Oxygen Transport In Red Blood Cells

Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 52,5 Mb
Release : 2016-08-18
Category : Medical
ISBN : 9781615047215

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Regulation of Tissue Oxygenation, Second Edition by Roland N. Pittman Pdf

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author : Claude Nicolau
Publisher : Elsevier
Page : 207 pages
File Size : 52,6 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483160443

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Oxygen Transport in Red Blood Cells by Claude Nicolau Pdf

Oxygen Transport in Red Blood Cells contains the proceedings of the 12th Aharon Katzir Katchalsky Conference held at Tours, France on April 4-7, 1984. Organized into 16 chapters, this book begins with a discussion on the influence of heme pocket geometry on ligand binding to heme proteins. Subsequent chapters describe a genetic approach to producing oxygen affinity differences; clinical importance of the oxygen transport function of preserved red blood cells; methods for the measurement of oxygen equilibrium curves of red cell suspensions and hemoglobin solutions; and aspects of oxygen supply to tissue. Other chapters elucidate interactions between hemoglobin and erythrocyte membrane and membrane protein oxidation; incorporation of allosteric effectors of hemoglobin in red blood cells; and significance of low hemoglobin oxygen affinity.The interaction of ligands and other molecules with hemoglobin and the storage of red blood cells having incorporated exogenous allosteric effectors of hemoglobin are also explained.

Author : Jurgon Grote
Publisher : Springer Science & Business Media
Page : 753 pages
File Size : 41,7 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781468432732

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Oxygen Transport to Tissue — II by Jurgon Grote Pdf

Author : G. di Prisco,B. Giardina,R.E. Weber
Publisher : Springer Science & Business Media
Page : 140 pages
File Size : 45,9 Mb
Release : 2011-06-28
Category : Science
ISBN : 9788847021112

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Hemoglobin Function in Vertebrates by G. di Prisco,B. Giardina,R.E. Weber Pdf

This volume comprises selected contributions by internationally renowned researchers and represents the state-of-the-art in the field of hemoglobin function in vertebrates living in extreme and temperate environments. The topics have been covered from several viewpoints, including protein chemistry, molecular biology, and evolution. All the contributions chosen for publication focus on phenotypic and genetic adaptations to changing environmental conditions and on gene expression and regulation. The book provides the reader with an update in this field, which is presently enjoying a true renaissance following developments in recent years of powerful methodologies such as site-directed mutagenesis and discoveries of new roles, for example, as oxygen sensors and in nitric oxide metabolism.

Author : Toby L. Simon,Jeffrey McCullough,Edward L. Snyder,Bjarte G. Solheim,Ronald G. Strauss
Publisher : John Wiley & Sons
Page : 754 pages
File Size : 42,5 Mb
Release : 2016-05-23
Category : Medical
ISBN : 9781119012993

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Rossi's Principles of Transfusion Medicine by Toby L. Simon,Jeffrey McCullough,Edward L. Snyder,Bjarte G. Solheim,Ronald G. Strauss Pdf

Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references

Author : Howard Franklin Bunn,Bernard G. Forget,Helen M. Ranney
Publisher : W.B. Saunders Company
Page : 456 pages
File Size : 40,9 Mb
Release : 1977
Category : Hemoglobin
ISBN : UOM:39015026019250

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Human Hemoglobins by Howard Franklin Bunn,Bernard G. Forget,Helen M. Ranney Pdf

Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.

Author : Mikko Nikinmaa
Publisher : Springer Science & Business Media
Page : 273 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642839092

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Vertebrate Red Blood Cells by Mikko Nikinmaa Pdf

This book reviews the respiratory function of vertebrate red cells. I have defined the phrase "respiratory function" broadly to include, in addition to the actual oxygen and carbon dioxide transport, erythropoiesis, haemoglobin synthesis, red cell structure, the deformability of red cells in circulation, ion and substrate transport across the cell membrane, cellular metabolism, and control of cellular volume and pH. All of these aspects of the red cell function may affect gas transport between the respiratory epithelia and the tissues. Throughout the book, I have tried to relate our current knowledge about the nucleated red cell function to the wealth of information about the function of mammalian red cells. However, whenever possible, I have placed the emphasis on the nucleated red cell function for two reasons. First, the erythro cytes of 90% of vertebrate species are nucleated, and, second, nucleated red cell function has not been reviewed earlier in a single volume. This being the case, I have tried to make the reference list as complete as I could with regard to nucleated red cells. I hope that the approach adopted is useful for both com parative and human physiologists. Many people have contributed to the making of this book directly or in directly. Antti Soivio started me in this field. Prof. Henrik Wallgren has always encouraged fresh scientific ideas in his department. My present ideas of red cell function have been influenced by work carried out with Prof. Roy E.

