Oxidative Eustress In Exercise Physiology

Author : James N. Cobley,Gareth W. Davison
Publisher : CRC Press
Page : 242 pages
File Size : 40,5 Mb
Release : 2022-06-20
Category : Science
ISBN : 9781000557329

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Oxidative Eustress in Exercise Physiology by James N. Cobley,Gareth W. Davison Pdf

Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Features Defines essential redox biology reactions and concepts in exercise physiology Assesses key redox parameters in an in vivo human exercise context Identifies the challenges, opportunities and boundaries of current knowledge Includes a critique of the underlying mechanisms Summarises examples of translationally important research relating to disease states Related Titles Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1) Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Author : James Cobley,Gareth Davison
Publisher : CRC Press
Page : 228 pages
File Size : 50,8 Mb
Release : 2022
Category : Health & Fitness
ISBN : 1003051618

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Oxidative Eustress in Exercise Physiology by James Cobley,Gareth Davison Pdf

Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Features Defines essential redox biology reactions and concepts in exercise physiology Assesses key redox parameters in an in vivo human exercise context Identifies the challenges, opportunities and boundaries of current knowledge Includes a critique of the underlying mechanisms Summarises examples of translationally important research relating to disease states Related Titles Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1) Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Author : Helmut Sies
Publisher : Academic Press
Page : 876 pages
File Size : 54,5 Mb
Release : 2019-11-07
Category : Science
ISBN : 9780128196960

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Oxidative Stress by Helmut Sies Pdf

Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.

Author : André Kleinridders
Publisher : CRC Press
Page : 416 pages
File Size : 52,6 Mb
Release : 2022-09-06
Category : Medical
ISBN : 9781000643206

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Physiological Consequences of Brain Insulin Action by André Kleinridders Pdf

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer ́s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin ́s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized. Key Features: Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior Describes potential behavioral and pharmacological approaches to support brain insulin signaling

Author : Andreas S. Reichert
Publisher : CRC Press
Page : 211 pages
File Size : 43,6 Mb
Release : 2024-04-15
Category : Science
ISBN : 9781040003220

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The Dynamic Nature of Mitochondria by Andreas S. Reichert Pdf

Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is linked to ageing and human diseases. The following sections give an updated view on mitochondria: Mitochondrial ultrastructure: molecular mechanisms shaping the inner membrane Mitochondrial cristae and lipid dynamics: from super-resolution microscopy to lipid-OXPHOS interplay Mitochondrial control of cellular homeostasis: from redox signalling to interorganellar contact sites Mitochondria in health and disease: from mtDNA release to Complex I assembly Advanced methods in mitochondrial biology and metabolism research Integrative view on mitochondrial research and outlook The field of mitochondrial research has always been full of surprises and has helped science to advance tremendously. It developed hand in hand with landmark developments in technology, such as super-resolution microscopy (nanoscopy), and is currently influencing an increasing number of scientific disciplines. There is still much ‘new’ to find out about this ‘old’ organelle and I think that you can find interesting and also unexpected aspects of mitochondrial biology in this book. I hope the book will enhance your scientific curiosity and inspire your own research.

Author : Iria Medraño-Fernandez,Gerd Patrick Bienert,Roberto Sitia
Publisher : CRC Press
Page : 245 pages
File Size : 41,8 Mb
Release : 2023-10-11
Category : Science
ISBN : 9781000927788

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Peroxiporins by Iria Medraño-Fernandez,Gerd Patrick Bienert,Roberto Sitia Pdf

To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling. Key Features: - Provides a brief history of the discovery and characterization of peroxiporins - Reviews key findings on hydrogen peroxide transport across biological membranes - Discusses the cartography of redox signaling in crowded cells - Includes lavish illustrations and comprehensive images to facilitate teaching - Highlights recent findings, outstanding controversies and open questions

