Pathophysiology Of Shock Sepsis And Organ Failure

Author : Günther Schlag,Heinz Redl
Publisher : Springer Science & Business Media
Page : 1180 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642767364

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Pathophysiology of Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Author : Günther Schlag,Heinz Redl
Publisher : Springer
Page : 1165 pages
File Size : 46,8 Mb
Release : 1993-05-17
Category : Medical
ISBN : 354054223X

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Pathophysiology of Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Author : Günther Schlag,Heinz Redl
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642586309

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Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.

Author : Günther Schlag,Heinz Redl,John H. Siegel
Publisher : Springer Science & Business Media
Page : 663 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642756443

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Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl,John H. Siegel Pdf

The First Wiggers Bernard Conference on Shock, Sepsis, and Organ Failure was envisaged as a meeting of American and European Scientists. It was named after two researchers, one from the "Old" and one from the "New World", who are wellknown for their outstanding achievements in shock research and experimental medicine. This meeting was a point of de parture for a series of workshops that will focus on two to three main topics dealt with in detail by experts in their respective fields. The First Wiggers Bernard Conference addressed three main questions: 1. Multi-organ-failure - is it a sequence of organ failures or a systemic disease? 2. Cellular events in trauma and sepsis - are they due to suppression, activation or both? 3. Mediators of organ failure - are LPS or sepsis necessary? Although many answers were given in this first session, numerous issues remain to be clarified due to the enormous complexity of the subject. How ever, the stage was set for encounters between clinicians and basic medical researchers, since theoretical knowledge will be useful to the clinician ex ploring new approaches to diagnosis, prophylaxis, and therapy. The conference could not have been organized without the generous sup port of the Immuno Company, Vienna, Austria. May we express our special thanks to Dr. Eibl, managing director and head of the research division of Immuno AG, not only for granting financial support but also for his valuable advice, encouragement, and scientific expertise.

Author : Gil Joon Suh
Publisher : Springer
Page : 147 pages
File Size : 47,6 Mb
Release : 2018-11-30
Category : Medical
ISBN : 9789811054068

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Essentials of Shock Management by Gil Joon Suh Pdf

This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of shock – septic, hemorrhagic, cardiogenic, anaphylactic, and obstructive – at all stages from initial response through to ICU admission. As well as management, the coverage encompasses pathophysiology, clinical presentation, diagnosis, and emerging trends. A further key feature is the use of a scenario-based approach to present a series of cases based on real-life experiences. Here, a narrative style and Q&A form are employed to vividly convey scenarios that may be encountered in clinical practice and to elucidate decision making in complex circumstances. When readers experience difficulty in answering the questions, the earlier sections can be consulted to identify the correct response. This book will be of great value for all health care professionals. In particular, it will be very helpful for novice or inexperienced practitioners in emergency medicine, critical care medicine, and traumatology.

Author : Webb
Publisher : Oxford University Press
Page : 1961 pages
File Size : 51,8 Mb
Release : 2020-01-10
Category : Medical
ISBN : 9780198855439

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Oxford Textbook of Critical Care by Webb Pdf

Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Author : A.E. Baue,G. Berlot,A. Gullo
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9788847022713

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Sepsis and Organ Dysfunction by A.E. Baue,G. Berlot,A. Gullo Pdf

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.

Author : Günther Schlag,Heinz Redl,John H. Siegel
Publisher : Springer Verlag
Page : 660 pages
File Size : 42,7 Mb
Release : 1990-01-01
Category : Medical
ISBN : 0387524959

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Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl,John H. Siegel Pdf

Chronicles the exploits of the mountain men who opened many trails and passages through the American West in the early nineteenth century.

Author : Gunther Schlag,Heinz Redl,John H Siegel
Publisher : Unknown
Page : 468 pages
File Size : 44,6 Mb
Release : 1991-05-17
Category : Electronic
ISBN : 3642765122

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Shock, Sepsis, and Organ Failure by Gunther Schlag,Heinz Redl,John H Siegel Pdf

Author : Konrad Reinhart,Klaus Eyrich,Charles Sprung
Publisher : Springer Science & Business Media
Page : 573 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642850363

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Sepsis by Konrad Reinhart,Klaus Eyrich,Charles Sprung Pdf

The comprehensive coverage of the incidence, etiology, pathophysiology, definition, and therapy of sepsis and septic shock gives you the knowledge you need to keep up with modern therapeutic strategies. The authors are either basic scientists or clinical researchers whose goal is to present the newest aspects of their work in comprehensible language. They clearly show the new perspectives that are emerging in the treatment of sepsis and septic shock.

Author : Arthur E. Baue,Eugen Faist,Donald Fry
Publisher : Springer Science & Business Media
Page : 712 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461212225

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Multiple Organ Failure by Arthur E. Baue,Eugen Faist,Donald Fry Pdf

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Author : G.B. Silva Junior,A. Ferreiro Fuentes,M. Nangaku,G. Remuzzi,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Page : 369 pages
File Size : 53,7 Mb
Release : 2021-11-02
Category : Medical
ISBN : 9783318069372

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Nephrology and Public Health Worldwide by G.B. Silva Junior,A. Ferreiro Fuentes,M. Nangaku,G. Remuzzi,C. Ronco Pdf

Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.

Author : Günther Schlag,Heinz Redl
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642793431

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Shock, Sepsis, and Organ Failure — Nitric Oxide by Günther Schlag,Heinz Redl Pdf

International experts examine the role of nitric oxide in various metabolic events such as septic shock, cardiovascular dysfunction, and trauma and hemorrhagic shock. The nitric oxide pathway and nitric oxide synthesis regulation are also discussed.

Author : Gunther Schlag,Heinz Redl
Publisher : Unknown
Page : 374 pages
File Size : 55,6 Mb
Release : 1995-03-16
Category : Electronic
ISBN : 3642793444

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Shock, Sepsis, and Organ Failure - Nitric Oxide by Gunther Schlag,Heinz Redl Pdf

Author : Jean-Louis Vincent,Jean Carlet,Steven M. Opal
Publisher : Springer Science & Business Media
Page : 848 pages
File Size : 55,5 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306476648

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The Sepsis Text by Jean-Louis Vincent,Jean Carlet,Steven M. Opal Pdf

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.