Palladium Assisted Synthesis Of Heterocycles

Author : Navjeet Kaur
Publisher : CRC Press
Page : 482 pages
File Size : 49,7 Mb
Release : 2019-05-01
Category : Medical
ISBN : 9781351242592

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Palladium Assisted Synthesis of Heterocycles by Navjeet Kaur Pdf

This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.

Author : Jie Jack Li,Gordon W. Gribble
Publisher : Elsevier
Page : 436 pages
File Size : 49,6 Mb
Release : 2000
Category : Science
ISBN : 0080437052

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Palladium in Heterocyclic Chemistry by Jie Jack Li,Gordon W. Gribble Pdf

For this text, Jack Li and Gordon Gribble have compiled an array of referenced examples of the use of palladium in heterocyclic chemistry.

Author : Jie Jack Li,Gordon W. Gribble
Publisher : Elsevier
Page : 658 pages
File Size : 53,8 Mb
Release : 2006-10-20
Category : Science
ISBN : 9780080465845

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Palladium in Heterocyclic Chemistry by Jie Jack Li,Gordon W. Gribble Pdf

Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially. These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 1. Palladium chemistry of heterocycles has its “idiosyncrasies stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of &agr and &bgr activation of heteroaryl halides, Pd-catalyzed chemistry may take place regioselectively at the activated positions, a phenomenon rarely seen in carbocyclic aryl halides. In addition, another salient peculiarity in palladium chemistry of heterocycles is the so-called "heteroaryl Heck reaction". For instance, while intermolecular palladium-catalyzed arylations of carbocyclic arenes are rare, palladium-catalyzed arylations of azoles and many other heterocycles readily take place. Therefore, the principal aim of this book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 2. A myriad of heterocycles are biologically active and therefore of paramount importance to medicinal and agricultural chemists. Many heterocycle-containing natural products (they are highlighted in boxes throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry will keep readers abreast of such a fast-growing field. We also hope this book will spur more interest and inspire ideas in such an extremely useful area. This book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle. The large body of data regarding palladium-mediated polymerization of heterocycles in material chemistry is not focused here; neither is coordination chemistry involving palladium and heterocycles. Many heterocycle-containing natural products (highlighted throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry keeps readers abreast of this fast-growing field. It is also hoped that this book will stimulate more interest and inspire new ideas in this exciting area. Contains the most up-to-date developments in this fast-moving field Includes 3 new chapters Incorporates material from selected well-respected authors on heterocyclic chemistry

Author : Navjeet Kaur
Publisher : CRC Press
Page : 404 pages
File Size : 53,9 Mb
Release : 2020-01-28
Category : Science
ISBN : 9781000733419

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Metals and Non-metals by Navjeet Kaur Pdf

Design of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities—chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a ‘foundational pillar’ of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.

Author : Tamás Patonay,Krisztina Kónya
Publisher : Springer
Page : 362 pages
File Size : 49,7 Mb
Release : 2016-06-15
Category : Science
ISBN : 9783319326108

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Synthesis and Modification of Heterocycles by Metal-Catalyzed Cross-coupling Reactions by Tamás Patonay,Krisztina Kónya Pdf

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.

Author : Jiro Tsuji
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 47,5 Mb
Release : 2005-07-06
Category : Science
ISBN : 3540239820

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Palladium in Organic Synthesis by Jiro Tsuji Pdf

with contributions by numerous experts

Author : Xiao-Feng Wu
Publisher : Catalytic Science Series
Page : 379 pages
File Size : 53,9 Mb
Release : 2016
Category : Heterocyclic chemistry
ISBN : 1783269235

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Noble Metal, Noble Value by Xiao-Feng Wu Pdf

Heterocyclic chemistry constitutes the largest branch of chemistry, covering almost two-thirds of literature in the field. In addition, around 90% of naturally-occurring molecules have heterocycles as their core structure. Therefore, as a central part of organic chemistry, the discovery of new methodologies in synthesizing heterocyclic compounds is essential to their continued application and development. Transition metal catalysts offer a low cost and often low toxicity pathway for heterocycles synthesis, while the use of noble metals represents an alternative form of experimentation which is discussed in the book. Noble Metals, Noble Value provides the first comprehensive analysis of the applications of the noble metals of ruthenium (Ru), rhodium (Rh) and palladium (Pd) catalysts in heterocycles synthesis. Pairs of chapters are dedicated to summarizing each of the metals when applied to either five- or six-membered heterocyclic syntheses. An introduction to the importance of heterocycles and possible procedures for the preparation of heterocyclic compounds is also given. With up to date research and findings, this review is excellently suited to academics and professionals in the field of chemistry, with a particular focus on the specialities of biological, catalytic and organic chemistry.

Author : Navjeet Kaur
Publisher : Elsevier
Page : 232 pages
File Size : 48,5 Mb
Release : 2022-04-04
Category : Science
ISBN : 9780323994934

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Raney Nickel-Assisted Synthesis of Heterocycles by Navjeet Kaur Pdf

Raney Nickel-Assisted Synthesis of Heterocycles covers the synthesis of heterocycles using Raney nickel. The book focuses on the use of Raney-Ni, a common catalyst in hydrogenation reaction and its uses in the synthesis and preparation of heterocycles. Furthermore, it explains how the development of new approaches and strategic deployments in known approaches for the formation of complex heterocyclic compounds continue to drive the field of synthetic organic chemistry, along with updates on efforts to prepare heterocycles through the development of new and efficient synthetic transformations. Heterocyclic chemistry is an inexhaustible source of novel compounds, providing the most diverse chemical, physical and biological properties through the design of a wide range of combinations of carbon, hydrogen and heteroatoms. Significant focus has been paid to novel approaches to the formation of heterocyclic compounds, which are of practical use acting as modifiers and additives in a wide range of industries such as reprography, plastics, cosmetics, vulcanization accelerators, solvents, antioxidants and information storage. Presents complete coverage of Raney Nickel assisted reactions Includes the discovery, reactivities, advantages, disadvantages and other characteristics of Raney nickel Presents new methodologies for the synthesis of heterocycles

Author : Navjeet Kaur
Publisher : Elsevier
Page : 352 pages
File Size : 49,6 Mb
Release : 2023-09-23
Category : Science
ISBN : 9780443161193

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Synthesis of 6- and 7-Membered Heterocycles by Navjeet Kaur Pdf

Synthesis of Six- and Seven-Membered Heterocycles: The Role of DMF and its Synthesis compares different synthetic approaches using DMF, including the advantages and disadvantages of those reactions, green methods, and the sustainability of reported synthetic methodologies, especially the microwave methods. The book presents several methodologies for the synthesis of six- and seven-membered heterocyclic compounds using dimethylformamide. Users will find the most up-to-date information in this fast-moving field which can be particularly challenging. With DMF drawing the attention of synthetic organic chemists, this book will help readers understand further developments in the uses of dimethylformamide beyond just its use as a polar solvent. As it can be expected that the use of dimethylformamide as a precursor will continue to grow in organic synthesis with new applications in sustainable and green chemistry, this book provides an ideal primer on the topics covered. Compares different methods, reagents, reaction conditions, advantages and disadvantages Discusses and compares different methodologies with green techniques Includes reaction schemes, reaction mechanisms and the structure of reactive intermediates

Author : Erik van der Eycken,C. Oliver Kappe
Publisher : Springer
Page : 309 pages
File Size : 43,5 Mb
Release : 2010-11-16
Category : Science
ISBN : 3540819045

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Microwave-Assisted Synthesis of Heterocycles by Erik van der Eycken,C. Oliver Kappe Pdf

Author : Xiao-Feng Wu,Matthias Beller
Publisher : Royal Society of Chemistry
Page : 315 pages
File Size : 46,8 Mb
Release : 2015
Category : Science
ISBN : 9781782621362

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Heterocycles from Double-Functionalized Arenes by Xiao-Feng Wu,Matthias Beller Pdf

The efficient synthesis of heterocycles has become one of the main branches in organic chemistry due to their use in the synthesis of natural products and pharmaceuticals. Current sythentic strategies based on C-H activation methodologies are met with many problems like harsh reaction conditions and low reaction efficiency. Double functionalized chemicals offer a perfect alternative for the synthesis of heterocycles. Heterocycles from Double-Functionalized Arenes starts with a short discussion on the importance of heterocycles and a brief introduction on the preparation of double-functionalized arenes. Specific chapters then look at five-membered heterocycles synthesis, six-membered heterocycles synthesis and macroheterocycles synthesis. This is the first book dedicated to the topic of transition metal catalyzed coupling reactions of double functionalized arenes in heterocycle synthesis and can be used as a handbook for senior researchers and as an introduction for organic chemistry students.

Author : Navjeet Kaur
Publisher : Elsevier
Page : 526 pages
File Size : 53,5 Mb
Release : 2020-05-13
Category : Science
ISBN : 9780128202821

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Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles by Navjeet Kaur Pdf

Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Highlights new methodologies for the synthesis of different six-membered heterocycles Provides an up-to-date overview of this fast-moving field with an easy-to-use structure Includes novel approaches used in the study and application of catalysts in synthetic organic reactions

Author : Hyung Yoon
Publisher : Springer Nature
Page : 236 pages
File Size : 42,7 Mb
Release : 2020-09-02
Category : Science
ISBN : 9783030540777

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Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles by Hyung Yoon Pdf

This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.

Author : Navjeet Kaur
Publisher : Elsevier
Page : 382 pages
File Size : 42,7 Mb
Release : 2023-02-09
Category : Science
ISBN : 9780443152269

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Iodine-Assisted Synthesis of Six- and Seven-Membered Heterocycles by Navjeet Kaur Pdf

Iodine-Assisted Synthesis of Six- and Seven-Membered Heterocycles covers both existing and the latest methods for the synthesis of various six- and seven-membered heterocycles using iodine. Covering an important and rapidly growing branch of heterocyclic chemistry, this book allows users easy access to the synthetic protocols for the synthesis of heterocycles, acting as a guide for how to make these important compounds employed as agrochemicals, pharmaceuticals, and veterinary products, using particular reagents. This book will be of interest to students, pharmacologists, biochemists, and organic and medicinal chemists. Covers different methodologies for the synthesis of six- and seven-membered heterocycles using iodine Includes the applications of six- and seven-membered heterocycles Includes reactions schemes, mechanisms, and illustrations of the structure of reactive intermediates

Author : Peter Joseph Bonk
Publisher : Unknown
Page : 852 pages
File Size : 50,6 Mb
Release : 1985
Category : Electronic
ISBN : WISC:89012850657

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Net [3+2]-type Heterocyclic Synthesis Via Organostannanes and Palladium Chemistry by Peter Joseph Bonk Pdf