Author : Giuseppe Valacchi,Andreas Daiber
Publisher : CRC Press
Page : 417 pages
File Size : 41,8 Mb
Release : 2023-12-15
Category : Science
ISBN : 9781000970104

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Environmental Stressors and OxInflammatory Tissues Responses by Giuseppe Valacchi,Andreas Daiber Pdf

Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of noncommunicable diseases. Accordingly, there is need for preclinical and clinical studies and comprehensive summary of major findings. This book is a state-of-the-art summary of these myriad severe life stressors. The chapters on the different pollutants focus on disease mechanisms (cardiovascular, neurological and metabolic disorders) and on oxidative stress and inflammation. The editors emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome, epigenetic pathways, and cognitive function by environmental stressors, and introduce the exposome concept while highlighting existing research gaps. Key Features: Links various environmental stressors to the incidence of noncommunicable diseases Includes chapters on airborne toxins, chemical pollutants, noise, and ultraviolet radiation stressors Contributions from an international team of leading researchers Summarizes the impacts of stressors on disease mechanisms

Author : Michael Hamlin,Nick Draper
Publisher : BoD – Books on Demand
Page : 242 pages
File Size : 45,5 Mb
Release : 2013-05-15
Category : Health & Fitness
ISBN : 9789535110316

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Current Issues in Sports and Exercise Medicine by Michael Hamlin,Nick Draper Pdf

This unique resource presents current issues in sports and exercise medicine which outlines new areas of knowledge and provides updates on current knowledge in the broad field of sports and exercise medicine. Written by experts in their own sub-disciplines, Current Issues in Sports and Exercise Medicine discusses the physiology behind sports injuries and presents new and exciting approaches to manage such injuries. In addition, the book explores the relationship between exercise, health and performance by providing new information in areas such as exercise and immunity, the use of iron supplementation for performance, how exercise affects reactive oxygen species, and the proposed benefits of real and simulated altitude training. This book is well referenced and illustrated and will be a valuable resource for sports medicine specialists, physiologists, coaches, physical conditioners, physiotherapists and graduate and medical school students.

Author : Canhua Huang,Yuanyuan Zhang
Publisher : Springer
Page : 0 pages
File Size : 41,5 Mb
Release : 2022-04-27
Category : Science
ISBN : 9811605246

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Oxidative Stress by Canhua Huang,Yuanyuan Zhang Pdf

This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Author : Faiza Alam,Rehana Rehman
Publisher : Elsevier
Page : 370 pages
File Size : 42,6 Mb
Release : 2024-04-26
Category : Medical
ISBN : 9780443188060

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Fundamental Principles of Oxidative Stress in Metabolism and Reproduction by Faiza Alam,Rehana Rehman Pdf

Fundamental Principles of Oxidative Stress in Metabolism and Reproduction: Prevention and Management is a comprehensive resource for anyone needing awareness and recognition of oxidative stress as a basic component of disease to determine the precise treatment plan considering the cause of the disease. It describes the effects of oxidative stress in the human body, the detection of metabolic changes, psychological impact and effect on reproductive outcomes. In addition, it discusses alterations at the cellular level occurring due to oxidative stress along with the genetic aspects involved in its pathogenesis. Provides a holistic approach to the impact of oxidative stress on various systems Incorporates recent advances in basic sciences for improvement in oxidative stress leading to better prognosis of metabolic conditions Summarizes knowledge to detect oxidative stress for improvement of fertility outcomes

Author : Marc-Antoine Custaud,Ronan Padraic Murphy,Olga Vinogradova,Claude Gharib,François Guerrero,Michael D. Delp
Publisher : Frontiers Media SA
Page : 302 pages
File Size : 54,5 Mb
Release : 2022-11-02
Category : Science
ISBN : 9782889748082

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Cardio-vascular Dysfunction and Physiological Manifestations Induced by Environmental Conditions by Marc-Antoine Custaud,Ronan Padraic Murphy,Olga Vinogradova,Claude Gharib,François Guerrero,Michael D. Delp Pdf

