Pain Genetics

Author : Jeffrey Steven Mogil
Publisher : Progress in Pain Research and
Page : 376 pages
File Size : 52,7 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015059102452

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The Genetics of Pain by Jeffrey Steven Mogil Pdf

Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).

Author : Inna Belfer,Luda Diatchenko
Publisher : John Wiley & Sons
Page : 255 pages
File Size : 54,8 Mb
Release : 2013-11-15
Category : Science
ISBN : 9781118398852

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Pain Genetics by Inna Belfer,Luda Diatchenko Pdf

Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.

Author : Stephen G. Waxman
Publisher : MIT Press
Page : 320 pages
File Size : 51,7 Mb
Release : 2018-03-09
Category : Medical
ISBN : 9780262037402

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Chasing Men on Fire by Stephen G. Waxman Pdf

A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire. Two soldiers, both with wounds injuring the same nerve, show very different responses: one is disabled by neuropathic pain, unable to touch the injured limb because even the lightest contact triggers excruciating discomfort; the other notices numbness but no pain at all. Could the difference lie in their genes? In this book, described in the foreword by Nobel Laureate James Rothman as “so well written that it reads like a detective novel,” Stephen Waxman recounts the search for a gene that controls pain—a search spanning more than thirty years and three continents. The story moves from genes to pain-signaling neurons that scream when they should be silent to people with a rare genetic disorder who feel they are on fire. Waxman explains that if pain-signaling neurons are injured by trauma or disease, they can become hyperactive and send pain signals to the brain even without external stimulus. Studying the hyperactive mutant pain gene in man on fire syndrome has pointed the way to molecules that produce pain more broadly within the general population, in the rest of us. Waxman's account of the many steps that led to discovery of the pain gene tells the story behind the science, of how science happens.

Author : Anonim
Publisher : Academic Press
Page : 248 pages
File Size : 43,5 Mb
Release : 2018-10-29
Category : Medical
ISBN : 9780128140710

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Epigenetics of Chronic Pain by Anonim Pdf

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Author : Susan G. Dorsey,Angela R. Starkweather
Publisher : Springer Nature
Page : 254 pages
File Size : 43,6 Mb
Release : 2020-06-15
Category : Medical
ISBN : 9783030216573

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Genomics of Pain and Co-Morbid Symptoms by Susan G. Dorsey,Angela R. Starkweather Pdf

This book provides an overview of the field of pain genomics and the genomics of related, or co-occuring, symptoms, the current state-of-the-science, and challenges that remain. It brings differing views in the field together and provides examples of translational science from using cellular and rodent models to human clinical trials. This book's structure leads the reader through the physiology of pain and genomics into how pain is studied, mechanisms of acute and chronic pain, various protocols that are used throughout the field along with the pros/cons of the current methods used, and project into the future of pain genomics. This work is intended for classroom teaching, for nurses, for novice researchers in symptom science and pain research as well as students and postdoctoral fellows.

Author : Inna Belfer,Luda Diatchenko
Publisher : Wiley-Blackwell
Page : 204 pages
File Size : 53,5 Mb
Release : 2013-12-13
Category : Science
ISBN : 1118398874

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Pain Genetics by Inna Belfer,Luda Diatchenko Pdf

Author : Lawrence Kruger,Alan R Light
Publisher : CRC Press
Page : 432 pages
File Size : 45,9 Mb
Release : 2009-11-24
Category : Health & Fitness
ISBN : 9781439812105

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Translational Pain Research by Lawrence Kruger,Alan R Light Pdf

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Author : Daniel M. Doleys PhD
Publisher : Oxford University Press
Page : 306 pages
File Size : 40,6 Mb
Release : 2014-02-18
Category : Medical
ISBN : 9780199331550

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Pain: Dynamics and Complexities by Daniel M. Doleys PhD Pdf

Despite the proliferation of pain clinics and various pain-oriented therapies, there is an absence of data supporting any substantial change in the statistics regarding the incidence, development and persistence of pain. As renowned pain clinician and scientist Daniel M. Doleys argues, there may be a need for a fundamental shift in the way we view pain. In this thoughtful work, Doleys presents the evolving concept and complex nature of pain with the intention of promoting a broadening of the existing paradigm within which pain is viewed and understood. Combining neuroscience, psychology, and philosophy of science, this book reviews the history of pain and outlines the current concepts and theories regarding the mechanisms involved in the experience of pain. Experimental and clinical research in a broad array of areas including neonatal pain, empathy and pain, psychogenic pain, and genetics and pain is summarized. The notion of pain as a disease process rather than a symptom is highlighted. Although there is a continued interest in activation of the peripheral nociceptive system as a determining factor in the experience of pain, the growing appreciation for the brain as the intimate 'pain generator' is emphasized. The definition of consciousness and conscious awareness and a theory as to how it relates to nociceptive processing is discussed. Finally, the author describes the potential benefit of incorporating some of the concepts from systems and quantum theory into our thinking about pain. The area of pain research and treatment seems on the precipice of change. This work intends to provide a glimpse of what these changes might be in the context of where pain research and therapy has come from, where it currently is, and where it might be headed.

