Patient Z

Author : Stefan Franzen
Publisher : Fulton Books, Inc.
Page : 463 pages
File Size : 45,5 Mb
Release : 2021-06-04
Category : Medical
ISBN : 9781649520340

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Patient Z by Stefan Franzen Pdf

The criminalization of opioid medications has made it all but impossible for pain patients to receive adequate treatment in the United States for more than one hundred years. In 1996, the pain medicine community of doctors attempted to expand the treatment to include patients with severe pain from diseases other than cancer or sickle cell disease. This movement of compassionate care ended definitively in 2016 when a small group of doctors who call themselves Physicians for Responsible Opioid Prescribing (PROP) convinced the Center for Disease Control to take an unusual step to publish new draconian prescribing guidelines. As implemented, current prescribing enforces a hard limit for prescriptions to all patients, regardless of their disease. Furthermore, the new guidelines have not improved either addiction or opioid-overdose rates. Meanwhile, the leaders of PROP are profiting from their role as consultants and expert witnesses for the law firms suing the opioid manufacturers. The book delves into the neurobiology of pain and addiction to explain why pain specialists believe that compassionate care can work. The movement was hijacked by opioid pharmaceutical companies that aggressively marketed opioids to doctors and government agencies that permitted their illegal practices to proceed. This book poses the question: Precisely, how is the massive reduction of prescription medications going to reduce the 80% of the overdose fatalities due to heroin and fentanyl? Instead of curtailing prescription medicine, the appropriate reform would be to treat addiction as a medical condition and include services to prevent and treat addiction as part of pain medicine. Patient Z is a pain patient whose treatment exposes deficiencies in the practice of pain medicine. The story of Patient Z is common to millions of people who have had their pain medication cut in recent years. Persistent pain can affect anyone. Anyone could become Patient Z.

Author : Priya Verma Gupta,Amitha M Hegde
Publisher : JP Medical Ltd
Page : 494 pages
File Size : 40,8 Mb
Release : 2016-03-30
Category : Medical
ISBN : 9789352501939

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Pediatric Dentistry for Special Child by Priya Verma Gupta,Amitha M Hegde Pdf

Pediatric Dentistry for Special Child is a comprehensive and highly illustrated guide to dentistry for children with special needs, covering a wide range of conditions, from Cerebral Palsy to liver disorders, cleft lip and palate, and dyslexia. Each chapter provides management strategies, relevant to a particular paediatric disability. This book is enhanced by over 360 full colour images and illustrations, making it an ideal reference guide for paediatric dentists and paediatricians.

Author : Jonathan Maberry
Publisher : St. Martin's Griffin
Page : 432 pages
File Size : 49,9 Mb
Release : 2009-03-03
Category : Fiction
ISBN : 9781429991629

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Patient Zero by Jonathan Maberry Pdf

When you have to kill the same terrorist twice in one week there's either something wrong with your world or something wrong with your skills... and there's nothing wrong with Joe Ledger's skills. And that's both a good, and a bad thing. It's good because he's a Baltimore detective that has just been secretly recruited by the government to lead a new taskforce created to deal with the problems that Homeland Security can't handle. This rapid response group is called the Department of Military Sciences or the DMS for short. It's bad because his first mission is to help stop a group of terrorists from releasing a dreadful bio-weapon that can turn ordinary people into zombies. The fate of the world hangs in the balance....

Author : Ying Yuan,Hoang Q. Nguyen,Peter F. Thall
Publisher : CRC Press
Page : 233 pages
File Size : 48,5 Mb
Release : 2017-12-19
Category : Mathematics
ISBN : 9781315354224

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Bayesian Designs for Phase I-II Clinical Trials by Ying Yuan,Hoang Q. Nguyen,Peter F. Thall Pdf

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

Author : Amanda Bridgeman
Publisher : Simon and Schuster
Page : 384 pages
File Size : 45,7 Mb
Release : 2021-09-28
Category : Fiction
ISBN : 9781839080210

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Pandemic: Patient Zero by Amanda Bridgeman Pdf

An exciting new series based on the hit family game Pandemic begins with a deadly disease breaking out in darkest Peru - it's up to a crack team of experts to find the source before it spreads, in this taut airport thriller. Bodhi Patel is the brand new Lead Epidemiologist for the world's top epidemic specialists, Global Health Agency, but there's no time to settle in: his new boss, Helen Taylor, deploys GHA to contain a mysterious new killer virus spreading into Brazil. On the ground they learn that the virus is loose in a region controlled by a heavily armed drug warlord, and the race against time to discover a cure just got a whole lot tougher. Meanwhile, Bodhi finds himself with a newly reshuffled team still smarting from the changes, including his ex - the last person he expected to be working with.