Author : Laura Dean
Publisher : Unknown
Page : 128 pages
File Size : 52,7 Mb
Release : 2005
Category : Blood group antigens
ISBN : OCLC:225053075

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Blood Groups and Red Cell Antigens by Laura Dean Pdf

Author : Forum on Blood Safety and Blood Availability,Institute of Medicine
Publisher : National Academies Press
Page : 132 pages
File Size : 42,7 Mb
Release : 1996-08-09
Category : Medical
ISBN : 9780309589628

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Blood Donors and the Supply of Blood and Blood Products by Forum on Blood Safety and Blood Availability,Institute of Medicine Pdf

This volume discusses the current state of the nation's blood supply--including studies of blood availability, ways of enhancing blood collection and distribution, frozen red cell technology, logistical concerns in prepositioning frozen blood, extended liquid storage of red cells, and blood substitutes.

Author : Hanns-Christian Gunga,Victoria Weller von Ahlefeld,Hans-Joachim Appell Coriolano,Andreas Werner,Uwe Hoffmann
Publisher : Springer
Page : 74 pages
File Size : 49,6 Mb
Release : 2016-07-14
Category : Medical
ISBN : 9783319332260

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Cardiovascular System, Red Blood Cells, and Oxygen Transport in Microgravity by Hanns-Christian Gunga,Victoria Weller von Ahlefeld,Hans-Joachim Appell Coriolano,Andreas Werner,Uwe Hoffmann Pdf

This book comprehensively describes the physiological changes and consequences that occur in humans during spaceflight. It specifically presents the adaptations of the cardiovascular and the respiratory system. Specific changes occurring after 10, 20 or more days in space are depicted. Furthermore, the book explains various effective countermeasures that are required upon return of the astronauts to Earth. The book is a must-have for all biomedical and clinical researchers in the field of cardiovascular biology and respiration, and a fascinating reading for all interested laymen, who wish to understand a bit more about spaceflight research and technology.

Author : Ewald R. Weibel
Publisher : Harvard University Press
Page : 448 pages
File Size : 42,9 Mb
Release : 1984
Category : Medical
ISBN : 0674657918

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The Pathway for Oxygen by Ewald R. Weibel Pdf

It is rare indeed for one book to be both a first-rate classroom text and a major contribution to scholarship. The Pathway for Oxygen is such a book, offering a new approach to respiratory physiology and morphology that quantitatively links the two. Professionalism in science has led to a compartmentalization of biology. Function is the domain of the physiologist, structure that of the morphologist, and they often operate with vastly disparate concepts and procedures. Yet the performance of the respiratory system depends both on structural and on functional properties that cannot be separated. The first chapter of The Pathway for Oxygen engages the student with the design and function of the vertebrate respiratory organs from a comparative viewpoint. The second chapter adds to that foundation the link between cell energetics and oxygen needs of the whole animal. With Chapter 3 the excitement begins--new ideas, fresh attacks on old problems, and a fuller account of the power of the quantitative approach Dr. Weibel has pioneered. The Pathway for Oxygen will be read eagerly by medical students, graduate students, advanced undergraduates in zoology--and by their professors.

Author : Duane F. Bruley
Publisher : Springer Science & Business Media
Page : 903 pages
File Size : 41,9 Mb
Release : 2013-03-14
Category : Nature
ISBN : 9781468448955

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Oxygen Transport to Tissue—VI by Duane F. Bruley Pdf