Author : Anonim
Publisher : Academic Press
Page : 648 pages
File Size : 53,8 Mb
Release : 2015-03-02
Category : Science
ISBN : 9780128014325

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Molecular and Cell Biology of Pain by Anonim Pdf

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about the future direction of the pain field.

Author : Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publisher : Cambridge University Press
Page : 361 pages
File Size : 52,8 Mb
Release : 2013-04-25
Category : Science
ISBN : 9781107355576

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Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo Pdf

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Author : Gérard Mick,Virginie Guastella
Publisher : Springer
Page : 0 pages
File Size : 48,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 3319374540

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Chronic Postsurgical Pain by Gérard Mick,Virginie Guastella Pdf

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

Author : Josh Dubnau
Publisher : Cambridge University Press
Page : 309 pages
File Size : 43,7 Mb
Release : 2014-06-26
Category : Medical
ISBN : 9781107009035

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Behavioral Genetics of the Fly (Drosophila Melanogaster) by Josh Dubnau Pdf

A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.

Author : Puneetpal Singh ,Monica Singh
Publisher : Bentham Science Publishers
Page : 209 pages
File Size : 52,9 Mb
Release : 2016-11-01
Category : Medical
ISBN : 9781681083711

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Pain: Causes, Concerns and Consequences by Puneetpal Singh ,Monica Singh Pdf

Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized medicine where every patient can be treated according to the set of genes they possess. However, the genetic basis for pain has largely been undefined so far. Research on epigenetic alterations and micro-RNA (miRNA) in relation to the assessment and prevention of pain is still in infancy. Pain: Causes, Concerns and Consequences focuses on pain in human diseases such as cardiac and non-cardiac disorders. This compendium on pain research offers basic information and useful updates on the pathology, genetics, and biomolecular pathways that cause pain. Additionally, readers will also learn about non-pharmacological therapies for pain. The monograph is a handy guide for medical students and doctors in different divisions such as oncology, surgery, neurology, psychiatry, psychology, physiotherapy and chiropractic care. The book also serves as a guide for life science researchers who are planning to develop methods to study pain in either a clinical or laboratory setting.

Author : Emeran A. Mayer,M. Catherine Bushnell
Publisher : Lippincott Williams & Wilkins
Page : 890 pages
File Size : 43,9 Mb
Release : 2015-06-01
Category : Medical
ISBN : 9781496332004

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Functional Pain Syndromes by Emeran A. Mayer,M. Catherine Bushnell Pdf

This book explores the connection of functional pain syndromes (e.g., irritable bowel syndrome and fibromyalgia) with anxiety, depression, chronic fatigue syndrome, and posttraumatic stress disorder. The authors address possible common pathophysiologies and review a range of treatment options, from antidepressants to cognitive-behavioral therapy. Who should buy this book? Whether you are a general practitioner, specialist, or scientist, this book is essential reading. It sheds new light on the complex links between various painful syndromes and disorders.

Author : Marni Jackson
Publisher : A&C Black
Page : 381 pages
File Size : 49,7 Mb
Release : 2012-03-01
Category : Body, Mind & Spirit
ISBN : 9781408830161

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Pain by Marni Jackson Pdf

Why is pain so poorly understood? Why do we still distinguish between mental pain and physical pain, when pain is always an emotional experience? How can it be that science is about to clone a human being but still can't cure the pain of a bad back? If pain is the reason why most people visit the doctor, why are most doctors so bad at addressing the problem of suffering? Marni Jackson's PAIN: THE FIFTH VITAL SIGN is a witty, personal and groundbreaking inquiry into the nature, treatment and definition of human pain, one of the most misunderstood and elusive subjects to challenge humankind. In the questing and narrative manner of Oliver Sacks, Jackson takes us back into the history of pain and forward into the possibilities of pain genetics, Jackson brings us stories both of people in pain and the pain pioneers: eccentrics and artists, wrestlers and writers, psychologists and philosophers, nurses and doctors. Above all, Pain makes an elusive subject vivid and readable. We all know what pain is. Now Marni Jackson has given it a voice.