Author : David Cella,Elizabeth A. Hahn,Sally E. Jensen,Zeeshan Butt,Cindy J. Nowinski,Nan Rothrock,Kathleen N. Lohr
Publisher : RTI Press
Page : 97 pages
File Size : 44,6 Mb
Release : 2015-09-17
Category : Medical
ISBN : 9781934831144

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Patient-Reported Outcomes in Performance Measurement by David Cella,Elizabeth A. Hahn,Sally E. Jensen,Zeeshan Butt,Cindy J. Nowinski,Nan Rothrock,Kathleen N. Lohr Pdf

Patient-reported outcomes (PROs) are measures of how patients feel or what they are able to do in the context of their health status; PROs are reports, usually on questionnaires, about a patient's health conditions, health behaviors, or experiences with health care that individuals report directly, without modification of responses by clinicians or others; thus, they directly reflect the voice of the patient. PROs cover domains such as physical health, mental and emotional health, functioning, symptoms and symptom burden, and health behaviors. They are relevant for many activities: helping patients and their clinicians make informed decisions about health care, monitoring the progress of care, setting policies for coverage and reimbursement of health services, improving the quality of health care services, and tracking or reporting on the performance of health care delivery organizations. We address the major methodological issues related to choosing, administering, and using PROs for these purposes, particularly in clinical practice settings. We include a framework for best practices in selecting PROs, focusing on choosing appropriate methods and modes for administering PRO measures to accommodate patients with diverse linguistic, cultural, educational, and functional skills, understanding measures developed through both classic and modern test theory, and addressing complex issues relating to scoring and analyzing PRO data.

Author : Guosheng Yin
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 40,9 Mb
Release : 2012-01-03
Category : Medical
ISBN : 9780470581711

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Clinical Trial Design by Guosheng Yin Pdf

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Author : Robert J. Hartsuiker
Publisher : Psychology Press
Page : 344 pages
File Size : 43,8 Mb
Release : 2005
Category : Language Arts & Disciplines
ISBN : 184169262X

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Phonological Encoding and Monitoring in Normal and Pathological Speech by Robert J. Hartsuiker Pdf

Bringing together a range of experts, the editors of this volume aim to show how psycholinguistic models of normal speech processing can be applied to the study of disorders of speech production, such as stuttering, aphasia and verbal dyspraxia.

Author : Rahul K. Shah,Sandip A. Godambe
Publisher : Springer Nature
Page : 394 pages
File Size : 53,7 Mb
Release : 2020-12-15
Category : Medical
ISBN : 9783030558291

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Patient Safety and Quality Improvement in Healthcare by Rahul K. Shah,Sandip A. Godambe Pdf

This text uses a case-based approach to share knowledge and techniques on how to operationalize much of the theoretical underpinnings of hospital quality and safety. Written and edited by leaders in healthcare, education, and engineering, these 22 chapters provide insights as to where the field of improvement and safety science is with regards to the views and aspirations of healthcare advocates and patients. Each chapter also includes vignettes to further solidify the theoretical underpinnings and drive home learning. End of chapter commentary by the editors highlight important concepts and connections between various chapters in the text. Patient Safety and Quality Improvement in Healthcare: A Case-Based Approach presents a novel approach towards hospital safety and quality with the goal to help healthcare providers reach zero harm within their organizations.

Author : Chris Code,Yves Joanette,Andre Roch Lecours,Claus-W. Wallesch
Publisher : Psychology Press
Page : 383 pages
File Size : 55,9 Mb
Release : 2013-01-11
Category : Psychology
ISBN : 9781135817237

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Classic Cases in Neuropsychology, Volume II by Chris Code,Yves Joanette,Andre Roch Lecours,Claus-W. Wallesch Pdf

From a contemporary perspective, Classic Cases in Neuropsychology, Volume II reviews important and significant cases described in historical and modern literature where brain damage has been sustained. The single case study has always been of central importance to the discipline of neuropsychology. Cognitive neuropsychology and cognitive neurolinguistics search for universal structures in thought processes, and single patients are an important means to that end. The role of the single case study in the historical development of the field and its increasing contribution to contemporary work is therefore recognised as crucial. This follow-up to the successful Classic Cases in Neuropsychology (1996) brings together more of the important case investigations which have shaped the way we think about the relationships between brain, behaviour and cognition. The book includes cases from the rich history of neuropsychology as well as important contemporary case studies in the fields of memory, language and perception. Some of the cases described are rare, some are seminal in the field, many were the first of their type to be described and gave rise to new theories, and some are still controversial. As in the first volume, each chapter highlights the relevance of the case to the development of neuropsychology and discusses the theoretical implication of the findings. Classic Cases in Neuropsychology, Volume II will be essential reading for students and researchers alike in the fields of neuropsychology and neuroscience. It will also be of interest to speech and language pathologists, therapists and clinicians in this area.

