Pancreatic Stem Cells

Author : Juan Domínguez-Bendala
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 50,9 Mb
Release : 2009-06-18
Category : Science
ISBN : 9781607611325

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Pancreatic Stem Cells by Juan Domínguez-Bendala Pdf

From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

Author : Juan Domínguez-Bendala
Publisher : Humana Press
Page : 154 pages
File Size : 46,5 Mb
Release : 2010-11-16
Category : Science
ISBN : 1607611368

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Pancreatic Stem Cells by Juan Domínguez-Bendala Pdf

From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

Author : Shimon Efrat
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 46,8 Mb
Release : 2009-12-01
Category : Medical
ISBN : 9781607613664

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Stem Cell Therapy for Diabetes by Shimon Efrat Pdf

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Author : Susumu Seino,Graeme I. Bell
Publisher : Springer Science & Business Media
Page : 475 pages
File Size : 44,7 Mb
Release : 2008-04-08
Category : Science
ISBN : 9784431754527

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Pancreatic Beta Cell in Health and Disease by Susumu Seino,Graeme I. Bell Pdf

The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

Author : Nadey S. Hakim
Publisher : Oxford University Press, USA
Page : 542 pages
File Size : 52,8 Mb
Release : 2010-08-26
Category : Health & Fitness
ISBN : 9780199565863

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Pancreas, Islet and Stem Cell Transplantation for Diabetes by Nadey S. Hakim Pdf

This new edition provides an authoritative account of the current status of whole organ pancreas transplantation and islet and pancreatic stem cell transplantation, reflecting recent advances in the field, including the growing interest in stem cell research applicable to this condition.

Author : Lorenzo Piemonti
Publisher : Springer Nature
Page : 597 pages
File Size : 43,6 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 9783031419430

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Pluripotent Stem Cell Therapy for Diabetes by Lorenzo Piemonti Pdf

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Publisher : National Academies Press
Page : 112 pages
File Size : 44,5 Mb
Release : 2002-01-25
Category : Science
ISBN : 9780309170420

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Stem Cells and the Future of Regenerative Medicine by Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research Pdf

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Author : Gerald Litwack
Publisher : Academic Press
Page : 456 pages
File Size : 46,9 Mb
Release : 2021-03-20
Category : Science
ISBN : 9780323855518

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Hormones and Stem Cells by Gerald Litwack Pdf

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones series Includes the latest information on Hormones and Synapse

Author : Anandwardhan A. Hardikar
Publisher : Springer
Page : 324 pages
File Size : 45,9 Mb
Release : 2016-10-25
Category : Science
ISBN : 9783319453071

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Pancreatic Islet Biology by Anandwardhan A. Hardikar Pdf

This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.

Author : Emanuel Lebenthal
Publisher : Raven Press (ID)
Page : 854 pages
File Size : 42,5 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015014489424

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Human Gastrointestinal Development by Emanuel Lebenthal Pdf

Author : Phuc Van Pham
Publisher : Springer
Page : 326 pages
File Size : 54,7 Mb
Release : 2017-06-07
Category : Science
ISBN : 9783319556871

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Pancreas, Kidney and Skin Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Author : Denis Corbeil
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 41,7 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9781461458944

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by Denis Corbeil Pdf

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Author : David J. Hill
Publisher : Bentham Science Publishers
Page : 253 pages
File Size : 53,8 Mb
Release : 2016-12-02
Category : Science
ISBN : 9781681083650

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Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes by David J. Hill Pdf

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

Author : Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner
Publisher : Academic Press
Page : 560 pages
File Size : 47,8 Mb
Release : 2019-11-10
Category : Science
ISBN : 9780128148327

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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner Pdf

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes

Author : Maria Gazouli,George E. Theodoropoulos
Publisher : Humana
Page : 0 pages
File Size : 52,8 Mb
Release : 2020-07-15
Category : Science
ISBN : 303011967X

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Digestive System Diseases by Maria Gazouli,George E. Theodoropoulos Pdf

This book reviews recent knowledge of the role of stem cells in the gastrointestinal system. It covers extensive topics for each organ, including the pancreas, esophagus, liver, and colon, while also discussing the contributions of stem cells to therapeutic approaches toward gastrointestinal diseases, including inflammatory bowel diseases. Comprehensive and cutting-edge, Digestive System Diseases: Stem Cell Mechanisms and Therapies deepens a reader’s theoretical expertise in gastrointestinal stem cell biology. It furthers scientists’ understanding of gastrointestinal stem cells and, most importantly, the development of novel therapeutic targets. Graduate and postdoctoral students, medical doctors (including gastroenterologists and surgeons), and principal investigators in both academia and industry will benefit from this book. In particular, it is a valuable resource for professionals within the fields of gastrointestinal research, pharmaceutical science, molecular biology, regenerative medicine, and genetics.