The theme of the 1983 annual ISOTT meeting emphasizes a dual scientific approach, utilizing interdisciplinary theoretical and experimental methodology, to unravel the secrets of oxygen transport to tissue. ISOTT is leading the way in the development and application of forefront techniques to allow a more basic understanding of this important physiological phenomena. The Society can be proud of its contributions in helping to advance the gross analysis techniques of the past to the synergistic study of tissue micro areas by sophisticated mathematical and experimental means. There is a tremendous need to continue the pursuit of basic knowledge at the regional tissue level and to move rapidly to the examination of fundamental biochemical reactions at the cellular level. To accomplish this, it will be necessary to take advantage of the most powerful computing machinery presently available and to apply state-of-the-art experimental methodology, such as polarographic, autoradiographic and nuclear magnetic resonance techniques in our studies. Our Society must continue to work hard to push back barriers to enhance our understanding of mechanisms that lead to pathology. Hopefully, our efforts will be significant in helping science to overcome the many dreadful diseases that mankind faces in today's world. Duane Bruley Haim Bicher Daniel Reneau v ACKNOWLEDGEMENT We are forever indebted to Connie Staggs and Ellie Topakoglu for their energy and sacrifice in preparing for and managing the 1983 ISOTT meeting.

Author : Joseph C. LaManna,Michelle A. Puchowicz,Kui Xu,David K. Harrison,Duane F. Bruley
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 51,6 Mb
Release : 2011-03-29
Category : Medical
ISBN : 9781441977564

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Oxygen Transport to Tissue XXXII by Joseph C. LaManna,Michelle A. Puchowicz,Kui Xu,David K. Harrison,Duane F. Bruley Pdf

This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

Author : Michael C. Hogan,Odile Mathieu-Costello,David C. Poole,Peter D. Wagner
Publisher : Springer Science & Business Media
Page : 627 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461518754

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Oxygen Transport to Tissue XVI by Michael C. Hogan,Odile Mathieu-Costello,David C. Poole,Peter D. Wagner Pdf

Since its inception in 1973, The International Society on Oxygen Transport to Tissue (ISOTT) has provided a unique forum to facilitate and encourage scientific interaction and debate. Welcoming scientists and clinicians from a broad spectrum of disciplines, each with their own particular skills and expertise, ISOTT unites them under the common theme of oxygen transport. The successful blend of scientific presentations and informal discussion which characterizes ISOTT is epitomized best by the many fundamental discoveries and technical advancements which it has spawned. The breadth and strengths of The Society's scientific base promotes the rapid progression of ideas from theoretical concepts to rigorous scientific testing and often, ultimately to the clinical arena. Each publication of the ISOTT proceedings has been recognized by Science Citation Index listing and the papers frequently establish scientific precedents and become considered as standard works in their respective fields. The 21st ISOTT Meeting was held in San Diego from August 14th through August 18th, 1993. The San Diego Meeting attracted about 150 registrants and 40 accompanying persons. Ten state-of-the-art lectures were presented by international experts in ~ transport and there were in addition two symposia -one dealing with assessment of tissue hypoxia and the other with functional heterogeneity in different organ systems. There were 100 free communications, consisting of posters accompanied by an abbreviated oral summary. All manuscripts were reviewed by the Editors for form and content, but as is customary for the ISOTT proceedings, rigorous scientific peer review was not undertaken.

Author : Peter Vaupel,Rolf Zander,Duane F. Bruley
Publisher : Springer Science & Business Media
Page : 920 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461524687

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Oxygen Transport to Tissue XV by Peter Vaupel,Rolf Zander,Duane F. Bruley Pdf

Seventeen years after the 2nd International Symposium on Oxygen Transport to Tissue, which was held in Mainz in March 1975, the local Organizing Committee and the Board of ISOTT were pleased to host the ISOTT Conference in Mainz on the Rhine again. The venue of the 20th meeting was the prestigious, fully restored Schloss Waldthausen (Waldthausen Castle) which provided a special setting for ISOTT 1992. The beautiful front view of the castle became part of the ISOTT 1992 logo. The 20th ISOTT Meeting was held in Mainz from August 26th through August 30th, 1992. The Conference attracted 200 active participants from 16 countries. The theme of this meeting emphasized oxygen transport to tumors but as in earlier meetings, essentially all aspects of oxygen transport within the body were covered as demonstrated by the manuscripts comprising this volume of the series "Oxygen Transport to Tissue". All manuscripts were reviewed. Extensive revisions were made in about 25% and modest revision in about another 30%. Because we had to compromise between the aim of rapid publication on the one hand and the need for thorough review on the other, minor errors in format and some typographical errors were not corrected. Except for some revisions, all of the original camera-ready manuscripts in this volume were prepared by the authors themselves and we greatly appreciate their cooperation.