Author : Wendy Gay Pearson,Susan Knabe
Publisher : arsenal pulp press
Page : 150 pages
File Size : 40,8 Mb
Release : 2012-01-03
Category : Performing Arts
ISBN : 9781551524238

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Zero Patience by Wendy Gay Pearson,Susan Knabe Pdf

A Queer Film Classic on John Greyson's controversial 1993 film musical about the AIDS crisis which combines experimental, camp musical, and documentary aesthetics while refuting the legend of Patient Zero, the male flight attendant accused in Randy Shilts' book And the Band Played On of bringing the AIDS crisis to North America. Wendy Gay Pearson and Susan Knabe both teach in the women's studies and Feminist Research department at the University of Western Ontario. Arsenal's Queer Film Classics series cover some of the most important and influential films about and by LGBTQ people.

Author : Anonim
Publisher : Unknown
Page : 700 pages
File Size : 46,7 Mb
Release : 1898
Category : Brain
ISBN : PRNC:32101074862051

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Brain by Anonim Pdf

Aimed at researchers and clinicians, this journal of neurology balances studies in neurological science with practical clinical articles.

Author : Yvonne Lindbäck
Publisher : Linköping University Electronic Press
Page : 86 pages
File Size : 41,6 Mb
Release : 2019-01-31
Category : Electronic
ISBN : 9789176852767

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Pre-surgery physiotherapy and pain thresholds in patients with degenerative lumbar spine disorders by Yvonne Lindbäck Pdf

Background: Patients scheduled for spinal surgery often experience long duration of pain, which may influence the pain-regulation system, function and health and have an impact on post-surgery outcome. Prehabilitation potentially augments functional capacity before surgery, which may have beneficial effects after surgery. Aim: The overall aim of the thesis is to study pre-surgery physiotherapy and somatosensory function in patients with degenerative lumbar spine disorders and to explore the patients’ experiences of pre-surgery physiotherapy. Methods: Somatosensory function was measured with quantitative sensory testing (QST). Pre-surgery physiotherapy was evaluated with patient-reported outcome measures (n = 197). Patients’ experiences of how symptoms are explained and their experiences of the influences on back-related health after pre-surgery physiotherapy were explored. Results: Half of the patients reported back or leg pain for more than 2 years. On a group level, the somatosensory profiles were within the reference range. On an individual level, an altered somatosensory profile was found in 23/105 patients, these were older, more often women, and reported higher pain, larger pain distribution and worse SF-36 MCS (mental health component summary). Patients with disc herniation, more sensitive to pressure pain in the hand presurgery, was associated with poorer function, self-efficacy, anxiety and depression score pre-surgery, worse function, self-efficacy and leg pain 3 months post-surgery and worse health related quality of life, self-efficacy, depression score 1 year postsurgery. The results for sensitivity for cold pain were similar, except that it even was associated with poorer function and pain 1 year post-surgery. The pre-surgery physiotherapy group had less back pain, better function, health, self-efficacy, fear avoidance score, depression score and physical activity level than the waiting-list group after the pre-surgery intervention. The effects were small. Both groups improved significantly after surgery, with no differences between groups, except that the higher physical activity level in the physiotherapy group remained at the 1-year follow-up. Only 58% of the patients reported a minimum of one visit for rehabilitation during the 1 year preceding the decision to undergo surgery. Patients experienced that pre-surgery physiotherapy had influenced symptoms, physical function, coping, well-being and social functioning to various degrees. Pre-surgery physiotherapy was experienced as a tool for reassurance and an opportunity to reflect about treatment and lifestyle. The patients mainly used biomedical explanatory models based on image reports to explain their backrelated symptoms. Both broader and more narrow, as well as lack of explanations of symptoms emerged. Further, wanting and sometimes struggling to be wellinformed about symptoms and interventions were described. Conclusions: Being more sensitive to pressure- and cold pain in the hand, as a sign of widespread pain pre-surgery, was associated with poorer function, pain and health at post-surgery in patients with disc herniation. Pre-surgery physiotherapy decreased pain, fear avoidance, improved health related quality of life; and it decreased the risk of a worsening in psychological well-being before surgery. The improvements were small, and improvements after surgery were similar for both groups. At the 1-year follow-up, the physiotherapy group still had a higher activity level than the waiting list group. The pre-surgery physiotherapy was well tolerated. Patients’ reported experiences also illustrates the influence on function, pain and health. Patients experienced that pre-surgery physiotherapy provided reassurance and gave time to reflect on treatments and lifestyle. Symptoms were mainly described in line with a biomedical explanatory model. Those using a broader explanation were confident that physiotherapy and self-management could influence their back-related symptoms.

Author : Disha Experts
Publisher : Disha Publications
Page : 599 pages
File Size : 49,6 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9789388919890

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10 in One Study Package for CBSE Mathematics Class 12 with Objective Questions & 3 Sample Papers 3rd Edition by Disha Experts Pdf

Author : Obstetrical Society of London
Publisher : Unknown
Page : 606 pages
File Size : 49,6 Mb
Release : 1889
Category : Obstetrics
ISBN : HARVARD:32044102961257

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Transactions of the Obstetrical Society of London by Obstetrical Society of London Pdf