Author : George Fink
Publisher : Academic Press
Page : 420 pages
File Size : 42,8 Mb
Release : 2019-01-12
Category : Science
ISBN : 9780128131473

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Stress: Physiology, Biochemistry, and Pathology by George Fink Pdf

Stress impacts the daily lives of humans and all species on Earth. Physiology, Biochemistry, and Pathology, the third volume of the Handbook of Stress series, covers stress-related or induced physiology, biochemistry, and pathology. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the physiology of stress. A sequel to Elsevier’s Encyclopedia of Stress (2000 and 2007), this Handbook of Stress series covers the many significant advances made since then and comprises self-contained volumes that each focus on a specific area within the field of stress. Targeted at scientific and clinical researchers in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, the social sciences, and stress and its management in the workplace, this volume and series are ideal for graduate students, post-doctoral fellows, and faculty interested in stress and its consequences. Chapters offer impressive scope, with topics addressing stress-related or induced physiology, biochemistry, and pathology Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter has a boxed “Key points call out section The volume is fully indexed All chapters are electronically available via ScienceDirect Affordably priced, self-contained volume for readers specifically interested in the physiology, biochemistry and pathology of stress, avoiding the need to purchase the whole Handbook series

Author : Yuwares Malila,Sandra G. Velleman,Casey M. Owens,Francesca Soglia,Marco Zampiga
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 55,5 Mb
Release : 2024-02-08
Category : Science
ISBN : 9782832544532

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The Association between Avian Physiology and Meat Quality by Yuwares Malila,Sandra G. Velleman,Casey M. Owens,Francesca Soglia,Marco Zampiga Pdf

The United Nations has recently released population projections suggesting that the global population will reach 9.7 billion by 2050 and exceed 11 billion by 2100. The increase in the world population may lead to food shortages, especially that of food protein. A variety of food protein alternatives have been developed and launched to the market to solve the problem of diminishing resources, particularly of land and water. In fact, animal protein has become a target in recent times for its greenhouse gas emissions. However, the UN has projected a steady increase in demand for poultry meat over the upcoming decades. The main demand will be from middle class and low-income families in particular and is due mainly to its high production efficiency for inexpensive, good-quality proteins. Nonetheless, due to limited resources, the poultry meat produced must be of high quality to ensure food security and minimize food waste.

Author : Terry McMorris,Phillip Tomporowski,Michel Audiffren
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 50,7 Mb
Release : 2009-04-01
Category : Medical
ISBN : 9780470740675

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Exercise and Cognitive Function by Terry McMorris,Phillip Tomporowski,Michel Audiffren Pdf

This textbook focuses on the relationship between physical exercise and cognition, a very timely and important topic with major theoretical and practical implications for a number of areas including ageing, neurorehabilitation, depression and dementia. It brings together a wide range of analytical approaches and experimental results to provide a very useful overview and synthesis of this growing field of study. The book is divided into three parts: Part I covers the conceptual, theoretical and methodological underpinnings and issues. Part II focuses on advances in exercise and cognition research, with appropriate sub-sections on ‘acute’ and ‘chronic’ exercise and cognition. Part III presents an overview of the area and makes suggestions for the direction of future research. This text provides a cutting-edge examination of this increasingly important area written by leading experts from around the world. The book will prove invaluable to researchers and practitioners in a number of fields, including exercise science, cognitive science, neuroscience and clinical medicine. Key Features: Unique in-depth investigation of the relationship between physical exercise and brain function. Covers theoretical approaches and experimental results and includes chapters on the latest developments in research design. Examines the effects of both acute and chronic exercise on brain function. International list of contributors, who are leading researchers in their field.

Author : Hubert Vaudry,Akira Arimura
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461502432

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Pituitary Adenylate Cyclase-Activating Polypeptide by Hubert Vaudry,Akira Arimura Pdf

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.