizabeth J Price,Anwar R Tappuni Pdf

Sjögren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know. The Oxford Textbook of Sjögren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.