Pathology For Toxicologists

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Pathology for Toxicologists

Elizabeth McInnes
Pathology for Toxicologists Book PDF

Author : Elizabeth McInnes
Publisher : John Wiley & Sons
Page : 210 pages
File Size : 43,7 Mb
Release : 2017-05-01
Category : Science
ISBN : 9781118755419

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Pathology for Toxicologists by Elizabeth McInnes Pdf

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary

A Toxicologist's Guide to Clinical Pathology in Animals

John E. Whalan
A Toxicologist s Guide to Clinical Pathology in Animals Book PDF

Author : John E. Whalan
Publisher : Springer
Page : 151 pages
File Size : 48,8 Mb
Release : 2015-03-25
Category : Medical
ISBN : 9783319158532

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A Toxicologist's Guide to Clinical Pathology in Animals by John E. Whalan Pdf

This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.

Fundamental Neuropathology for Pathologists and Toxicologists

Brad Bolon,Mark Butt
Fundamental Neuropathology for Pathologists and Toxicologists Book PDF

Author : Brad Bolon,Mark Butt
Publisher : John Wiley & Sons
Page : 661 pages
File Size : 50,6 Mb
Release : 2011-10-04
Category : Science
ISBN : 9780470227336

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Fundamental Neuropathology for Pathologists and Toxicologists by Brad Bolon,Mark Butt Pdf

This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Fundamentals of Toxicologic Pathology

Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig
Fundamentals of Toxicologic Pathology Book PDF

Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig
Publisher : Academic Press
Page : 714 pages
File Size : 41,7 Mb
Release : 2009-11-23
Category : Medical
ISBN : 0080919324

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Fundamentals of Toxicologic Pathology by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig Pdf

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Toxicologic Pathology for Non-Pathologists

Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza
Toxicologic Pathology for Non Pathologists Book PDF

Author : Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza
Publisher : Springer Nature
Page : 919 pages
File Size : 54,7 Mb
Release : 2019-10-31
Category : Medical
ISBN : 9781493997770

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Toxicologic Pathology for Non-Pathologists by Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza Pdf

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Essentials of Pathology for Toxicologists

Paul Grasso
Essentials of Pathology for Toxicologists Book PDF

Author : Paul Grasso
Publisher : CRC Press
Page : 140 pages
File Size : 46,9 Mb
Release : 2002-03-21
Category : Medical
ISBN : 9780203361535

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Essentials of Pathology for Toxicologists by Paul Grasso Pdf

Currently, the only pathology books available to pathologists are large tomes written for medical and veterinary students. Essentials of Pathology for Toxicologists is an outstanding starting point for those coming to grips with the fundamentals such as cell damage and cell death. It includes discussion on inflammation, hypertrophy, neoplasia, thro

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

Wanda M. Haschek-Hock,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon
Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 1 Principles and Practice of Toxicologic Pathology Book PDF

Author : Wanda M. Haschek-Hock,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon
Publisher : Academic Press
Page : 1154 pages
File Size : 48,7 Mb
Release : 2021-10-20
Category : Medical
ISBN : 9780128218297

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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology by Wanda M. Haschek-Hock,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon Pdf

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Essentials of Pathology for Toxicologists

Paul Grasso
Essentials of Pathology for Toxicologists Book PDF

Author : Paul Grasso
Publisher : CRC Press
Page : 190 pages
File Size : 55,5 Mb
Release : 2002-03-21
Category : Medical
ISBN : 9780415257954

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Essentials of Pathology for Toxicologists by Paul Grasso Pdf

Currently, the only pathology books available to pathologists are large tomes written for medical and veterinary students. Essentials of Pathology for Toxicologists is an outstanding starting point for those coming to grips with the fundamentals such as cell damage and cell death. It includes discussion on inflammation, hypertrophy, neoplasia, thrombosis, restoration and repair, and immune disease. It also contains guidelines for understanding pathologists' reports and their working methods - written specifically for the toxicologist. A thorough hematology glossary also helps toxicologists familiarize themselves with key pathology terms.

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski
The Illustrated Dictionary of Toxicologic Pathology and Safety Science Book PDF

Author : Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski
Publisher : CRC Press
Page : 1741 pages
File Size : 53,8 Mb
Release : 2019-04-26
Category : Medical
ISBN : 9780429655623

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The Illustrated Dictionary of Toxicologic Pathology and Safety Science by Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski Pdf

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Forensic Toxicology

Robert H. Powers,Dorothy E. Dean
Forensic Toxicology Book PDF

Author : Robert H. Powers,Dorothy E. Dean
Publisher : CRC Press
Page : 273 pages
File Size : 46,8 Mb
Release : 2015-12-01
Category : Law
ISBN : 9781466581951

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Forensic Toxicology by Robert H. Powers,Dorothy E. Dean Pdf

Designed for upper-level undergraduate and graduate-level courses, Forensic Toxicology: Mechanisms and Pathology introduces toxicology concepts from a forensic perspective. The book provides an understanding of the mechanistic basis of the action of drugs and toxins, addressing their physiologic and pathologic consequences on the affected organ sys

Toxicologic Pathology

Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath
Toxicologic Pathology Book PDF

Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath
Publisher : CRC Press
Page : 987 pages
File Size : 51,5 Mb
Release : 2013-04-09
Category : Medical
ISBN : 9781439872123

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Toxicologic Pathology by Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath Pdf

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Saf

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski
The Illustrated Dictionary of Toxicologic Pathology and Safety Science Book PDF

Author : Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski
Publisher : CRC Press
Page : 672 pages
File Size : 52,5 Mb
Release : 2019-04-26
Category : Medical
ISBN : 9780429658068

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The Illustrated Dictionary of Toxicologic Pathology and Safety Science by Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski Pdf

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

Pathology for Toxicologists

Elizabeth McInnes
Pathology for Toxicologists Book PDF

Author : Elizabeth McInnes
Publisher : John Wiley & Sons
Page : 216 pages
File Size : 50,5 Mb
Release : 2017-03-24
Category : Science
ISBN : 9781118755303

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Pathology for Toxicologists by Elizabeth McInnes Pdf

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary

Toxicologic Pathology

Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Toxicologic Pathology Book PDF

Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Publisher : CRC Press
Page : 1897 pages
File Size : 55,7 Mb
Release : 2018-08-14
Category : Medical
ISBN : 9780429997457

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Toxicologic Pathology by Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard Pdf

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Background Lesions in Laboratory Animals E-Book

Elizabeth Fiona McInnes
Background Lesions in Laboratory Animals E Book Book PDF

Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
Page : 256 pages
File Size : 42,9 Mb
Release : 2011-10-24
Category : Medical
ISBN : 9780702049248

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Background Lesions in Laboratory Animals E-Book by Elizabeth Fiona McInnes Pdf

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies